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P16639

- ATE1_YEAST

UniProt

P16639 - ATE1_YEAST

Protein

Arginyl-tRNA--protein transferase 1

Gene

ATE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues By similarity.By similarity

    Catalytic activityi

    L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

    GO - Molecular functioni

    1. arginyltransferase activity Source: SGD

    GO - Biological processi

    1. protein arginylation Source: SGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:YGL017W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
    Short name:
    Arginyltransferase 1
    Short name:
    R-transferase 1
    Alternative name(s):
    Arginine-tRNA--protein transferase 1
    Gene namesi
    Name:ATE1
    Ordered Locus Names:YGL017W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL017w.
    SGDiS000002985. ATE1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Arginyl-tRNA--protein transferase 1PRO_0000195092Add
    BLAST

    Proteomic databases

    MaxQBiP16639.
    PaxDbiP16639.
    PeptideAtlasiP16639.

    Expressioni

    Gene expression databases

    GenevestigatoriP16639.

    Interactioni

    Protein-protein interaction databases

    BioGridi33229. 14 interactions.
    DIPiDIP-6572N.
    IntActiP16639. 2 interactions.
    MINTiMINT-685454.
    STRINGi4932.YGL017W.

    Structurei

    3D structure databases

    ProteinModelPortaliP16639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the R-transferase family.Curated

    Phylogenomic databases

    eggNOGiCOG2935.
    GeneTreeiENSGT00500000044926.
    HOGENOMiHOG000034123.
    KOiK00685.
    OMAiFLCDTPF.
    OrthoDBiEOG7FV40Z.

    Family and domain databases

    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR017137. Arg-tRNA-P_Trfase_1_euk.
    IPR007472. Arg-tRNA-P_Trfase_C.
    IPR007471. Arg_tRNA_PTrfase_N.
    [Graphical view]
    PfamiPF04377. ATE_C. 1 hit.
    PF04376. ATE_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037207. ATE1_euk. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P16639-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRFVIWAP SMHNEPAAKC GYCHGNKGGN MDQLFALDSW AHRYMNKMDV    50
    VKIENCTIGS FVEHMDVATY DRMCNMGFRR SGKFLYKVDP LRNCCRLYTI 100
    RTAPQELNMT KELKKCISRF ATRITSEDYC PAAVASSDFV GKIVNAEMNS 150
    KTFYTRFEPA LYSEEKYHLF VKYQEKVHQD YNNSPKSFKR FLCDTPFGPE 200
    AVLGTQESWE QLNNWQRMKP GEKLKHMGPV HECYYYEGKL IAITVSDILP 250
    SGISSVYFIW DPDYSKWSLG KLSALRDLAI IQRTNLQYYY LGYYIEDCPK 300
    MNYKANYGAE VLDVCHSKYI PLKPIQDMIS RGKLFVIGEE ETKVTKELYL 350
    VDSETGRGEG FPTDNVVKYK NIAEEIYGVG GCAFKSANES ALELKELYGI 400
    PYEEEDLDTI YHLKEHNGHA PNGIPNVVPG LLPLWELLDI MQSGKITDLE 450
    GRLFLFEIET EGIRPLINFY SEPPNVKKRI CDVIRLFGFE TCMKAVILYS 500
    EQM 503
    Length:503
    Mass (Da):57,930
    Last modified:October 1, 1996 - v2
    Checksum:i4A4A8F1099C0825F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221T → S in AAA34439. (PubMed:2185248)Curated
    Sequence conflicti122 – 1221T → S in AAD13904. (PubMed:1882553)Curated
    Sequence conflicti402 – 4021Y → I in AAA34439. (PubMed:2185248)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05404 Genomic DNA. Translation: AAA34439.1.
    S58126 Genomic DNA. Translation: AAD13904.1.
    Z72539 Genomic DNA. Translation: CAA96717.1.
    BK006941 Genomic DNA. Translation: DAA08081.1.
    PIRiS64019.
    RefSeqiNP_011498.1. NM_001180882.1.

    Genome annotation databases

    EnsemblFungiiYGL017W; YGL017W; YGL017W.
    GeneIDi852867.
    KEGGisce:YGL017W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05404 Genomic DNA. Translation: AAA34439.1 .
    S58126 Genomic DNA. Translation: AAD13904.1 .
    Z72539 Genomic DNA. Translation: CAA96717.1 .
    BK006941 Genomic DNA. Translation: DAA08081.1 .
    PIRi S64019.
    RefSeqi NP_011498.1. NM_001180882.1.

    3D structure databases

    ProteinModelPortali P16639.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33229. 14 interactions.
    DIPi DIP-6572N.
    IntActi P16639. 2 interactions.
    MINTi MINT-685454.
    STRINGi 4932.YGL017W.

    Proteomic databases

    MaxQBi P16639.
    PaxDbi P16639.
    PeptideAtlasi P16639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL017W ; YGL017W ; YGL017W .
    GeneIDi 852867.
    KEGGi sce:YGL017W.

    Organism-specific databases

    CYGDi YGL017w.
    SGDi S000002985. ATE1.

    Phylogenomic databases

    eggNOGi COG2935.
    GeneTreei ENSGT00500000044926.
    HOGENOMi HOG000034123.
    KOi K00685.
    OMAi FLCDTPF.
    OrthoDBi EOG7FV40Z.

    Enzyme and pathway databases

    BioCyci YEAST:YGL017W-MONOMER.

    Miscellaneous databases

    NextBioi 972487.
    PROi P16639.

    Gene expression databases

    Genevestigatori P16639.

    Family and domain databases

    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR017137. Arg-tRNA-P_Trfase_1_euk.
    IPR007472. Arg-tRNA-P_Trfase_C.
    IPR007471. Arg_tRNA_PTrfase_N.
    [Graphical view ]
    Pfami PF04377. ATE_C. 1 hit.
    PF04376. ATE_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037207. ATE1_euk. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae."
      Balzi E., Choder M., Chen W., Varshavsky A., Goffeau A.
      J. Biol. Chem. 265:7464-7471(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance."
      Chen W., Balzi E., Capieaux E., Choder M., Goffeau A.
      Yeast 7:287-299(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 46191 / IL125-2B.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATE1_YEAST
    AccessioniPrimary (citable) accession number: P16639
    Secondary accession number(s): D6VUC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2030 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3