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P16639

- ATE1_YEAST

UniProt

P16639 - ATE1_YEAST

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Protein

Arginyl-tRNA--protein transferase 1

Gene

ATE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).By similarity

Catalytic activityi

L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

GO - Molecular functioni

  1. arginyltransferase activity Source: SGD

GO - Biological processi

  1. protein arginylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:YGL017W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
Gene namesi
Name:ATE1
Ordered Locus Names:YGL017W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL017w.
SGDiS000002985. ATE1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Arginyl-tRNA--protein transferase 1PRO_0000195092Add
BLAST

Proteomic databases

MaxQBiP16639.
PaxDbiP16639.
PeptideAtlasiP16639.

Expressioni

Gene expression databases

GenevestigatoriP16639.

Interactioni

Protein-protein interaction databases

BioGridi33229. 15 interactions.
DIPiDIP-6572N.
IntActiP16639. 2 interactions.
MINTiMINT-685454.
STRINGi4932.YGL017W.

Structurei

3D structure databases

ProteinModelPortaliP16639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

eggNOGiCOG2935.
GeneTreeiENSGT00500000044926.
HOGENOMiHOG000034123.
InParanoidiP16639.
KOiK00685.
OMAiFLCDTPF.
OrthoDBiEOG7FV40Z.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR017137. Arg-tRNA-P_Trfase_1_euk.
IPR007472. Arg-tRNA-P_Trfase_C.
IPR007471. Arg_tRNA_PTrfase_N.
[Graphical view]
PfamiPF04377. ATE_C. 1 hit.
PF04376. ATE_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037207. ATE1_euk. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

P16639-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRFVIWAP SMHNEPAAKC GYCHGNKGGN MDQLFALDSW AHRYMNKMDV
60 70 80 90 100
VKIENCTIGS FVEHMDVATY DRMCNMGFRR SGKFLYKVDP LRNCCRLYTI
110 120 130 140 150
RTAPQELNMT KELKKCISRF ATRITSEDYC PAAVASSDFV GKIVNAEMNS
160 170 180 190 200
KTFYTRFEPA LYSEEKYHLF VKYQEKVHQD YNNSPKSFKR FLCDTPFGPE
210 220 230 240 250
AVLGTQESWE QLNNWQRMKP GEKLKHMGPV HECYYYEGKL IAITVSDILP
260 270 280 290 300
SGISSVYFIW DPDYSKWSLG KLSALRDLAI IQRTNLQYYY LGYYIEDCPK
310 320 330 340 350
MNYKANYGAE VLDVCHSKYI PLKPIQDMIS RGKLFVIGEE ETKVTKELYL
360 370 380 390 400
VDSETGRGEG FPTDNVVKYK NIAEEIYGVG GCAFKSANES ALELKELYGI
410 420 430 440 450
PYEEEDLDTI YHLKEHNGHA PNGIPNVVPG LLPLWELLDI MQSGKITDLE
460 470 480 490 500
GRLFLFEIET EGIRPLINFY SEPPNVKKRI CDVIRLFGFE TCMKAVILYS

EQM
Length:503
Mass (Da):57,930
Last modified:October 1, 1996 - v2
Checksum:i4A4A8F1099C0825F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221T → S in AAA34439. (PubMed:2185248)Curated
Sequence conflicti122 – 1221T → S in AAD13904. (PubMed:1882553)Curated
Sequence conflicti402 – 4021Y → I in AAA34439. (PubMed:2185248)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05404 Genomic DNA. Translation: AAA34439.1.
S58126 Genomic DNA. Translation: AAD13904.1.
Z72539 Genomic DNA. Translation: CAA96717.1.
BK006941 Genomic DNA. Translation: DAA08081.1.
PIRiS64019.
RefSeqiNP_011498.1. NM_001180882.1.

Genome annotation databases

EnsemblFungiiYGL017W; YGL017W; YGL017W.
GeneIDi852867.
KEGGisce:YGL017W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05404 Genomic DNA. Translation: AAA34439.1 .
S58126 Genomic DNA. Translation: AAD13904.1 .
Z72539 Genomic DNA. Translation: CAA96717.1 .
BK006941 Genomic DNA. Translation: DAA08081.1 .
PIRi S64019.
RefSeqi NP_011498.1. NM_001180882.1.

3D structure databases

ProteinModelPortali P16639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33229. 15 interactions.
DIPi DIP-6572N.
IntActi P16639. 2 interactions.
MINTi MINT-685454.
STRINGi 4932.YGL017W.

Proteomic databases

MaxQBi P16639.
PaxDbi P16639.
PeptideAtlasi P16639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL017W ; YGL017W ; YGL017W .
GeneIDi 852867.
KEGGi sce:YGL017W.

Organism-specific databases

CYGDi YGL017w.
SGDi S000002985. ATE1.

Phylogenomic databases

eggNOGi COG2935.
GeneTreei ENSGT00500000044926.
HOGENOMi HOG000034123.
InParanoidi P16639.
KOi K00685.
OMAi FLCDTPF.
OrthoDBi EOG7FV40Z.

Enzyme and pathway databases

BioCyci YEAST:YGL017W-MONOMER.

Miscellaneous databases

NextBioi 972487.
PROi P16639.

Gene expression databases

Genevestigatori P16639.

Family and domain databases

InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR017137. Arg-tRNA-P_Trfase_1_euk.
IPR007472. Arg-tRNA-P_Trfase_C.
IPR007471. Arg_tRNA_PTrfase_N.
[Graphical view ]
Pfami PF04377. ATE_C. 1 hit.
PF04376. ATE_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF037207. ATE1_euk. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae."
    Balzi E., Choder M., Chen W., Varshavsky A., Goffeau A.
    J. Biol. Chem. 265:7464-7471(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance."
    Chen W., Balzi E., Capieaux E., Choder M., Goffeau A.
    Yeast 7:287-299(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 46191 / IL125-2B.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATE1_YEAST
AccessioniPrimary (citable) accession number: P16639
Secondary accession number(s): D6VUC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2030 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3