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Protein

Arginyl-tRNA--protein transferase 1

Gene

ATE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).By similarity

Miscellaneous

Present with 2030 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

GO - Molecular functioni

  • arginyltransferase activity Source: SGD

GO - Biological processi

  • protein arginylation Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:YGL017W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
Gene namesi
Name:ATE1
Ordered Locus Names:YGL017W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL017W
SGDiS000002985 ATE1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950921 – 503Arginyl-tRNA--protein transferase 1Add BLAST503

Proteomic databases

MaxQBiP16639
PaxDbiP16639
PRIDEiP16639

Interactioni

Protein-protein interaction databases

BioGridi33229, 24 interactors
DIPiDIP-6572N
IntActiP16639, 3 interactors
MINTiP16639
STRINGi4932.YGL017W

Structurei

3D structure databases

ProteinModelPortaliP16639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

GeneTreeiENSGT00500000044926
HOGENOMiHOG000034123
InParanoidiP16639
KOiK00685
OMAiCCRLYTI
OrthoDBiEOG092C3AJH

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR030700 N-end_Aminoacyl_Trfase
IPR007472 N-end_Aminoacyl_Trfase_C
IPR007471 N-end_Aminoacyl_Trfase_N
PANTHERiPTHR21367 PTHR21367, 2 hits
PfamiView protein in Pfam
PF04377 ATE_C, 1 hit
PF04376 ATE_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

P16639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRFVIWAP SMHNEPAAKC GYCHGNKGGN MDQLFALDSW AHRYMNKMDV
60 70 80 90 100
VKIENCTIGS FVEHMDVATY DRMCNMGFRR SGKFLYKVDP LRNCCRLYTI
110 120 130 140 150
RTAPQELNMT KELKKCISRF ATRITSEDYC PAAVASSDFV GKIVNAEMNS
160 170 180 190 200
KTFYTRFEPA LYSEEKYHLF VKYQEKVHQD YNNSPKSFKR FLCDTPFGPE
210 220 230 240 250
AVLGTQESWE QLNNWQRMKP GEKLKHMGPV HECYYYEGKL IAITVSDILP
260 270 280 290 300
SGISSVYFIW DPDYSKWSLG KLSALRDLAI IQRTNLQYYY LGYYIEDCPK
310 320 330 340 350
MNYKANYGAE VLDVCHSKYI PLKPIQDMIS RGKLFVIGEE ETKVTKELYL
360 370 380 390 400
VDSETGRGEG FPTDNVVKYK NIAEEIYGVG GCAFKSANES ALELKELYGI
410 420 430 440 450
PYEEEDLDTI YHLKEHNGHA PNGIPNVVPG LLPLWELLDI MQSGKITDLE
460 470 480 490 500
GRLFLFEIET EGIRPLINFY SEPPNVKKRI CDVIRLFGFE TCMKAVILYS

EQM
Length:503
Mass (Da):57,930
Last modified:October 1, 1996 - v2
Checksum:i4A4A8F1099C0825F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122T → S in AAA34439 (PubMed:2185248).Curated1
Sequence conflicti122T → S in AAD13904 (PubMed:1882553).Curated1
Sequence conflicti402Y → I in AAA34439 (PubMed:2185248).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05404 Genomic DNA Translation: AAA34439.1
S58126 Genomic DNA Translation: AAD13904.1
Z72539 Genomic DNA Translation: CAA96717.1
BK006941 Genomic DNA Translation: DAA08081.1
PIRiS64019
RefSeqiNP_011498.1, NM_001180882.1

Genome annotation databases

EnsemblFungiiYGL017W; YGL017W; YGL017W
GeneIDi852867
KEGGisce:YGL017W

Similar proteinsi

Entry informationi

Entry nameiATE1_YEAST
AccessioniPrimary (citable) accession number: P16639
Secondary accession number(s): D6VUC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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