Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock 70 kDa protein 1-like

Gene

Hspa1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17ATPBy similarity4
Nucleotide bindingi204 – 206ATPBy similarity3
Nucleotide bindingi270 – 277ATPBy similarity8
Nucleotide bindingi341 – 344ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 1-like
Short name:
Heat shock 70 kDa protein 1L
Alternative name(s):
Heat shock 70 kDa-like protein 1
Spermatid-specific heat shock protein 70
Gene namesi
Name:Hspa1l
Synonyms:Hsc70t
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96231. Hspa1l.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: MGI
  • cell body Source: MGI
  • COP9 signalosome Source: Ensembl
  • cytosol Source: MGI
  • mitochondrial matrix Source: Ensembl
  • zona pellucida receptor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782561 – 641Heat shock 70 kDa protein 1-likeAdd BLAST641

Proteomic databases

EPDiP16627.
MaxQBiP16627.
PaxDbiP16627.
PRIDEiP16627.

2D gel databases

REPRODUCTION-2DPAGEIPI00133208.
P16627.

PTM databases

iPTMnetiP16627.
PhosphoSitePlusiP16627.
SwissPalmiP16627.

Expressioni

Tissue specificityi

Expressed in spermatids.

Developmental stagei

Specifically expressed in postmeiotic phases of spermatogenesis.

Gene expression databases

BgeeiENSMUSG00000007033.
CleanExiMM_HSPA1L.
ExpressionAtlasiP16627. baseline and differential.
GenevisibleiP16627. MM.

Interactioni

Subunit structurei

Interacts with PARK2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200429. 3 interactors.
IntActiP16627. 5 interactors.
MINTiMINT-120078.
STRINGi10090.ENSMUSP00000007248.

Structurei

3D structure databases

ProteinModelPortaliP16627.
SMRiP16627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00860000133911.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiP16627.
KOiK03283.
OMAiKELENMC.
OrthoDBiEOG091G03SF.
PhylomeDBiP16627.
TreeFamiTF105042.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANKGMAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQSDMK LWPFQVINEA
110 120 130 140 150
GKPKVMVSYK GEKKAFYPEE ISSMVLTKMK ETAEAFLGHN VTNAVITVPA
160 170 180 190 200
YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKG SHGERHVLIF
210 220 230 240 250
DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK
260 270 280 290 300
HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT
310 320 330 340 350
RARFEELCAD LFRGTLEPVE KSLRDAKMDK AKIHDIVLVG GSTRIPKVQK
360 370 380 390 400
LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP
410 420 430 440 450
LSLGLETAGG VMTVLIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA
460 470 480 490 500
MTRDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TAMDKSTGKA
510 520 530 540 550
NKITITNDKG RLSKEEIERM VQEAERYKAE DEGQREKIAA KNALESYAFN
560 570 580 590 600
MKSAVGDEGL KDKISESDKK KILDKCNEVL SWLEANQLAE KDEFDHKRKE
610 620 630 640
LENMCNPIIT KLYQSGCTGP TCTPGYTPGR AATGPTIEEV D
Length:641
Mass (Da):70,637
Last modified:December 21, 2004 - v4
Checksum:i94CA15217B03BC28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti570K → N in BAA32522 (PubMed:9685725).Curated1
Sequence conflicti634G → D in AAA74906 (PubMed:2302214).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32218 mRNA. Translation: AAA74906.1.
L27086 Genomic DNA. Translation: AAA59362.1.
D85732 mRNA. Translation: BAA32522.1.
AF109906 Genomic DNA. Translation: AAC84170.1.
CCDSiCCDS28670.1.
PIRiA34041.
I49761.
RefSeqiNP_038586.2. NM_013558.2.
UniGeneiMm.14287.

Genome annotation databases

EnsembliENSMUST00000007248; ENSMUSP00000007248; ENSMUSG00000007033.
GeneIDi15482.
KEGGimmu:15482.
UCSCiuc008ceq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32218 mRNA. Translation: AAA74906.1.
L27086 Genomic DNA. Translation: AAA59362.1.
D85732 mRNA. Translation: BAA32522.1.
AF109906 Genomic DNA. Translation: AAC84170.1.
CCDSiCCDS28670.1.
PIRiA34041.
I49761.
RefSeqiNP_038586.2. NM_013558.2.
UniGeneiMm.14287.

3D structure databases

ProteinModelPortaliP16627.
SMRiP16627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200429. 3 interactors.
IntActiP16627. 5 interactors.
MINTiMINT-120078.
STRINGi10090.ENSMUSP00000007248.

PTM databases

iPTMnetiP16627.
PhosphoSitePlusiP16627.
SwissPalmiP16627.

2D gel databases

REPRODUCTION-2DPAGEIPI00133208.
P16627.

Proteomic databases

EPDiP16627.
MaxQBiP16627.
PaxDbiP16627.
PRIDEiP16627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007248; ENSMUSP00000007248; ENSMUSG00000007033.
GeneIDi15482.
KEGGimmu:15482.
UCSCiuc008ceq.1. mouse.

Organism-specific databases

CTDi3305.
MGIiMGI:96231. Hspa1l.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00860000133911.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiP16627.
KOiK03283.
OMAiKELENMC.
OrthoDBiEOG091G03SF.
PhylomeDBiP16627.
TreeFamiTF105042.

Miscellaneous databases

PROiP16627.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007033.
CleanExiMM_HSPA1L.
ExpressionAtlasiP16627. baseline and differential.
GenevisibleiP16627. MM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS71L_MOUSE
AccessioniPrimary (citable) accession number: P16627
Secondary accession number(s): O88686, Q61693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.