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P16620

- PTP69_DROME

UniProt

P16620 - PTP69_DROME

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Protein
Tyrosine-protein phosphatase 69D
Gene
Ptp69D, DPTP, CG10975
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible cell adhesion receptor.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1097 – 10971Phosphocysteine intermediate By similarity
Active sitei1391 – 13911Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: FlyBase
  2. transmembrane receptor protein tyrosine phosphatase activity Source: FlyBase

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. axonal defasciculation Source: FlyBase
  3. axonogenesis Source: FlyBase
  4. cell adhesion Source: UniProtKB-KW
  5. defasciculation of motor neuron axon Source: FlyBase
  6. dendrite morphogenesis Source: FlyBase
  7. lateral inhibition Source: FlyBase
  8. motor neuron axon guidance Source: FlyBase
  9. peptidyl-tyrosine dephosphorylation Source: GOC
  10. protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 69D (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase
Short name:
DPTP
Gene namesi
Name:Ptp69D
Synonyms:DPTP
ORF Names:CG10975
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0014007. Ptp69D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 805777Extracellular Reviewed prediction
Add
BLAST
Transmembranei806 – 82318Helical; Reviewed prediction
Add
BLAST
Topological domaini824 – 1462639Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: FlyBase
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 14621434Tyrosine-protein phosphatase 69D
PRO_0000025428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi45 ↔ 112 Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi154 ↔ 214 Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi255 – 2551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi429 – 4291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi613 – 6131N-linked (GlcNAc...)1 Publication
Glycosylationi701 – 7011N-linked (GlcNAc...)1 Publication
Glycosylationi755 – 7551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16620.
PRIDEiP16620.

Expressioni

Gene expression databases

BgeeiP16620.

Interactioni

Protein-protein interaction databases

BioGridi64791. 6 interactions.
IntActiP16620. 3 interactions.
MINTiMINT-5227360.

Structurei

3D structure databases

ProteinModelPortaliP16620.
SMRiP16620. Positions 853-1447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12597Ig-like C2-type 1
Add
BLAST
Domaini131 – 230100Ig-like C2-type 2
Add
BLAST
Domaini237 – 33296Fibronectin type-III 1
Add
BLAST
Domaini334 – 435102Fibronectin type-III 2
Add
BLAST
Domaini439 – 547109Fibronectin type-III 3
Add
BLAST
Domaini893 – 1156264Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1187 – 1450264Tyrosine-protein phosphatase 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00680000099951.
InParanoidiP16620.
KOiK01104.
OMAiYNGWPTV.
OrthoDBiEOG7034G2.
PhylomeDBiP16620.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P16620-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALLYRRMSM LLNIILAYIF LCAICVQGSV KQEWAEIGKN VSLECASENE     50
AVAWKLGNQT INKNHTRYKI RTEPLKSNDD GSENNDSQDF IKYKNVLALL 100
DVNIKDSGNY TCTAQTGQNH STEFQVRPYL PSKVLQSTPD RIKRKIKQDV 150
MLYCLIEMYP QNETTNRNLK WLKDGSQFEF LDTFSSISKL NDTHLNFTLE 200
FTEVYKKENG TYKCTVFDDT GLEITSKEIT LFVMEVPQVS IDFAKAVGAN 250
KIYLNWTVND GNDPIQKFFI TLQEAGTPTF TYHKDFINGS HTSYILDHFK 300
PNTTYFLRIV GKNSIGNGQP TQYPQGITTL SYDPIFIPKV ETTGSTASTI 350
TIGWNPPPPD LIDYIQYYEL IVSESGEVPK VIEEAIYQQN SRNLPYMFDK 400
LKTATDYEFR VRACSDLTKT CGPWSENVNG TTMDGVATKP TNLSIQCHHD 450
NVTRGNSIAI NWDVPKTPNG KVVSYLIHLL GNPMSTVDRE MWGPKIRRID 500
EPHHKTLYES VSPNTNYTVT VSAITRHKKN GEPATGSCLM PVSTPDAIGR 550
TMWSKVNLDS KYVLKLYLPK ISERNGPICC YRLYLVRINN DNKELPDPEK 600
LNIATYQEVH SDNVTRSSAY IAEMISSKYF RPEIFLGDEK RFSENNDIIR 650
DNDEICRKCL EGTPFLRKPE IIHIPPQGSL SNSDSELPIL SEKDNLIKGA 700
NLTEHALKIL ESKLRDKRNA VTSDENPILS AVNPNVPLHD SSRDVFDGEI 750
DINSNYTGFL EIIVRDRNNA LMAYSKYFDI ITPATEAEPI QSLNNMDYYL 800
SIGVKAGAVL LGVILVFIVL WVFHHKKTKN ELQGEDTLTL RDSLSRALFG 850
RRNHNHSHFI TSGNHKGFDA GPIHRLDLEN AYKNRHKDTD YGFLREYEML 900
PNRFSDRTTK NSDLKENACK NRYPDIKAYD QTRVKLAVIN GLQTTDYINA 950
NFVIGYKERK KFICAQGPME STIDDFWRMI WEQHLEIIVM LTNLEEYNKA 1000
KCAKYWPEKV FDTKQFGDIL VKFAQERKTG DYIERTLNVS KNKANVGEEE 1050
DRRQITQYHY LTWKDFMAPE HPHGIIKFIR QINSVYSLQR GPILVHCSAG 1100
VGRTGTLVAL DSLIQQLEEE DSVSIYNTVC DLRHQRNFLV QSLKQYIFLY 1150
RALLDTGTFG NTDICIDTMA SAIESLKRKP NEGKCKLEVE FEKLLATADE 1200
ISKSCSVGEN EENNMKNRSQ EIIPYDRNRV ILTPLPMREN STYINASFIE 1250
GYDNSETFII AQDPLENTIG DFWRMISEQS VTTLVMISEI GDGPRKCPRY 1300
WADDEVQYDH ILVKYVHSES CPYYTRREFY VTNCKIDDTL KVTQFQYNGW 1350
PTVDGEVPEV CRGIIELVDQ AYNHYKNNKN SGCRSPLTVH CSLGTDRSSI 1400
FVAMCILVQH LRLEKCVDIC ATTRKLRSQR TGLINSYAQY EFLHRAIINY 1450
SDLHHIAEST LD 1462
Length:1,462
Mass (Da):167,460
Last modified:August 30, 2005 - v2
Checksum:i61214ADC778D319A
GO
Isoform B (identifier: P16620-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     845-845: Missing.

Note: No experimental confirmation available.

Show »
Length:1,461
Mass (Da):167,373
Checksum:i6E5B21C7402C65DD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei845 – 8451Missing in isoform B.
VSP_015257

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911I → M in AAA28842. 1 Publication
Sequence conflicti98 – 981A → T in AAA28842. 1 Publication
Sequence conflicti105 – 1051K → N in AAA28842. 1 Publication
Sequence conflicti127 – 1271R → K in AAA28842. 1 Publication
Sequence conflicti638 – 6381D → A in AAA28842. 1 Publication
Sequence conflicti651 – 6511D → G in AAA28842. 1 Publication
Sequence conflicti990 – 9901M → I in AAA28842. 1 Publication
Sequence conflicti1189 – 11891V → M in AAA28842. 1 Publication
Sequence conflicti1265 – 12651L → F in AAA28842. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27699 mRNA. Translation: AAA28842.1.
AE014296 Genomic DNA. Translation: AAF49892.2.
AE014296 Genomic DNA. Translation: AAO41254.1.
BT001531 mRNA. Translation: AAN71286.1.
PIRiB36182.
RefSeqiNP_524048.2. NM_079324.3. [P16620-1]
NP_788502.1. NM_176324.2. [P16620-2]
UniGeneiDm.945.

Genome annotation databases

EnsemblMetazoaiFBtr0075913; FBpp0075645; FBgn0014007. [P16620-1]
GeneIDi39443.
KEGGidme:Dmel_CG10975.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27699 mRNA. Translation: AAA28842.1 .
AE014296 Genomic DNA. Translation: AAF49892.2 .
AE014296 Genomic DNA. Translation: AAO41254.1 .
BT001531 mRNA. Translation: AAN71286.1 .
PIRi B36182.
RefSeqi NP_524048.2. NM_079324.3. [P16620-1 ]
NP_788502.1. NM_176324.2. [P16620-2 ]
UniGenei Dm.945.

3D structure databases

ProteinModelPortali P16620.
SMRi P16620. Positions 853-1447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64791. 6 interactions.
IntActi P16620. 3 interactions.
MINTi MINT-5227360.

Proteomic databases

PaxDbi P16620.
PRIDEi P16620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0075913 ; FBpp0075645 ; FBgn0014007 . [P16620-1 ]
GeneIDi 39443.
KEGGi dme:Dmel_CG10975.

Organism-specific databases

CTDi 39443.
FlyBasei FBgn0014007. Ptp69D.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00680000099951.
InParanoidi P16620.
KOi K01104.
OMAi YNGWPTV.
OrthoDBi EOG7034G2.
PhylomeDBi P16620.

Miscellaneous databases

GenomeRNAii 39443.
NextBioi 813657.

Gene expression databases

Bgeei P16620.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila."
    Streuli M., Krueger N.X., Tsai A.Y.M., Saito H.
    Proc. Natl. Acad. Sci. U.S.A. 86:8698-8702(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), POSSIBLE FUNCTION, CATALYTIC ACTIVITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-613 AND ASN-701, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPTP69_DROME
AccessioniPrimary (citable) accession number: P16620
Secondary accession number(s): Q8IGY3, Q9VU03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi