P16620 (PTP69_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase 69D
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase
Short name=DPTP

Gene names

Name:	Ptp69D
Synonyms:	DPTP
ORF Names:	CG10975

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possible cell adhesion receptor. Ref.1
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Ref.1
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. Contains 3 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW defasciculation of motor neuron axon Inferred from mutant phenotype PubMed 8598046. Source: FlyBase dendrite morphogenesis Inferred from mutant phenotype PubMed 17164414. Source: FlyBase lateral inhibition Inferred from mutant phenotype PubMed 19363474. Source: FlyBase motor neuron axon guidance Inferred from mutant phenotype PubMed 8598046. Source: FlyBase
Cellular_component	axon Inferred from direct assay PubMed 18237413. Source: FlyBase integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 20462449. Source: FlyBase
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Inferred from sequence or structural similarity Ref.1. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P16620-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P16620-2)

The sequence of this isoform differs from the canonical sequence as follows:
     845-845: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1462	1434	Tyrosine-protein phosphatase 69D		PRO_0000025428
Regions
	Topological domain	29 – 805	777	Extracellular Potential
	Transmembrane	806 – 823	18	Helical; Potential
	Topological domain	824 – 1462	639	Cytoplasmic Potential
	Domain	29 – 125	97	Ig-like C2-type 1
	Domain	131 – 230	100	Ig-like C2-type 2
	Domain	234 – 327	94	Fibronectin type-III 1
	Domain	338 – 432	95	Fibronectin type-III 2
	Domain	436 – 540	105	Fibronectin type-III 3
	Domain	893 – 1156	264	Tyrosine-protein phosphatase 1
	Domain	1187 – 1450	264	Tyrosine-protein phosphatase 2
Sites
	Active site	1097	1	Phosphocysteine intermediate By similarity
	Active site	1391	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Glycosylation	58	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
	Glycosylation	196	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	429	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential
	Glycosylation	516	1	N-linked (GlcNAc...) Potential
	Glycosylation	613	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	701	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	755	1	N-linked (GlcNAc...) Potential
	Disulfide bond	45 ↔ 112		Potential
	Disulfide bond	154 ↔ 214		Potential
Natural variations
	Alternative sequence	845	1	Missing in isoform B.		VSP_015257
Experimental info
	Sequence conflict	91	1	I → M in AAA28842. Ref.1
	Sequence conflict	98	1	A → T in AAA28842. Ref.1
	Sequence conflict	105	1	K → N in AAA28842. Ref.1
	Sequence conflict	127	1	R → K in AAA28842. Ref.1
	Sequence conflict	638	1	D → A in AAA28842. Ref.1
	Sequence conflict	651	1	D → G in AAA28842. Ref.1
	Sequence conflict	990	1	M → I in AAA28842. Ref.1
	Sequence conflict	1189	1	V → M in AAA28842. Ref.1
	Sequence conflict	1265	1	L → F in AAA28842. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified August 30, 2005. Version 2. Checksum: 61214ADC778D319A	FASTA	1,462	167,460
	10 20 30 40 50 60 MALLYRRMSM LLNIILAYIF LCAICVQGSV KQEWAEIGKN VSLECASENE AVAWKLGNQT 70 80 90 100 110 120 INKNHTRYKI RTEPLKSNDD GSENNDSQDF IKYKNVLALL DVNIKDSGNY TCTAQTGQNH 130 140 150 160 170 180 STEFQVRPYL PSKVLQSTPD RIKRKIKQDV MLYCLIEMYP QNETTNRNLK WLKDGSQFEF 190 200 210 220 230 240 LDTFSSISKL NDTHLNFTLE FTEVYKKENG TYKCTVFDDT GLEITSKEIT LFVMEVPQVS 250 260 270 280 290 300 IDFAKAVGAN KIYLNWTVND GNDPIQKFFI TLQEAGTPTF TYHKDFINGS HTSYILDHFK 310 320 330 340 350 360 PNTTYFLRIV GKNSIGNGQP TQYPQGITTL SYDPIFIPKV ETTGSTASTI TIGWNPPPPD 370 380 390 400 410 420 LIDYIQYYEL IVSESGEVPK VIEEAIYQQN SRNLPYMFDK LKTATDYEFR VRACSDLTKT 430 440 450 460 470 480 CGPWSENVNG TTMDGVATKP TNLSIQCHHD NVTRGNSIAI NWDVPKTPNG KVVSYLIHLL 490 500 510 520 530 540 GNPMSTVDRE MWGPKIRRID EPHHKTLYES VSPNTNYTVT VSAITRHKKN GEPATGSCLM 550 560 570 580 590 600 PVSTPDAIGR TMWSKVNLDS KYVLKLYLPK ISERNGPICC YRLYLVRINN DNKELPDPEK 610 620 630 640 650 660 LNIATYQEVH SDNVTRSSAY IAEMISSKYF RPEIFLGDEK RFSENNDIIR DNDEICRKCL 670 680 690 700 710 720 EGTPFLRKPE IIHIPPQGSL SNSDSELPIL SEKDNLIKGA NLTEHALKIL ESKLRDKRNA 730 740 750 760 770 780 VTSDENPILS AVNPNVPLHD SSRDVFDGEI DINSNYTGFL EIIVRDRNNA LMAYSKYFDI 790 800 810 820 830 840 ITPATEAEPI QSLNNMDYYL SIGVKAGAVL LGVILVFIVL WVFHHKKTKN ELQGEDTLTL 850 860 870 880 890 900 RDSLSRALFG RRNHNHSHFI TSGNHKGFDA GPIHRLDLEN AYKNRHKDTD YGFLREYEML 910 920 930 940 950 960 PNRFSDRTTK NSDLKENACK NRYPDIKAYD QTRVKLAVIN GLQTTDYINA NFVIGYKERK 970 980 990 1000 1010 1020 KFICAQGPME STIDDFWRMI WEQHLEIIVM LTNLEEYNKA KCAKYWPEKV FDTKQFGDIL 1030 1040 1050 1060 1070 1080 VKFAQERKTG DYIERTLNVS KNKANVGEEE DRRQITQYHY LTWKDFMAPE HPHGIIKFIR 1090 1100 1110 1120 1130 1140 QINSVYSLQR GPILVHCSAG VGRTGTLVAL DSLIQQLEEE DSVSIYNTVC DLRHQRNFLV 1150 1160 1170 1180 1190 1200 QSLKQYIFLY RALLDTGTFG NTDICIDTMA SAIESLKRKP NEGKCKLEVE FEKLLATADE 1210 1220 1230 1240 1250 1260 ISKSCSVGEN EENNMKNRSQ EIIPYDRNRV ILTPLPMREN STYINASFIE GYDNSETFII 1270 1280 1290 1300 1310 1320 AQDPLENTIG DFWRMISEQS VTTLVMISEI GDGPRKCPRY WADDEVQYDH ILVKYVHSES 1330 1340 1350 1360 1370 1380 CPYYTRREFY VTNCKIDDTL KVTQFQYNGW PTVDGEVPEV CRGIIELVDQ AYNHYKNNKN 1390 1400 1410 1420 1430 1440 SGCRSPLTVH CSLGTDRSSI FVAMCILVQH LRLEKCVDIC ATTRKLRSQR TGLINSYAQY 1450 1460 EFLHRAIINY SDLHHIAEST LD
	Isoform B [UniParc]. Checksum: 6E5B21C7402C65DD	FASTA	1,461	167,373
	10 20 30 40 50 60 MALLYRRMSM LLNIILAYIF LCAICVQGSV KQEWAEIGKN VSLECASENE AVAWKLGNQT 70 80 90 100 110 120 INKNHTRYKI RTEPLKSNDD GSENNDSQDF IKYKNVLALL DVNIKDSGNY TCTAQTGQNH 130 140 150 160 170 180 STEFQVRPYL PSKVLQSTPD RIKRKIKQDV MLYCLIEMYP QNETTNRNLK WLKDGSQFEF 190 200 210 220 230 240 LDTFSSISKL NDTHLNFTLE FTEVYKKENG TYKCTVFDDT GLEITSKEIT LFVMEVPQVS 250 260 270 280 290 300 IDFAKAVGAN KIYLNWTVND GNDPIQKFFI TLQEAGTPTF TYHKDFINGS HTSYILDHFK 310 320 330 340 350 360 PNTTYFLRIV GKNSIGNGQP TQYPQGITTL SYDPIFIPKV ETTGSTASTI TIGWNPPPPD 370 380 390 400 410 420 LIDYIQYYEL IVSESGEVPK VIEEAIYQQN SRNLPYMFDK LKTATDYEFR VRACSDLTKT 430 440 450 460 470 480 CGPWSENVNG TTMDGVATKP TNLSIQCHHD NVTRGNSIAI NWDVPKTPNG KVVSYLIHLL 490 500 510 520 530 540 GNPMSTVDRE MWGPKIRRID EPHHKTLYES VSPNTNYTVT VSAITRHKKN GEPATGSCLM 550 560 570 580 590 600 PVSTPDAIGR TMWSKVNLDS KYVLKLYLPK ISERNGPICC YRLYLVRINN DNKELPDPEK 610 620 630 640 650 660 LNIATYQEVH SDNVTRSSAY IAEMISSKYF RPEIFLGDEK RFSENNDIIR DNDEICRKCL 670 680 690 700 710 720 EGTPFLRKPE IIHIPPQGSL SNSDSELPIL SEKDNLIKGA NLTEHALKIL ESKLRDKRNA 730 740 750 760 770 780 VTSDENPILS AVNPNVPLHD SSRDVFDGEI DINSNYTGFL EIIVRDRNNA LMAYSKYFDI 790 800 810 820 830 840 ITPATEAEPI QSLNNMDYYL SIGVKAGAVL LGVILVFIVL WVFHHKKTKN ELQGEDTLTL 850 860 870 880 890 900 RDSLRALFGR RNHNHSHFIT SGNHKGFDAG PIHRLDLENA YKNRHKDTDY GFLREYEMLP 910 920 930 940 950 960 NRFSDRTTKN SDLKENACKN RYPDIKAYDQ TRVKLAVING LQTTDYINAN FVIGYKERKK 970 980 990 1000 1010 1020 FICAQGPMES TIDDFWRMIW EQHLEIIVML TNLEEYNKAK CAKYWPEKVF DTKQFGDILV 1030 1040 1050 1060 1070 1080 KFAQERKTGD YIERTLNVSK NKANVGEEED RRQITQYHYL TWKDFMAPEH PHGIIKFIRQ 1090 1100 1110 1120 1130 1140 INSVYSLQRG PILVHCSAGV GRTGTLVALD SLIQQLEEED SVSIYNTVCD LRHQRNFLVQ 1150 1160 1170 1180 1190 1200 SLKQYIFLYR ALLDTGTFGN TDICIDTMAS AIESLKRKPN EGKCKLEVEF EKLLATADEI 1210 1220 1230 1240 1250 1260 SKSCSVGENE ENNMKNRSQE IIPYDRNRVI LTPLPMRENS TYINASFIEG YDNSETFIIA 1270 1280 1290 1300 1310 1320 QDPLENTIGD FWRMISEQSV TTLVMISEIG DGPRKCPRYW ADDEVQYDHI LVKYVHSESC 1330 1340 1350 1360 1370 1380 PYYTRREFYV TNCKIDDTLK VTQFQYNGWP TVDGEVPEVC RGIIELVDQA YNHYKNNKNS 1390 1400 1410 1420 1430 1440 GCRSPLTVHC SLGTDRSSIF VAMCILVQHL RLEKCVDICA TTRKLRSQRT GLINSYAQYE 1450 1460 FLHRAIINYS DLHHIAESTL D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila." Streuli M., Krueger N.X., Tsai A.Y.M., Saito H. Proc. Natl. Acad. Sci. U.S.A. 86:8698-8702(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), POSSIBLE FUNCTION, CATALYTIC ACTIVITY.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Strain: Berkeley. Tissue: Embryo.
[5]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-613 AND ASN-701, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M27699 mRNA. Translation: AAA28842.1. AE014296 Genomic DNA. Translation: AAF49892.2. AE014296 Genomic DNA. Translation: AAO41254.1. BT001531 mRNA. Translation: AAN71286.1.
PIR	B36182.
RefSeq	NP_524048.2. NM_079324.3. NP_788502.1. NM_176324.2.
UniGene	Dm.945.
3D structure databases
ProteinModelPortal	P16620.
SMR	P16620. Positions 853-1447.
ModBase	Search...
Protein-protein interaction databases
IntAct	P16620. 2 interactions.
Proteomic databases
PaxDb	P16620.
PRIDE	P16620.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0075913; FBpp0075645; FBgn0014007.
GeneID	39443.
KEGG	dme:Dmel_CG10975.
Organism-specific databases
CTD	39443.
FlyBase	FBgn0014007. Ptp69D.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00680000099951.
InParanoid	P16620.
KO	K01104.
OMA	NWTVNDG.
OrthoDB	EOG4N5TBN.
PhylomeDB	P16620.
Gene expression databases
Bgee	P16620.
GermOnline	CG10975. Drosophila melanogaster.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 3 hits. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 3 hits. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 3 hits. PS50835. IG_LIKE. 2 hits. PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	39443.
NextBio	813657.

Entry information

Entry name

PTP69_DROME

Accession

Primary (citable) accession number: P16620
Secondary accession number(s): Q8IGY3, Q9VU03

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project