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P16619

- CL3L1_HUMAN

UniProt

P16619 - CL3L1_HUMAN

Protein

C-C motif chemokine 3-like 1

Gene

CCL3L1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei25 – 262Cleavage; by DPP4Curated

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB
    4. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 3-like 1
    Alternative name(s):
    G0/G1 switch regulatory protein 19-2
    LD78-beta(1-70)
    PAT 464.2
    Small-inducible cytokine A3-like 1
    Tonsillar lymphocyte LD78 beta protein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CCL3L1
    Synonyms:D17S1718, G0S19-2, SCYA3L1
    AND
    Name:CCL3L3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10628. CCL3L1.
    HGNC:30554. CCL3L3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9370C-C motif chemokine 3-like 1PRO_0000005161Add
    BLAST
    Chaini26 – 9368LD78-beta(3-70)PRO_0000005162Add
    BLAST
    Chaini28 – 9366LD78-beta(5-70)PRO_0000005163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Post-translational modificationi

    The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP16619.
    PRIDEiP16619.

    Miscellaneous databases

    PMAP-CutDBP16619.

    Expressioni

    Gene expression databases

    BgeeiP16619.
    CleanExiHS_CCL3L1.
    HS_CCL3L3.
    GenevestigatoriP16619.

    Interactioni

    Protein-protein interaction databases

    BioGridi112253. 3 interactions.
    STRINGi9606.ENSP00000367605.

    Structurei

    3D structure databases

    ProteinModelPortaliP16619.
    SMRiP16619. Positions 27-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG304839.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP16619.
    KOiK05408.
    OMAiLCAMALC.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiP16619.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVSTAALAV LLCTMALCNQ VLSAPLAADT PTACCFSYTS RQIPQNFIAD   50
    YFETSSQCSK PSVIFLTKRG RQVCADPSEE WVQKYVSDLE LSA 93
    Length:93
    Mass (Da):10,161
    Last modified:August 1, 1990 - v1
    Checksum:iA7A79E774006D61E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911L → P in AAP35429. 1 PublicationCurated
    Sequence conflicti91 – 911L → P in AAH07783. (PubMed:15489334)Curated

    Polymorphismi

    The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52149 mRNA. Translation: CAA36397.1.
    M24110 Genomic DNA. Translation: AAA35859.1.
    D90145 Genomic DNA. Translation: BAA14173.1.
    BT006783 mRNA. Translation: AAP35429.1.
    BC007783 mRNA. Translation: AAH07783.1.
    BC027888 mRNA. Translation: AAH27888.1.
    BC107710 mRNA. Translation: AAI07711.1.
    BC146914 mRNA. Translation: AAI46915.1.
    BC146919 mRNA. Translation: AAI46920.1.
    BC147008 mRNA. Translation: AAI47009.1.
    BC147013 mRNA. Translation: AAI47014.1.
    CCDSiCCDS11310.1.
    CCDS32626.1.
    PIRiB35673.
    RefSeqiNP_001001437.2. NM_001001437.3.
    NP_066286.1. NM_021006.5.
    UniGeneiHs.454713.
    Hs.512683.

    Genome annotation databases

    GeneIDi414062.
    6349.
    KEGGihsa:414062.
    hsa:6349.
    UCSCiuc002hlf.2. human.

    Polymorphism databases

    DMDMi127077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52149 mRNA. Translation: CAA36397.1 .
    M24110 Genomic DNA. Translation: AAA35859.1 .
    D90145 Genomic DNA. Translation: BAA14173.1 .
    BT006783 mRNA. Translation: AAP35429.1 .
    BC007783 mRNA. Translation: AAH07783.1 .
    BC027888 mRNA. Translation: AAH27888.1 .
    BC107710 mRNA. Translation: AAI07711.1 .
    BC146914 mRNA. Translation: AAI46915.1 .
    BC146919 mRNA. Translation: AAI46920.1 .
    BC147008 mRNA. Translation: AAI47009.1 .
    BC147013 mRNA. Translation: AAI47014.1 .
    CCDSi CCDS11310.1.
    CCDS32626.1.
    PIRi B35673.
    RefSeqi NP_001001437.2. NM_001001437.3.
    NP_066286.1. NM_021006.5.
    UniGenei Hs.454713.
    Hs.512683.

    3D structure databases

    ProteinModelPortali P16619.
    SMRi P16619. Positions 27-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112253. 3 interactions.
    STRINGi 9606.ENSP00000367605.

    Polymorphism databases

    DMDMi 127077.

    Proteomic databases

    PaxDbi P16619.
    PRIDEi P16619.

    Protocols and materials databases

    DNASUi 6349.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414062.
    6349.
    KEGGi hsa:414062.
    hsa:6349.
    UCSCi uc002hlf.2. human.

    Organism-specific databases

    CTDi 414062.
    6349.
    GeneCardsi GC17M034523.
    GC17M034623.
    H-InvDB HIX0023281.
    HIX0135348.
    HGNCi HGNC:10628. CCL3L1.
    HGNC:30554. CCL3L3.
    MIMi 601395. gene.
    609468. gene.
    neXtProti NX_P16619.
    PharmGKBi PA35560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304839.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P16619.
    KOi K05408.
    OMAi LCAMALC.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi P16619.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    GeneWikii CCL3L1.
    NextBioi 108388.
    PMAP-CutDB P16619.
    PROi P16619.
    SOURCEi Search...

    Gene expression databases

    Bgeei P16619.
    CleanExi HS_CCL3L1.
    HS_CCL3L3.
    Genevestigatori P16619.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q."
      Irving S.G., Zipfel P.F., Balke J., McBride O.W., Morton C.C., Burd P.R., Siebenlist U., Kelly K.
      Nucleic Acids Res. 18:3261-3270(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.
    2. "Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation."
      Blum S., Forsdyke R.E., Forsdyke D.R.
      DNA Cell Biol. 9:589-602(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structures of human genes coding for cytokine LD78 and their expression."
      Nakao M., Nomiyama H., Shimada K.
      Mol. Cell. Biol. 10:3646-3658(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell, Brain, Pancreas and Spleen.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38.
    7. "Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist."
      Proost P., Menten P., Struyf S., Schutyser E., De Meester I., Van Damme J.
      Blood 96:1674-1680(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF LD78-BETA(3-70) AND LD78-BETA(5-70), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.
    8. "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils."
      Struyf S., Menten P., Lenaerts J.-P., Put W., D'Haese A., De Clercq E., Schols D., Proost P., Van Damme J.
      Eur. J. Immunol. 31:2170-2178(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."
      Shao W., Tang J., Song W., Wang C., Li Y., Wilson C.M., Kaslow R.A.
      Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM OF GENE COPY NUMBER.

    Entry informationi

    Entry nameiCL3L1_HUMAN
    AccessioniPrimary (citable) accession number: P16619
    Secondary accession number(s): A6NGK6
    , B2RUX4, Q3B7A8, Q53YA5, Q96I68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3