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P16619 (CL3L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 3-like 1
Alternative name(s):
G0/G1 switch regulatory protein 19-2
LD78-beta(1-70)
PAT 464.2
Small-inducible cytokine A3-like 1
Tonsillar lymphocyte LD78 beta protein

Cleaved into the following 2 chains:

  1. LD78-beta(3-70)
  2. LD78-beta(5-70)
Gene names
Name:CCL3L1
Synonyms:D17S1718, G0S19-2, SCYA3L1
AND
Name:CCL3L3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Ref.7 Ref.8

Subcellular location

Secreted.

Post-translational modification

The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.

Polymorphism

The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 9370C-C motif chemokine 3-like 1
PRO_0000005161
Chain26 – 9368LD78-beta(3-70)
PRO_0000005162
Chain28 – 9366LD78-beta(5-70)
PRO_0000005163

Sites

Site25 – 262Cleavage; by DPP4 Probable

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Experimental info

Sequence conflict911L → P in AAP35429. Ref.4
Sequence conflict911L → P in AAH07783. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P16619 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: A7A79E774006D61E

FASTA9310,161
        10         20         30         40         50         60 
MQVSTAALAV LLCTMALCNQ VLSAPLAADT PTACCFSYTS RQIPQNFIAD YFETSSQCSK 

        70         80         90 
PSVIFLTKRG RQVCADPSEE WVQKYVSDLE LSA 

« Hide

References

« Hide 'large scale' references
[1]"Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q."
Irving S.G., Zipfel P.F., Balke J., McBride O.W., Morton C.C., Burd P.R., Siebenlist U., Kelly K.
Nucleic Acids Res. 18:3261-3270(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[2]"Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation."
Blum S., Forsdyke R.E., Forsdyke D.R.
DNA Cell Biol. 9:589-602(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structures of human genes coding for cytokine LD78 and their expression."
Nakao M., Nomiyama H., Shimada K.
Mol. Cell. Biol. 10:3646-3658(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell, Brain, Pancreas and Spleen.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[7]"Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist."
Proost P., Menten P., Struyf S., Schutyser E., De Meester I., Van Damme J.
Blood 96:1674-1680(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF LD78-BETA(3-70) AND LD78-BETA(5-70), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.
[8]"Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils."
Struyf S., Menten P., Lenaerts J.-P., Put W., D'Haese A., De Clercq E., Schols D., Proost P., Van Damme J.
Eur. J. Immunol. 31:2170-2178(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."
Shao W., Tang J., Song W., Wang C., Li Y., Wilson C.M., Kaslow R.A.
Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM OF GENE COPY NUMBER.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52149 mRNA. Translation: CAA36397.1.
M24110 Genomic DNA. Translation: AAA35859.1.
D90145 Genomic DNA. Translation: BAA14173.1.
BT006783 mRNA. Translation: AAP35429.1.
BC007783 mRNA. Translation: AAH07783.1.
BC027888 mRNA. Translation: AAH27888.1.
BC107710 mRNA. Translation: AAI07711.1.
BC146914 mRNA. Translation: AAI46915.1.
BC146919 mRNA. Translation: AAI46920.1.
BC147008 mRNA. Translation: AAI47009.1.
BC147013 mRNA. Translation: AAI47014.1.
PIRB35673.
RefSeqNP_001001437.2. NM_001001437.3.
NP_066286.1. NM_021006.4.
UniGeneHs.454713.
Hs.512683.

3D structure databases

ProteinModelPortalP16619.
SMRP16619. Positions 27-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112253. 3 interactions.
STRING9606.ENSP00000367605.

Polymorphism databases

DMDM127077.

Proteomic databases

PaxDbP16619.
PRIDEP16619.

Protocols and materials databases

DNASU6349.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378354; ENSP00000367605; ENSG00000256515.
ENST00000422211; ENSP00000408984; ENSG00000205021.
ENST00000565629; ENSP00000457469; ENSG00000260199.
GeneID414062.
6349.
KEGGhsa:414062.
hsa:6349.
UCSCuc002hlf.2. human.

Organism-specific databases

CTD414062.
6349.
GeneCardsGC17M034523.
GC17M034623.
H-InvDBHIX0023281.
HIX0135348.
HGNCHGNC:10628. CCL3L1.
HGNC:30554. CCL3L3.
MIM601395. gene.
609468. gene.
neXtProtNX_P16619.
PharmGKBPA35560.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304839.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP16619.
KOK05408.
OMASAPFGAD.
OrthoDBEOG7CVQ1F.
PhylomeDBP16619.
TreeFamTF334888.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP16619.
CleanExHS_CCL3L1.
HS_CCL3L3.
GenevestigatorP16619.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCL3L1.
NextBio108388.
PMAP-CutDBP16619.
PROP16619.
SOURCESearch...

Entry information

Entry nameCL3L1_HUMAN
AccessionPrimary (citable) accession number: P16619
Secondary accession number(s): A6NGK6 expand/collapse secondary AC list , B2RUX4, Q3B7A8, Q53YA5, Q96I68
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM