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Protein

C-C motif chemokine 3-like 1

Gene

CCL3L1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-6783783. Interleukin-10 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3-like 1
Alternative name(s):
G0/G1 switch regulatory protein 19-2
LD78-beta(1-70)
PAT 464.2
Small-inducible cytokine A3-like 1
Tonsillar lymphocyte LD78 beta protein
Cleaved into the following 2 chains:
Gene namesi
Name:CCL3L1
Synonyms:D17S1718, G0S19-2, SCYA3L1
AND
Name:CCL3L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000276085.1.
HGNCiHGNC:10628. CCL3L1.
HGNC:30554. CCL3L3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi414062.
6349.
MalaCardsiCCL3L1.
OpenTargetsiENSG00000276085.
PharmGKBiPA35560.

Polymorphism and mutation databases

BioMutaiCCL3L1.
DMDMi127077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000516124 – 93C-C motif chemokine 3-like 1Add BLAST70
ChainiPRO_000000516226 – 93LD78-beta(3-70)Add BLAST68
ChainiPRO_000000516328 – 93LD78-beta(5-70)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Post-translational modificationi

The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei25 – 26Cleavage; by DPP4Curated2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP16619.
PeptideAtlasiP16619.
PRIDEiP16619.

Miscellaneous databases

PMAP-CutDBiP16619.

Expressioni

Gene expression databases

BgeeiENSG00000276085.
CleanExiHS_CCL3L1.
HS_CCL3L3.
GenevisibleiP16619. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112253. 4 interactors.
135929. 34 interactors.
IntActiP16619. 2 interactors.
STRINGi9606.ENSP00000408984.

Structurei

3D structure databases

ProteinModelPortaliP16619.
SMRiP16619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP16619.
KOiK05408.
OMAiMALCNQV.
OrthoDBiEOG091G14Y2.
PhylomeDBiP16619.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTMALCNQ VLSAPLAADT PTACCFSYTS RQIPQNFIAD
60 70 80 90
YFETSSQCSK PSVIFLTKRG RQVCADPSEE WVQKYVSDLE LSA
Length:93
Mass (Da):10,161
Last modified:August 1, 1990 - v1
Checksum:iA7A79E774006D61E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91L → P in AAP35429 (Ref. 4) Curated1
Sequence conflicti91L → P in AAH07783 (PubMed:15489334).Curated1

Polymorphismi

The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52149 mRNA. Translation: CAA36397.1.
M24110 Genomic DNA. Translation: AAA35859.1.
D90145 Genomic DNA. Translation: BAA14173.1.
BT006783 mRNA. Translation: AAP35429.1.
BC007783 mRNA. Translation: AAH07783.1.
BC027888 mRNA. Translation: AAH27888.1.
BC107710 mRNA. Translation: AAI07711.1.
BC146914 mRNA. Translation: AAI46915.1.
BC146919 mRNA. Translation: AAI46920.1.
BC147008 mRNA. Translation: AAI47009.1.
BC147013 mRNA. Translation: AAI47014.1.
CCDSiCCDS32626.1.
PIRiB35673.
RefSeqiNP_001001437.2. NM_001001437.3.
NP_066286.1. NM_021006.5.
UniGeneiHs.454713.
Hs.512683.

Genome annotation databases

EnsembliENST00000612067; ENSP00000484704; ENSG00000277796.
ENST00000615140; ENSP00000480051; ENSG00000277768.
ENST00000619989; ENSP00000480558; ENSG00000276085.
ENST00000621940; ENSP00000482487; ENSG00000277336.
GeneIDi414062.
6349.
KEGGihsa:414062.
hsa:6349.
UCSCiuc002hlf.4. human.

Similar proteinsi

Entry informationi

Entry nameiCL3L1_HUMAN
AccessioniPrimary (citable) accession number: P16619
Secondary accession number(s): A6NGK6
, B2RUX4, Q3B7A8, Q53YA5, Q96I68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 27, 2017
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families