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Protein

C-C motif chemokine 3-like 1

Gene

CCL3L1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei25 – 262Cleavage; by DPP4Curated

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3-like 1
Alternative name(s):
G0/G1 switch regulatory protein 19-2
LD78-beta(1-70)
PAT 464.2
Small-inducible cytokine A3-like 1
Tonsillar lymphocyte LD78 beta protein
Cleaved into the following 2 chains:
Gene namesi
Name:CCL3L1
Synonyms:D17S1718, G0S19-2, SCYA3L1
AND
Name:CCL3L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10628. CCL3L1.
HGNC:30554. CCL3L3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9370C-C motif chemokine 3-like 1PRO_0000005161Add
BLAST
Chaini26 – 9368LD78-beta(3-70)PRO_0000005162Add
BLAST
Chaini28 – 9366LD78-beta(5-70)PRO_0000005163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Post-translational modificationi

The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP16619.
PRIDEiP16619.

Miscellaneous databases

PMAP-CutDBP16619.

Expressioni

Gene expression databases

BgeeiP16619.
CleanExiHS_CCL3L1.
HS_CCL3L3.
GenevestigatoriP16619.

Interactioni

Protein-protein interaction databases

BioGridi112253. 3 interactions.
STRINGi9606.ENSP00000367605.

Structurei

3D structure databases

ProteinModelPortaliP16619.
SMRiP16619. Positions 27-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG304839.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP16619.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP16619.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16619-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTMALCNQ VLSAPLAADT PTACCFSYTS RQIPQNFIAD
60 70 80 90
YFETSSQCSK PSVIFLTKRG RQVCADPSEE WVQKYVSDLE LSA
Length:93
Mass (Da):10,161
Last modified:August 1, 1990 - v1
Checksum:iA7A79E774006D61E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911L → P in AAP35429. 1 PublicationCurated
Sequence conflicti91 – 911L → P in AAH07783. (PubMed:15489334)Curated

Polymorphismi

The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52149 mRNA. Translation: CAA36397.1.
M24110 Genomic DNA. Translation: AAA35859.1.
D90145 Genomic DNA. Translation: BAA14173.1.
BT006783 mRNA. Translation: AAP35429.1.
BC007783 mRNA. Translation: AAH07783.1.
BC027888 mRNA. Translation: AAH27888.1.
BC107710 mRNA. Translation: AAI07711.1.
BC146914 mRNA. Translation: AAI46915.1.
BC146919 mRNA. Translation: AAI46920.1.
BC147008 mRNA. Translation: AAI47009.1.
BC147013 mRNA. Translation: AAI47014.1.
CCDSiCCDS32626.1.
PIRiB35673.
RefSeqiNP_001001437.2. NM_001001437.3.
NP_066286.1. NM_021006.5.
UniGeneiHs.454713.
Hs.512683.

Genome annotation databases

EnsembliENST00000612067; ENSP00000484704; ENSG00000277796.
ENST00000615140; ENSP00000480051; ENSG00000277768.
ENST00000619989; ENSP00000480558; ENSG00000276085.
ENST00000621940; ENSP00000482487; ENSG00000277336.
GeneIDi414062.
6349.
KEGGihsa:414062.
hsa:6349.
UCSCiuc002hlf.2. human.

Polymorphism databases

DMDMi127077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52149 mRNA. Translation: CAA36397.1.
M24110 Genomic DNA. Translation: AAA35859.1.
D90145 Genomic DNA. Translation: BAA14173.1.
BT006783 mRNA. Translation: AAP35429.1.
BC007783 mRNA. Translation: AAH07783.1.
BC027888 mRNA. Translation: AAH27888.1.
BC107710 mRNA. Translation: AAI07711.1.
BC146914 mRNA. Translation: AAI46915.1.
BC146919 mRNA. Translation: AAI46920.1.
BC147008 mRNA. Translation: AAI47009.1.
BC147013 mRNA. Translation: AAI47014.1.
CCDSiCCDS32626.1.
PIRiB35673.
RefSeqiNP_001001437.2. NM_001001437.3.
NP_066286.1. NM_021006.5.
UniGeneiHs.454713.
Hs.512683.

3D structure databases

ProteinModelPortaliP16619.
SMRiP16619. Positions 27-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112253. 3 interactions.
STRINGi9606.ENSP00000367605.

Polymorphism databases

DMDMi127077.

Proteomic databases

PaxDbiP16619.
PRIDEiP16619.

Protocols and materials databases

DNASUi6349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612067; ENSP00000484704; ENSG00000277796.
ENST00000615140; ENSP00000480051; ENSG00000277768.
ENST00000619989; ENSP00000480558; ENSG00000276085.
ENST00000621940; ENSP00000482487; ENSG00000277336.
GeneIDi414062.
6349.
KEGGihsa:414062.
hsa:6349.
UCSCiuc002hlf.2. human.

Organism-specific databases

CTDi414062.
6349.
GeneCardsiGC17M034523.
GC17M034623.
H-InvDBHIX0023281.
HIX0135348.
HGNCiHGNC:10628. CCL3L1.
HGNC:30554. CCL3L3.
MIMi601395. gene.
609468. gene.
neXtProtiNX_P16619.
PharmGKBiPA35560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304839.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP16619.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP16619.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

GeneWikiiCCL3L1.
NextBioi108388.
PMAP-CutDBP16619.
PROiP16619.
SOURCEiSearch...

Gene expression databases

BgeeiP16619.
CleanExiHS_CCL3L1.
HS_CCL3L3.
GenevestigatoriP16619.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q."
    Irving S.G., Zipfel P.F., Balke J., McBride O.W., Morton C.C., Burd P.R., Siebenlist U., Kelly K.
    Nucleic Acids Res. 18:3261-3270(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation."
    Blum S., Forsdyke R.E., Forsdyke D.R.
    DNA Cell Biol. 9:589-602(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structures of human genes coding for cytokine LD78 and their expression."
    Nakao M., Nomiyama H., Shimada K.
    Mol. Cell. Biol. 10:3646-3658(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell, Brain, Pancreas and Spleen.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  7. "Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist."
    Proost P., Menten P., Struyf S., Schutyser E., De Meester I., Van Damme J.
    Blood 96:1674-1680(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF LD78-BETA(3-70) AND LD78-BETA(5-70), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.
  8. "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils."
    Struyf S., Menten P., Lenaerts J.-P., Put W., D'Haese A., De Clercq E., Schols D., Proost P., Van Damme J.
    Eur. J. Immunol. 31:2170-2178(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."
    Shao W., Tang J., Song W., Wang C., Li Y., Wilson C.M., Kaslow R.A.
    Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM OF GENE COPY NUMBER.

Entry informationi

Entry nameiCL3L1_HUMAN
AccessioniPrimary (citable) accession number: P16619
Secondary accession number(s): A6NGK6
, B2RUX4, Q3B7A8, Q53YA5, Q96I68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 4, 2015
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.