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P16617 (PGK1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase 1

EC=2.7.2.3
Gene names
Name:Pgk1
Synonyms:Pgk-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 417416Phosphoglycerate kinase 1 HAMAP-Rule MF_00145
PRO_0000145840

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue61N6-succinyllysine By similarity
Modified residue111N6-acetyllysine By similarity
Modified residue481N6-acetyllysine; alternate By similarity
Modified residue481N6-succinyllysine; alternate By similarity
Modified residue751N6-acetyllysine By similarity
Modified residue761Phosphotyrosine By similarity
Modified residue861N6-acetyllysine By similarity
Modified residue911N6-acetyllysine By similarity
Modified residue971N6-acetyllysine By similarity
Modified residue1311N6-acetyllysine; alternate By similarity
Modified residue1311N6-malonyllysine; alternate By similarity
Modified residue1461N6-acetyllysine By similarity
Modified residue1911N6-succinyllysine By similarity
Modified residue1961Phosphotyrosine By similarity
Modified residue1991N6-acetyllysine By similarity
Modified residue2031Phosphoserine By similarity
Modified residue2671N6-acetyllysine By similarity
Modified residue2911N6-acetyllysine By similarity
Modified residue3611N6-acetyllysine By similarity

Experimental info

Sequence conflict561K → N in AAA41838. Ref.1
Sequence conflict2711A → T in AAA41838. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P16617 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 58E6D9CA85550A20

FASTA41744,538
        10         20         30         40         50         60 
MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC LDNGAKSVVL 

        70         80         90        100        110        120 
MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV GSEVENACAN PAAGTVILLE 

       130        140        150        160        170        180 
NLRFHVEEEG KGKDASGNKV KAEPAKIDAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN 

       190        200        210        220        230        240 
LPQKAGGFLM KKELNYFAKA LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM 

       250        260        270        280        290        300 
AFTFLKVLNN MEIGTSLYDE EGAKIVKDLM AKAEKNGVKI TLPVDFVTAD KFDENAKTGQ 

       310        320        330        340        350        360 
ATVASGIPAG WMGLDCGTES SKKYAEAVAR AKQIVWNGPV GVFEWEAFAR GTKSLMDEVV 

       370        380        390        400        410 
KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSNV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and cDNA sequence of the rat X-chromosome linked phosphoglycerate kinase."
Ciccarese S., Tommasi S., Vonghia G.
Biochem. Biophys. Res. Commun. 165:1337-1344(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Pituitary.
[3]Lubec G., Afjehi-Sadat L., Diao W.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 98-123; 157-171; 200-216; 280-297 AND 333-350, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus and Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31788 mRNA. Translation: AAA41838.1.
BC063161 mRNA. Translation: AAH63161.1.
BC087651 mRNA. Translation: AAH87651.1.
PIRA33792.
RefSeqNP_445743.2. NM_053291.3.
UniGeneRn.108127.

3D structure databases

ProteinModelPortalP16617.
SMRP16617. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246779. 3 interactions.
IntActP16617. 2 interactions.
MINTMINT-4577521.

Chemistry

ChEMBLCHEMBL2176815.

PTM databases

PhosphoSiteP16617.

2D gel databases

World-2DPAGE0004:P16617.

Proteomic databases

PaxDbP16617.
PRIDEP16617.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003390; ENSRNOP00000003390; ENSRNOG00000002467.
GeneID24644.
KEGGrno:24644.
UCSCRGD:619878. rat.

Organism-specific databases

CTD5230.
RGD619878. Pgk1.

Phylogenomic databases

eggNOGCOG0126.
GeneTreeENSGT00390000008820.
HOGENOMHOG000227107.
HOVERGENHBG008177.
InParanoidP16617.
KOK00927.
OMAASCCAKW.
OrthoDBEOG74R1QN.
PhylomeDBP16617.
TreeFamTF300489.

Enzyme and pathway databases

SABIO-RKP16617.
UniPathwayUPA00109; UER00185.

Gene expression databases

GenevestigatorP16617.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603950.
PROP16617.

Entry information

Entry namePGK1_RAT
AccessionPrimary (citable) accession number: P16617
Secondary accession number(s): Q5M945, Q6P508
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways