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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

ADCYAP1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:ADCYAP1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001150625 – 80Add BLAST56
PeptideiPRO_000001150782 – 129PACAP-related peptideAdd BLAST48
PeptideiPRO_0000011508132 – 169Pituitary adenylate cyclase-activating polypeptide 38Add BLAST38
PeptideiPRO_0000011509132 – 158Pituitary adenylate cyclase-activating polypeptide 27Add BLAST27
PropeptideiPRO_0000011510173 – 1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158Leucine amide1 Publication1
Modified residuei169Lysine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP16613
SMRiP16613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 158Important for receptor bindingBy similarity9

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG018069
KOiK05262

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
PRINTSiPR00275 GLUCAGON
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMCSGARLA LLVYGILMHS SVYGSPAASG LRFPGIRPEN EAYDEDGNPQ
60 70 80 90 100
QDFYDSEPPG VGSPASALRD AYALYYPAEE RDVAHGILDK AYRKVLDQLS
110 120 130 140 150
ARRYLQTLMA KGLGGTPGGG ADDDSEPLSK RHSDGIFTDS YSRYRKQMAV
160 170
KKYLAAVLGK RYKQRVKNKG RRIPYL
Length:176
Mass (Da):19,459
Last modified:August 1, 1990 - v1
Checksum:iFBADC68CA56361C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32216 mRNA Translation: AAA31575.1
S83511 mRNA Translation: AAB21469.1
PIRiA34044
RefSeqiNP_001009776.1, NM_001009776.1
UniGeneiOar.695

Genome annotation databases

GeneIDi443337
KEGGioas:443337

Similar proteinsi

Entry informationi

Entry nameiPACA_SHEEP
AccessioniPrimary (citable) accession number: P16613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health