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P16611

- IBP3_PIG

UniProt

P16611 - IBP3_PIG

Protein

Insulin-like growth factor-binding protein 3

Gene

IGFBP3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

    GO - Molecular functioni

    1. protein tyrosine phosphatase activator activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of apoptotic process Source: UniProtKB
    2. positive regulation of catalytic activity Source: GOC
    3. positive regulation of myoblast differentiation Source: UniProtKB
    4. regulation of cell growth Source: InterPro

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 3
    Short name:
    IBP-3
    Short name:
    IGF-binding protein 3
    Short name:
    IGFBP-3
    Gene namesi
    Name:IGFBP3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 293266Insulin-like growth factor-binding protein 3PRO_0000045904Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi215 ↔ 242PROSITE-ProRule annotation
    Disulfide bondi253 ↔ 264PROSITE-ProRule annotation
    Disulfide bondi266 ↔ 287PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP16611.
    SMRiP16611. Positions 38-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 11984IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 28776Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG002631.
    KOiK10138.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012211. IGFBP-3.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF3. PTHR11551:SF3. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01979. IGFBPFAMILY3.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16611-1 [UniParc]FASTAAdd to Basket

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    MQRARPALWA AALIALALLR GPPAARAGSG AAGTGPVVRC EPCDARALAQ    50
    CAPPPAAPPC AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP 100
    GEPRPLQALL DGRGICANAS AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS 150
    MENQALPSTH RVPDSKLHSV HTKMDVIKKG HAKDSQRYKV DYESQSTDTQ 200
    NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP NCDKKGFYKK 250
    KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK 293
    Length:293
    Mass (Da):31,690
    Last modified:February 7, 2006 - v3
    Checksum:iB2ECED337B91DA83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231P → S in AAF23229. (PubMed:12553871)Curated
    Sequence conflicti32 – 321A → V(PubMed:12553871)Curated
    Sequence conflicti32 – 321A → V(PubMed:1688850)Curated
    Sequence conflicti170 – 1701V → I in AAF23229. (PubMed:12553871)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085482 mRNA. Translation: AAF23229.1.
    AY464121 Genomic DNA. Translation: AAR87008.1.
    J05228 mRNA. Translation: AAA31054.1.
    AY422045 Genomic DNA. Translation: AAQ97624.1.
    PIRiA35037.
    JH0516.
    RefSeqiNP_001005156.1. NM_001005156.1.
    UniGeneiSsc.42774.

    Genome annotation databases

    GeneIDi448812.
    KEGGissc:448812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085482 mRNA. Translation: AAF23229.1 .
    AY464121 Genomic DNA. Translation: AAR87008.1 .
    J05228 mRNA. Translation: AAA31054.1 .
    AY422045 Genomic DNA. Translation: AAQ97624.1 .
    PIRi A35037.
    JH0516.
    RefSeqi NP_001005156.1. NM_001005156.1.
    UniGenei Ssc.42774.

    3D structure databases

    ProteinModelPortali P16611.
    SMRi P16611. Positions 38-118.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I31.952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 448812.
    KEGGi ssc:448812.

    Organism-specific databases

    CTDi 3486.

    Phylogenomic databases

    HOVERGENi HBG002631.
    KOi K10138.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012211. IGFBP-3.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF3. PTHR11551:SF3. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01979. IGFBPFAMILY3.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I."
      Pampusch M.S., Kamanga-Sollo E., White M.E., Hathaway M.R., Dayton W.R.
      J. Endocrinol. 176:227-235(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Insulin-like growth factor-binding protein-3 in porcine ovarian granulosa cells: gene cloning, promoter mapping, and follicle-stimulating hormone regulation."
      Ongeri E.M., Zhu Q., Verderame M.F., Hammond J.M.
      Endocrinology 145:1776-1785(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein."
      Shimasaki S., Shimonaka M., Ui M., Inouye S., Shibata F., Ling N.
      J. Biol. Chem. 265:2198-2202(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-293.
    4. "Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum."
      Coleman M.E., Pan Y.-C.E., Etherton T.D.
      Biochem. Biophys. Res. Commun. 181:1131-1136(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-42.
    5. "Study on SNPs of porcine IGFBP-3 gene."
      Liu D., Zhang Y., Zhang X., Yang G.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-293.

    Entry informationi

    Entry nameiIBP3_PIG
    AccessioniPrimary (citable) accession number: P16611
    Secondary accession number(s): Q6S6K2, Q9TTI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3