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P16611

- IBP3_PIG

UniProt

P16611 - IBP3_PIG

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Protein
Insulin-like growth factor-binding protein 3
Gene
IGFBP3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

  1. protein tyrosine phosphatase activator activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. positive regulation of apoptotic process Source: UniProtKB
  2. positive regulation of catalytic activity Source: GOC
  3. positive regulation of myoblast differentiation Source: UniProtKB
  4. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:IGFBP3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 Publication
Add
BLAST
Chaini28 – 293266Insulin-like growth factor-binding protein 3
PRO_0000045904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi215 ↔ 242 By similarity
Disulfide bondi253 ↔ 264 By similarity
Disulfide bondi266 ↔ 287 By similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP16611.
SMRiP16611. Positions 38-118.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11984IGFBP N-terminal
Add
BLAST
Domaini212 – 28776Thyroglobulin type-1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002631.
KOiK10138.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012211. IGFBP-3.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF3. PTHR11551:SF3. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01979. IGFBPFAMILY3.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16611-1 [UniParc]FASTAAdd to Basket

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MQRARPALWA AALIALALLR GPPAARAGSG AAGTGPVVRC EPCDARALAQ    50
CAPPPAAPPC AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP 100
GEPRPLQALL DGRGICANAS AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS 150
MENQALPSTH RVPDSKLHSV HTKMDVIKKG HAKDSQRYKV DYESQSTDTQ 200
NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP NCDKKGFYKK 250
KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK 293
Length:293
Mass (Da):31,690
Last modified:February 7, 2006 - v3
Checksum:iB2ECED337B91DA83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231P → S in AAF23229. 1 Publication
Sequence conflicti32 – 321A → V1 Publication
Sequence conflicti32 – 321A → V1 Publication
Sequence conflicti170 – 1701V → I in AAF23229. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085482 mRNA. Translation: AAF23229.1.
AY464121 Genomic DNA. Translation: AAR87008.1.
J05228 mRNA. Translation: AAA31054.1.
AY422045 Genomic DNA. Translation: AAQ97624.1.
PIRiA35037.
JH0516.
RefSeqiNP_001005156.1. NM_001005156.1.
UniGeneiSsc.42774.

Genome annotation databases

GeneIDi448812.
KEGGissc:448812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085482 mRNA. Translation: AAF23229.1 .
AY464121 Genomic DNA. Translation: AAR87008.1 .
J05228 mRNA. Translation: AAA31054.1 .
AY422045 Genomic DNA. Translation: AAQ97624.1 .
PIRi A35037.
JH0516.
RefSeqi NP_001005156.1. NM_001005156.1.
UniGenei Ssc.42774.

3D structure databases

ProteinModelPortali P16611.
SMRi P16611. Positions 38-118.
ModBasei Search...

Protein family/group databases

MEROPSi I31.952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448812.
KEGGi ssc:448812.

Organism-specific databases

CTDi 3486.

Phylogenomic databases

HOVERGENi HBG002631.
KOi K10138.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012211. IGFBP-3.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF3. PTHR11551:SF3. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01979. IGFBPFAMILY3.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I."
    Pampusch M.S., Kamanga-Sollo E., White M.E., Hathaway M.R., Dayton W.R.
    J. Endocrinol. 176:227-235(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Insulin-like growth factor-binding protein-3 in porcine ovarian granulosa cells: gene cloning, promoter mapping, and follicle-stimulating hormone regulation."
    Ongeri E.M., Zhu Q., Verderame M.F., Hammond J.M.
    Endocrinology 145:1776-1785(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein."
    Shimasaki S., Shimonaka M., Ui M., Inouye S., Shibata F., Ling N.
    J. Biol. Chem. 265:2198-2202(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-293.
  4. "Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum."
    Coleman M.E., Pan Y.-C.E., Etherton T.D.
    Biochem. Biophys. Res. Commun. 181:1131-1136(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42.
  5. "Study on SNPs of porcine IGFBP-3 gene."
    Liu D., Zhang Y., Zhang X., Yang G.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-293.

Entry informationi

Entry nameiIBP3_PIG
AccessioniPrimary (citable) accession number: P16611
Secondary accession number(s): Q6S6K2, Q9TTI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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