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Protein

Insulin-like growth factor-binding protein 3

Gene

IGFBP3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-SSC-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-SSC-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-SSC-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:IGFBP3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000004590428 – 293Insulin-like growth factor-binding protein 3Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei150PhosphoserineBy similarity1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei203PhosphoserineBy similarity1
Disulfide bondi215 ↔ 242PROSITE-ProRule annotation
Disulfide bondi253 ↔ 264PROSITE-ProRule annotation
Disulfide bondi266 ↔ 287PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP16611
PRIDEiP16611

Interactioni

Subunit structurei

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017719

Structurei

3D structure databases

ProteinModelPortaliP16611
SMRiP16611
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 119IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST84
Domaini212 – 287Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHZU Eukaryota
ENOG4111MF3 LUCA
GeneTreeiENSGT00550000074457
HOVERGENiHBG002631
InParanoidiP16611
KOiK10138

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.101 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012211 IGFBP-3
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF3 PTHR11551:SF3, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01979 IGFBPFAMILY3
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRARPALWA AALIALALLR GPPAARAGSG AAGTGPVVRC EPCDARALAQ
60 70 80 90 100
CAPPPAAPPC AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP
110 120 130 140 150
GEPRPLQALL DGRGICANAS AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS
160 170 180 190 200
MENQALPSTH RVPDSKLHSV HTKMDVIKKG HAKDSQRYKV DYESQSTDTQ
210 220 230 240 250
NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP NCDKKGFYKK
260 270 280 290
KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK
Length:293
Mass (Da):31,690
Last modified:February 7, 2006 - v3
Checksum:iB2ECED337B91DA83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23P → S in AAF23229 (PubMed:12553871).Curated1
Sequence conflicti32A → V (PubMed:12553871).Curated1
Sequence conflicti32A → V (PubMed:1688850).Curated1
Sequence conflicti170V → I in AAF23229 (PubMed:12553871).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085482 mRNA Translation: AAF23229.1
AY464121 Genomic DNA Translation: AAR87008.1
J05228 mRNA Translation: AAA31054.1
AY422045 Genomic DNA Translation: AAQ97624.1
PIRiA35037
JH0516
RefSeqiNP_001005156.1, NM_001005156.1
UniGeneiSsc.42774

Genome annotation databases

EnsembliENSSSCT00000061542; ENSSSCP00000056649; ENSSSCG00000038783
GeneIDi448812
KEGGissc:448812

Similar proteinsi

Entry informationi

Entry nameiIBP3_PIG
AccessioniPrimary (citable) accession number: P16611
Secondary accession number(s): Q6S6K2, Q9TTI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 7, 2006
Last modified: February 28, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome