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Protein

Substance-K receptor

Gene

Tacr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

GO - Molecular functioni

  • substance K receptor activity Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • intestine smooth muscle contraction Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • operant conditioning Source: RGD
  • positive regulation of acetylcholine secretion, neurotransmission Source: RGD
  • positive regulation of ion transport Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • prolactin secretion Source: RGD
  • response to electrical stimulus Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:Tacr2
Synonyms:Tac2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3812. Tacr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 56Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini57 – 69CytoplasmicSequence analysisAdd BLAST13
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 107ExtracellularSequence analysisAdd BLAST17
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 196ExtracellularSequence analysisAdd BLAST26
Transmembranei197 – 218Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini219 – 251CytoplasmicSequence analysisAdd BLAST33
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 290ExtracellularSequence analysisAdd BLAST18
Transmembranei291 – 310Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini311 – 390CytoplasmicSequence analysisAdd BLAST80

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4554.
GuidetoPHARMACOLOGYi361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698971 – 390Substance-K receptorAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16610.

PTM databases

iPTMnetiP16610.
PhosphoSitePlusiP16610.

Expressioni

Gene expression databases

BgeeiENSRNOG00000050658.
GenevisibleiP16610. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067266.

Structurei

3D structure databases

ProteinModelPortaliP16610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG103412.
InParanoidiP16610.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG091G0WYG.
PhylomeDBiP16610.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRAIVSDA NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG
60 70 80 90 100
NATVIWIILA HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
IIAGIWLVAL ALASPQCFYS TITVDEGATK CVVAWPNDNG GKMLLLYHLV
210 220 230 240 250
VFVLIYFLPL LVMFGAYSVI GLTLWKRAVP RHQAHGANLR HLQAKKKFVK
260 270 280 290 300
AMVLVVLTFA ICWLPYHLYF ILGTFQEDIY YHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDRLELTH TPSLSRRVNR
360 370 380 390
CHTKETLFMT GDMTHSEATN GQVGSPQDGE PAGPICKAQA
Length:390
Mass (Da):43,853
Last modified:August 1, 1990 - v1
Checksum:iA6C4FF70194726DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31838 mRNA. Translation: AAA42150.1.
PIRiA36737.
RefSeqiNP_542946.1. NM_080768.1.
UniGeneiRn.202846.

Genome annotation databases

EnsembliENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
GeneIDi25007.
KEGGirno:25007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31838 mRNA. Translation: AAA42150.1.
PIRiA36737.
RefSeqiNP_542946.1. NM_080768.1.
UniGeneiRn.202846.

3D structure databases

ProteinModelPortaliP16610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067266.

Chemistry databases

ChEMBLiCHEMBL4554.
GuidetoPHARMACOLOGYi361.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP16610.
PhosphoSitePlusiP16610.

Proteomic databases

PaxDbiP16610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
GeneIDi25007.
KEGGirno:25007.

Organism-specific databases

CTDi6865.
RGDi3812. Tacr2.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG103412.
InParanoidiP16610.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG091G0WYG.
PhylomeDBiP16610.

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP16610.

Gene expression databases

BgeeiENSRNOG00000050658.
GenevisibleiP16610. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK2R_RAT
AccessioniPrimary (citable) accession number: P16610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.