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Protein

Substance-K receptor

Gene

Tacr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

GO - Molecular functioni

  • substance K receptor activity Source: RGD

GO - Biological processi

  • intestine smooth muscle contraction Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • operant conditioning Source: RGD
  • positive regulation of acetylcholine secretion, neurotransmission Source: RGD
  • positive regulation of ion transport Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • prolactin secretion Source: RGD
  • response to electrical stimulus Source: RGD
  • tachykinin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:Tacr2
Synonyms:Tac2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3812. Tacr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5624Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6913CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10717ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21822Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 25133CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini273 – 29018ExtracellularSequence analysisAdd
BLAST
Transmembranei291 – 31020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini311 – 39080CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4554.
GuidetoPHARMACOLOGYi361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Substance-K receptorPRO_0000069897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324 – 3241S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16610.

PTM databases

PhosphoSiteiP16610.

Expressioni

Gene expression databases

GenevisibleiP16610. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067266.

Chemistry

BindingDBiP16610.

Structurei

3D structure databases

ProteinModelPortaliP16610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG103412.
InParanoidiP16610.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG7N37FW.
PhylomeDBiP16610.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRAIVSDA NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG
60 70 80 90 100
NATVIWIILA HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
IIAGIWLVAL ALASPQCFYS TITVDEGATK CVVAWPNDNG GKMLLLYHLV
210 220 230 240 250
VFVLIYFLPL LVMFGAYSVI GLTLWKRAVP RHQAHGANLR HLQAKKKFVK
260 270 280 290 300
AMVLVVLTFA ICWLPYHLYF ILGTFQEDIY YHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDRLELTH TPSLSRRVNR
360 370 380 390
CHTKETLFMT GDMTHSEATN GQVGSPQDGE PAGPICKAQA
Length:390
Mass (Da):43,853
Last modified:August 1, 1990 - v1
Checksum:iA6C4FF70194726DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31838 mRNA. Translation: AAA42150.1.
PIRiA36737.
RefSeqiNP_542946.1. NM_080768.1.
UniGeneiRn.202846.

Genome annotation databases

EnsembliENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
GeneIDi25007.
KEGGirno:25007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31838 mRNA. Translation: AAA42150.1.
PIRiA36737.
RefSeqiNP_542946.1. NM_080768.1.
UniGeneiRn.202846.

3D structure databases

ProteinModelPortaliP16610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067266.

Chemistry

BindingDBiP16610.
ChEMBLiCHEMBL4554.
GuidetoPHARMACOLOGYi361.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP16610.

Proteomic databases

PaxDbiP16610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
GeneIDi25007.
KEGGirno:25007.

Organism-specific databases

CTDi6865.
RGDi3812. Tacr2.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOVERGENiHBG103412.
InParanoidiP16610.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG7N37FW.
PhylomeDBiP16610.

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi605071.
PROiP16610.

Gene expression databases

GenevisibleiP16610. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of rat substance K receptor and its mRNAs."
    Sasai Y., Nakanishi S.
    Biochem. Biophys. Res. Commun. 165:695-702(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNK2R_RAT
AccessioniPrimary (citable) accession number: P16610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.