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P16600 (KITH_SHEVK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismSheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))
Taxonomic identifier10269 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeCapripoxvirus
Virus hostOvis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Thymidine kinase
PRO_0000174929

Regions

Nucleotide binding11 – 188ATP By similarity
Region157 – 1615Substrate binding By similarity

Sites

Active site831Proton acceptor Potential
Metal binding1381Zinc By similarity
Metal binding1411Zinc By similarity
Metal binding1701Zinc By similarity
Metal binding1731Zinc By similarity
Binding site1131Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P16600 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 093E53E555F8E2C8

FASTA17720,447
        10         20         30         40         50         60 
MDYGYIHLII GPMFSGKSTE LIRIVKRYQI AQYKCCVVKY LKDIRYGNSV YTHDNNHVSA 

        70         80         90        100        110        120 
ISTTLLYDVV DKIMNFDIIG IDEGQFFKDI VSFSENMANM GKIIIIAALD STFQRKEFND 

       130        140        150        160        170 
ILKLIPLSEK VTKLNAVCME CYKDAAFSKR ITKEKEIELI GGKEKYKSVC RKCYFLE 

« Hide

References

[1]"The nucleotide sequence around the capripoxvirus thymidine kinase gene reveals a gene shared specifically with leporipoxvirus."
Gershon P.D., Black D.N.
J. Gen. Virol. 70:525-533(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00423 Genomic DNA. Translation: BAA00324.1.
PIRKIVZCP. B31813.

3D structure databases

ProteinModelPortalP16600.
SMRP16600. Positions 4-175.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_SHEVK
AccessionPrimary (citable) accession number: P16600
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families