Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 alpha

Gene

Il1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

  • acute inflammatory response Source: RGD
  • cellular response to heat Source: UniProtKB
  • cytokine-mediated signaling pathway Source: GO_Central
  • fever generation Source: UniProtKB-KW
  • heart development Source: RGD
  • immune response Source: InterPro
  • keratinization Source: RGD
  • negative regulation of establishment of Sertoli cell barrier Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of JNK cascade Source: RGD
  • positive regulation of neutrophil migration Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of steroid biosynthetic process Source: RGD
  • positive regulation of stress-activated MAPK cascade Source: RGD
  • regulation of actin cytoskeleton organization Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to copper ion Source: UniProtKB
  • response to gamma radiation Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to L-ascorbic acid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to ozone Source: RGD
  • spermatogenesis Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:Il1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2890. Il1a.

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

  • cell surface Source: RGD
  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152791 – 114Add BLAST114
ChainiPRO_0000015280115 – 270Interleukin-1 alphaAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Modified residuei90PhosphoserineBy similarity1
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP16598.
PRIDEiP16598.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006113.

Chemistry databases

BindingDBiP16598.

Structurei

3D structure databases

ProteinModelPortaliP16598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP16598.
KOiK04383.
PhylomeDBiP16598.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENEE YSSAIDHLSL NQKSFYDASY GSLHENCTDK
60 70 80 90 100
FVSLRTSETS KMSTFTFKES RVVVSATSNK GKILKKRRLS FNQPFTEDDL
110 120 130 140 150
EAIAHDLEET IQPRSAPHSF QNNLRYKLIR IVKQEFIMND SLNQNIYVDM
160 170 180 190 200
DRIHLKAASL NDLQLEVKFD MYAYSSGGDD SKYPVTLKVS NTQLFVSAQG
210 220 230 240 250
EDKPVLLKEI PETPKLITGS ETDLIFFWEK INSKNYFTSA AFPELLIATK
260 270
EQSQVHLARG LPSMIDFQIS
Length:270
Mass (Da):30,856
Last modified:August 1, 1990 - v1
Checksum:iE3EB22F576F291DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00403 mRNA. Translation: BAA00306.1.
AJ245642 mRNA. Translation: CAC03995.1.
PIRiJX0064.
RefSeqiNP_058715.1. NM_017019.1.
UniGeneiRn.12300.

Genome annotation databases

GeneIDi24493.
KEGGirno:24493.
UCSCiRGD:2890. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00403 mRNA. Translation: BAA00306.1.
AJ245642 mRNA. Translation: CAC03995.1.
PIRiJX0064.
RefSeqiNP_058715.1. NM_017019.1.
UniGeneiRn.12300.

3D structure databases

ProteinModelPortaliP16598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006113.

Chemistry databases

BindingDBiP16598.

Proteomic databases

PaxDbiP16598.
PRIDEiP16598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24493.
KEGGirno:24493.
UCSCiRGD:2890. rat.

Organism-specific databases

CTDi3552.
RGDi2890. Il1a.

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP16598.
KOiK04383.
PhylomeDBiP16598.

Miscellaneous databases

PROiP16598.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1A_RAT
AccessioniPrimary (citable) accession number: P16598
Secondary accession number(s): Q546R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.