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Protein

Interleukin-1 alpha

Gene

Il1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • cellular response to heat Source: UniProtKB
  • connective tissue replacement involved in inflammatory response wound healing Source: RGD
  • cytokine-mediated signaling pathway Source: RGD
  • ectopic germ cell programmed cell death Source: RGD
  • extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
  • fever generation Source: UniProtKB-KW
  • heart development Source: RGD
  • immune response Source: InterPro
  • inflammatory response Source: RGD
  • interleukin-1-mediated signaling pathway Source: RGD
  • keratinization Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of establishment of Sertoli cell barrier Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cytokine secretion Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  • positive regulation of interleukin-2 biosynthetic process Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of JNK cascade Source: RGD
  • positive regulation of mitotic nuclear division Source: RGD
  • positive regulation of monocyte chemotactic protein-1 production Source: RGD
  • positive regulation of neutrophil extravasation Source: RGD
  • positive regulation of neutrophil migration Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of protein secretion Source: RGD
  • positive regulation of steroid biosynthetic process Source: RGD
  • positive regulation of stress-activated MAPK cascade Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of vascular endothelial growth factor production Source: RGD
  • regulation of actin cytoskeleton organization Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to copper ion Source: UniProtKB
  • response to gamma radiation Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to L-ascorbic acid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to ozone Source: RGD
  • spermatogenesis Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:Il1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2890 Il1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152791 – 114Add BLAST114
ChainiPRO_0000015280115 – 270Interleukin-1 alphaAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei90PhosphoserineBy similarity1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP16598
PRIDEiP16598

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006113

Chemistry databases

BindingDBiP16598

Structurei

3D structure databases

ProteinModelPortaliP16598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP16598
KOiK04383
PhylomeDBiP16598

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENEE YSSAIDHLSL NQKSFYDASY GSLHENCTDK
60 70 80 90 100
FVSLRTSETS KMSTFTFKES RVVVSATSNK GKILKKRRLS FNQPFTEDDL
110 120 130 140 150
EAIAHDLEET IQPRSAPHSF QNNLRYKLIR IVKQEFIMND SLNQNIYVDM
160 170 180 190 200
DRIHLKAASL NDLQLEVKFD MYAYSSGGDD SKYPVTLKVS NTQLFVSAQG
210 220 230 240 250
EDKPVLLKEI PETPKLITGS ETDLIFFWEK INSKNYFTSA AFPELLIATK
260 270
EQSQVHLARG LPSMIDFQIS
Length:270
Mass (Da):30,856
Last modified:August 1, 1990 - v1
Checksum:iE3EB22F576F291DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00403 mRNA Translation: BAA00306.1
AJ245642 mRNA Translation: CAC03995.1
PIRiJX0064
RefSeqiNP_058715.1, NM_017019.1
UniGeneiRn.12300

Genome annotation databases

GeneIDi24493
KEGGirno:24493
UCSCiRGD:2890 rat

Similar proteinsi

Entry informationi

Entry nameiIL1A_RAT
AccessioniPrimary (citable) accession number: P16598
Secondary accession number(s): Q546R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health