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P16593

- VP6_ROTPG

UniProt

P16593 - VP6_ROTPG

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Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus A (strain Pig/United States/Gottfried/1983 G4-P2B[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531Zinc; shared with all trimeric partnersBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus A (strain Pig/United States/Gottfried/1983 G4-P2B[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1) (RV-A)
Taxonomic identifieri10917 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

Virion
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).By similarity

GO - Cellular componenti

  1. viral envelope Source: InterPro
  2. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Intermediate capsid protein VP6PRO_0000149575Add
BLAST

Post-translational modificationi

The N-terminus is blocked.By similarity

Interactioni

Subunit structurei

Homotrimer. Interacts with VP2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP16593.
SMRiP16593. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.Curated

Family and domain databases

InterProiIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

P16593-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVLYSLSKT LKDARDKIVE GTLYSNVSDL IQQFNQMIVT MNGNDFQTGG
60 70 80 90 100
IGNLPVRNWT FDFGLLGTTL LNLDANYVET ARTTIEYFID FIDNVCMDEM
110 120 130 140 150
ARESQRNGIA PQSEAFRKLA GIKFKRINFD NSSEYIENWN LQNRRQRTGF
160 170 180 190 200
IFHKPNIFPY SASFTLNRSQ PMHDNLMGTM WLNAGSEIQV AGFDYSCAIN
210 220 230 240 250
APANIQQFEH IVQLRRALTT ATITLLPDAE RFSFPRVINS ADGATTWFFN
260 270 280 290 300
PVILRPNNVE VEFLLNGQII NTYQARFGTI VARNFDTIRL SFQLMRPPNM
310 320 330 340 350
TPAVDALFPQ AQPFQHHATV GLTLRIESAV CESVLADANE TLLANVTAVR
360 370 380 390
QEYAIPVGPV FPPGMNWTEL ITNYSPSRED NLQRVFTVAS IRSMLIK
Length:397
Mass (Da):44,965
Last modified:August 1, 1990 - v1
Checksum:iA3E0F6A3CB9C14D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00326 Genomic RNA. Translation: BAA00238.1.
PIRiJS0249. VPXRGT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00326 Genomic RNA. Translation: BAA00238.1 .
PIRi JS0249. VPXRGT.

3D structure databases

ProteinModelPortali P16593.
SMRi P16593. Positions 1-397.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view ]
Pfami PF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view ]
ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative sequence analysis of the genomic segment 6 of four rotaviruses each with a different subgroup specificity."
    Gorziglia M., Hoshino Y., Nishikawa K., Maloy W.L., Jones R.W., Kapikian A.Z., Chanock R.M.
    J. Gen. Virol. 69:1659-1669(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP6_ROTPG
AccessioniPrimary (citable) accession number: P16593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases (By similarity).By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3