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Protein

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Gene

PDE6C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92cGMPBy similarity1
Binding sitei116cGMPBy similarity1
Binding sitei171cGMPBy similarity1
Active sitei557Proton donorBy similarity1
Metal bindingi561Divalent metal cation 1By similarity1
Metal bindingi597Divalent metal cation 1By similarity1
Metal bindingi598Divalent metal cation 1By similarity1
Metal bindingi598Divalent metal cation 2By similarity1
Metal bindingi718Divalent metal cation 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 167cGMPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC:3.1.4.35)
Alternative name(s):
PDE V-C1
cGMP phosphodiesterase 6C
Gene namesi
Name:PDE6C
Synonyms:PDEA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988301 – 852Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Add BLAST852
PropeptideiPRO_0000370787853 – 855Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852Cysteine methyl esterSequence analysis1
Lipidationi852S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP16586.
PRIDEiP16586.

Interactioni

Subunit structurei

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000569.

Chemistry databases

BindingDBiP16586.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JABelectron microscopy11.00C/O563-726[»]
3JBQelectron microscopy11.00B/F556-811[»]
ProteinModelPortaliP16586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 219GAF 1Add BLAST150
Domaini251 – 428GAF 2Add BLAST178

Sequence similaritiesi

Contains 2 GAF domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
HOGENOMiHOG000007069.
HOVERGENiHBG053539.
InParanoidiP16586.
KOiK13757.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEISQETVE KYLEANPQFA KEYFNRKLQV EVPSGGAQAP ASASFPGRTL
60 70 80 90 100
AEEAALYLEL LEVLLEEAGS VELAAHRALQ RLAQLLQADR CSMFLCRARN
110 120 130 140 150
GTPEVASKLL DVTPTSKFED NLVVPDREAV FPLDVGIVGW VAHTKKTFNV
160 170 180 190 200
PDVKKNSHFS DFMDKQTGYV TRNLLATPIV MGKEVLAVFM AVNKVDASEF
210 220 230 240 250
SKQDEEVFSK YLSFVSIILK LHHTNYLYNI ESRRSQILMW SANKVFEELT
260 270 280 290 300
DVERQFHKAL YTVRTYLNCE RYSIGLLDMT KEKEFYDEWP VKLGEVEPYK
310 320 330 340 350
GPKTPDGREV IFYKIIDYIL HGKEEIKVIP TPPMDHWTLI SGLPTYVAEN
360 370 380 390 400
GFICNMLNAP ADEYFTFQKG PVDETGWVIK NVLSLPIVNK KEDIVGVATF
410 420 430 440 450
YNRKDGKPFD EYDEHIAETL TQFLGWSLLN TDTYEKMNKL ENRKDIAQEM
460 470 480 490 500
LMNHTKATPD EIKSILKFKE KLNIDVIEDC EEKQLVTILK EDLPDPRTAD
510 520 530 540 550
LYEFRFRHLP ITEHELIKCG LRLFFEINVV EKFKVPVEVL TRWMYTVRKG
560 570 580 590 600
YRAVTYHNWR HGFNVGQTMF TLLMTGRLKK YYTDLEAFAM LAAAFCHDID
610 620 630 640 650
HRGTNNLYQM KSTSPLARLH GSSILERHHL EYSKTLLQDE SLNIFQNLNK
660 670 680 690 700
RQYETVIHLF EVAIIATDLA LYFKKRTMFQ KIVDACEKME TEEEAIKYVT
710 720 730 740 750
IDPTKKEIIM AMMMTACDLS AITKPWEVQS QVALLVANEF WEQGDLERTV
760 770 780 790 800
LQQQPIPMMD RNKKDELPKL QVGFIDFVCT FVYKEFSRFH KEITPMLNGL
810 820 830 840 850
QNNRVEWKSL ADEYDEKMKV IEEMKKQEEG NTTEKAVEDS GGGGDDKKSK

TCLML
Length:855
Mass (Da):98,798
Last modified:August 1, 1990 - v1
Checksum:i1FCFFFD045686D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37838 mRNA. Translation: AAA30687.1.
M33140 mRNA. Translation: AAA30688.1.
PIRiA34810.
RefSeqiNP_776844.1. NM_174419.1.
UniGeneiBt.444.

Genome annotation databases

GeneIDi281975.
KEGGibta:281975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37838 mRNA. Translation: AAA30687.1.
M33140 mRNA. Translation: AAA30688.1.
PIRiA34810.
RefSeqiNP_776844.1. NM_174419.1.
UniGeneiBt.444.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JABelectron microscopy11.00C/O563-726[»]
3JBQelectron microscopy11.00B/F556-811[»]
ProteinModelPortaliP16586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000569.

Chemistry databases

BindingDBiP16586.
ChEMBLiCHEMBL3479.

Proteomic databases

PaxDbiP16586.
PRIDEiP16586.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281975.
KEGGibta:281975.

Organism-specific databases

CTDi5146.

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
HOGENOMiHOG000007069.
HOVERGENiHBG053539.
InParanoidiP16586.
KOiK13757.

Miscellaneous databases

PROiP16586.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDE6C_BOVIN
AccessioniPrimary (citable) accession number: P16586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.