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P16586

- PDE6C_BOVIN

UniProt

P16586 - PDE6C_BOVIN

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Protein

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Gene

PDE6C

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921cGMPBy similarity
Binding sitei116 – 1161cGMPBy similarity
Binding sitei171 – 1711cGMPBy similarity
Active sitei557 – 5571Proton donorBy similarity
Metal bindingi561 – 5611Divalent metal cation 1By similarity
Metal bindingi597 – 5971Divalent metal cation 1By similarity
Metal bindingi598 – 5981Divalent metal cation 1By similarity
Metal bindingi598 – 5981Divalent metal cation 2By similarity
Metal bindingi718 – 7181Divalent metal cation 1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1674cGMPBy similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC:3.1.4.35)
Alternative name(s):
PDE V-C1
cGMP phosphodiesterase 6C
Gene namesi
Name:PDE6C
Synonyms:PDEA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'PRO_0000198830Add
BLAST
Propeptidei853 – 8553Removed in mature formSequence AnalysisPRO_0000370787

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei852 – 8521Cysteine methyl esterSequence Analysis
Lipidationi852 – 8521S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP16586.

Interactioni

Subunit structurei

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049725.

Structurei

3D structure databases

ProteinModelPortaliP16586.
SMRiP16586. Positions 52-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 219150GAF 1Add
BLAST
Domaini251 – 428178GAF 2Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG290744.
HOGENOMiHOG000007069.
HOVERGENiHBG053539.
InParanoidiP16586.
KOiK13757.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16586 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEISQETVE KYLEANPQFA KEYFNRKLQV EVPSGGAQAP ASASFPGRTL
60 70 80 90 100
AEEAALYLEL LEVLLEEAGS VELAAHRALQ RLAQLLQADR CSMFLCRARN
110 120 130 140 150
GTPEVASKLL DVTPTSKFED NLVVPDREAV FPLDVGIVGW VAHTKKTFNV
160 170 180 190 200
PDVKKNSHFS DFMDKQTGYV TRNLLATPIV MGKEVLAVFM AVNKVDASEF
210 220 230 240 250
SKQDEEVFSK YLSFVSIILK LHHTNYLYNI ESRRSQILMW SANKVFEELT
260 270 280 290 300
DVERQFHKAL YTVRTYLNCE RYSIGLLDMT KEKEFYDEWP VKLGEVEPYK
310 320 330 340 350
GPKTPDGREV IFYKIIDYIL HGKEEIKVIP TPPMDHWTLI SGLPTYVAEN
360 370 380 390 400
GFICNMLNAP ADEYFTFQKG PVDETGWVIK NVLSLPIVNK KEDIVGVATF
410 420 430 440 450
YNRKDGKPFD EYDEHIAETL TQFLGWSLLN TDTYEKMNKL ENRKDIAQEM
460 470 480 490 500
LMNHTKATPD EIKSILKFKE KLNIDVIEDC EEKQLVTILK EDLPDPRTAD
510 520 530 540 550
LYEFRFRHLP ITEHELIKCG LRLFFEINVV EKFKVPVEVL TRWMYTVRKG
560 570 580 590 600
YRAVTYHNWR HGFNVGQTMF TLLMTGRLKK YYTDLEAFAM LAAAFCHDID
610 620 630 640 650
HRGTNNLYQM KSTSPLARLH GSSILERHHL EYSKTLLQDE SLNIFQNLNK
660 670 680 690 700
RQYETVIHLF EVAIIATDLA LYFKKRTMFQ KIVDACEKME TEEEAIKYVT
710 720 730 740 750
IDPTKKEIIM AMMMTACDLS AITKPWEVQS QVALLVANEF WEQGDLERTV
760 770 780 790 800
LQQQPIPMMD RNKKDELPKL QVGFIDFVCT FVYKEFSRFH KEITPMLNGL
810 820 830 840 850
QNNRVEWKSL ADEYDEKMKV IEEMKKQEEG NTTEKAVEDS GGGGDDKKSK

TCLML
Length:855
Mass (Da):98,798
Last modified:August 1, 1990 - v1
Checksum:i1FCFFFD045686D65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37838 mRNA. Translation: AAA30687.1.
M33140 mRNA. Translation: AAA30688.1.
PIRiA34810.
RefSeqiNP_776844.1. NM_174419.1.
UniGeneiBt.444.

Genome annotation databases

GeneIDi281975.
KEGGibta:281975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37838 mRNA. Translation: AAA30687.1 .
M33140 mRNA. Translation: AAA30688.1 .
PIRi A34810.
RefSeqi NP_776844.1. NM_174419.1.
UniGenei Bt.444.

3D structure databases

ProteinModelPortali P16586.
SMRi P16586. Positions 52-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000049725.

Chemistry

BindingDBi P16586.
ChEMBLi CHEMBL3479.

Proteomic databases

PRIDEi P16586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281975.
KEGGi bta:281975.

Organism-specific databases

CTDi 5146.

Phylogenomic databases

eggNOGi NOG290744.
HOGENOMi HOG000007069.
HOVERGENi HBG053539.
InParanoidi P16586.
KOi K13757.

Miscellaneous databases

NextBioi 20805846.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone."
    Li T., Volpp K., Applebury M.L.
    Proc. Natl. Acad. Sci. U.S.A. 87:293-297(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases."
    Charbonneau H., Prusti R.K., Letrong H., Sonnenburg W.K., Mullaney P.J., Walsh K., Beavo J.A.
    Proc. Natl. Acad. Sci. U.S.A. 87:288-292(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 308-502, PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiPDE6C_BOVIN
AccessioniPrimary (citable) accession number: P16586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3