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P16586

- PDE6C_BOVIN

UniProt

P16586 - PDE6C_BOVIN

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Protein
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Gene
PDE6C, PDEA2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921cGMP By similarity
Binding sitei116 – 1161cGMP By similarity
Binding sitei171 – 1711cGMP By similarity
Active sitei557 – 5571Proton donor By similarity
Metal bindingi561 – 5611Divalent metal cation 1 By similarity
Metal bindingi597 – 5971Divalent metal cation 1 By similarity
Metal bindingi598 – 5981Divalent metal cation 1 By similarity
Metal bindingi598 – 5981Divalent metal cation 2 By similarity
Metal bindingi718 – 7181Divalent metal cation 1 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1674cGMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP, cGMP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC:3.1.4.35)
Alternative name(s):
PDE V-C1
cGMP phosphodiesterase 6C
Gene namesi
Name:PDE6C
Synonyms:PDEA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
PRO_0000198830Add
BLAST
Propeptidei853 – 8553Removed in mature form Reviewed prediction
PRO_0000370787

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei852 – 8521Cysteine methyl ester Reviewed prediction
Lipidationi852 – 8521S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP16586.

Interactioni

Subunit structurei

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049725.

Structurei

3D structure databases

ProteinModelPortaliP16586.
SMRiP16586. Positions 52-220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 219150GAF 1
Add
BLAST
Domaini251 – 428178GAF 2
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG290744.
HOGENOMiHOG000007069.
HOVERGENiHBG053539.
KOiK13757.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16586-1 [UniParc]FASTAAdd to Basket

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MGEISQETVE KYLEANPQFA KEYFNRKLQV EVPSGGAQAP ASASFPGRTL    50
AEEAALYLEL LEVLLEEAGS VELAAHRALQ RLAQLLQADR CSMFLCRARN 100
GTPEVASKLL DVTPTSKFED NLVVPDREAV FPLDVGIVGW VAHTKKTFNV 150
PDVKKNSHFS DFMDKQTGYV TRNLLATPIV MGKEVLAVFM AVNKVDASEF 200
SKQDEEVFSK YLSFVSIILK LHHTNYLYNI ESRRSQILMW SANKVFEELT 250
DVERQFHKAL YTVRTYLNCE RYSIGLLDMT KEKEFYDEWP VKLGEVEPYK 300
GPKTPDGREV IFYKIIDYIL HGKEEIKVIP TPPMDHWTLI SGLPTYVAEN 350
GFICNMLNAP ADEYFTFQKG PVDETGWVIK NVLSLPIVNK KEDIVGVATF 400
YNRKDGKPFD EYDEHIAETL TQFLGWSLLN TDTYEKMNKL ENRKDIAQEM 450
LMNHTKATPD EIKSILKFKE KLNIDVIEDC EEKQLVTILK EDLPDPRTAD 500
LYEFRFRHLP ITEHELIKCG LRLFFEINVV EKFKVPVEVL TRWMYTVRKG 550
YRAVTYHNWR HGFNVGQTMF TLLMTGRLKK YYTDLEAFAM LAAAFCHDID 600
HRGTNNLYQM KSTSPLARLH GSSILERHHL EYSKTLLQDE SLNIFQNLNK 650
RQYETVIHLF EVAIIATDLA LYFKKRTMFQ KIVDACEKME TEEEAIKYVT 700
IDPTKKEIIM AMMMTACDLS AITKPWEVQS QVALLVANEF WEQGDLERTV 750
LQQQPIPMMD RNKKDELPKL QVGFIDFVCT FVYKEFSRFH KEITPMLNGL 800
QNNRVEWKSL ADEYDEKMKV IEEMKKQEEG NTTEKAVEDS GGGGDDKKSK 850
TCLML 855
Length:855
Mass (Da):98,798
Last modified:August 1, 1990 - v1
Checksum:i1FCFFFD045686D65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37838 mRNA. Translation: AAA30687.1.
M33140 mRNA. Translation: AAA30688.1.
PIRiA34810.
RefSeqiNP_776844.1. NM_174419.1.
UniGeneiBt.444.

Genome annotation databases

GeneIDi281975.
KEGGibta:281975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37838 mRNA. Translation: AAA30687.1 .
M33140 mRNA. Translation: AAA30688.1 .
PIRi A34810.
RefSeqi NP_776844.1. NM_174419.1.
UniGenei Bt.444.

3D structure databases

ProteinModelPortali P16586.
SMRi P16586. Positions 52-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000049725.

Chemistry

BindingDBi P16586.
ChEMBLi CHEMBL2096979.

Proteomic databases

PRIDEi P16586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281975.
KEGGi bta:281975.

Organism-specific databases

CTDi 5146.

Phylogenomic databases

eggNOGi NOG290744.
HOGENOMi HOG000007069.
HOVERGENi HBG053539.
KOi K13757.

Miscellaneous databases

NextBioi 20805846.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone."
    Li T., Volpp K., Applebury M.L.
    Proc. Natl. Acad. Sci. U.S.A. 87:293-297(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases."
    Charbonneau H., Prusti R.K., Letrong H., Sonnenburg W.K., Mullaney P.J., Walsh K., Beavo J.A.
    Proc. Natl. Acad. Sci. U.S.A. 87:288-292(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 308-502, PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiPDE6C_BOVIN
AccessioniPrimary (citable) accession number: P16586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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