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P16581

- LYAM2_HUMAN

UniProt

P16581 - LYAM2_HUMAN

Protein

E-selectin

Gene

SELE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 178 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.1 Publication

    GO - Molecular functioni

    1. oligosaccharide binding Source: BHF-UCL
    2. phospholipase binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. sialic acid binding Source: BHF-UCL
    5. transmembrane signaling receptor activity Source: BHF-UCL

    GO - Biological processi

    1. actin filament-based process Source: BHF-UCL
    2. activation of phospholipase C activity Source: BHF-UCL
    3. blood coagulation Source: Reactome
    4. calcium-mediated signaling Source: BHF-UCL
    5. heterophilic cell-cell adhesion Source: BHF-UCL
    6. inflammatory response Source: ProtInc
    7. leukocyte cell-cell adhesion Source: BHF-UCL
    8. leukocyte migration Source: Reactome
    9. leukocyte migration involved in inflammatory response Source: BHF-UCL
    10. leukocyte tethering or rolling Source: BHF-UCL
    11. positive regulation of leukocyte migration Source: Ensembl
    12. positive regulation of receptor internalization Source: BHF-UCL
    13. regulation of inflammatory response Source: BHF-UCL
    14. response to interleukin-1 Source: BHF-UCL
    15. response to lipopolysaccharide Source: BHF-UCL
    16. response to tumor necrosis factor Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E-selectin
    Alternative name(s):
    CD62 antigen-like family member E
    Endothelial leukocyte adhesion molecule 1
    Short name:
    ELAM-1
    Leukocyte-endothelial cell adhesion molecule 2
    Short name:
    LECAM2
    CD_antigen: CD62E
    Gene namesi
    Name:SELE
    Synonyms:ELAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10718. SELE.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: BHF-UCL
    2. coated pit Source: BHF-UCL
    3. cortical cytoskeleton Source: BHF-UCL
    4. extracellular space Source: BHF-UCL
    5. integral component of membrane Source: UniProtKB-KW
    6. membrane raft Source: BHF-UCL
    7. perinuclear region of cytoplasm Source: BHF-UCL
    8. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti34145. Berger disease.
    PharmGKBiPA35640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 610589E-selectinPRO_0000017492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 1381 Publication
    Disulfide bondi111 ↔ 1301 Publication
    Disulfide bondi143 ↔ 1541 Publication
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 1631 Publication
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi165 ↔ 1741 Publication
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 224By similarity
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi210 ↔ 237By similarity
    Disulfide bondi242 ↔ 286By similarity
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 299By similarity
    Disulfide bondi304 ↔ 349By similarity
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi335 ↔ 362By similarity
    Disulfide bondi367 ↔ 412By similarity
    Disulfide bondi398 ↔ 425By similarity
    Disulfide bondi430 ↔ 475By similarity
    Disulfide bondi461 ↔ 488By similarity
    Disulfide bondi493 ↔ 534By similarity
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi520 ↔ 547By similarity
    Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP16581.
    PRIDEiP16581.

    PTM databases

    PhosphoSiteiP16581.

    Expressioni

    Gene expression databases

    ArrayExpressiP16581.
    BgeeiP16581.
    GenevestigatoriP16581.

    Organism-specific databases

    HPAiCAB002143.

    Interactioni

    Subunit structurei

    Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.2 Publications

    Protein-protein interaction databases

    BioGridi112301. 8 interactions.
    DIPiDIP-58639N.
    IntActiP16581. 1 interaction.
    MINTiMINT-8020220.
    STRINGi9606.ENSP00000331736.

    Structurei

    Secondary structure

    1
    610
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 264
    Helixi33 – 4311
    Beta strandi44 – 474
    Helixi53 – 6210
    Beta strandi70 – 778
    Beta strandi80 – 834
    Turni84 – 863
    Turni92 – 943
    Beta strandi111 – 1144
    Beta strandi119 – 1213
    Beta strandi125 – 1284
    Beta strandi134 – 1407
    Helixi147 – 1504
    Beta strandi151 – 1577
    Beta strandi160 – 1656
    Beta strandi169 – 1713

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ESLX-ray2.00A22-183[»]
    1G1TX-ray1.50A22-178[»]
    1KJAmodel-A22-141[»]
    ProteinModelPortaliP16581.
    SMRiP16581. Positions 22-178, 205-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP16581.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 556535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini579 – 61032CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei557 – 57822HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 139118C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 17536EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 23962Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 30162Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 36462Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini366 – 42762Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini429 – 49062Sushi 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini491 – 54959Sushi 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the selectin/LECAM family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242963.
    HOGENOMiHOG000236254.
    HOVERGENiHBG052375.
    InParanoidiP16581.
    KOiK06494.
    OMAiLECTSQG.
    OrthoDBiEOG7DZ8J9.
    PhylomeDBiP16581.
    TreeFamiTF326910.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 6 hits.
    [Graphical view]
    PRINTSiPR00343. SELECTIN.
    SMARTiSM00032. CCP. 6 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 6 hits.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI    50
    QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG 100
    EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG 150
    HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF 200
    SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN 250
    GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK 300
    AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT 350
    TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ 400
    GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE 450
    FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG 500
    KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP 550
    TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD 600
    GSYQKPSYIL 610
    Length:610
    Mass (Da):66,655
    Last modified:August 1, 1990 - v1
    Checksum:i7D43E3C0D1229229
    GO

    Polymorphismi

    A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211A → S.1 Publication
    Corresponds to variant rs3917407 [ dbSNP | Ensembl ].
    VAR_014300
    Natural varianti31 – 311M → I.1 Publication
    Corresponds to variant rs3917408 [ dbSNP | Ensembl ].
    VAR_014301
    Natural varianti130 – 1301C → W.
    Corresponds to variant rs5360 [ dbSNP | Ensembl ].
    VAR_011790
    Natural varianti149 – 1491S → R Polymorphism associated with coronary artery disease. 5 Publications
    Corresponds to variant rs5361 [ dbSNP | Ensembl ].
    VAR_004191
    Natural varianti257 – 2571Q → P.1 Publication
    Corresponds to variant rs3917422 [ dbSNP | Ensembl ].
    VAR_014302
    Natural varianti295 – 2951E → K.1 Publication
    Corresponds to variant rs5364 [ dbSNP | Ensembl ].
    VAR_011791
    Natural varianti421 – 4211E → Q.1 Publication
    Corresponds to variant rs5366 [ dbSNP | Ensembl ].
    VAR_011792
    Natural varianti468 – 4681H → Y.2 Publications
    Corresponds to variant rs5368 [ dbSNP | Ensembl ].
    VAR_011793
    Natural varianti550 – 5501P → S.1 Publication
    Corresponds to variant rs3917429 [ dbSNP | Ensembl ].
    VAR_014303
    Natural varianti575 – 5751L → F.4 Publications
    Corresponds to variant rs5355 [ dbSNP | Ensembl ].
    VAR_011794

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30640 mRNA. Translation: AAA52377.1.
    M61893
    , M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA. Translation: AAA52375.1.
    M24736 mRNA. Translation: AAA52376.1.
    AF540378 Genomic DNA. Translation: AAN01237.1.
    AL021940 Genomic DNA. Translation: CAA17434.1.
    CH471067 Genomic DNA. Translation: EAW90860.1.
    BC131551 mRNA. Translation: AAI31552.1.
    BC142677 mRNA. Translation: AAI42678.1.
    BC142711 mRNA. Translation: AAI42712.1.
    CCDSiCCDS1283.1.
    PIRiA38615. A35046.
    RefSeqiNP_000441.2. NM_000450.2.
    UniGeneiHs.82848.

    Genome annotation databases

    EnsembliENST00000333360; ENSP00000331736; ENSG00000007908.
    GeneIDi6401.
    KEGGihsa:6401.
    UCSCiuc001ggm.4. human.

    Polymorphism databases

    DMDMi126180.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPs
    Functional Glycomics Gateway - Glycan Binding

    E-selectin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30640 mRNA. Translation: AAA52377.1 .
    M61893
    , M61895 , M61887 , M61888 , M61890 , M61891 , M61892 Genomic DNA. Translation: AAA52375.1 .
    M24736 mRNA. Translation: AAA52376.1 .
    AF540378 Genomic DNA. Translation: AAN01237.1 .
    AL021940 Genomic DNA. Translation: CAA17434.1 .
    CH471067 Genomic DNA. Translation: EAW90860.1 .
    BC131551 mRNA. Translation: AAI31552.1 .
    BC142677 mRNA. Translation: AAI42678.1 .
    BC142711 mRNA. Translation: AAI42712.1 .
    CCDSi CCDS1283.1.
    PIRi A38615. A35046.
    RefSeqi NP_000441.2. NM_000450.2.
    UniGenei Hs.82848.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ESL X-ray 2.00 A 22-183 [» ]
    1G1T X-ray 1.50 A 22-178 [» ]
    1KJA model - A 22-141 [» ]
    ProteinModelPortali P16581.
    SMRi P16581. Positions 22-178, 205-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112301. 8 interactions.
    DIPi DIP-58639N.
    IntActi P16581. 1 interaction.
    MINTi MINT-8020220.
    STRINGi 9606.ENSP00000331736.

    Chemistry

    BindingDBi P16581.
    ChEMBLi CHEMBL3890.

    PTM databases

    PhosphoSitei P16581.

    Polymorphism databases

    DMDMi 126180.

    Proteomic databases

    PaxDbi P16581.
    PRIDEi P16581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333360 ; ENSP00000331736 ; ENSG00000007908 .
    GeneIDi 6401.
    KEGGi hsa:6401.
    UCSCi uc001ggm.4. human.

    Organism-specific databases

    CTDi 6401.
    GeneCardsi GC01M169691.
    HGNCi HGNC:10718. SELE.
    HPAi CAB002143.
    MIMi 131210. gene.
    neXtProti NX_P16581.
    Orphaneti 34145. Berger disease.
    PharmGKBi PA35640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242963.
    HOGENOMi HOG000236254.
    HOVERGENi HBG052375.
    InParanoidi P16581.
    KOi K06494.
    OMAi LECTSQG.
    OrthoDBi EOG7DZ8J9.
    PhylomeDBi P16581.
    TreeFami TF326910.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    EvolutionaryTracei P16581.
    GeneWikii E-selectin.
    GenomeRNAii 6401.
    NextBioi 24870.
    PROi P16581.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16581.
    Bgeei P16581.
    Genevestigatori P16581.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 6 hits.
    [Graphical view ]
    PRINTSi PR00343. SELECTIN.
    SMARTi SM00032. CCP. 6 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 6 hits.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."
      Hession C., Osborn L., Goff D., Chi-Rosso G., Vassallo C., Pasek M., Pittack C., Tizard R., Goelz S., McCarthy K., Hopple S., Lobb R.
      Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
      Tissue: Umbilical vein endothelial cell.
    2. "Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."
      Bevilacqua M.P., Stengelin S., Gimbrone M.A. Jr., Seed B.
      Science 243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."
      Collins T., Williams A., Johnston G.I., Kim J., Eddy R., Shows T., Gimbrone M.A. Jr., Bevilacqua M.P.
      J. Biol. Chem. 266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. SeattleSNPs variation discovery resource
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."
      Phillips M.L., Nudelman E., Gaeta F.C., Perez M., Singhal A.K., Hakomori S., Paulson J.C.
      Science 250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND.
    9. "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
      Kerr S.C., Fieger C.B., Snapp K.R., Rosen S.D.
      J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PODXL2.
    10. "Modelling the carbohydrate recognition domain of human E-selectin."
      Mills A.
      FEBS Lett. 319:5-11(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
    11. "Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."
      Graves B.J., Crowther R.L., Chandran C., Rumberger J.M., Li S., Huang K.-S., Presky D.H., Familletti P.C., Wolitzky B.A., Burns D.K.
      Nature 367:532-538(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-178.
    12. "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
      Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
      Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 22-178 IN COMPLEX WITH CALCIUM IONS AND SELPLG, SUBUNIT, DISULFIDE BONDS.
    13. Erratum
      Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
      Cell 105:971-971(2001)
    14. Cited for: VARIANT ARG-149.
    15. "DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
      Wenzel K., Ernst M., Rohde K., Baumann G., Speer A.
      Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-149 AND PHE-575.
    16. "A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."
      Ye S.Q., Usher D., Virgil D., Zhang L.Q., Yochim S.E., Gupta R.
      J. Biomed. Sci. 6:18-21(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-149.
    17. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
      Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575.
    18. "Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."
      Sass C., Pallaud C., Zannad F., Visvikis S.
      Hum. Genet. 107:58-61(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PHE-575.

    Entry informationi

    Entry nameiLYAM2_HUMAN
    AccessioniPrimary (citable) accession number: P16581
    Secondary accession number(s): A2RRD6, P16111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 178 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3