Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P16581

- LYAM2_HUMAN

UniProt

P16581 - LYAM2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

E-selectin

Gene

SELE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.1 Publication

GO - Molecular functioni

  1. oligosaccharide binding Source: BHF-UCL
  2. phospholipase binding Source: BHF-UCL
  3. sialic acid binding Source: BHF-UCL
  4. transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

  1. actin filament-based process Source: BHF-UCL
  2. activation of phospholipase C activity Source: BHF-UCL
  3. blood coagulation Source: Reactome
  4. calcium-mediated signaling Source: BHF-UCL
  5. heterophilic cell-cell adhesion Source: BHF-UCL
  6. inflammatory response Source: ProtInc
  7. leukocyte cell-cell adhesion Source: BHF-UCL
  8. leukocyte migration Source: Reactome
  9. leukocyte migration involved in inflammatory response Source: BHF-UCL
  10. leukocyte tethering or rolling Source: BHF-UCL
  11. positive regulation of leukocyte migration Source: Ensembl
  12. positive regulation of receptor internalization Source: BHF-UCL
  13. regulation of inflammatory response Source: BHF-UCL
  14. response to interleukin-1 Source: BHF-UCL
  15. response to lipopolysaccharide Source: BHF-UCL
  16. response to tumor necrosis factor Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:SELE
Synonyms:ELAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10718. SELE.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: BHF-UCL
  2. coated pit Source: BHF-UCL
  3. cortical cytoskeleton Source: BHF-UCL
  4. extracellular space Source: BHF-UCL
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane raft Source: BHF-UCL
  7. perinuclear region of cytoplasm Source: BHF-UCL
  8. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti34145. Berger disease.
PharmGKBiPA35640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 610589E-selectinPRO_0000017492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi40 ↔ 1381 Publication
Disulfide bondi111 ↔ 1301 Publication
Disulfide bondi143 ↔ 1541 Publication
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi148 ↔ 1631 Publication
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi165 ↔ 1741 Publication
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi180 ↔ 224By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi210 ↔ 237By similarity
Disulfide bondi242 ↔ 286By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi272 ↔ 299By similarity
Disulfide bondi304 ↔ 349By similarity
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi335 ↔ 362By similarity
Disulfide bondi367 ↔ 412By similarity
Disulfide bondi398 ↔ 425By similarity
Disulfide bondi430 ↔ 475By similarity
Disulfide bondi461 ↔ 488By similarity
Disulfide bondi493 ↔ 534By similarity
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi520 ↔ 547By similarity
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16581.
PRIDEiP16581.

PTM databases

PhosphoSiteiP16581.

Expressioni

Gene expression databases

BgeeiP16581.
ExpressionAtlasiP16581. baseline and differential.
GenevestigatoriP16581.

Organism-specific databases

HPAiCAB002143.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.2 Publications

Protein-protein interaction databases

BioGridi112301. 9 interactions.
DIPiDIP-58639N.
IntActiP16581. 1 interaction.
MINTiMINT-8020220.
STRINGi9606.ENSP00000331736.

Structurei

Secondary structure

1
610
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 264
Helixi33 – 4311
Beta strandi44 – 474
Helixi53 – 6210
Beta strandi70 – 778
Beta strandi80 – 834
Turni84 – 863
Turni92 – 943
Beta strandi111 – 1144
Beta strandi119 – 1213
Beta strandi125 – 1284
Beta strandi134 – 1407
Helixi147 – 1504
Beta strandi151 – 1577
Beta strandi160 – 1656
Beta strandi169 – 1713

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESLX-ray2.00A22-183[»]
1G1TX-ray1.50A22-178[»]
1KJAmodel-A22-141[»]
4C16X-ray1.93A/B22-301[»]
ProteinModelPortaliP16581.
SMRiP16581. Positions 22-549.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16581.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 556535ExtracellularSequence AnalysisAdd
BLAST
Topological domaini579 – 61032CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei557 – 57822HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 139118C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 17536EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini178 – 23962Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 30162Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini303 – 36462Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 42762Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 49062Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini491 – 54959Sushi 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242963.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP16581.
KOiK06494.
OMAiLECTSQG.
OrthoDBiEOG7DZ8J9.
PhylomeDBiP16581.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI
60 70 80 90 100
QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG
160 170 180 190 200
HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF
210 220 230 240 250
SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN
260 270 280 290 300
GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
310 320 330 340 350
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT
360 370 380 390 400
TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ
410 420 430 440 450
GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE
460 470 480 490 500
FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG
510 520 530 540 550
KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP
560 570 580 590 600
TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
610
GSYQKPSYIL
Length:610
Mass (Da):66,655
Last modified:August 1, 1990 - v1
Checksum:i7D43E3C0D1229229
GO

Polymorphismi

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211A → S.1 Publication
Corresponds to variant rs3917407 [ dbSNP | Ensembl ].
VAR_014300
Natural varianti31 – 311M → I.1 Publication
Corresponds to variant rs3917408 [ dbSNP | Ensembl ].
VAR_014301
Natural varianti130 – 1301C → W.
Corresponds to variant rs5360 [ dbSNP | Ensembl ].
VAR_011790
Natural varianti149 – 1491S → R Polymorphism associated with coronary artery disease. 5 Publications
Corresponds to variant rs5361 [ dbSNP | Ensembl ].
VAR_004191
Natural varianti257 – 2571Q → P.1 Publication
Corresponds to variant rs3917422 [ dbSNP | Ensembl ].
VAR_014302
Natural varianti295 – 2951E → K.1 Publication
Corresponds to variant rs5364 [ dbSNP | Ensembl ].
VAR_011791
Natural varianti421 – 4211E → Q.1 Publication
Corresponds to variant rs5366 [ dbSNP | Ensembl ].
VAR_011792
Natural varianti468 – 4681H → Y.2 Publications
Corresponds to variant rs5368 [ dbSNP | Ensembl ].
VAR_011793
Natural varianti550 – 5501P → S.1 Publication
Corresponds to variant rs3917429 [ dbSNP | Ensembl ].
VAR_014303
Natural varianti575 – 5751L → F.4 Publications
Corresponds to variant rs5355 [ dbSNP | Ensembl ].
VAR_011794

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30640 mRNA. Translation: AAA52377.1.
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA. Translation: AAA52375.1.
M24736 mRNA. Translation: AAA52376.1.
AF540378 Genomic DNA. Translation: AAN01237.1.
AL021940 Genomic DNA. Translation: CAA17434.1.
CH471067 Genomic DNA. Translation: EAW90860.1.
BC131551 mRNA. Translation: AAI31552.1.
BC142677 mRNA. Translation: AAI42678.1.
BC142711 mRNA. Translation: AAI42712.1.
CCDSiCCDS1283.1.
PIRiA38615. A35046.
RefSeqiNP_000441.2. NM_000450.2.
UniGeneiHs.82848.

Genome annotation databases

EnsembliENST00000333360; ENSP00000331736; ENSG00000007908.
GeneIDi6401.
KEGGihsa:6401.
UCSCiuc001ggm.4. human.

Polymorphism databases

DMDMi126180.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

E-selectin

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30640 mRNA. Translation: AAA52377.1 .
M61893
, M61895 , M61887 , M61888 , M61890 , M61891 , M61892 Genomic DNA. Translation: AAA52375.1 .
M24736 mRNA. Translation: AAA52376.1 .
AF540378 Genomic DNA. Translation: AAN01237.1 .
AL021940 Genomic DNA. Translation: CAA17434.1 .
CH471067 Genomic DNA. Translation: EAW90860.1 .
BC131551 mRNA. Translation: AAI31552.1 .
BC142677 mRNA. Translation: AAI42678.1 .
BC142711 mRNA. Translation: AAI42712.1 .
CCDSi CCDS1283.1.
PIRi A38615. A35046.
RefSeqi NP_000441.2. NM_000450.2.
UniGenei Hs.82848.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ESL X-ray 2.00 A 22-183 [» ]
1G1T X-ray 1.50 A 22-178 [» ]
1KJA model - A 22-141 [» ]
4C16 X-ray 1.93 A/B 22-301 [» ]
ProteinModelPortali P16581.
SMRi P16581. Positions 22-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112301. 9 interactions.
DIPi DIP-58639N.
IntActi P16581. 1 interaction.
MINTi MINT-8020220.
STRINGi 9606.ENSP00000331736.

Chemistry

BindingDBi P16581.
ChEMBLi CHEMBL3890.
DrugBanki DB01136. Carvedilol.

PTM databases

PhosphoSitei P16581.

Polymorphism databases

DMDMi 126180.

Proteomic databases

PaxDbi P16581.
PRIDEi P16581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333360 ; ENSP00000331736 ; ENSG00000007908 .
GeneIDi 6401.
KEGGi hsa:6401.
UCSCi uc001ggm.4. human.

Organism-specific databases

CTDi 6401.
GeneCardsi GC01M169691.
HGNCi HGNC:10718. SELE.
HPAi CAB002143.
MIMi 131210. gene.
neXtProti NX_P16581.
Orphaneti 34145. Berger disease.
PharmGKBi PA35640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242963.
GeneTreei ENSGT00760000118803.
HOGENOMi HOG000236254.
HOVERGENi HBG052375.
InParanoidi P16581.
KOi K06494.
OMAi LECTSQG.
OrthoDBi EOG7DZ8J9.
PhylomeDBi P16581.
TreeFami TF326910.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTracei P16581.
GeneWikii E-selectin.
GenomeRNAii 6401.
NextBioi 24870.
PROi P16581.
SOURCEi Search...

Gene expression databases

Bgeei P16581.
ExpressionAtlasi P16581. baseline and differential.
Genevestigatori P16581.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view ]
PRINTSi PR00343. SELECTIN.
SMARTi SM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."
    Hession C., Osborn L., Goff D., Chi-Rosso G., Vassallo C., Pasek M., Pittack C., Tizard R., Goelz S., McCarthy K., Hopple S., Lobb R.
    Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    Tissue: Umbilical vein endothelial cell.
  2. "Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."
    Bevilacqua M.P., Stengelin S., Gimbrone M.A. Jr., Seed B.
    Science 243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."
    Collins T., Williams A., Johnston G.I., Kim J., Eddy R., Shows T., Gimbrone M.A. Jr., Bevilacqua M.P.
    J. Biol. Chem. 266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. SeattleSNPs variation discovery resource
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."
    Phillips M.L., Nudelman E., Gaeta F.C., Perez M., Singhal A.K., Hakomori S., Paulson J.C.
    Science 250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND.
  9. "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
    Kerr S.C., Fieger C.B., Snapp K.R., Rosen S.D.
    J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PODXL2.
  10. "Modelling the carbohydrate recognition domain of human E-selectin."
    Mills A.
    FEBS Lett. 319:5-11(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
  11. "Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."
    Graves B.J., Crowther R.L., Chandran C., Rumberger J.M., Li S., Huang K.-S., Presky D.H., Familletti P.C., Wolitzky B.A., Burns D.K.
    Nature 367:532-538(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-178.
  12. "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
    Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
    Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 22-178 IN COMPLEX WITH CALCIUM IONS AND SELPLG, SUBUNIT, DISULFIDE BONDS.
  13. Erratum
    Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
    Cell 105:971-971(2001)
  14. Cited for: VARIANT ARG-149.
  15. "DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
    Wenzel K., Ernst M., Rohde K., Baumann G., Speer A.
    Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARG-149 AND PHE-575.
  16. "A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."
    Ye S.Q., Usher D., Virgil D., Zhang L.Q., Yochim S.E., Gupta R.
    J. Biomed. Sci. 6:18-21(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-149.
  17. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575.
  18. "Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."
    Sass C., Pallaud C., Zannad F., Visvikis S.
    Hum. Genet. 107:58-61(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PHE-575.

Entry informationi

Entry nameiLYAM2_HUMAN
AccessioniPrimary (citable) accession number: P16581
Secondary accession number(s): A2RRD6, P16111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3