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Protein

E-selectin

Gene

SELE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.1 Publication

GO - Molecular functioni

  • oligosaccharide binding Source: BHF-UCL
  • phospholipase binding Source: BHF-UCL
  • sialic acid binding Source: BHF-UCL
  • transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

  • actin filament-based process Source: BHF-UCL
  • activation of phospholipase C activity Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  • inflammatory response Source: ProtInc
  • leukocyte cell-cell adhesion Source: BHF-UCL
  • leukocyte migration Source: Reactome
  • leukocyte migration involved in inflammatory response Source: BHF-UCL
  • leukocyte tethering or rolling Source: BHF-UCL
  • positive regulation of receptor internalization Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • response to interleukin-1 Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • response to tumor necrosis factor Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
SIGNORiP16581.

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:SELE
Synonyms:ELAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10718. SELE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 556535ExtracellularSequence analysisAdd
BLAST
Transmembranei557 – 57822HelicalSequence analysisAdd
BLAST
Topological domaini579 – 61032CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: BHF-UCL
  • clathrin-coated pit Source: BHF-UCL
  • cortical cytoskeleton Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti34145. Berger disease.
PharmGKBiPA35640.

Chemistry

ChEMBLiCHEMBL3890.
DrugBankiDB01136. Carvedilol.

Polymorphism and mutation databases

BioMutaiSELE.
DMDMi126180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 610589E-selectinPRO_0000017492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi40 ↔ 1381 Publication
Disulfide bondi111 ↔ 1301 Publication
Disulfide bondi143 ↔ 1541 Publication
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi148 ↔ 1631 Publication
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 1741 Publication
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi180 ↔ 224By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi210 ↔ 237By similarity
Disulfide bondi242 ↔ 286By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi272 ↔ 299By similarity
Disulfide bondi304 ↔ 349By similarity
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi335 ↔ 362By similarity
Disulfide bondi367 ↔ 412By similarity
Disulfide bondi398 ↔ 425By similarity
Disulfide bondi430 ↔ 475By similarity
Disulfide bondi461 ↔ 488By similarity
Disulfide bondi493 ↔ 534By similarity
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi520 ↔ 547By similarity
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16581.
PeptideAtlasiP16581.
PRIDEiP16581.

PTM databases

iPTMnetiP16581.
PhosphoSiteiP16581.

Expressioni

Gene expression databases

BgeeiENSG00000007908.
ExpressionAtlasiP16581. baseline and differential.
GenevisibleiP16581. HS.

Organism-specific databases

HPAiCAB002143.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.2 Publications

GO - Molecular functioni

  • phospholipase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112301. 16 interactions.
DIPiDIP-58639N.
IntActiP16581. 1 interaction.
MINTiMINT-8020220.
STRINGi9606.ENSP00000331736.

Chemistry

BindingDBiP16581.

Structurei

Secondary structure

1
610
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 264Combined sources
Helixi33 – 4311Combined sources
Beta strandi44 – 474Combined sources
Helixi53 – 6210Combined sources
Beta strandi70 – 778Combined sources
Beta strandi80 – 834Combined sources
Turni84 – 863Combined sources
Turni92 – 943Combined sources
Beta strandi111 – 1144Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi134 – 1407Combined sources
Helixi147 – 1504Combined sources
Beta strandi151 – 1577Combined sources
Beta strandi160 – 1656Combined sources
Beta strandi169 – 1713Combined sources
Beta strandi189 – 1946Combined sources
Beta strandi196 – 1983Combined sources
Beta strandi205 – 2106Combined sources
Beta strandi214 – 2174Combined sources
Beta strandi222 – 2243Combined sources
Beta strandi230 – 2323Combined sources
Beta strandi237 – 2393Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi267 – 2726Combined sources
Beta strandi277 – 2804Combined sources
Beta strandi282 – 2865Combined sources
Beta strandi292 – 2943Combined sources
Beta strandi298 – 3003Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESLX-ray2.00A22-183[»]
1G1TX-ray1.50A22-178[»]
1KJAmodel-A22-141[»]
4C16X-ray1.93A/B22-301[»]
4CSYX-ray2.41A/B22-301[»]
ProteinModelPortaliP16581.
SMRiP16581. Positions 22-549.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 139118C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 17536EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini178 – 23962Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 30162Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini303 – 36462Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 42762Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 49062Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini491 – 54959Sushi 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP16581.
KOiK06494.
OMAiAFQCTAL.
OrthoDBiEOG091G04KC.
PhylomeDBiP16581.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI
60 70 80 90 100
QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG
160 170 180 190 200
HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF
210 220 230 240 250
SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN
260 270 280 290 300
GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
310 320 330 340 350
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT
360 370 380 390 400
TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ
410 420 430 440 450
GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE
460 470 480 490 500
FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG
510 520 530 540 550
KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP
560 570 580 590 600
TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
610
GSYQKPSYIL
Length:610
Mass (Da):66,655
Last modified:August 1, 1990 - v1
Checksum:i7D43E3C0D1229229
GO

Polymorphismi

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211A → S.1 Publication
Corresponds to variant rs3917407 [ dbSNP | Ensembl ].
VAR_014300
Natural varianti31 – 311M → I.1 Publication
Corresponds to variant rs3917408 [ dbSNP | Ensembl ].
VAR_014301
Natural varianti130 – 1301C → W.
Corresponds to variant rs5360 [ dbSNP | Ensembl ].
VAR_011790
Natural varianti149 – 1491S → R Polymorphism associated with coronary artery disease; no effect on ligand-specificity; may increase levels of rolling and adhesion of neutrophils and peripheral blood mononuclear cells to the endothelium; may induce constitutive stimulation of the MAPK signaling pathway, in the absence of leukocyte adhesion. 7 Publications
Corresponds to variant rs5361 [ dbSNP | Ensembl ].
VAR_004191
Natural varianti257 – 2571Q → P.1 Publication
Corresponds to variant rs3917422 [ dbSNP | Ensembl ].
VAR_014302
Natural varianti295 – 2951E → K.1 Publication
Corresponds to variant rs5364 [ dbSNP | Ensembl ].
VAR_011791
Natural varianti421 – 4211E → Q.1 Publication
Corresponds to variant rs5366 [ dbSNP | Ensembl ].
VAR_011792
Natural varianti468 – 4681H → Y.2 Publications
Corresponds to variant rs5368 [ dbSNP | Ensembl ].
VAR_011793
Natural varianti545 – 5451P → L.1 Publication
VAR_074189
Natural varianti550 – 5501P → S.1 Publication
Corresponds to variant rs3917429 [ dbSNP | Ensembl ].
VAR_014303
Natural varianti575 – 5751L → F.4 Publications
Corresponds to variant rs5355 [ dbSNP | Ensembl ].
VAR_011794

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30640 mRNA. Translation: AAA52377.1.
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA. Translation: AAA52375.1.
M24736 mRNA. Translation: AAA52376.1.
AF540378 Genomic DNA. Translation: AAN01237.1.
AL021940 Genomic DNA. Translation: CAA17434.1.
CH471067 Genomic DNA. Translation: EAW90860.1.
BC131551 mRNA. Translation: AAI31552.1.
BC142677 mRNA. Translation: AAI42678.1.
BC142711 mRNA. Translation: AAI42712.1.
CCDSiCCDS1283.1.
PIRiA38615. A35046.
RefSeqiNP_000441.2. NM_000450.2.
UniGeneiHs.82848.

Genome annotation databases

EnsembliENST00000333360; ENSP00000331736; ENSG00000007908.
GeneIDi6401.
KEGGihsa:6401.
UCSCiuc001ggm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

E-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30640 mRNA. Translation: AAA52377.1.
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA. Translation: AAA52375.1.
M24736 mRNA. Translation: AAA52376.1.
AF540378 Genomic DNA. Translation: AAN01237.1.
AL021940 Genomic DNA. Translation: CAA17434.1.
CH471067 Genomic DNA. Translation: EAW90860.1.
BC131551 mRNA. Translation: AAI31552.1.
BC142677 mRNA. Translation: AAI42678.1.
BC142711 mRNA. Translation: AAI42712.1.
CCDSiCCDS1283.1.
PIRiA38615. A35046.
RefSeqiNP_000441.2. NM_000450.2.
UniGeneiHs.82848.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESLX-ray2.00A22-183[»]
1G1TX-ray1.50A22-178[»]
1KJAmodel-A22-141[»]
4C16X-ray1.93A/B22-301[»]
4CSYX-ray2.41A/B22-301[»]
ProteinModelPortaliP16581.
SMRiP16581. Positions 22-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112301. 16 interactions.
DIPiDIP-58639N.
IntActiP16581. 1 interaction.
MINTiMINT-8020220.
STRINGi9606.ENSP00000331736.

Chemistry

BindingDBiP16581.
ChEMBLiCHEMBL3890.
DrugBankiDB01136. Carvedilol.

PTM databases

iPTMnetiP16581.
PhosphoSiteiP16581.

Polymorphism and mutation databases

BioMutaiSELE.
DMDMi126180.

Proteomic databases

PaxDbiP16581.
PeptideAtlasiP16581.
PRIDEiP16581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333360; ENSP00000331736; ENSG00000007908.
GeneIDi6401.
KEGGihsa:6401.
UCSCiuc001ggm.5. human.

Organism-specific databases

CTDi6401.
GeneCardsiSELE.
HGNCiHGNC:10718. SELE.
HPAiCAB002143.
MIMi131210. gene.
neXtProtiNX_P16581.
Orphaneti34145. Berger disease.
PharmGKBiPA35640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP16581.
KOiK06494.
OMAiAFQCTAL.
OrthoDBiEOG091G04KC.
PhylomeDBiP16581.
TreeFamiTF326910.

Enzyme and pathway databases

ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
SIGNORiP16581.

Miscellaneous databases

EvolutionaryTraceiP16581.
GeneWikiiE-selectin.
GenomeRNAii6401.
PROiP16581.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007908.
ExpressionAtlasiP16581. baseline and differential.
GenevisibleiP16581. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM2_HUMAN
AccessioniPrimary (citable) accession number: P16581
Secondary accession number(s): A2RRD6, P16111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 194 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.