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P16581 (LYAM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 173. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name=ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name=LECAM2
CD_antigen=CD62E
Gene names
Name:SELE
Synonyms:ELAM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Ref.1

Subunit structure

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction. Ref.9 Ref.12

Subcellular location

Membrane; Single-pass type I membrane protein.

Polymorphism

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence similarities

Belongs to the selectin/LECAM family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 6 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament-based process

Inferred from direct assay PubMed 8609175. Source: BHF-UCL

activation of phospholipase C activity

Inferred from mutant phenotype PubMed 12960351. Source: BHF-UCL

blood coagulation

Traceable author statement. Source: Reactome

calcium-mediated signaling

Traceable author statement PubMed 12960351. Source: BHF-UCL

heterophilic cell-cell adhesion

Inferred from mutant phenotype PubMed 18029551. Source: BHF-UCL

inflammatory response

Traceable author statement Ref.2. Source: ProtInc

leukocyte cell-cell adhesion

Inferred from direct assay PubMed 7680663. Source: BHF-UCL

leukocyte migration

Traceable author statement. Source: Reactome

leukocyte migration involved in inflammatory response

Traceable author statement PubMed 18029551. Source: BHF-UCL

leukocyte tethering or rolling

Inferred from mutant phenotype PubMed 18029551. Source: BHF-UCL

positive regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor internalization

Inferred from direct assay PubMed 9312078. Source: BHF-UCL

regulation of inflammatory response

Traceable author statement PubMed 18029551. Source: BHF-UCL

response to interleukin-1

Inferred from direct assay PubMed 8609175. Source: BHF-UCL

response to lipopolysaccharide

Traceable author statement PubMed 18029551. Source: BHF-UCL

response to tumor necrosis factor

Traceable author statement PubMed 18029551. Source: BHF-UCL

   Cellular_componentcaveola

Inferred from direct assay PubMed 12960351. Source: BHF-UCL

coated pit

Inferred from direct assay PubMed 18029551. Source: BHF-UCL

cortical cytoskeleton

Inferred from direct assay PubMed 8609175. Source: BHF-UCL

extracellular space

Inferred from direct assay PubMed 9290466. Source: BHF-UCL

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from direct assay PubMed 18029551. Source: BHF-UCL

perinuclear region of cytoplasm

Inferred from direct assay PubMed 12960351. Source: BHF-UCL

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionoligosaccharide binding

Inferred from direct assay PubMed 7680663. Source: BHF-UCL

phospholipase binding

Inferred from direct assay PubMed 12960351. Source: BHF-UCL

sialic acid binding

Inferred from direct assay PubMed 7680663. Source: BHF-UCL

transmembrane signaling receptor activity

Inferred from mutant phenotype PubMed 12960351. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 610589E-selectin
PRO_0000017492

Regions

Topological domain22 – 556535Extracellular Potential
Transmembrane557 – 57822Helical; Potential
Topological domain579 – 61032Cytoplasmic Potential
Domain22 – 139118C-type lectin
Domain140 – 17536EGF-like
Domain178 – 23962Sushi 1
Domain240 – 30162Sushi 2
Domain303 – 36462Sushi 3
Domain366 – 42762Sushi 4
Domain429 – 49062Sushi 5
Domain491 – 54959Sushi 6

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3321N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Potential
Glycosylation5271N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 138 Ref.12
Disulfide bond111 ↔ 130 Ref.12
Disulfide bond143 ↔ 154 Ref.12
Disulfide bond148 ↔ 163 Ref.12
Disulfide bond165 ↔ 174 Ref.12
Disulfide bond180 ↔ 224 By similarity
Disulfide bond210 ↔ 237 By similarity
Disulfide bond242 ↔ 286 By similarity
Disulfide bond272 ↔ 299 By similarity
Disulfide bond304 ↔ 349 By similarity
Disulfide bond335 ↔ 362 By similarity
Disulfide bond367 ↔ 412 By similarity
Disulfide bond398 ↔ 425 By similarity
Disulfide bond430 ↔ 475 By similarity
Disulfide bond461 ↔ 488 By similarity
Disulfide bond493 ↔ 534 By similarity
Disulfide bond520 ↔ 547 By similarity

Natural variations

Natural variant211A → S. Ref.4
Corresponds to variant rs3917407 [ dbSNP | Ensembl ].
VAR_014300
Natural variant311M → I. Ref.4
Corresponds to variant rs3917408 [ dbSNP | Ensembl ].
VAR_014301
Natural variant1301C → W.
Corresponds to variant rs5360 [ dbSNP | Ensembl ].
VAR_011790
Natural variant1491S → R Polymorphism associated with coronary artery disease. Ref.4 Ref.14 Ref.15 Ref.16 Ref.17
Corresponds to variant rs5361 [ dbSNP | Ensembl ].
VAR_004191
Natural variant2571Q → P. Ref.4
Corresponds to variant rs3917422 [ dbSNP | Ensembl ].
VAR_014302
Natural variant2951E → K. Ref.4
Corresponds to variant rs5364 [ dbSNP | Ensembl ].
VAR_011791
Natural variant4211E → Q. Ref.4
Corresponds to variant rs5366 [ dbSNP | Ensembl ].
VAR_011792
Natural variant4681H → Y. Ref.4 Ref.17
Corresponds to variant rs5368 [ dbSNP | Ensembl ].
VAR_011793
Natural variant5501P → S. Ref.4
Corresponds to variant rs3917429 [ dbSNP | Ensembl ].
VAR_014303
Natural variant5751L → F. Ref.4 Ref.15 Ref.17 Ref.18
Corresponds to variant rs5355 [ dbSNP | Ensembl ].
VAR_011794

Secondary structure

.............................. 610
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P16581 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 7D43E3C0D1229229

FASTA61066,655
        10         20         30         40         50         60 
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN 

        70         80         90        100        110        120 
SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK 

       130        140        150        160        170        180 
DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC 

       190        200        210        220        230        240 
TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV 

       250        260        270        280        290        300 
ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK 

       310        320        330        340        350        360 
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP 

       370        380        390        400        410        420 
VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN 

       430        440        450        460        470        480 
EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ 

       490        500        510        520        530        540 
WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW 

       550        560        570        580        590        600 
SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD 

       610 
GSYQKPSYIL 

« Hide

References

« Hide 'large scale' references
[1]"Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."
Hession C., Osborn L., Goff D., Chi-Rosso G., Vassallo C., Pasek M., Pittack C., Tizard R., Goelz S., McCarthy K., Hopple S., Lobb R.
Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
Tissue: Umbilical vein endothelial cell.
[2]"Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."
Bevilacqua M.P., Stengelin S., Gimbrone M.A. Jr., Seed B.
Science 243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."
Collins T., Williams A., Johnston G.I., Kim J., Eddy R., Shows T., Gimbrone M.A. Jr., Bevilacqua M.P.
J. Biol. Chem. 266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]SeattleSNPs variation discovery resource
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."
Phillips M.L., Nudelman E., Gaeta F.C., Perez M., Singhal A.K., Hakomori S., Paulson J.C.
Science 250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND.
[9]"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
Kerr S.C., Fieger C.B., Snapp K.R., Rosen S.D.
J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PODXL2.
[10]"Modelling the carbohydrate recognition domain of human E-selectin."
Mills A.
FEBS Lett. 319:5-11(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
[11]"Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."
Graves B.J., Crowther R.L., Chandran C., Rumberger J.M., Li S., Huang K.-S., Presky D.H., Familletti P.C., Wolitzky B.A., Burns D.K.
Nature 367:532-538(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-178.
[12]"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 22-178 IN COMPLEX WITH CALCIUM IONS AND SELPLG, SUBUNIT, DISULFIDE BONDS.
[13]Erratum
Somers W.S., Tang J., Shaw G.D., Camphausen R.T.
Cell 105:971-971(2001)
[14]"E-selectin polymorphism and atherosclerosis: an association study."
Wenzel K., Felix S., Kleber F.X., Brachold R., Menke T., Schattke S., Schulte K.L., Glaser C., Rohde K., Baumann G., Speer A.
Hum. Mol. Genet. 3:1935-1937(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARG-149.
[15]"DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
Wenzel K., Ernst M., Rohde K., Baumann G., Speer A.
Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARG-149 AND PHE-575.
[16]"A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."
Ye S.Q., Usher D., Virgil D., Zhang L.Q., Yochim S.E., Gupta R.
J. Biomed. Sci. 6:18-21(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARG-149.
[17]"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575.
[18]"Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."
Sass C., Pallaud C., Zannad F., Visvikis S.
Hum. Genet. 107:58-61(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT PHE-575.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30640 mRNA. Translation: AAA52377.1.
M61893 expand/collapse EMBL AC list , M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA. Translation: AAA52375.1.
M24736 mRNA. Translation: AAA52376.1.
AF540378 Genomic DNA. Translation: AAN01237.1.
AL021940 Genomic DNA. Translation: CAA17434.1.
CH471067 Genomic DNA. Translation: EAW90860.1.
BC131551 mRNA. Translation: AAI31552.1.
BC142677 mRNA. Translation: AAI42678.1.
BC142711 mRNA. Translation: AAI42712.1.
PIRA35046. A38615.
RefSeqNP_000441.2. NM_000450.2.
UniGeneHs.82848.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESLX-ray2.00A22-183[»]
1G1TX-ray1.50A22-178[»]
1KJAmodel-A22-141[»]
ProteinModelPortalP16581.
SMRP16581. Positions 22-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112301. 8 interactions.
DIPDIP-58639N.
IntActP16581. 1 interaction.
MINTMINT-8020220.
STRING9606.ENSP00000331736.

Chemistry

BindingDBP16581.
ChEMBLCHEMBL3890.

PTM databases

PhosphoSiteP16581.

Polymorphism databases

DMDM126180.

Proteomic databases

PaxDbP16581.
PRIDEP16581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333360; ENSP00000331736; ENSG00000007908.
GeneID6401.
KEGGhsa:6401.
UCSCuc001ggm.4. human.

Organism-specific databases

CTD6401.
GeneCardsGC01M169691.
HGNCHGNC:10718. SELE.
HPACAB002143.
MIM131210. gene.
neXtProtNX_P16581.
Orphanet34145. Berger disease.
PharmGKBPA35640.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242963.
HOGENOMHOG000236254.
HOVERGENHBG052375.
InParanoidP16581.
KOK06494.
OMAGEPNNKQ.
OrthoDBEOG7DZ8J9.
PhylomeDBP16581.
TreeFamTF326910.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressP16581.
BgeeP16581.
GenevestigatorP16581.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSPR00343. SELECTIN.
SMARTSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP16581.
GeneWikiE-selectin.
GenomeRNAi6401.
NextBio24870.
PROP16581.
SOURCESearch...

Entry information

Entry nameLYAM2_HUMAN
AccessionPrimary (citable) accession number: P16581
Secondary accession number(s): A2RRD6, P16111
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries