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Protein

Cysteine-rich secretory protein 2

Gene

Crisp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 2
Short name:
CRISP-2
Alternative name(s):
Testis-specific protein TPX-1
Gene namesi
Name:Crisp2
Synonyms:Tpx-1, Tpx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98815. Crisp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000626623 – 243Cysteine-rich secretory protein 2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi189 ↔ 196PROSITE-ProRule annotation1 Publication
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation1 Publication
Disulfide bondi205 ↔ 238PROSITE-ProRule annotation1 Publication
Disulfide bondi214 ↔ 232PROSITE-ProRule annotation1 Publication
Disulfide bondi223 ↔ 236PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP16563.
PRIDEiP16563.

PTM databases

iPTMnetiP16563.
PhosphoSitePlusiP16563.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSMUSG00000023930.
CleanExiMM_CRISP2.
ExpressionAtlasiP16563. baseline and differential.
GenevisibleiP16563. MM.

Interactioni

Subunit structurei

Interacts with NSUN4 isoform 3.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024724.

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi197 – 200Combined sources4
Helixi214 – 220Combined sources7
Helixi228 – 231Combined sources4
Helixi233 – 236Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A05NMR-A189-243[»]
ProteinModelPortaliP16563.
SMRiP16563.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 169SCPAdd BLAST128
Domaini205 – 238ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiP16563.
KOiK19919.
OMAiCKHELLK.
OrthoDBiEOG091G0D4V.
PhylomeDBiP16563.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWFQVMLFV FALLLRSPLT EGKDPDFTSL LTNQLQVQRE IVNKHNELRR
60 70 80 90 100
SVNPTGSDIL KMEWSIQATT NAQKWANKCI LEHSSKDDRK INIRCGENLY
110 120 130 140 150
MSTDPTLWST VIQSWYNENE DFVYGVGAKP NSAVGHYTQL VWYSSFKIGC
160 170 180 190 200
GIAYCPNQDN LKYFYVCHYC PMGNNVMKKS TPYQQGTPCA SCPNNCENGL
210 220 230 240
CTNSCDFEDL LSNCESLKTS AGCKHELLKT KCQATCLCED KIH
Length:243
Mass (Da):27,605
Last modified:August 1, 1990 - v1
Checksum:i6E707F569ACAA244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25533 mRNA. Translation: AAA40472.1.
BC049615 mRNA. Translation: AAH49615.1.
CCDSiCCDS28786.1.
PIRiA33329.
RefSeqiNP_001191000.1. NM_001204071.1.
NP_033446.1. NM_009420.2.
UniGeneiMm.1296.

Genome annotation databases

EnsembliENSMUST00000024724; ENSMUSP00000024724; ENSMUSG00000023930.
GeneIDi22024.
KEGGimmu:22024.
UCSCiuc008coj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25533 mRNA. Translation: AAA40472.1.
BC049615 mRNA. Translation: AAH49615.1.
CCDSiCCDS28786.1.
PIRiA33329.
RefSeqiNP_001191000.1. NM_001204071.1.
NP_033446.1. NM_009420.2.
UniGeneiMm.1296.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A05NMR-A189-243[»]
ProteinModelPortaliP16563.
SMRiP16563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024724.

PTM databases

iPTMnetiP16563.
PhosphoSitePlusiP16563.

Proteomic databases

PaxDbiP16563.
PRIDEiP16563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024724; ENSMUSP00000024724; ENSMUSG00000023930.
GeneIDi22024.
KEGGimmu:22024.
UCSCiuc008coj.2. mouse.

Organism-specific databases

CTDi7180.
MGIiMGI:98815. Crisp2.

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiP16563.
KOiK19919.
OMAiCKHELLK.
OrthoDBiEOG091G0D4V.
PhylomeDBiP16563.
TreeFamiTF316148.

Miscellaneous databases

EvolutionaryTraceiP16563.
PROiP16563.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023930.
CleanExiMM_CRISP2.
ExpressionAtlasiP16563. baseline and differential.
GenevisibleiP16563. MM.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIS2_MOUSE
AccessioniPrimary (citable) accession number: P16563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.