Cysteine-rich secretory protein 2 precursor

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P16563 (CRIS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cysteine-rich secretory protein 2
Short name=CRISP-2

Alternative name(s):
Testis-specific protein TPX-1

Gene names

Name:	Crisp2
Synonyms:	Tpx-1, Tpx1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. Ref.4
Subunit structure	Interacts with NSUN4 isoform 3. Ref.3
Subcellular location	Secreted Probable.
Tissue specificity	Testis.
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain. Contains 1 ShKT domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Potential

Chain

23 – 243

221

Cysteine-rich secretory protein 2

PRO_0000006266

Regions

Domain

42 – 169

128

SCP

Domain

205 – 238

ShKT

Amino acid modifications

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Disulfide bond

Secondary structure

243

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P16563 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 6E707F569ACAA244
Show »

FASTA

243

27,605

        10         20         30         40         50         60 
MAWFQVMLFV FALLLRSPLT EGKDPDFTSL LTNQLQVQRE IVNKHNELRR SVNPTGSDIL 

        70         80         90        100        110        120 
KMEWSIQATT NAQKWANKCI LEHSSKDDRK INIRCGENLY MSTDPTLWST VIQSWYNENE 

       130        140        150        160        170        180 
DFVYGVGAKP NSAVGHYTQL VWYSSFKIGC GIAYCPNQDN LKYFYVCHYC PMGNNVMKKS 

       190        200        210        220        230        240 
TPYQQGTPCA SCPNNCENGL CTNSCDFEDL LSNCESLKTS AGCKHELLKT KCQATCLCED 


KIH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene." Kasahara M., Gutknecht J., Brew K., Spurr N., Goodfellow P.N. Genomics 5:527-534(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse." Jamsai D., Rijal S., Bianco D.M., O'Connor A.E., Merriner D.J., Smith S.J., Gibbs G.M., O'Bryan M.K. Biol. Cell 102:93-106(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NSUN4.
[4]	"The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling." Gibbs G.M., Scanlon M.J., Swarbrick J., Curtis S., Gallant E., Dulhunty A.F., O'Bryan M.K. J. Biol. Chem. 281:4156-4163(2006) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 189-243, FUNCTION, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M25533 mRNA. Translation: AAA40472.1.
BC049615 mRNA. Translation: AAH49615.1.

IPI

IPI00135918.

PIR

A33329.

RefSeq

NP_001191000.1. NM_001204071.1.
NP_033446.1. NM_009420.2.

UniGene

Mm.1296.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2A05	NMR	-	A	189-243	[»]

ProteinModelPortal

P16563.

SMR

P16563. Positions 26-243.

ModBase

Search...

Protein-protein interaction databases

STRING

10090.ENSMUSP00000024724.

PTM databases

PhosphoSite

P16563.

Proteomic databases

PaxDb

P16563.

PRIDE

P16563.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000024724; ENSMUSP00000024724; ENSMUSG00000023930.

GeneID

22024.

KEGG

mmu:22024.

UCSC

uc008coj.2. mouse.

Organism-specific databases

CTD

7180.

MGI

MGI:98815. Crisp2.

Phylogenomic databases

eggNOG

NOG312931.

GeneTree

ENSGT00700000104242.

HOGENOM

HOG000236338.

HOVERGEN

HBG004184.

InParanoid

P16563.

OMA

CKHELLK.

OrthoDB

EOG4XKV7K.

Gene expression databases

ArrayExpress

P16563.

Bgee

P16563.

CleanEx

MM_CRISP2.

Genevestigator

P16563.

GermOnline

ENSMUSG00000023930. Mus musculus.

Family and domain databases

Gene3D

3.40.33.10. 1 hit.

InterPro

IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
[Graphical view]

PANTHER

PTHR10334. PTHR10334. 1 hit.

Pfam

PF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]

PRINTS

PR00837. V5TPXLIKE.

SMART

SM00198. SCP. 1 hit.
[Graphical view]

SUPFAM

SSF55797. SCP-like_extracellular. 1 hit.

PROSITE

PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P16563.

NextBio

301760.

SOURCE

Search...

Entry information

Entry name

CRIS2_MOUSE

Accession

Primary (citable) accession number: P16563

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 29, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents