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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

FMO1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FADBy similarity1
Sitei208Important for substrate binding1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADBy similarity5
Nucleotide bindingi40 – 41FADBy similarity2
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi61 – 62FADBy similarity2
Nucleotide bindingi195 – 198NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • drug metabolic process Source: Ensembl
  • NADPH oxidation Source: BHF-UCL
  • organic acid metabolic process Source: BHF-UCL
  • toxin metabolic process Source: BHF-UCL

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiR-SSC-217271 FMO oxidises nucleophiles
SABIO-RKiP16549

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:FMO1
Synonyms:FMO-1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001476412 – 532Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Glycosylationi120N-linked (GlcNAc...) (high mannose) asparagine1 Publication1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP16549
PeptideAtlasiP16549
PRIDEiP16549

PTM databases

iPTMnetiP16549

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiENSSSCG00000015268
GenevisibleiP16549 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016191

Structurei

3D structure databases

ProteinModelPortaliP16549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiP16549
KOiK00485
OMAiDWEVYVW
OrthoDBiEOG091G0465
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002253 Flavin_mOase_1
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01121 FMOXYGENASE1
SUPFAMiSSF51905 SSF51905, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSCKEMSCYP DFPFPEDYPN YVPNSHFLEY LRMYANQFNL
110 120 130 140 150
LKCIQFKTKV CSVTKHEDFN TTGQWDVVTL CEGKQESAVF DAVMVCTGFL
160 170 180 190 200
TNPYLPLDSF PGINTFKGQY FHSRQYKHPD IFKDKSVLVV GMGNSGTDIA
210 220 230 240 250
VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMVFMTRFQ NMFRNSLPTP
260 270 280 290 300
IVNWLIAKKM NSWFNHANYG LIPEDRIQLR EPVLNDELPG RIITGKVLIK
310 320 330 340 350
PSIKEVKENS VVFNSSPEEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LQKPTLAVIG LIKPLGSLLP TGDTQARWAV RVLKGVNKLP
410 420 430 440 450
PSSVMIQEVN TRKENKPSGF GLCYCKALQS DYIAYIDELL TYIDAKPNMF
460 470 480 490 500
SLLLTDPHLA LTIFFGPCTP YQFRLTGPGK WEGARNAIMT QWDRTFKVTK
510 520 530
TRIVKESPSP FASLLKLFSF LALLVAIFQI FL
Length:532
Mass (Da):59,952
Last modified:January 23, 2007 - v3
Checksum:i5E475E7F2F3B8A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32031 mRNA Translation: AAA31033.1
PIRiA33768
RefSeqiNP_999229.1, NM_214064.1
XP_005656702.1, XM_005656645.2
UniGeneiSsc.229

Genome annotation databases

EnsembliENSSSCT00000016637; ENSSSCP00000016191; ENSSSCG00000015268
ENSSSCT00000056435; ENSSSCP00000036498; ENSSSCG00000015268
ENSSSCT00000059500; ENSSSCP00000051826; ENSSSCG00000015268
GeneIDi397132
KEGGissc:397132

Similar proteinsi

Entry informationi

Entry nameiFMO1_PIG
AccessioniPrimary (citable) accession number: P16549
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health