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P16547 (OM45_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial outer membrane protein OM45
Alternative name(s):
Outer membrane protein of 45 kDa
Gene names
Name:OM45
Ordered Locus Names:YIL136W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with AIM5, FCJ1 and MOS1. Ref.7

Subcellular location

Mitochondrion outer membrane Ref.5.

Miscellaneous

Present with 6490 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Mitochondrial outer membrane protein OM45
PRO_0000058041

Regions

Topological domain1 – 44Mitochondrial intermembrane Potential
Transmembrane5 – 2218Helical; Potential
Topological domain23 – 393371Cytoplasmic Potential

Experimental info

Sequence conflict511P → A in AAA34827. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P16547 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 77154D522E578225

FASTA39344,580
        10         20         30         40         50         60 
MSSRIIVGSA ALAAAITASI MVREQKAKGQ RREGNVSAYY NGQEYGSSAP PQLGKLHNIK 

        70         80         90        100        110        120 
QGIKEDALSL KDALLGVSQK AREEAPKVTK RVISPEEDAQ TRKQLGQKAK DSSSQSIFNW 

       130        140        150        160        170        180 
GFSEAERRKA IAIGEFDTAK KRFEEAVDRN EKELLSTVMR EKKAALDRAS IEYERYGRAR 

       190        200        210        220        230        240 
DFNELSDKLD QQERNSNPLK RLLKNNTGDA NTEEAAARSV QGWGDTAQEF GREELEEAKR 

       250        260        270        280        290        300 
NASSEPSEAQ KRLDELKKIK EKGWFGYNKG EQSEQQIAER VARGLEGWGE TAAQLSKDEM 

       310        320        330        340        350        360 
DDLRWNYENS KKQLDKNVSD AMDSLSKAKE DLKQYGSHWW SGWTSKVDND KQALKDEAQK 

       370        380        390 
KYDEALKKYD EAKNKFKEWN DKGDGKFWSS KKD 

« Hide

References

« Hide 'large scale' references
[1]"The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function."
Yaffe M.P., Jensen R.E., Guido E.C.
J. Biol. Chem. 264:21091-21096(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 129-136 AND 251-257, SUBCELLULAR LOCATION.
Strain: ATCC 201238 / W303-1B.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AIM5; FCJ1 AND MOS1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38059 Genomic DNA. Translation: CAA86142.1.
M31796 Genomic DNA. Translation: AAA34827.1.
AY692773 Genomic DNA. Translation: AAT92792.1.
BK006942 Genomic DNA. Translation: DAA08416.1.
PIRS48398. A34185.
RefSeqNP_012130.1. NM_001179484.1.

3D structure databases

ProteinModelPortalP16547.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34855. 37 interactions.
DIPDIP-5289N.
IntActP16547. 1 interaction.
MINTMINT-550085.
STRING4932.YIL136W.

Proteomic databases

PaxDbP16547.
PeptideAtlasP16547.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL136W; YIL136W; YIL136W.
GeneID854670.
KEGGsce:YIL136W.

Organism-specific databases

CYGDYIL136w.
SGDS000001398. OM45.

Phylogenomic databases

eggNOGNOG84398.
OrthoDBEOG75TMQ7.

Enzyme and pathway databases

BioCycYEAST:G3O-31387-MONOMER.

Gene expression databases

GenevestigatorP16547.

Family and domain databases

ProtoNetSearch...

Other

NextBio977256.

Entry information

Entry nameOM45_YEAST
AccessionPrimary (citable) accession number: P16547
Secondary accession number(s): D6VVF0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD