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P16547

- OM45_YEAST

UniProt

P16547 - OM45_YEAST

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Protein

Mitochondrial outer membrane protein OM45

Gene

OM45

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31387-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein OM45
Alternative name(s):
Outer membrane protein of 45 kDa
Gene namesi
Name:OM45
Ordered Locus Names:YIL136W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL136w.
SGDiS000001398. OM45.

Subcellular locationi

Mitochondrion outer membrane 1 Publication

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: SGD
  2. mitochondrial outer membrane Source: SGD
  3. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Mitochondrial outer membrane protein OM45PRO_0000058041Add
BLAST

Proteomic databases

MaxQBiP16547.
PaxDbiP16547.
PeptideAtlasiP16547.

Expressioni

Gene expression databases

GenevestigatoriP16547.

Interactioni

Subunit structurei

Interacts with AIM5, FCJ1 and MOS1.1 Publication

Protein-protein interaction databases

BioGridi34855. 37 interactions.
DIPiDIP-5289N.
IntActiP16547. 1 interaction.
MINTiMINT-550085.
STRINGi4932.YIL136W.

Structurei

3D structure databases

ProteinModelPortaliP16547.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Mitochondrial intermembraneSequence Analysis
Topological domaini23 – 393371CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2218HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84398.
InParanoidiP16547.
OMAiASIEYER.
OrthoDBiEOG75TMQ7.

Sequencei

Sequence statusi: Complete.

P16547-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRIIVGSA ALAAAITASI MVREQKAKGQ RREGNVSAYY NGQEYGSSAP
60 70 80 90 100
PQLGKLHNIK QGIKEDALSL KDALLGVSQK AREEAPKVTK RVISPEEDAQ
110 120 130 140 150
TRKQLGQKAK DSSSQSIFNW GFSEAERRKA IAIGEFDTAK KRFEEAVDRN
160 170 180 190 200
EKELLSTVMR EKKAALDRAS IEYERYGRAR DFNELSDKLD QQERNSNPLK
210 220 230 240 250
RLLKNNTGDA NTEEAAARSV QGWGDTAQEF GREELEEAKR NASSEPSEAQ
260 270 280 290 300
KRLDELKKIK EKGWFGYNKG EQSEQQIAER VARGLEGWGE TAAQLSKDEM
310 320 330 340 350
DDLRWNYENS KKQLDKNVSD AMDSLSKAKE DLKQYGSHWW SGWTSKVDND
360 370 380 390
KQALKDEAQK KYDEALKKYD EAKNKFKEWN DKGDGKFWSS KKD
Length:393
Mass (Da):44,580
Last modified:February 1, 1995 - v2
Checksum:i77154D522E578225
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511P → A in AAA34827. (PubMed:2687271)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86142.1.
M31796 Genomic DNA. Translation: AAA34827.1.
AY692773 Genomic DNA. Translation: AAT92792.1.
BK006942 Genomic DNA. Translation: DAA08416.1.
PIRiA34185. S48398.
RefSeqiNP_012130.1. NM_001179484.1.

Genome annotation databases

EnsemblFungiiYIL136W; YIL136W; YIL136W.
GeneIDi854670.
KEGGisce:YIL136W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86142.1 .
M31796 Genomic DNA. Translation: AAA34827.1 .
AY692773 Genomic DNA. Translation: AAT92792.1 .
BK006942 Genomic DNA. Translation: DAA08416.1 .
PIRi A34185. S48398.
RefSeqi NP_012130.1. NM_001179484.1.

3D structure databases

ProteinModelPortali P16547.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34855. 37 interactions.
DIPi DIP-5289N.
IntActi P16547. 1 interaction.
MINTi MINT-550085.
STRINGi 4932.YIL136W.

Proteomic databases

MaxQBi P16547.
PaxDbi P16547.
PeptideAtlasi P16547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL136W ; YIL136W ; YIL136W .
GeneIDi 854670.
KEGGi sce:YIL136W.

Organism-specific databases

CYGDi YIL136w.
SGDi S000001398. OM45.

Phylogenomic databases

eggNOGi NOG84398.
InParanoidi P16547.
OMAi ASIEYER.
OrthoDBi EOG75TMQ7.

Enzyme and pathway databases

BioCyci YEAST:G3O-31387-MONOMER.

Miscellaneous databases

NextBioi 977256.

Gene expression databases

Genevestigatori P16547.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function."
    Yaffe M.P., Jensen R.E., Guido E.C.
    J. Biol. Chem. 264:21091-21096(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
    Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
    Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 129-136 AND 251-257, SUBCELLULAR LOCATION.
    Strain: ATCC 201238 / W303-1B.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AIM5; FCJ1 AND MOS1.

Entry informationi

Entry nameiOM45_YEAST
AccessioniPrimary (citable) accession number: P16547
Secondary accession number(s): D6VVF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6490 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3