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P16547

- OM45_YEAST

UniProt

P16547 - OM45_YEAST

Protein

Mitochondrial outer membrane protein OM45

Gene

OM45

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31387-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial outer membrane protein OM45
    Alternative name(s):
    Outer membrane protein of 45 kDa
    Gene namesi
    Name:OM45
    Ordered Locus Names:YIL136W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL136w.
    SGDiS000001398. OM45.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: SGD
    2. mitochondrial outer membrane Source: SGD
    3. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Mitochondrial outer membrane protein OM45PRO_0000058041Add
    BLAST

    Proteomic databases

    MaxQBiP16547.
    PaxDbiP16547.
    PeptideAtlasiP16547.

    Expressioni

    Gene expression databases

    GenevestigatoriP16547.

    Interactioni

    Subunit structurei

    Interacts with AIM5, FCJ1 and MOS1.1 Publication

    Protein-protein interaction databases

    BioGridi34855. 37 interactions.
    DIPiDIP-5289N.
    IntActiP16547. 1 interaction.
    MINTiMINT-550085.
    STRINGi4932.YIL136W.

    Structurei

    3D structure databases

    ProteinModelPortaliP16547.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44Mitochondrial intermembraneSequence Analysis
    Topological domaini23 – 393371CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2218HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84398.
    OMAiASIEYER.
    OrthoDBiEOG75TMQ7.

    Sequencei

    Sequence statusi: Complete.

    P16547-1 [UniParc]FASTAAdd to Basket

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    MSSRIIVGSA ALAAAITASI MVREQKAKGQ RREGNVSAYY NGQEYGSSAP    50
    PQLGKLHNIK QGIKEDALSL KDALLGVSQK AREEAPKVTK RVISPEEDAQ 100
    TRKQLGQKAK DSSSQSIFNW GFSEAERRKA IAIGEFDTAK KRFEEAVDRN 150
    EKELLSTVMR EKKAALDRAS IEYERYGRAR DFNELSDKLD QQERNSNPLK 200
    RLLKNNTGDA NTEEAAARSV QGWGDTAQEF GREELEEAKR NASSEPSEAQ 250
    KRLDELKKIK EKGWFGYNKG EQSEQQIAER VARGLEGWGE TAAQLSKDEM 300
    DDLRWNYENS KKQLDKNVSD AMDSLSKAKE DLKQYGSHWW SGWTSKVDND 350
    KQALKDEAQK KYDEALKKYD EAKNKFKEWN DKGDGKFWSS KKD 393
    Length:393
    Mass (Da):44,580
    Last modified:February 1, 1995 - v2
    Checksum:i77154D522E578225
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511P → A in AAA34827. (PubMed:2687271)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86142.1.
    M31796 Genomic DNA. Translation: AAA34827.1.
    AY692773 Genomic DNA. Translation: AAT92792.1.
    BK006942 Genomic DNA. Translation: DAA08416.1.
    PIRiA34185. S48398.
    RefSeqiNP_012130.1. NM_001179484.1.

    Genome annotation databases

    EnsemblFungiiYIL136W; YIL136W; YIL136W.
    GeneIDi854670.
    KEGGisce:YIL136W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86142.1 .
    M31796 Genomic DNA. Translation: AAA34827.1 .
    AY692773 Genomic DNA. Translation: AAT92792.1 .
    BK006942 Genomic DNA. Translation: DAA08416.1 .
    PIRi A34185. S48398.
    RefSeqi NP_012130.1. NM_001179484.1.

    3D structure databases

    ProteinModelPortali P16547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34855. 37 interactions.
    DIPi DIP-5289N.
    IntActi P16547. 1 interaction.
    MINTi MINT-550085.
    STRINGi 4932.YIL136W.

    Proteomic databases

    MaxQBi P16547.
    PaxDbi P16547.
    PeptideAtlasi P16547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL136W ; YIL136W ; YIL136W .
    GeneIDi 854670.
    KEGGi sce:YIL136W.

    Organism-specific databases

    CYGDi YIL136w.
    SGDi S000001398. OM45.

    Phylogenomic databases

    eggNOGi NOG84398.
    OMAi ASIEYER.
    OrthoDBi EOG75TMQ7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31387-MONOMER.

    Miscellaneous databases

    NextBioi 977256.

    Gene expression databases

    Genevestigatori P16547.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function."
      Yaffe M.P., Jensen R.E., Guido E.C.
      J. Biol. Chem. 264:21091-21096(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
      Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
      Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 129-136 AND 251-257, SUBCELLULAR LOCATION.
      Strain: ATCC 201238 / W303-1B.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
      Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
      J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AIM5; FCJ1 AND MOS1.

    Entry informationi

    Entry nameiOM45_YEAST
    AccessioniPrimary (citable) accession number: P16547
    Secondary accession number(s): D6VVF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6490 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3