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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-SSC-114608. Platelet degranulation.
R-SSC-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-SSC-2428928. IRS-related events triggered by IGF1R.
R-SSC-2428933. SHC-related events triggered by IGF1R.
R-SSC-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-SSC-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48PRO_0000015672
Signal peptidei1 – ?
Chaini49 – 11870Insulin-like growth factor IPRO_0000015673Add
BLAST
Propeptidei119 – 15335E peptidePRO_0000015674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96By similarity
Disulfide bondi66 ↔ 109By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP16545.

Expressioni

Gene expression databases

ExpressionAtlasiP16545. differential.
GenevisibleiP16545. SS.

Interactioni

Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000915.

Structurei

3D structure databases

ProteinModelPortaliP16545.
SMRiP16545. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729BAdd
BLAST
Regioni78 – 8912CAdd
BLAST
Regioni90 – 11021AAdd
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP16545.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KVKMHITSSS HLFYLALCLL SFTSSATAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC
110 120 130 140 150
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KAQKEVHLKN TSRGSSGNKN

YRM
Length:153
Mass (Da):17,010
Last modified:August 1, 1990 - v1
Checksum:i6098792DCDA0CD7D
GO

Sequence cautioni

The sequence AAA31043.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201L → Y in AAA31043 (PubMed:3211153).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17492 mRNA. Translation: CAA35527.1.
X52388 Genomic DNA. Translation: CAA36617.1.
X52077 Genomic DNA. Translation: CAA36296.1.
M31175 mRNA. Translation: AAA31043.1. Different initiation.
X17638 Genomic DNA. Translation: CAA35632.1.
PIRiS12825.
RefSeqiNP_999421.1. NM_214256.1.
XP_005664255.1. XM_005664198.2.
UniGeneiSsc.16231.

Genome annotation databases

EnsembliENSSSCT00000000936; ENSSSCP00000000916; ENSSSCG00000000857.
ENSSSCT00000035604; ENSSSCP00000030873; ENSSSCG00000000857.
GeneIDi397491.
KEGGissc:397491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17492 mRNA. Translation: CAA35527.1.
X52388 Genomic DNA. Translation: CAA36617.1.
X52077 Genomic DNA. Translation: CAA36296.1.
M31175 mRNA. Translation: AAA31043.1. Different initiation.
X17638 Genomic DNA. Translation: CAA35632.1.
PIRiS12825.
RefSeqiNP_999421.1. NM_214256.1.
XP_005664255.1. XM_005664198.2.
UniGeneiSsc.16231.

3D structure databases

ProteinModelPortaliP16545.
SMRiP16545. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000915.

Proteomic databases

PaxDbiP16545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000000936; ENSSSCP00000000916; ENSSSCG00000000857.
ENSSSCT00000035604; ENSSSCP00000030873; ENSSSCG00000000857.
GeneIDi397491.
KEGGissc:397491.

Organism-specific databases

CTDi3479.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP16545.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.

Enzyme and pathway databases

ReactomeiR-SSC-114608. Platelet degranulation.
R-SSC-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-SSC-2428928. IRS-related events triggered by IGF1R.
R-SSC-2428933. SHC-related events triggered by IGF1R.
R-SSC-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-SSC-422085. Synthesis, secretion, and deacylation of Ghrelin.

Gene expression databases

ExpressionAtlasiP16545. differential.
GenevisibleiP16545. SS.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of porcine insulin-like growth factor I: 5' untranslated region, exons 1 to 2 and mRNA."
    Mueller M., Brem G.
    Nucleic Acids Res. 18:364-364(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Porcine insulin-like growth factor-I (pIGF-I): complementary deoxyribonucleic acid cloning and uterine expression of messenger ribonucleic acid encoding evolutionarily conserved IGF-I peptides."
    Tavakkol A., Simmen F.A., Simmen R.C.M.
    Mol. Endocrinol. 2:674-681(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-153.
  3. "The porcine insulin-like growth factor-I gene: characterization and expression of alternate transcription sites."
    Weller P.A., Dickson M.C., Huskisson N.S., Dauncey M.J., Buttery P.J., Gilmour R.S.
    J. Mol. Endocrinol. 11:201-211(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
    Strain: White Landrace.
    Tissue: Liver.

Entry informationi

Entry nameiIGF1_PIG
AccessioniPrimary (citable) accession number: P16545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.