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Protein

Putative ketoacyl reductase

Gene

actIII

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63NADP2 Publications1
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorPROSITE-ProRule annotation1
Binding sitei161NADP2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 39NADP2 PublicationsAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ketoacyl reductase (EC:1.3.1.-)
Gene namesi
Name:actIII
Ordered Locus Names:SCO5086
ORF Names:SCBAC28G1.12c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544471 – 261Putative ketoacyl reductaseAdd BLAST261

Proteomic databases

PRIDEiP16544.

Interactioni

Subunit structurei

Homotetramer.2 Publications

Protein-protein interaction databases

STRINGi100226.SCO5086.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi17 – 28Combined sources12
Beta strandi32 – 38Combined sources7
Helixi40 – 52Combined sources13
Beta strandi57 – 61Combined sources5
Helixi67 – 80Combined sources14
Beta strandi85 – 89Combined sources5
Helixi99 – 101Combined sources3
Helixi104 – 114Combined sources11
Helixi116 – 126Combined sources11
Turni127 – 129Combined sources3
Helixi131 – 134Combined sources4
Beta strandi136 – 142Combined sources7
Helixi145 – 147Combined sources3
Helixi155 – 175Combined sources21
Turni176 – 178Combined sources3
Beta strandi179 – 187Combined sources9
Beta strandi189 – 192Combined sources4
Helixi193 – 206Combined sources14
Helixi210 – 220Combined sources11
Helixi229 – 240Combined sources12
Helixi242 – 244Combined sources3
Beta strandi251 – 255Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W4ZX-ray2.50A/B1-261[»]
1X7GX-ray2.30A/B1-261[»]
1X7HX-ray2.30A/B1-261[»]
1XR3X-ray2.71A/B1-261[»]
2RH4X-ray2.30A/B1-261[»]
2RHCX-ray2.10A/B1-261[»]
2RHRX-ray2.50A/B1-261[»]
3CSDX-ray2.29A/B1-261[»]
3QRWX-ray2.79A/B1-261[»]
3RI3X-ray2.29A/B1-261[»]
4DBZX-ray2.64A/B1-261[»]
4DC0X-ray2.81A/B1-261[»]
4DC1X-ray2.82A/B1-261[»]
ProteinModelPortaliP16544.
SMRiP16544.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16544.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DTD. Bacteria.
ENOG410XPTP. LUCA.
InParanoidiP16544.
KOiK12420.
OMAiSRGAYGQ.
OrthoDBiPOG091H012M.
PhylomeDBiP16544.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQDSEVAL VTGATSGIGL EIARRLGKEG LRVFVCARGE EGLRTTLKEL
60 70 80 90 100
REAGVEADGR TCDVRSVPEI EALVAAVVER YGPVDVLVNN AGRPGGGATA
110 120 130 140 150
ELADELWLDV VETNLTGVFR VTKQVLKAGG MLERGTGRIV NIASTGGKQG
160 170 180 190 200
VVHAAPYSAS KHGVVGFTKA LGLELARTGI TVNAVCPGFV ETPMAASVRE
210 220 230 240 250
HYSDIWEVST EEAFDRITAR VPIGRYVQPS EVAEMVAYLI GPGAAAVTAQ
260
ALNVCGGLGN Y
Length:261
Mass (Da):27,265
Last modified:August 1, 1990 - v1
Checksum:iB87C83F45A88B7A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19536 Genomic DNA. Translation: AAA26688.1.
AL939122 Genomic DNA. Translation: CAC44199.1.
PIRiJS0108. A28788.
RefSeqiNP_629236.1. NC_003888.3.
WP_003973892.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44199; CAC44199; CAC44199.
GeneIDi1100527.
KEGGisco:SCO5086.
PATRICi23740012. VBIStrCoe124346_5166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19536 Genomic DNA. Translation: AAA26688.1.
AL939122 Genomic DNA. Translation: CAC44199.1.
PIRiJS0108. A28788.
RefSeqiNP_629236.1. NC_003888.3.
WP_003973892.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W4ZX-ray2.50A/B1-261[»]
1X7GX-ray2.30A/B1-261[»]
1X7HX-ray2.30A/B1-261[»]
1XR3X-ray2.71A/B1-261[»]
2RH4X-ray2.30A/B1-261[»]
2RHCX-ray2.10A/B1-261[»]
2RHRX-ray2.50A/B1-261[»]
3CSDX-ray2.29A/B1-261[»]
3QRWX-ray2.79A/B1-261[»]
3RI3X-ray2.29A/B1-261[»]
4DBZX-ray2.64A/B1-261[»]
4DC0X-ray2.81A/B1-261[»]
4DC1X-ray2.82A/B1-261[»]
ProteinModelPortaliP16544.
SMRiP16544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5086.

Proteomic databases

PRIDEiP16544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44199; CAC44199; CAC44199.
GeneIDi1100527.
KEGGisco:SCO5086.
PATRICi23740012. VBIStrCoe124346_5166.

Phylogenomic databases

eggNOGiENOG4105DTD. Bacteria.
ENOG410XPTP. LUCA.
InParanoidiP16544.
KOiK12420.
OMAiSRGAYGQ.
OrthoDBiPOG091H012M.
PhylomeDBiP16544.

Enzyme and pathway databases

UniPathwayiUPA00173.

Miscellaneous databases

EvolutionaryTraceiP16544.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACT3_STRCO
AccessioniPrimary (citable) accession number: P16544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.