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Protein

Myristoylated alanine-rich C-kinase substrate

Gene

MARCKS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name:
MARCKS
Gene namesi
Name:MARCKS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  1. Cytoplasmcytoskeleton Curated
  2. Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 281280Myristoylated alanine-rich C-kinase substratePRO_0000157151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP16527.

Interactioni

Protein-protein interaction databases

BioGridi676720. 1 interaction.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 14125Calmodulin-binding (PSD)Add
BLAST

Sequence similaritiesi

Belongs to the MARCKS family.Curated

Phylogenomic databases

InParanoidiP16527.
KOiK12561.

Family and domain databases

InterProiIPR002101. MARCKS.
[Graphical view]
PANTHERiPTHR14353. PTHR14353. 1 hit.
PfamiPF02063. MARCKS. 1 hit.
[Graphical view]
PRINTSiPR00963. MARCKS.
PROSITEiPS00826. MARCKS_1. 1 hit.
PS00827. MARCKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE
60 70 80 90 100
AGKEEVQANG SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS
110 120 130 140 150
PKTEEGATPS SSSETPKKKK KRFSFKKSFK LSGFSFKKNK KEAGEGAESE
160 170 180 190 200
GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA AEEASAAAAG SREAAKEEAG
210 220 230 240 250
DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG AAATSEAGSG
260 270 280
EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E
Length:281
Mass (Da):27,728
Last modified:January 23, 2007 - v2
Checksum:iCCAF4875E9FD176E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31650 mRNA. Translation: AAA48946.1.
PIRiA41400.
RefSeqiNP_990811.1. NM_205480.1.
UniGeneiGga.48522.

Genome annotation databases

GeneIDi396473.
KEGGigga:396473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31650 mRNA. Translation: AAA48946.1.
PIRiA41400.
RefSeqiNP_990811.1. NM_205480.1.
UniGeneiGga.48522.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676720. 1 interaction.

Proteomic databases

PRIDEiP16527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396473.
KEGGigga:396473.

Organism-specific databases

CTDi4082.

Phylogenomic databases

InParanoidiP16527.
KOiK12561.

Miscellaneous databases

NextBioi20816512.
PROiP16527.

Family and domain databases

InterProiIPR002101. MARCKS.
[Graphical view]
PANTHERiPTHR14353. PTHR14353. 1 hit.
PfamiPF02063. MARCKS. 1 hit.
[Graphical view]
PRINTSiPR00963. MARCKS.
PROSITEiPS00826. MARCKS_1. 1 hit.
PS00827. MARCKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)."
    Graff J.M., Stumpo D.J., Blackshear P.J.
    Mol. Endocrinol. 3:1903-1906(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiMARCS_CHICK
AccessioniPrimary (citable) accession number: P16527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.