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P16527

- MARCS_CHICK

UniProt

P16527 - MARCS_CHICK

Protein

Myristoylated alanine-rich C-kinase substrate

Gene

MARCKS

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

    Keywords - Ligandi

    Actin-binding, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myristoylated alanine-rich C-kinase substrate
    Short name:
    MARCKS
    Gene namesi
    Name:MARCKS
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasmcytoskeleton Curated. Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 281280Myristoylated alanine-rich C-kinase substratePRO_0000157151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PRIDEiP16527.

    Interactioni

    Protein-protein interaction databases

    BioGridi676720. 1 interaction.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 14125Calmodulin-binding (PSD)Add
    BLAST

    Sequence similaritiesi

    Belongs to the MARCKS family.Curated

    Phylogenomic databases

    KOiK12561.

    Family and domain databases

    InterProiIPR002101. MARCKS.
    [Graphical view]
    PANTHERiPTHR14353. PTHR14353. 1 hit.
    PfamiPF02063. MARCKS. 1 hit.
    [Graphical view]
    PRINTSiPR00963. MARCKS.
    PROSITEiPS00826. MARCKS_1. 1 hit.
    PS00827. MARCKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16527-1 [UniParc]FASTAAdd to Basket

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    MGAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE    50
    AGKEEVQANG SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS 100
    PKTEEGATPS SSSETPKKKK KRFSFKKSFK LSGFSFKKNK KEAGEGAESE 150
    GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA AEEASAAAAG SREAAKEEAG 200
    DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG AAATSEAGSG 250
    EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E 281
    Length:281
    Mass (Da):27,728
    Last modified:January 23, 2007 - v2
    Checksum:iCCAF4875E9FD176E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31650 mRNA. Translation: AAA48946.1.
    PIRiA41400.
    RefSeqiNP_990811.1. NM_205480.1.
    UniGeneiGga.48522.

    Genome annotation databases

    GeneIDi396473.
    KEGGigga:396473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31650 mRNA. Translation: AAA48946.1 .
    PIRi A41400.
    RefSeqi NP_990811.1. NM_205480.1.
    UniGenei Gga.48522.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676720. 1 interaction.

    Proteomic databases

    PRIDEi P16527.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396473.
    KEGGi gga:396473.

    Organism-specific databases

    CTDi 4082.

    Phylogenomic databases

    KOi K12561.

    Miscellaneous databases

    NextBioi 20816512.
    PROi P16527.

    Family and domain databases

    InterProi IPR002101. MARCKS.
    [Graphical view ]
    PANTHERi PTHR14353. PTHR14353. 1 hit.
    Pfami PF02063. MARCKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00963. MARCKS.
    PROSITEi PS00826. MARCKS_1. 1 hit.
    PS00827. MARCKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)."
      Graff J.M., Stumpo D.J., Blackshear P.J.
      Mol. Endocrinol. 3:1903-1906(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiMARCS_CHICK
    AccessioniPrimary (citable) accession number: P16527
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3