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P16527

- MARCS_CHICK

UniProt

P16527 - MARCS_CHICK

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Protein
Myristoylated alanine-rich C-kinase substrate
Gene
MARCKS
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name:
MARCKS
Gene namesi
Name:MARCKS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton Inferred. Membrane; Lipid-anchor By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 281280Myristoylated alanine-rich C-kinase substrate
PRO_0000157151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP16527.

Interactioni

Protein-protein interaction databases

BioGridi676720. 1 interaction.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 14125Calmodulin-binding (PSD)
Add
BLAST

Sequence similaritiesi

Belongs to the MARCKS family.

Phylogenomic databases

KOiK12561.

Family and domain databases

InterProiIPR002101. MARCKS.
[Graphical view]
PANTHERiPTHR14353. PTHR14353. 1 hit.
PfamiPF02063. MARCKS. 1 hit.
[Graphical view]
PRINTSiPR00963. MARCKS.
PROSITEiPS00826. MARCKS_1. 1 hit.
PS00827. MARCKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16527-1 [UniParc]FASTAAdd to Basket

« Hide

MGAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE    50
AGKEEVQANG SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS 100
PKTEEGATPS SSSETPKKKK KRFSFKKSFK LSGFSFKKNK KEAGEGAESE 150
GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA AEEASAAAAG SREAAKEEAG 200
DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG AAATSEAGSG 250
EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E 281
Length:281
Mass (Da):27,728
Last modified:January 23, 2007 - v2
Checksum:iCCAF4875E9FD176E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31650 mRNA. Translation: AAA48946.1.
PIRiA41400.
RefSeqiNP_990811.1. NM_205480.1.
UniGeneiGga.48522.

Genome annotation databases

GeneIDi396473.
KEGGigga:396473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31650 mRNA. Translation: AAA48946.1 .
PIRi A41400.
RefSeqi NP_990811.1. NM_205480.1.
UniGenei Gga.48522.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676720. 1 interaction.

Proteomic databases

PRIDEi P16527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396473.
KEGGi gga:396473.

Organism-specific databases

CTDi 4082.

Phylogenomic databases

KOi K12561.

Miscellaneous databases

NextBioi 20816512.
PROi P16527.

Family and domain databases

InterProi IPR002101. MARCKS.
[Graphical view ]
PANTHERi PTHR14353. PTHR14353. 1 hit.
Pfami PF02063. MARCKS. 1 hit.
[Graphical view ]
PRINTSi PR00963. MARCKS.
PROSITEi PS00826. MARCKS_1. 1 hit.
PS00827. MARCKS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)."
    Graff J.M., Stumpo D.J., Blackshear P.J.
    Mol. Endocrinol. 3:1903-1906(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiMARCS_CHICK
AccessioniPrimary (citable) accession number: P16527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi