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P16527 (MARCS_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myristoylated alanine-rich C-kinase substrate

Short name=MARCKS
Gene names
Name:MARCKS
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Subcellular location

Cytoplasmcytoskeleton Probable. Membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the MARCKS family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 281280Myristoylated alanine-rich C-kinase substrate
PRO_0000157151

Regions

Region117 – 14125Calmodulin-binding (PSD)

Amino acid modifications

Lipidation21N-myristoyl glycine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P16527 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CCAF4875E9FD176E

FASTA28127,728
        10         20         30         40         50         60 
MGAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE AGKEEVQANG 

        70         80         90        100        110        120 
SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS PKTEEGATPS SSSETPKKKK 

       130        140        150        160        170        180 
KRFSFKKSFK LSGFSFKKNK KEAGEGAESE GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA 

       190        200        210        220        230        240 
AEEASAAAAG SREAAKEEAG DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG 

       250        260        270        280 
AAATSEAGSG EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E 

« Hide

References

[1]"Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)."
Graff J.M., Stumpo D.J., Blackshear P.J.
Mol. Endocrinol. 3:1903-1906(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31650 mRNA. Translation: AAA48946.1.
PIRA41400.
RefSeqNP_990811.1. NM_205480.1.
UniGeneGga.48522.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid676720. 1 interaction.

Proteomic databases

PRIDEP16527.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396473.
KEGGgga:396473.

Organism-specific databases

CTD4082.

Phylogenomic databases

KOK12561.

Family and domain databases

InterProIPR002101. MARCKS.
[Graphical view]
PANTHERPTHR14353. PTHR14353. 1 hit.
PfamPF02063. MARCKS. 1 hit.
[Graphical view]
PRINTSPR00963. MARCKS.
PROSITEPS00826. MARCKS_1. 1 hit.
PS00827. MARCKS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816512.
PROP16527.

Entry information

Entry nameMARCS_CHICK
AccessionPrimary (citable) accession number: P16527
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families