P16527 (MARCS_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myristoylated alanine-rich C-kinase substrate
Short name=MARCKS

Gene names

Name:

MARCKS

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Subcellular location	Cytoplasm › cytoskeleton Probable. Membrane; Lipid-anchor By similarity.
Sequence similarities	Belongs to the MARCKS family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane
Ligand	Actin-binding Calmodulin-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 281	280	Myristoylated alanine-rich C-kinase substrate		PRO_0000157151
Regions
	Region	117 – 141	25	Calmodulin-binding (PSD)
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine

Sequences

	Sequence		Length	Mass (Da)
	P16527 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CCAF4875E9FD176E	FASTA	281	27,728
	10 20 30 40 50 60 MGAQFSKTAA KGEAAAEKPG EAVAASPSKA NGQENGHVKV NGDASPAAAE AGKEEVQANG 70 80 90 100 110 120 SAPAEETGKE EAASSEPASE KEAAEAESTE PASPAEGEAS PKTEEGATPS SSSETPKKKK 130 140 150 160 170 180 KRFSFKKSFK LSGFSFKKNK KEAGEGAESE GGAAAAAEGG KEEAAAAAPE AAGGEEGKAA 190 200 210 220 230 240 AEEASAAAAG SREAAKEEAG DSQEAKSDEA APEKATGEEA PAAEEQQQQQ QQEKAAEEAG 250 260 270 280 AAATSEAGSG EQEAAPAEEP AAARQEAPSE SSPEGPAEPA E

References

[1]

"Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)." Graff J.M., Stumpo D.J., Blackshear P.J. Mol. Endocrinol. 3:1903-1906(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M31650 mRNA. Translation: AAA48946.1.
IPI	IPI00591767.
PIR	A41400.
RefSeq	NP_990811.1. NM_205480.1.
UniGene	Gga.48522.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P16527.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396473.
KEGG	gga:396473.
Organism-specific databases
CTD	4082.
Phylogenomic databases
KO	K12561.
Family and domain databases
InterPro	IPR002101. MARCKS. [Graphical view]
PANTHER	PTHR14353. PTHR14353. 1 hit.
Pfam	PF02063. MARCKS. 1 hit. [Graphical view]
PRINTS	PR00963. MARCKS.
PROSITE	PS00826. MARCKS_1. 1 hit. PS00827. MARCKS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816512.

Entry information

Entry name

MARCS_CHICK

Accession

Primary (citable) accession number: P16527

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program