ID   MER1_YEAST              Reviewed;         270 AA.
AC   P16523; D6W0Y0;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   24-JAN-2024, entry version 148.
DE   RecName: Full=Meiotic recombination 1 protein;
GN   Name=MER1; OrderedLocusNames=YNL210W; ORFNames=N1330;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2183032; DOI=10.1128/mcb.10.5.2379-2389.1990;
RA   Engebrecht J., Roeder G.S.;
RT   "MER1, a yeast gene required for chromosome pairing and genetic
RT   recombination, is induced in meiosis.";
RL   Mol. Cell. Biol. 10:2379-2389(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=7762305; DOI=10.1002/yea.320110111;
RA   Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.;
RT   "The sequence of a 13.5 kb DNA segment from the left arm of yeast
RT   chromosome XIV reveals MER1; RAP1; a new putative member of the DNA
RT   replication complex and a new putative serine/threonine phosphatase gene.";
RL   Yeast 11:85-91(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169873;
RA   Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA   Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA   Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA   Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA   Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA   Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA   Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA   Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA   Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA   Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA   Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA   Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA   Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA   Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA   Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA   Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA   Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT   evolutionary implications.";
RL   Nature 387:93-98(1997).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: Required for chromosome pairing and genetic recombination.
CC       MER1 may function to bring the axial elements of the synaptonemal
CC       complex corresponding to homologous chromosomes together by initiating
CC       recombination. MER1 might be responsible for regulating the MER2 gene
CC       and/or gene product.
CC   -!- DEVELOPMENTAL STAGE: MER1 is synthesized only during meiosis.
CC   -!- INDUCTION: Its expression is meiotically induced and required the IME1
CC       protein.
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DR   EMBL; M31304; AAA34771.1; -; Genomic_DNA.
DR   EMBL; X78898; CAA55497.1; -; Genomic_DNA.
DR   EMBL; Z71486; CAA96112.1; -; Genomic_DNA.
DR   EMBL; AY693028; AAT93047.1; -; Genomic_DNA.
DR   EMBL; BK006947; DAA10346.1; -; Genomic_DNA.
DR   PIR; A34717; A34717.
DR   RefSeq; NP_014189.1; NM_001183048.1.
DR   AlphaFoldDB; P16523; -.
DR   SMR; P16523; -.
DR   BioGRID; 35626; 34.
DR   DIP; DIP-1436N; -.
DR   IntAct; P16523; 4.
DR   MINT; P16523; -.
DR   STRING; 4932.YNL210W; -.
DR   PaxDb; 4932-YNL210W; -.
DR   PeptideAtlas; P16523; -.
DR   EnsemblFungi; YNL210W_mRNA; YNL210W; YNL210W.
DR   GeneID; 855511; -.
DR   KEGG; sce:YNL210W; -.
DR   AGR; SGD:S000005154; -.
DR   SGD; S000005154; MER1.
DR   VEuPathDB; FungiDB:YNL210W; -.
DR   eggNOG; ENOG502SDMY; Eukaryota.
DR   HOGENOM; CLU_083073_0_0_1; -.
DR   InParanoid; P16523; -.
DR   OMA; MTAHERN; -.
DR   OrthoDB; 2039085at2759; -.
DR   BioCyc; YEAST:G3O-33216-MONOMER; -.
DR   BioGRID-ORCS; 855511; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P16523; -.
DR   Proteomes; UP000002311; Chromosome XIV.
DR   RNAct; P16523; Protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0003729; F:mRNA binding; IDA:SGD.
DR   GO; GO:1990446; F:U1 snRNP binding; IDA:SGD.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IMP:SGD.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   Pfam; PF00013; KH_1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   2: Evidence at transcript level;
KW   Meiosis; Reference proteome; RNA-binding.
FT   CHAIN           1..270
FT                   /note="Meiotic recombination 1 protein"
FT                   /id="PRO_0000050120"
FT   DOMAIN          191..225
FT                   /note="KH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
SQ   SEQUENCE   270 AA;  31111 MW;  D23EC9B4849D73BA CRC64;
     MSNQHSPQPF CLDTKLVKLL EELQEGKQFN NKNIFPEKAL YLKLALDYSF FRKNLLEFCV
     HLDKIKGVIR PNYDTIYILC LLEVDLLNLV FTDNILEICL PRFVSREDLR VFNNTFYTYH
     DNRLRILQED FSQLFKKIKT KASVLCFTVE EIFLTNQEIL PQNSTVAELQ KSTNKVQTNG
     PQRHDFIVTL EIKLNKTQIT FLIGAKGTRI ESLREKSGAS IKIIPISDKM TAHERNHPES
     VQQTILISGD LYSIALAVTS IESALITLDL
//