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Protein

Meiotic recombination 1 protein

Gene

MER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.

GO - Molecular functioni

  1. mRNA binding Source: SGD

GO - Biological processi

  1. positive regulation of mRNA splicing, via spliceosome Source: SGD
  2. reciprocal meiotic recombination Source: SGD
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination 1 protein
Gene namesi
Name:MER1
Ordered Locus Names:YNL210W
ORF Names:N1330
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL210w.
SGDiS000005154. MER1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Meiotic recombination 1 proteinPRO_0000050120Add
BLAST

Expressioni

Developmental stagei

MER1 is synthesized only during meiosis.

Inductioni

Its expression is meiotically induced and required the IME1 protein.

Gene expression databases

GenevestigatoriP16523.

Interactioni

Protein-protein interaction databases

BioGridi35626. 14 interactions.
DIPiDIP-1436N.
IntActiP16523. 2 interactions.
MINTiMINT-387064.
STRINGi4932.YNL210W.

Structurei

3D structure databases

ProteinModelPortaliP16523.
SMRiP16523. Positions 186-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 22535KHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG79838.
InParanoidiP16523.
OrthoDBiEOG7647CX.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQHSPQPF CLDTKLVKLL EELQEGKQFN NKNIFPEKAL YLKLALDYSF
60 70 80 90 100
FRKNLLEFCV HLDKIKGVIR PNYDTIYILC LLEVDLLNLV FTDNILEICL
110 120 130 140 150
PRFVSREDLR VFNNTFYTYH DNRLRILQED FSQLFKKIKT KASVLCFTVE
160 170 180 190 200
EIFLTNQEIL PQNSTVAELQ KSTNKVQTNG PQRHDFIVTL EIKLNKTQIT
210 220 230 240 250
FLIGAKGTRI ESLREKSGAS IKIIPISDKM TAHERNHPES VQQTILISGD
260 270
LYSIALAVTS IESALITLDL
Length:270
Mass (Da):31,111
Last modified:August 1, 1990 - v1
Checksum:iD23EC9B4849D73BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31304 Genomic DNA. Translation: AAA34771.1.
X78898 Genomic DNA. Translation: CAA55497.1.
Z71486 Genomic DNA. Translation: CAA96112.1.
AY693028 Genomic DNA. Translation: AAT93047.1.
BK006947 Genomic DNA. Translation: DAA10346.1.
PIRiA34717.
RefSeqiNP_014189.1. NM_001183048.1.

Genome annotation databases

EnsemblFungiiYNL210W; YNL210W; YNL210W.
GeneIDi855511.
KEGGisce:YNL210W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31304 Genomic DNA. Translation: AAA34771.1.
X78898 Genomic DNA. Translation: CAA55497.1.
Z71486 Genomic DNA. Translation: CAA96112.1.
AY693028 Genomic DNA. Translation: AAT93047.1.
BK006947 Genomic DNA. Translation: DAA10346.1.
PIRiA34717.
RefSeqiNP_014189.1. NM_001183048.1.

3D structure databases

ProteinModelPortaliP16523.
SMRiP16523. Positions 186-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35626. 14 interactions.
DIPiDIP-1436N.
IntActiP16523. 2 interactions.
MINTiMINT-387064.
STRINGi4932.YNL210W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL210W; YNL210W; YNL210W.
GeneIDi855511.
KEGGisce:YNL210W.

Organism-specific databases

CYGDiYNL210w.
SGDiS000005154. MER1.

Phylogenomic databases

eggNOGiNOG79838.
InParanoidiP16523.
OrthoDBiEOG7647CX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33216-MONOMER.

Miscellaneous databases

NextBioi979529.

Gene expression databases

GenevestigatoriP16523.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis."
    Engebrecht J., Roeder G.S.
    Mol. Cell. Biol. 10:2379-2389(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene."
    Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.
    Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiMER1_YEAST
AccessioniPrimary (citable) accession number: P16523
Secondary accession number(s): D6W0Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.