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P16523

- MER1_YEAST

UniProt

P16523 - MER1_YEAST

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Protein

Meiotic recombination 1 protein

Gene
MER1, YNL210W, N1330
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.

GO - Molecular functioni

  1. mRNA binding Source: SGD

GO - Biological processi

  1. positive regulation of mRNA splicing, via spliceosome Source: SGD
  2. reciprocal meiotic recombination Source: SGD
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination 1 protein
Gene namesi
Name:MER1
Ordered Locus Names:YNL210W
ORF Names:N1330
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL210w.
SGDiS000005154. MER1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Meiotic recombination 1 proteinPRO_0000050120Add
BLAST

Expressioni

Developmental stagei

MER1 is synthesized only during meiosis.

Inductioni

Its expression is meiotically induced and required the IME1 protein.

Gene expression databases

GenevestigatoriP16523.

Interactioni

Protein-protein interaction databases

BioGridi35626. 14 interactions.
DIPiDIP-1436N.
IntActiP16523. 2 interactions.
MINTiMINT-387064.
STRINGi4932.YNL210W.

Structurei

3D structure databases

ProteinModelPortaliP16523.
SMRiP16523. Positions 186-265.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 22535KHAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.

Phylogenomic databases

eggNOGiNOG79838.
OMAiIANEEYS.
OrthoDBiEOG7647CX.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16523-1 [UniParc]FASTAAdd to Basket

« Hide

MSNQHSPQPF CLDTKLVKLL EELQEGKQFN NKNIFPEKAL YLKLALDYSF    50
FRKNLLEFCV HLDKIKGVIR PNYDTIYILC LLEVDLLNLV FTDNILEICL 100
PRFVSREDLR VFNNTFYTYH DNRLRILQED FSQLFKKIKT KASVLCFTVE 150
EIFLTNQEIL PQNSTVAELQ KSTNKVQTNG PQRHDFIVTL EIKLNKTQIT 200
FLIGAKGTRI ESLREKSGAS IKIIPISDKM TAHERNHPES VQQTILISGD 250
LYSIALAVTS IESALITLDL 270
Length:270
Mass (Da):31,111
Last modified:August 1, 1990 - v1
Checksum:iD23EC9B4849D73BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31304 Genomic DNA. Translation: AAA34771.1.
X78898 Genomic DNA. Translation: CAA55497.1.
Z71486 Genomic DNA. Translation: CAA96112.1.
AY693028 Genomic DNA. Translation: AAT93047.1.
BK006947 Genomic DNA. Translation: DAA10346.1.
PIRiA34717.
RefSeqiNP_014189.1. NM_001183048.1.

Genome annotation databases

EnsemblFungiiYNL210W; YNL210W; YNL210W.
GeneIDi855511.
KEGGisce:YNL210W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31304 Genomic DNA. Translation: AAA34771.1 .
X78898 Genomic DNA. Translation: CAA55497.1 .
Z71486 Genomic DNA. Translation: CAA96112.1 .
AY693028 Genomic DNA. Translation: AAT93047.1 .
BK006947 Genomic DNA. Translation: DAA10346.1 .
PIRi A34717.
RefSeqi NP_014189.1. NM_001183048.1.

3D structure databases

ProteinModelPortali P16523.
SMRi P16523. Positions 186-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35626. 14 interactions.
DIPi DIP-1436N.
IntActi P16523. 2 interactions.
MINTi MINT-387064.
STRINGi 4932.YNL210W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL210W ; YNL210W ; YNL210W .
GeneIDi 855511.
KEGGi sce:YNL210W.

Organism-specific databases

CYGDi YNL210w.
SGDi S000005154. MER1.

Phylogenomic databases

eggNOGi NOG79838.
OMAi IANEEYS.
OrthoDBi EOG7647CX.

Enzyme and pathway databases

BioCyci YEAST:G3O-33216-MONOMER.

Miscellaneous databases

NextBioi 979529.

Gene expression databases

Genevestigatori P16523.

Family and domain databases

Gene3Di 3.30.1370.10. 1 hit.
InterProi IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF00013. KH_1. 1 hit.
[Graphical view ]
SMARTi SM00322. KH. 1 hit.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis."
    Engebrecht J., Roeder G.S.
    Mol. Cell. Biol. 10:2379-2389(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene."
    Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.
    Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiMER1_YEAST
AccessioniPrimary (citable) accession number: P16523
Secondary accession number(s): D6W0Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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