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P16523

- MER1_YEAST

UniProt

P16523 - MER1_YEAST

Protein

Meiotic recombination 1 protein

Gene

MER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.

    GO - Molecular functioni

    1. mRNA binding Source: SGD

    GO - Biological processi

    1. positive regulation of mRNA splicing, via spliceosome Source: SGD
    2. reciprocal meiotic recombination Source: SGD

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33216-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Meiotic recombination 1 protein
    Gene namesi
    Name:MER1
    Ordered Locus Names:YNL210W
    ORF Names:N1330
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL210w.
    SGDiS000005154. MER1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Meiotic recombination 1 proteinPRO_0000050120Add
    BLAST

    Expressioni

    Developmental stagei

    MER1 is synthesized only during meiosis.

    Inductioni

    Its expression is meiotically induced and required the IME1 protein.

    Gene expression databases

    GenevestigatoriP16523.

    Interactioni

    Protein-protein interaction databases

    BioGridi35626. 14 interactions.
    DIPiDIP-1436N.
    IntActiP16523. 2 interactions.
    MINTiMINT-387064.
    STRINGi4932.YNL210W.

    Structurei

    3D structure databases

    ProteinModelPortaliP16523.
    SMRiP16523. Positions 186-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 22535KHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 KH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG79838.
    OMAiIANEEYS.
    OrthoDBiEOG7647CX.

    Family and domain databases

    Gene3Di3.30.1370.10. 1 hit.
    InterProiIPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF00013. KH_1. 1 hit.
    [Graphical view]
    SMARTiSM00322. KH. 1 hit.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16523-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNQHSPQPF CLDTKLVKLL EELQEGKQFN NKNIFPEKAL YLKLALDYSF    50
    FRKNLLEFCV HLDKIKGVIR PNYDTIYILC LLEVDLLNLV FTDNILEICL 100
    PRFVSREDLR VFNNTFYTYH DNRLRILQED FSQLFKKIKT KASVLCFTVE 150
    EIFLTNQEIL PQNSTVAELQ KSTNKVQTNG PQRHDFIVTL EIKLNKTQIT 200
    FLIGAKGTRI ESLREKSGAS IKIIPISDKM TAHERNHPES VQQTILISGD 250
    LYSIALAVTS IESALITLDL 270
    Length:270
    Mass (Da):31,111
    Last modified:August 1, 1990 - v1
    Checksum:iD23EC9B4849D73BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31304 Genomic DNA. Translation: AAA34771.1.
    X78898 Genomic DNA. Translation: CAA55497.1.
    Z71486 Genomic DNA. Translation: CAA96112.1.
    AY693028 Genomic DNA. Translation: AAT93047.1.
    BK006947 Genomic DNA. Translation: DAA10346.1.
    PIRiA34717.
    RefSeqiNP_014189.1. NM_001183048.1.

    Genome annotation databases

    EnsemblFungiiYNL210W; YNL210W; YNL210W.
    GeneIDi855511.
    KEGGisce:YNL210W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31304 Genomic DNA. Translation: AAA34771.1 .
    X78898 Genomic DNA. Translation: CAA55497.1 .
    Z71486 Genomic DNA. Translation: CAA96112.1 .
    AY693028 Genomic DNA. Translation: AAT93047.1 .
    BK006947 Genomic DNA. Translation: DAA10346.1 .
    PIRi A34717.
    RefSeqi NP_014189.1. NM_001183048.1.

    3D structure databases

    ProteinModelPortali P16523.
    SMRi P16523. Positions 186-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35626. 14 interactions.
    DIPi DIP-1436N.
    IntActi P16523. 2 interactions.
    MINTi MINT-387064.
    STRINGi 4932.YNL210W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL210W ; YNL210W ; YNL210W .
    GeneIDi 855511.
    KEGGi sce:YNL210W.

    Organism-specific databases

    CYGDi YNL210w.
    SGDi S000005154. MER1.

    Phylogenomic databases

    eggNOGi NOG79838.
    OMAi IANEEYS.
    OrthoDBi EOG7647CX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33216-MONOMER.

    Miscellaneous databases

    NextBioi 979529.

    Gene expression databases

    Genevestigatori P16523.

    Family and domain databases

    Gene3Di 3.30.1370.10. 1 hit.
    InterProi IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF00013. KH_1. 1 hit.
    [Graphical view ]
    SMARTi SM00322. KH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis."
      Engebrecht J., Roeder G.S.
      Mol. Cell. Biol. 10:2379-2389(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene."
      Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.
      Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiMER1_YEAST
    AccessioniPrimary (citable) accession number: P16523
    Secondary accession number(s): D6W0Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3