P16523 (MER1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiotic recombination 1 protein

Gene names

Name:	MER1
Ordered Locus Names:	YNL210W
ORF Names:	N1330

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for chromosome pairing and genetic recombination. MER1 may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.
Developmental stage	MER1 is synthesized only during meiosis.
Induction	Its expression is meiotically induced and required the IME1 protein.
Sequence similarities	Contains 1 KH domain.

Ontologies

Keywords
Biological process	Meiosis
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of mRNA splicing, via spliceosome Inferred from mutant phenotype PubMed 10983980. Source: SGD reciprocal meiotic recombination Inferred from mutant phenotype PubMed 2659434. Source: SGD
Cellular_component	nucleus Inferred from direct assay PubMed 7891689. Source: SGD
Molecular_function	mRNA binding Inferred from direct assay PubMed 10983980. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Meiotic recombination 1 protein		PRO_0000050120
Regions
	Domain	191 – 225	35	KH

Sequences

	Sequence		Length	Mass (Da)
	P16523 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: D23EC9B4849D73BA	FASTA	270	31,111
	10 20 30 40 50 60 MSNQHSPQPF CLDTKLVKLL EELQEGKQFN NKNIFPEKAL YLKLALDYSF FRKNLLEFCV 70 80 90 100 110 120 HLDKIKGVIR PNYDTIYILC LLEVDLLNLV FTDNILEICL PRFVSREDLR VFNNTFYTYH 130 140 150 160 170 180 DNRLRILQED FSQLFKKIKT KASVLCFTVE EIFLTNQEIL PQNSTVAELQ KSTNKVQTNG 190 200 210 220 230 240 PQRHDFIVTL EIKLNKTQIT FLIGAKGTRI ESLREKSGAS IKIIPISDKM TAHERNHPES 250 260 270 VQQTILISGD LYSIALAVTS IESALITLDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis." Engebrecht J., Roeder G.S. Mol. Cell. Biol. 10:2379-2389(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The sequence of a 13.5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene." Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A. Yeast 11:85-91(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M31304 Genomic DNA. Translation: AAA34771.1. X78898 Genomic DNA. Translation: CAA55497.1. Z71486 Genomic DNA. Translation: CAA96112.1. AY693028 Genomic DNA. Translation: AAT93047.1. BK006947 Genomic DNA. Translation: DAA10346.1.
PIR	A34717.
RefSeq	NP_014189.1. NM_001183048.1.
3D structure databases
ProteinModelPortal	P16523.
SMR	P16523. Positions 185-265.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1436N.
IntAct	P16523. 4 interactions.
MINT	MINT-387064.
STRING	4932.YNL210W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL210W; YNL210W; YNL210W.
GeneID	855511.
KEGG	sce:YNL210W.
Organism-specific databases
CYGD	YNL210w.
SGD	S000005154. MER1.
Phylogenomic databases
eggNOG	NOG79838.
OrthoDB	EOG4TF3W5.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33216-MONOMER.
Gene expression databases
Genevestigator	P16523.
GermOnline	YNL210W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004087. KH_dom. IPR004088. KH_dom_type_1. [Graphical view]
Pfam	PF00013. KH_1. 1 hit. [Graphical view]
SMART	SM00322. KH. 1 hit. [Graphical view]
PROSITE	PS50084. KH_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	979529.

Entry information

Entry name

MER1_YEAST

Accession

Primary (citable) accession number: P16523
Secondary accession number(s): D6W0Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program