##gff-version 3
P16519	UniProtKB	Signal peptide	1	25	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16519	UniProtKB	Propeptide	26	109	.	.	.	ID=PRO_0000027065;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16519	UniProtKB	Chain	110	638	.	.	.	ID=PRO_0000027066;Note=Neuroendocrine convertase 2	
P16519	UniProtKB	Domain	129	453	.	.	.	Note=Peptidase S8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P16519	UniProtKB	Domain	461	597	.	.	.	Note=P/Homo B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01173	
P16519	UniProtKB	Active site	167	167	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P16519	UniProtKB	Active site	208	208	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P16519	UniProtKB	Active site	384	384	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P16519	UniProtKB	Glycosylation	375	375	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16519	UniProtKB	Glycosylation	514	514	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16519	UniProtKB	Glycosylation	524	524	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P16519	UniProtKB	Disulfide bond	225	376	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P23188	
P16519	UniProtKB	Disulfide bond	317	347	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P23188	
P16519	UniProtKB	Disulfide bond	468	494	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P23188	
P16519	UniProtKB	Alternative sequence	1	19	.	.	.	ID=VSP_045873;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
P16519	UniProtKB	Alternative sequence	60	94	.	.	.	ID=VSP_043358;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P16519	UniProtKB	Natural variant	77	77	.	.	.	ID=VAR_079730;Note=No effect on secretion%3B no effect on proglucagon processing. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28719828;Dbxref=dbSNP:rs201718679,PMID:28719828	
P16519	UniProtKB	Natural variant	244	244	.	.	.	ID=VAR_069075;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854040,PMID:15489334	
P16519	UniProtKB	Natural variant	267	267	.	.	.	ID=VAR_079731;Note=Decreased secretion%3B reduced proglucagon processing. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28719828;Dbxref=dbSNP:rs144151196,PMID:28719828	
P16519	UniProtKB	Natural variant	424	424	.	.	.	ID=VAR_036548;Note=In a colorectal cancer sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs780820865,PMID:16959974	
P16519	UniProtKB	Natural variant	430	430	.	.	.	ID=VAR_079732;Note=No effect on secretion%3B no effect on proglucagon processing. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28719828;Dbxref=dbSNP:rs200711626,PMID:28719828	
P16519	UniProtKB	Natural variant	484	484	.	.	.	ID=VAR_069076;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857236,PMID:15489334	
P16519	UniProtKB	Natural variant	525	525	.	.	.	ID=VAR_079733;Note=No effect on secretion%3B no effect on proglucagon processing. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28719828;Dbxref=dbSNP:rs139619496,PMID:28719828	
P16519	UniProtKB	Sequence conflict	283	284	.	.	.	Note=EL->DV;Ontology_term=ECO:0000305;evidence=ECO:0000305