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Protein

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.1 Publication

Catalytic activityi

Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671Charge relay systemBy similarity
Active sitei208 – 2081Charge relay systemBy similarity
Active sitei384 – 3841Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: BHF-UCL

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. enkephalin processing Source: BHF-UCL
  3. insulin processing Source: BHF-UCL
  4. islet amyloid polypeptide processing Source: BHF-UCL
  5. nervous system development Source: Ensembl
  6. protein autoprocessing Source: Ensembl
  7. proteolysis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_15550. Insulin processing.
SignaLinkiP16519.

Protein family/group databases

MEROPSiS08.073.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroendocrine convertase 2 (EC:3.4.21.94)
Short name:
NEC 2
Alternative name(s):
KEX2-like endoprotease 2
Prohormone convertase 2
Proprotein convertase 2
Short name:
PC2
Gene namesi
Name:PCSK2
Synonyms:NEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:8744. PCSK2.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle
Note: Localized in the secretion granules.

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. extracellular space Source: BHF-UCL
  3. membrane Source: BHF-UCL
  4. perikaryon Source: Ensembl
  5. secretory granule lumen Source: Reactome
  6. transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 10984Sequence AnalysisPRO_0000027065Add
BLAST
Chaini110 – 638529Neuroendocrine convertase 2PRO_0000027066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi225 ↔ 376By similarity
Disulfide bondi317 ↔ 347By similarity
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi468 ↔ 494By similarity
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP16519.
PRIDEiP16519.

Expressioni

Gene expression databases

BgeeiP16519.
CleanExiHS_PCSK2.
ExpressionAtlasiP16519. baseline and differential.
GenevestigatoriP16519.

Organism-specific databases

HPAiHPA048851.
HPA049627.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262545.

Structurei

3D structure databases

ProteinModelPortaliP16519.
SMRiP16519. Positions 123-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 453292Peptidase S8Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family. Furin subfamily.Curated
Contains 1 peptidase S8 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiP16519.
KOiK01360.
OMAiYHCEAGE.
OrthoDBiEOG7BW0JD.
PhylomeDBiP16519.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA
60 70 80 90 100
AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ
110 120 130 140 150
QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE
160 170 180 190 200
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY
210 220 230 240 250
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII
260 270 280 290 300
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
310 320 330 340 350
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST
360 370 380 390 400
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA
410 420 430 440 450
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG
460 470 480 490 500
AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF
510 520 530 540 550
VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD
560 570 580 590 600
KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
610 620 630
DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN
Length:638
Mass (Da):70,565
Last modified:February 20, 2001 - v2
Checksum:i323623FBDA6086B2
GO
Isoform 2 (identifier: P16519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-94: Missing.

Note: No experimental confirmation available.

Show »
Length:603
Mass (Da):66,312
Checksum:i7D25259EECDA94EE
GO
Isoform 3 (identifier: P16519-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Note: No experimental confirmation available.

Show »
Length:619
Mass (Da):68,580
Checksum:iFCC1B2B87F1A5B71
GO

Sequence cautioni

The sequence CAA21069.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB89428.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB96732.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2842EL → DV in AAA60032 (PubMed:2154467).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441P → Q.1 Publication
Corresponds to variant rs17854040 [ dbSNP | Ensembl ].
VAR_069075
Natural varianti424 – 4241D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036548
Natural varianti484 – 4841K → E.1 Publication
Corresponds to variant rs17857236 [ dbSNP | Ensembl ].
VAR_069076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919Missing in isoform 3. 1 PublicationVSP_045873Add
BLAST
Alternative sequencei60 – 9435Missing in isoform 2. 1 PublicationVSP_043358Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05252 mRNA. Translation: AAA60032.1.
M95971
, M95960, M95961, M95962, M95963, M95964, M95965, M95966, M95967, M95968, M95969, M95970 Genomic DNA. Translation: AAA59919.1.
AK294200 mRNA. Translation: BAG57514.1.
AK312341 mRNA. Translation: BAG35262.1.
AL031675
, AL031664, AL121779, AL359511 Genomic DNA. Translation: CAA21069.2. Different initiation.
AL031664
, AL031675, AL121779, AL359511 Genomic DNA. Translation: CAB89428.2. Different initiation.
AL121779
, AL031664, AL031675, AL359511 Genomic DNA. Translation: CAB96732.2. Different initiation.
AL359511
, AL031664, AL031675, AL121779 Genomic DNA. Translation: CAC34957.2.
AL121779
, AL031664, AL031675, AL359511 Genomic DNA. Translation: CAI19155.1.
AL359511
, AL031664, AL031675, AL121779 Genomic DNA. Translation: CAI20085.1.
AL031664
, AL031675, AL121779, AL359511 Genomic DNA. Translation: CAI21690.1.
AL031675
, AL031664, AL121779, AL359511 Genomic DNA. Translation: CAI22648.1.
CH471133 Genomic DNA. Translation: EAX10279.1.
CH471133 Genomic DNA. Translation: EAX10280.1.
CH471133 Genomic DNA. Translation: EAX10281.1.
BC005815 mRNA. Translation: AAH05815.1.
BC040546 mRNA. Translation: AAH40546.1.
S75955 Genomic DNA. Translation: AAD14202.1.
CCDSiCCDS13125.1. [P16519-1]
CCDS56179.1. [P16519-2]
CCDS56180.1. [P16519-3]
PIRiA45382. KXHUC2.
RefSeqiNP_001188457.1. NM_001201528.1. [P16519-3]
NP_001188458.1. NM_001201529.2. [P16519-2]
NP_002585.2. NM_002594.4. [P16519-1]
UniGeneiHs.315186.

Genome annotation databases

EnsembliENST00000262545; ENSP00000262545; ENSG00000125851. [P16519-1]
ENST00000377899; ENSP00000367131; ENSG00000125851. [P16519-3]
ENST00000536609; ENSP00000437458; ENSG00000125851. [P16519-2]
GeneIDi5126.
KEGGihsa:5126.
UCSCiuc002wpl.3. human. [P16519-1]
uc010zrm.2. human. [P16519-2]

Polymorphism databases

DMDMi13124785.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05252 mRNA. Translation: AAA60032.1.
M95971
, M95960, M95961, M95962, M95963, M95964, M95965, M95966, M95967, M95968, M95969, M95970 Genomic DNA. Translation: AAA59919.1.
AK294200 mRNA. Translation: BAG57514.1.
AK312341 mRNA. Translation: BAG35262.1.
AL031675
, AL031664, AL121779, AL359511 Genomic DNA. Translation: CAA21069.2. Different initiation.
AL031664
, AL031675, AL121779, AL359511 Genomic DNA. Translation: CAB89428.2. Different initiation.
AL121779
, AL031664, AL031675, AL359511 Genomic DNA. Translation: CAB96732.2. Different initiation.
AL359511
, AL031664, AL031675, AL121779 Genomic DNA. Translation: CAC34957.2.
AL121779
, AL031664, AL031675, AL359511 Genomic DNA. Translation: CAI19155.1.
AL359511
, AL031664, AL031675, AL121779 Genomic DNA. Translation: CAI20085.1.
AL031664
, AL031675, AL121779, AL359511 Genomic DNA. Translation: CAI21690.1.
AL031675
, AL031664, AL121779, AL359511 Genomic DNA. Translation: CAI22648.1.
CH471133 Genomic DNA. Translation: EAX10279.1.
CH471133 Genomic DNA. Translation: EAX10280.1.
CH471133 Genomic DNA. Translation: EAX10281.1.
BC005815 mRNA. Translation: AAH05815.1.
BC040546 mRNA. Translation: AAH40546.1.
S75955 Genomic DNA. Translation: AAD14202.1.
CCDSiCCDS13125.1. [P16519-1]
CCDS56179.1. [P16519-2]
CCDS56180.1. [P16519-3]
PIRiA45382. KXHUC2.
RefSeqiNP_001188457.1. NM_001201528.1. [P16519-3]
NP_001188458.1. NM_001201529.2. [P16519-2]
NP_002585.2. NM_002594.4. [P16519-1]
UniGeneiHs.315186.

3D structure databases

ProteinModelPortaliP16519.
SMRiP16519. Positions 123-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262545.

Chemistry

BindingDBiP16519.
ChEMBLiCHEMBL2433.
DrugBankiDB00071. "Insulin.
DB00030. Insulin Regular.

Protein family/group databases

MEROPSiS08.073.

Polymorphism databases

DMDMi13124785.

Proteomic databases

PaxDbiP16519.
PRIDEiP16519.

Protocols and materials databases

DNASUi5126.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262545; ENSP00000262545; ENSG00000125851. [P16519-1]
ENST00000377899; ENSP00000367131; ENSG00000125851. [P16519-3]
ENST00000536609; ENSP00000437458; ENSG00000125851. [P16519-2]
GeneIDi5126.
KEGGihsa:5126.
UCSCiuc002wpl.3. human. [P16519-1]
uc010zrm.2. human. [P16519-2]

Organism-specific databases

CTDi5126.
GeneCardsiGC20P017206.
HGNCiHGNC:8744. PCSK2.
HPAiHPA048851.
HPA049627.
MIMi162151. gene.
neXtProtiNX_P16519.
PharmGKBiPA33091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiP16519.
KOiK01360.
OMAiYHCEAGE.
OrthoDBiEOG7BW0JD.
PhylomeDBiP16519.
TreeFamiTF314277.

Enzyme and pathway databases

ReactomeiREACT_15550. Insulin processing.
SignaLinkiP16519.

Miscellaneous databases

ChiTaRSiPCSK2. human.
GeneWikiiProprotein_convertase_2.
GenomeRNAii5126.
NextBioi19758.
PROiP16519.
SOURCEiSearch...

Gene expression databases

BgeeiP16519.
CleanExiHS_PCSK2.
ExpressionAtlasiP16519. baseline and differential.
GenevestigatoriP16519.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2."
    Smeekens S.P., Steiner D.F.
    J. Biol. Chem. 265:2997-3000(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Insulinoma.
  2. "Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues."
    Ohagi S., Lamendola J., Lebeau M.M., Espinosa R., Takeda J., Smeekens S.P., Chan S.J., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Brain cortex.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLN-244 AND GLU-484.
    Tissue: Brain and Lung.
  7. "Analysis of the gene encoding human PC2, a prohormone processing enzyme."
    Ohagi S., Yoshida H., Nanjo K.
    Nippon Rinsho 52:2544-2549(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
  8. "Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."
    Rouille Y., Bianchi M., Irminger J.C., Halban P.A.
    FEBS Lett. 413:119-123(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-424.

Entry informationi

Entry nameiNEC2_HUMAN
AccessioniPrimary (citable) accession number: P16519
Secondary accession number(s): B1ANH9
, B4DFQ3, Q14927, Q5JYQ1, Q8IWA8, Q9NQG3, Q9NUG1, Q9UJC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1990
Last sequence update: February 20, 2001
Last modified: January 6, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.