P16519 (NEC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroendocrine convertase 2
Short name=NEC 2
EC=3.4.21.94

Alternative name(s):
KEX2-like endoprotease 2
Prohormone convertase 2
Proprotein convertase 2
Short name=PC2

Gene names

Name:	PCSK2
Synonyms:	NEC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. Ref.8
Catalytic activity	Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
Subcellular location	Cytoplasmic vesicle › secretory vesicle. Note: Localized in the secretion granules.
Sequence similarities	Belongs to the peptidase S8 family. Furin subfamily.
Sequence caution	The sequence CAA21069.2 differs from that shown. Reason: Erroneous initiation. The sequence CAB89428.2 differs from that shown. Reason: Erroneous initiation. The sequence CAB96732.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein metabolic process Traceable author statement. Source: Reactome embryo development Inferred from electronic annotation. Source: Compara enkephalin processing Inferred from sequence or structural similarity. Source: BHF-UCL insulin processing Inferred from direct assay PubMed 7626024. Source: BHF-UCL islet amyloid polypeptide processing Inferred from sequence or structural similarity. Source: BHF-UCL nervous system development Inferred from electronic annotation. Source: Compara protein autoprocessing Inferred from electronic annotation. Source: Compara proteolysis Inferred from direct assay PubMed 7626024. Source: BHF-UCL
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 9020868. Source: BHF-UCL membrane Inferred from direct assay PubMed 8034613. Source: BHF-UCL perikaryon Inferred from electronic annotation. Source: Compara secretory granule lumen Traceable author statement. Source: Reactome transport vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase activity Inferred from direct assay PubMed 7626024. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P16519-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P16519-2)

The sequence of this isoform differs from the canonical sequence as follows:
     60-94: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P16519-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 109	84	Potential		PRO_0000027065
	Chain	110 – 638	529	Neuroendocrine convertase 2		PRO_0000027066
Regions
	Region	122 – 415	294	Catalytic
Sites
	Active site	167	1	Charge relay system By similarity
	Active site	208	1	Charge relay system By similarity
	Active site	384	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	514	1	N-linked (GlcNAc...) Potential
	Glycosylation	524	1	N-linked (GlcNAc...) Potential
	Disulfide bond	225 ↔ 376		By similarity
	Disulfide bond	317 ↔ 347		By similarity
	Disulfide bond	468 ↔ 494		By similarity
Natural variations
	Alternative sequence	1 – 19	19	Missing in isoform 3.		VSP_045873
	Alternative sequence	60 – 94	35	Missing in isoform 2.		VSP_043358
	Natural variant	244	1	P → Q. Ref.6 Corresponds to variant rs17854040 [ dbSNP | Ensembl ].		VAR_069075
	Natural variant	424	1	D → N in a colorectal cancer sample; somatic mutation. Ref.9		VAR_036548
	Natural variant	484	1	K → E. Ref.6 Corresponds to variant rs17857236 [ dbSNP | Ensembl ].		VAR_069076
Experimental info
	Sequence conflict	283 – 284	2	EL → DV in AAA60032. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 323623FBDA6086B2	FASTA	638	70,565
	10 20 30 40 50 60 MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA AEHGFGVRKL 70 80 90 100 110 120 PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ QEGFDRKKRG YRDINEIDIN 130 140 150 160 170 180 MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN 190 200 210 220 230 240 YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM 250 260 270 280 290 300 LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 310 320 330 340 350 360 GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK 370 380 390 400 410 420 RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN 430 440 450 460 470 480 QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQDPEKIP 490 500 510 520 530 540 STGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP 550 560 570 580 590 600 RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 610 620 630 DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN
	Isoform 2 [UniParc]. Checksum: 7D25259EECDA94EE	FASTA	603	66,312
	10 20 30 40 50 60 MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA AEHGFGVRKV 70 80 90 100 110 120 KMALQQEGFD RKKRGYRDIN EIDINMNDPL FTKQWYLINT GQADGTPGLD LNVAEAWELG 130 140 150 160 170 180 YTGKGVTIGI MDDGIDYLHP DLASNYNAEA SYDFSSNDPY PYPRYTDDWF NSHGTRCAGE 190 200 210 220 230 240 VSAAANNNIC GVGVAYNSKV AGIRMLDQPF MTDIIEASSI SHMPQLIDIY SASWGPTDNG 250 260 270 280 290 300 KTVDGPRELT LQAMADGVNK GRGGKGSIYV WASGDGGSYD DCNCDGYASS MWTISINSAI 310 320 330 340 350 360 NDGRTALYDE SCSSTLASTF SNGRKRNPEA GVATTDLYGN CTLRHSGTSA AAPEAAGVFA 370 380 390 400 410 420 LALEANLGLT WRDMQHLTVL TSKRNQLHDE VHQWRRNGVG LEFNHLFGYG VLDAGAMVKM 430 440 450 460 470 480 AKDWKTVPER FHCVGGSVQD PEKIPSTGKL VLTLTTDACE GKENFVRYLE HVQAVITVNA 490 500 510 520 530 540 TRRGDLNINM TSPMGTKSIL LSRRPRDDDS KVGFDKWPFM TTHTWGEDAR GTWTLELGFV 550 560 570 580 590 600 GSAPQKGVLK EWTLMLHGTQ SAPYIDQVVR DYQSKLAMSK KEELEEELDE AVERSLKSIL NKN
	Isoform 3 [UniParc]. Checksum: FCC1B2B87F1A5B71	FASTA	619	68,580
	10 20 30 40 50 60 MVFASAERPV FTNHFLVELH KGGEDKARQV AAEHGFGVRK LPFAEGLYHF YHNGLAKAKR 70 80 90 100 110 120 RRSLHHKQQL ERDPRVKMAL QQEGFDRKKR GYRDINEIDI NMNDPLFTKQ WYLINTGQAD 130 140 150 160 170 180 GTPGLDLNVA EAWELGYTGK GVTIGIMDDG IDYLHPDLAS NYNAEASYDF SSNDPYPYPR 190 200 210 220 230 240 YTDDWFNSHG TRCAGEVSAA ANNNICGVGV AYNSKVAGIR MLDQPFMTDI IEASSISHMP 250 260 270 280 290 300 QLIDIYSASW GPTDNGKTVD GPRELTLQAM ADGVNKGRGG KGSIYVWASG DGGSYDDCNC 310 320 330 340 350 360 DGYASSMWTI SINSAINDGR TALYDESCSS TLASTFSNGR KRNPEAGVAT TDLYGNCTLR 370 380 390 400 410 420 HSGTSAAAPE AAGVFALALE ANLGLTWRDM QHLTVLTSKR NQLHDEVHQW RRNGVGLEFN 430 440 450 460 470 480 HLFGYGVLDA GAMVKMAKDW KTVPERFHCV GGSVQDPEKI PSTGKLVLTL TTDACEGKEN 490 500 510 520 530 540 FVRYLEHVQA VITVNATRRG DLNINMTSPM GTKSILLSRR PRDDDSKVGF DKWPFMTTHT 550 560 570 580 590 600 WGEDARGTWT LELGFVGSAP QKGVLKEWTL MLHGTQSAPY IDQVVRDYQS KLAMSKKEEL 610 EEELDEAVER SLKSILNKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2." Smeekens S.P., Steiner D.F. J. Biol. Chem. 265:2997-3000(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Insulinoma.
[2]	"Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues." Ohagi S., Lamendola J., Lebeau M.M., Espinosa R., Takeda J., Smeekens S.P., Chan S.J., Steiner D.F. Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Amygdala and Brain cortex.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLN-244 AND GLU-484. Tissue: Brain and Lung.
[7]	"Analysis of the gene encoding human PC2, a prohormone processing enzyme." Ohagi S., Yoshida H., Nanjo K. Nippon Rinsho 52:2544-2549(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
[8]	"Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon." Rouille Y., Bianchi M., Irminger J.C., Halban P.A. FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-424.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05252 mRNA. Translation: AAA60032.1. M95971 , M95960, M95961, M95962, M95963, M95964, M95965, M95966, M95967, M95968, M95969, M95970 Genomic DNA. Translation: AAA59919.1. AK294200 mRNA. Translation: BAG57514.1. AK312341 mRNA. Translation: BAG35262.1. AL031675 , AL031664, AL121779, AL359511 Genomic DNA. Translation: CAA21069.2. Different initiation. AL031664 , AL031675, AL121779, AL359511 Genomic DNA. Translation: CAB89428.2. Different initiation. AL121779 , AL031664, AL031675, AL359511 Genomic DNA. Translation: CAB96732.2. Different initiation. AL359511 , AL031664, AL031675, AL121779 Genomic DNA. Translation: CAC34957.2. AL121779 , AL031664, AL031675, AL359511 Genomic DNA. Translation: CAI19155.1. AL359511 , AL031664, AL031675, AL121779 Genomic DNA. Translation: CAI20085.1. AL031664 , AL031675, AL121779, AL359511 Genomic DNA. Translation: CAI21690.1. AL031675 , AL031664, AL121779, AL359511 Genomic DNA. Translation: CAI22648.1. CH471133 Genomic DNA. Translation: EAX10279.1. CH471133 Genomic DNA. Translation: EAX10280.1. CH471133 Genomic DNA. Translation: EAX10281.1. BC005815 mRNA. Translation: AAH05815.1. BC040546 mRNA. Translation: AAH40546.1. S75955 Genomic DNA. Translation: AAD14202.1.
IPI	IPI00029131. IPI00643663. IPI00980710.
PIR	KXHUC2. A45382.
RefSeq	NP_001188457.1. NM_001201528.1. NP_001188458.1. NM_001201529.1. NP_002585.2. NM_002594.3.
UniGene	Hs.315186.
3D structure databases
ProteinModelPortal	P16519.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000262545.
Protein family/group databases
MEROPS	S08.073.
Polymorphism databases
DMDM	13124785.
Proteomic databases
PaxDb	P16519.
PRIDE	P16519.
Protocols and materials databases
DNASU	5126.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262545; ENSP00000262545; ENSG00000125851. ENST00000377899; ENSP00000367131; ENSG00000125851. ENST00000536609; ENSP00000437458; ENSG00000125851.
GeneID	5126.
KEGG	hsa:5126.
UCSC	uc002wpl.3. human. uc010zrm.2. human.
Organism-specific databases
CTD	5126.
GeneCards	GC20P017206.
HGNC	HGNC:8744. PCSK2.
HPA	HPA048851. HPA049627.
MIM	162151. gene.
neXtProt	NX_P16519.
PharmGKB	PA33091.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4935.
HOGENOM	HOG000192536.
HOVERGEN	HBG008705.
InParanoid	P16519.
KO	K01360.
OMA	YHCEAGE.
PhylomeDB	P16519.
Enzyme and pathway databases
Reactome	REACT_116125. Disease.
SignaLink	P16519.
Gene expression databases
ArrayExpress	P16519.
Bgee	P16519.
CleanEx	HS_PCSK2.
Genevestigator	P16519.
GermOnline	ENSG00000125851. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.260. 1 hit. 3.40.50.200. 1 hit.
InterPro	IPR008979. Galactose-bd-like. IPR000209. Peptidase_S8/S53_dom. IPR023827. Peptidase_S8_Asp-AS. IPR022398. Peptidase_S8_His-AS. IPR023828. Peptidase_S8_Ser-AS. IPR015500. Peptidase_S8_subtilisin-rel. IPR009020. Prot_inh_propept. IPR002884. PrprotnconvertsP. [Graphical view]
PANTHER	PTHR10795. PTHR10795. 1 hit.
Pfam	PF01483. P_proprotein. 1 hit. PF00082. Peptidase_S8. 1 hit. [Graphical view]
PRINTS	PR00723. SUBTILISIN.
SUPFAM	SSF49785. Gal_bind_like. 1 hit. SSF52743. Pept_S8_S53. 1 hit. SSF54897. Prot_inh_propept. 1 hit.
PROSITE	PS00136. SUBTILASE_ASP. 1 hit. PS00137. SUBTILASE_HIS. 1 hit. PS00138. SUBTILASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P16519.
ChEMBL	CHEMBL2433.
DrugBank	DB00047. Insulin Glargine recombinant. DB00046. Insulin Lyspro recombinant. DB00030. Insulin recombinant. DB00071. Insulin, porcine.
GenomeRNAi	5126.
NextBio	19758.
SOURCE	Search...

Entry information

Entry name

NEC2_HUMAN

Accession

Primary (citable) accession number: P16519
Secondary accession number(s): B1ANH9 , B4DFQ3, Q14927, Q5JYQ1, Q8IWA8, Q9NQG3, Q9NUG1, Q9UJC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	February 21, 2001
Last modified:	May 29, 2013
This is version 136 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.