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P16519

- NEC2_HUMAN

UniProt

P16519 - NEC2_HUMAN

Protein

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.1 Publication

    Catalytic activityi

    Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671Charge relay systemBy similarity
    Active sitei208 – 2081Charge relay systemBy similarity
    Active sitei384 – 3841Charge relay systemBy similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. serine-type endopeptidase activity Source: BHF-UCL

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. embryo development Source: Ensembl
    3. enkephalin processing Source: BHF-UCL
    4. insulin processing Source: BHF-UCL
    5. islet amyloid polypeptide processing Source: BHF-UCL
    6. nervous system development Source: Ensembl
    7. protein autoprocessing Source: Ensembl
    8. proteolysis Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_15550. Insulin processing.
    SignaLinkiP16519.

    Protein family/group databases

    MEROPSiS08.073.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroendocrine convertase 2 (EC:3.4.21.94)
    Short name:
    NEC 2
    Alternative name(s):
    KEX2-like endoprotease 2
    Prohormone convertase 2
    Proprotein convertase 2
    Short name:
    PC2
    Gene namesi
    Name:PCSK2
    Synonyms:NEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:8744. PCSK2.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle
    Note: Localized in the secretion granules.

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. extracellular space Source: BHF-UCL
    3. membrane Source: BHF-UCL
    4. perikaryon Source: Ensembl
    5. secretory granule lumen Source: Reactome
    6. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33091.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 10984Sequence AnalysisPRO_0000027065Add
    BLAST
    Chaini110 – 638529Neuroendocrine convertase 2PRO_0000027066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi225 ↔ 376By similarity
    Disulfide bondi317 ↔ 347By similarity
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi468 ↔ 494By similarity
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP16519.
    PRIDEiP16519.

    Expressioni

    Gene expression databases

    ArrayExpressiP16519.
    BgeeiP16519.
    CleanExiHS_PCSK2.
    GenevestigatoriP16519.

    Organism-specific databases

    HPAiHPA048851.
    HPA049627.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000262545.

    Structurei

    3D structure databases

    ProteinModelPortaliP16519.
    SMRiP16519. Positions 123-594.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 453292Peptidase S8Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S8 family. Furin subfamily.Curated
    Contains 1 peptidase S8 domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4935.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    InParanoidiP16519.
    KOiK01360.
    OMAiDVQHLTV.
    OrthoDBiEOG7BW0JD.
    PhylomeDBiP16519.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P16519-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA    50
    AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ 100
    QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE 150
    AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY 200
    TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII 250
    EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 300
    GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST 350
    LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA 400
    NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG 450
    AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF 500
    VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD 550
    KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 600
    DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN 638
    Length:638
    Mass (Da):70,565
    Last modified:February 21, 2001 - v2
    Checksum:i323623FBDA6086B2
    GO
    Isoform 2 (identifier: P16519-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-94: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:603
    Mass (Da):66,312
    Checksum:i7D25259EECDA94EE
    GO
    Isoform 3 (identifier: P16519-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:619
    Mass (Da):68,580
    Checksum:iFCC1B2B87F1A5B71
    GO

    Sequence cautioni

    The sequence CAA21069.2 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB89428.2 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB96732.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti283 – 2842EL → DV in AAA60032. (PubMed:2154467)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti244 – 2441P → Q.1 Publication
    Corresponds to variant rs17854040 [ dbSNP | Ensembl ].
    VAR_069075
    Natural varianti424 – 4241D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036548
    Natural varianti484 – 4841K → E.1 Publication
    Corresponds to variant rs17857236 [ dbSNP | Ensembl ].
    VAR_069076

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1919Missing in isoform 3. 1 PublicationVSP_045873Add
    BLAST
    Alternative sequencei60 – 9435Missing in isoform 2. 1 PublicationVSP_043358Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05252 mRNA. Translation: AAA60032.1.
    M95971
    , M95960, M95961, M95962, M95963, M95964, M95965, M95966, M95967, M95968, M95969, M95970 Genomic DNA. Translation: AAA59919.1.
    AK294200 mRNA. Translation: BAG57514.1.
    AK312341 mRNA. Translation: BAG35262.1.
    AL031675
    , AL031664, AL121779, AL359511 Genomic DNA. Translation: CAA21069.2. Different initiation.
    AL031664
    , AL031675, AL121779, AL359511 Genomic DNA. Translation: CAB89428.2. Different initiation.
    AL121779
    , AL031664, AL031675, AL359511 Genomic DNA. Translation: CAB96732.2. Different initiation.
    AL359511
    , AL031664, AL031675, AL121779 Genomic DNA. Translation: CAC34957.2.
    AL121779
    , AL031664, AL031675, AL359511 Genomic DNA. Translation: CAI19155.1.
    AL359511
    , AL031664, AL031675, AL121779 Genomic DNA. Translation: CAI20085.1.
    AL031664
    , AL031675, AL121779, AL359511 Genomic DNA. Translation: CAI21690.1.
    AL031675
    , AL031664, AL121779, AL359511 Genomic DNA. Translation: CAI22648.1.
    CH471133 Genomic DNA. Translation: EAX10279.1.
    CH471133 Genomic DNA. Translation: EAX10280.1.
    CH471133 Genomic DNA. Translation: EAX10281.1.
    BC005815 mRNA. Translation: AAH05815.1.
    BC040546 mRNA. Translation: AAH40546.1.
    S75955 Genomic DNA. Translation: AAD14202.1.
    CCDSiCCDS13125.1. [P16519-1]
    CCDS56179.1. [P16519-2]
    CCDS56180.1. [P16519-3]
    PIRiA45382. KXHUC2.
    RefSeqiNP_001188457.1. NM_001201528.1. [P16519-3]
    NP_001188458.1. NM_001201529.2. [P16519-2]
    NP_002585.2. NM_002594.4. [P16519-1]
    UniGeneiHs.315186.

    Genome annotation databases

    EnsembliENST00000262545; ENSP00000262545; ENSG00000125851. [P16519-1]
    ENST00000377899; ENSP00000367131; ENSG00000125851. [P16519-3]
    ENST00000536609; ENSP00000437458; ENSG00000125851. [P16519-2]
    GeneIDi5126.
    KEGGihsa:5126.
    UCSCiuc002wpl.3. human. [P16519-1]
    uc010zrm.2. human. [P16519-2]

    Polymorphism databases

    DMDMi13124785.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05252 mRNA. Translation: AAA60032.1 .
    M95971
    , M95960 , M95961 , M95962 , M95963 , M95964 , M95965 , M95966 , M95967 , M95968 , M95969 , M95970 Genomic DNA. Translation: AAA59919.1 .
    AK294200 mRNA. Translation: BAG57514.1 .
    AK312341 mRNA. Translation: BAG35262.1 .
    AL031675
    , AL031664 , AL121779 , AL359511 Genomic DNA. Translation: CAA21069.2 . Different initiation.
    AL031664
    , AL031675 , AL121779 , AL359511 Genomic DNA. Translation: CAB89428.2 . Different initiation.
    AL121779
    , AL031664 , AL031675 , AL359511 Genomic DNA. Translation: CAB96732.2 . Different initiation.
    AL359511
    , AL031664 , AL031675 , AL121779 Genomic DNA. Translation: CAC34957.2 .
    AL121779
    , AL031664 , AL031675 , AL359511 Genomic DNA. Translation: CAI19155.1 .
    AL359511
    , AL031664 , AL031675 , AL121779 Genomic DNA. Translation: CAI20085.1 .
    AL031664
    , AL031675 , AL121779 , AL359511 Genomic DNA. Translation: CAI21690.1 .
    AL031675
    , AL031664 , AL121779 , AL359511 Genomic DNA. Translation: CAI22648.1 .
    CH471133 Genomic DNA. Translation: EAX10279.1 .
    CH471133 Genomic DNA. Translation: EAX10280.1 .
    CH471133 Genomic DNA. Translation: EAX10281.1 .
    BC005815 mRNA. Translation: AAH05815.1 .
    BC040546 mRNA. Translation: AAH40546.1 .
    S75955 Genomic DNA. Translation: AAD14202.1 .
    CCDSi CCDS13125.1. [P16519-1 ]
    CCDS56179.1. [P16519-2 ]
    CCDS56180.1. [P16519-3 ]
    PIRi A45382. KXHUC2.
    RefSeqi NP_001188457.1. NM_001201528.1. [P16519-3 ]
    NP_001188458.1. NM_001201529.2. [P16519-2 ]
    NP_002585.2. NM_002594.4. [P16519-1 ]
    UniGenei Hs.315186.

    3D structure databases

    ProteinModelPortali P16519.
    SMRi P16519. Positions 123-594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000262545.

    Chemistry

    BindingDBi P16519.
    ChEMBLi CHEMBL2433.
    DrugBanki DB00047. Insulin Glargine recombinant.
    DB00046. Insulin Lyspro recombinant.
    DB00030. Insulin recombinant.
    DB00071. Insulin, porcine.

    Protein family/group databases

    MEROPSi S08.073.

    Polymorphism databases

    DMDMi 13124785.

    Proteomic databases

    PaxDbi P16519.
    PRIDEi P16519.

    Protocols and materials databases

    DNASUi 5126.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262545 ; ENSP00000262545 ; ENSG00000125851 . [P16519-1 ]
    ENST00000377899 ; ENSP00000367131 ; ENSG00000125851 . [P16519-3 ]
    ENST00000536609 ; ENSP00000437458 ; ENSG00000125851 . [P16519-2 ]
    GeneIDi 5126.
    KEGGi hsa:5126.
    UCSCi uc002wpl.3. human. [P16519-1 ]
    uc010zrm.2. human. [P16519-2 ]

    Organism-specific databases

    CTDi 5126.
    GeneCardsi GC20P017206.
    HGNCi HGNC:8744. PCSK2.
    HPAi HPA048851.
    HPA049627.
    MIMi 162151. gene.
    neXtProti NX_P16519.
    PharmGKBi PA33091.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4935.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    InParanoidi P16519.
    KOi K01360.
    OMAi DVQHLTV.
    OrthoDBi EOG7BW0JD.
    PhylomeDBi P16519.
    TreeFami TF314277.

    Enzyme and pathway databases

    Reactomei REACT_15550. Insulin processing.
    SignaLinki P16519.

    Miscellaneous databases

    GeneWikii Proprotein_convertase_2.
    GenomeRNAii 5126.
    NextBioi 19758.
    PROi P16519.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16519.
    Bgeei P16519.
    CleanExi HS_PCSK2.
    Genevestigatori P16519.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2."
      Smeekens S.P., Steiner D.F.
      J. Biol. Chem. 265:2997-3000(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Insulinoma.
    2. "Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues."
      Ohagi S., Lamendola J., Lebeau M.M., Espinosa R., Takeda J., Smeekens S.P., Chan S.J., Steiner D.F.
      Proc. Natl. Acad. Sci. U.S.A. 89:4977-4981(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala and Brain cortex.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLN-244 AND GLU-484.
      Tissue: Brain and Lung.
    7. "Analysis of the gene encoding human PC2, a prohormone processing enzyme."
      Ohagi S., Yoshida H., Nanjo K.
      Nippon Rinsho 52:2544-2549(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
    8. "Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."
      Rouille Y., Bianchi M., Irminger J.C., Halban P.A.
      FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-424.

    Entry informationi

    Entry nameiNEC2_HUMAN
    AccessioniPrimary (citable) accession number: P16519
    Secondary accession number(s): B1ANH9
    , B4DFQ3, Q14927, Q5JYQ1, Q8IWA8, Q9NQG3, Q9NUG1, Q9UJC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3