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P16502

- RDRP_I56A0

UniProt

P16502 - RDRP_I56A0

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Protein
RNA-directed RNA polymerase catalytic subunit
Gene
PB1
Organism
Influenza A virus (strain A/Beijing/11/1956 H1N1)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase catalytic subunit (EC:2.7.7.48)
Alternative name(s):
Polymerase basic protein 1
Short name:
PB1
RNA-directed RNA polymerase subunit P1
Gene namesi
Name:PB1
OrganismiInfluenza A virus (strain A/Beijing/11/1956 H1N1)
Taxonomic identifieri384500 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

Host nucleus Reviewed prediction

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757RNA-directed RNA polymerase catalytic subunit
PRO_0000078745Add
BLAST

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Structurei

3D structure databases

ProteinModelPortaliP16502.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 483198RdRp catalytic
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni249 – 2568Promoter-binding site By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi187 – 1959Nuclear localization signal By similarity
Motifi203 – 21614Nuclear localization signal By similarity
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007099. RNA-dir_pol_NSvirus.
IPR001407. RNA_pol_PB1_influenza.
[Graphical view]
PfamiPF00602. Flu_PB1. 1 hit.
[Graphical view]
PIRSFiPIRSF000827. RdRPol_OMV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16502-1 [UniParc]FASTAAdd to Basket

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MDVNPTLLFL KVPAQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS    50
ERGRWTKNTE TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP 100
GIFENSCIET MEVVQQTRVD KLTQGRQTYD WTLNRNQPAA TALANTIEVF 150
RSNGLMANES GRLIDFLKDV MESMDKEEIE ITTHFQRKRR VRDNVTKKMV 200
TQRTIGKKKQ RLNKRSYLIR ALTLNTMTKD AERGKLKRRA IATPGMQIRG 250
FVYFVETLAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTEISF 300
TITGDNTKWN ENQNPRMFLA VITYITRNQP EWFRNILSIA PIMFSNKMAR 350
LGKGYMFESK SMKLRTQISA EMLANIDLKY FNDSTRKKIE KIRPLLIDGT 400
ASLSPGMMMG MFNMLSTVLG VSILNLGQKR YTKTTYWWDG LQSSDDFALI 450
VNAPNHAGIQ AGVDRFYRTC KLLGINMSKK KSYINRTGTF EFTSFFYRYG 500
FVANFSMELP SFGVSGINES ADMSIGVTVI KNNMINNDLG PATAQMALQL 550
FIKDYRYTYR CHRGDTQIQT RRSFEIKKLW EQTRSKAGLL VSDGGPNLYN 600
IRNLHTPEVC LKWELMDEDY QGRLCNPLNP FVSHKEIESV NNAVMMPAHG 650
PAKNMEYDAV ATTHSWVPKR NRSILNTSQR GILEDEQMYQ RCCNLFERFF 700
PSSSYRRPVG ISSMVEAMVS RARIDARIDF ESGRIKKEDF TEIMKICSTI 750
EELRRQK 757
Length:757
Mass (Da):86,535
Last modified:August 1, 1990 - v1
Checksum:i99352A1EF01109DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25932 Genomic RNA. Translation: AAA43641.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25932 Genomic RNA. Translation: AAA43641.1 .

3D structure databases

ProteinModelPortali P16502.
ModBasei Search...
MobiDBi Search...

Chemistry

DrugBanki DB00811. Ribavirin.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007099. RNA-dir_pol_NSvirus.
IPR001407. RNA_pol_PB1_influenza.
[Graphical view ]
Pfami PF00602. Flu_PB1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000827. RdRPol_OMV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics."
    Kawaoka Y., Krauss S., Webster R.G.
    J. Virol. 63:4603-4608(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_I56A0
AccessioniPrimary (citable) accession number: P16502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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