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P16501

- IGF1A_XENLA

UniProt

P16501 - IGF1A_XENLA

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Protein

Insulin-like growth factor I-A

Gene

igf1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis.2 Publications

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. head morphogenesis Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
  3. negative regulation of apoptotic process Source: UniProtKB
  4. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  5. negative regulation of Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I-A
Short name:
IGF-I'
Short name:
IGF-IA
Short name:
xIGF-1
Alternative name(s):
Somatomedin
Gene namesi
Name:igf1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252361. igf1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48PRO_0000015708
Signal peptidei1 – ?
Chaini49 – 11870Insulin-like growth factor I-APRO_0000015709Add
BLAST
Propeptidei119 – 15335E peptidePRO_0000015710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96By similarity
Disulfide bondi66 ↔ 109By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in adult liver, lung, heart, kidney and peritoneal fat.2 Publications

Developmental stagei

Expressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the tailbud stage.2 Publications

Structurei

3D structure databases

ProteinModelPortaliP16501.
SMRiP16501. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729BAdd
BLAST
Regioni78 – 8912CAdd
BLAST
Regioni90 – 11021AAdd
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK05459.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16501-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METNNNLSTQ LFKCYFCDIL KLKMHKMSCI HLLYLVLCFL TLTHSAAAGP
60 70 80 90 100
ETLCGAELVD TLQFVCGDRG FYFSKPTGYG SNNRRSHHRG IVDECCFQSC
110 120 130 140 150
DFRRLEMYCA PAKQAKSARS VRTQRHTDMP KAQKEVHPKN TSRGNTGSRG

FRM
Length:153
Mass (Da):17,410
Last modified:March 7, 2006 - v2
Checksum:iF83BC8AA17AFDBEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141Q → P in AAA70330. (PubMed:2330002)Curated
Sequence conflicti123 – 1231T → A in AAA70330. (PubMed:2330002)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29857 mRNA. Translation: AAA70330.1.
PIRiA34049.
A36079.
RefSeqiNP_001156865.1. NM_001163393.1.
UniGeneiXl.23602.

Genome annotation databases

GeneIDi378699.
KEGGixla:378699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29857 mRNA. Translation: AAA70330.1 .
PIRi A34049.
A36079.
RefSeqi NP_001156865.1. NM_001163393.1.
UniGenei Xl.23602.

3D structure databases

ProteinModelPortali P16501.
SMRi P16501. Positions 49-118.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378699.
KEGGi xla:378699.

Organism-specific databases

CTDi 3479.
Xenbasei XB-GENE-6252361. igf1.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K05459.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of insulin-like growth factor I (IGF-I): structure and expression of an IGF-I precursor from Xenopus laevis."
    Kajimoto Y., Rotwein P.
    Mol. Endocrinol. 4:217-226(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes."
    Shuldiner A.R., Nirula A., Scott L.A., Roth J.
    Biochem. Biophys. Res. Commun. 166:223-230(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-125, TISSUE SPECIFICITY.
  3. "Neural and head induction by insulin-like growth factor signals."
    Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
    Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  4. "The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus."
    Richard-Parpaillon L., Heligon C., Chesnel F., Boujard D., Philpott A.
    Dev. Biol. 244:407-417(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIGF1A_XENLA
AccessioniPrimary (citable) accession number: P16501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 7, 2006
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3