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P16501

- IGF1A_XENLA

UniProt

P16501 - IGF1A_XENLA

Protein

Insulin-like growth factor I-A

Gene

igf1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis.2 Publications

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB

    GO - Biological processi

    1. head morphogenesis Source: UniProtKB
    2. multicellular organismal development Source: UniProtKB-KW
    3. negative regulation of apoptotic process Source: UniProtKB
    4. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
    5. negative regulation of Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor I-A
    Short name:
    IGF-I'
    Short name:
    IGF-IA
    Short name:
    xIGF-1
    Alternative name(s):
    Somatomedin
    Gene namesi
    Name:igf1-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252361. igf1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 48PRO_0000015708
    Signal peptidei1 – ?
    Chaini49 – 11870Insulin-like growth factor I-APRO_0000015709Add
    BLAST
    Propeptidei119 – 15335E peptidePRO_0000015710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 96By similarity
    Disulfide bondi66 ↔ 109By similarity
    Disulfide bondi95 ↔ 100By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed in adult liver, lung, heart, kidney and peritoneal fat.2 Publications

    Developmental stagei

    Expressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the tailbud stage.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliP16501.
    SMRiP16501. Positions 49-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 7729BAdd
    BLAST
    Regioni78 – 8912CAdd
    BLAST
    Regioni90 – 11021AAdd
    BLAST
    Regioni111 – 1188D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.
    KOiK05459.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16501-1 [UniParc]FASTAAdd to Basket

    « Hide

    METNNNLSTQ LFKCYFCDIL KLKMHKMSCI HLLYLVLCFL TLTHSAAAGP    50
    ETLCGAELVD TLQFVCGDRG FYFSKPTGYG SNNRRSHHRG IVDECCFQSC 100
    DFRRLEMYCA PAKQAKSARS VRTQRHTDMP KAQKEVHPKN TSRGNTGSRG 150
    FRM 153
    Length:153
    Mass (Da):17,410
    Last modified:March 7, 2006 - v2
    Checksum:iF83BC8AA17AFDBEE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141Q → P in AAA70330. (PubMed:2330002)Curated
    Sequence conflicti123 – 1231T → A in AAA70330. (PubMed:2330002)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29857 mRNA. Translation: AAA70330.1.
    PIRiA34049.
    A36079.
    RefSeqiNP_001156865.1. NM_001163393.1.
    UniGeneiXl.23602.

    Genome annotation databases

    GeneIDi378699.
    KEGGixla:378699.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29857 mRNA. Translation: AAA70330.1 .
    PIRi A34049.
    A36079.
    RefSeqi NP_001156865.1. NM_001163393.1.
    UniGenei Xl.23602.

    3D structure databases

    ProteinModelPortali P16501.
    SMRi P16501. Positions 49-118.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 378699.
    KEGGi xla:378699.

    Organism-specific databases

    CTDi 3479.
    Xenbasei XB-GENE-6252361. igf1.

    Phylogenomic databases

    HOVERGENi HBG006137.
    KOi K05459.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of insulin-like growth factor I (IGF-I): structure and expression of an IGF-I precursor from Xenopus laevis."
      Kajimoto Y., Rotwein P.
      Mol. Endocrinol. 4:217-226(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes."
      Shuldiner A.R., Nirula A., Scott L.A., Roth J.
      Biochem. Biophys. Res. Commun. 166:223-230(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-125, TISSUE SPECIFICITY.
    3. "Neural and head induction by insulin-like growth factor signals."
      Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
      Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    4. "The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus."
      Richard-Parpaillon L., Heligon C., Chesnel F., Boujard D., Philpott A.
      Dev. Biol. 244:407-417(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiIGF1A_XENLA
    AccessioniPrimary (citable) accession number: P16501
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3