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Protein

Insulin-like growth factor I-A

Gene

igf1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis.2 Publications

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. head morphogenesis Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
  3. negative regulation of apoptotic process Source: UniProtKB
  4. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  5. negative regulation of Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I-A
Short name:
IGF-I'
Short name:
IGF-IA
Short name:
xIGF-1
Alternative name(s):
Somatomedin
Gene namesi
Name:igf1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252361. igf1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48PRO_0000015708
Signal peptidei1 – ?
Chaini49 – 11870Insulin-like growth factor I-APRO_0000015709Add
BLAST
Propeptidei119 – 15335E peptidePRO_0000015710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96By similarity
Disulfide bondi66 ↔ 109By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in adult liver, lung, heart, kidney and peritoneal fat.2 Publications

Developmental stagei

Expressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the tailbud stage.2 Publications

Structurei

3D structure databases

ProteinModelPortaliP16501.
SMRiP16501. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729BAdd
BLAST
Regioni78 – 8912CAdd
BLAST
Regioni90 – 11021AAdd
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK05459.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNNNLSTQ LFKCYFCDIL KLKMHKMSCI HLLYLVLCFL TLTHSAAAGP
60 70 80 90 100
ETLCGAELVD TLQFVCGDRG FYFSKPTGYG SNNRRSHHRG IVDECCFQSC
110 120 130 140 150
DFRRLEMYCA PAKQAKSARS VRTQRHTDMP KAQKEVHPKN TSRGNTGSRG

FRM
Length:153
Mass (Da):17,410
Last modified:March 7, 2006 - v2
Checksum:iF83BC8AA17AFDBEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141Q → P in AAA70330 (PubMed:2330002).Curated
Sequence conflicti123 – 1231T → A in AAA70330 (PubMed:2330002).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29857 mRNA. Translation: AAA70330.1.
PIRiA34049.
A36079.
RefSeqiNP_001156865.1. NM_001163393.1.
UniGeneiXl.23602.

Genome annotation databases

GeneIDi378699.
KEGGixla:378699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29857 mRNA. Translation: AAA70330.1.
PIRiA34049.
A36079.
RefSeqiNP_001156865.1. NM_001163393.1.
UniGeneiXl.23602.

3D structure databases

ProteinModelPortaliP16501.
SMRiP16501. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378699.
KEGGixla:378699.

Organism-specific databases

CTDi3479.
XenbaseiXB-GENE-6252361. igf1.

Phylogenomic databases

HOVERGENiHBG006137.
KOiK05459.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of insulin-like growth factor I (IGF-I): structure and expression of an IGF-I precursor from Xenopus laevis."
    Kajimoto Y., Rotwein P.
    Mol. Endocrinol. 4:217-226(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes."
    Shuldiner A.R., Nirula A., Scott L.A., Roth J.
    Biochem. Biophys. Res. Commun. 166:223-230(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-125, TISSUE SPECIFICITY.
  3. "Neural and head induction by insulin-like growth factor signals."
    Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
    Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  4. "The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus."
    Richard-Parpaillon L., Heligon C., Chesnel F., Boujard D., Philpott A.
    Dev. Biol. 244:407-417(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIGF1A_XENLA
AccessioniPrimary (citable) accession number: P16501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 7, 2006
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.