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P16495

- NCAP_BUNYW

UniProt

P16495 - NCAP_BUNYW

Protein

Nucleoprotein

Gene

N

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation.1 Publication

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiBunyamwera virus (BUNV)
    Taxonomic identifieri35304 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002476: Genome

    Subcellular locationi

    Virion
    Note: Internal protein of virus particle.

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. ribonucleoprotein complex Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233NucleoproteinPRO_0000221992Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid By similarity. Binds to viral genomic RNA By similarity. Interacts with host PABP1.By similarity1 Publication

    Structurei

    Secondary structure

    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 66
    Helixi19 – 2911
    Beta strandi31 – 333
    Helixi36 – 449
    Helixi46 – 5510
    Beta strandi59 – 657
    Beta strandi68 – 736
    Helixi78 – 803
    Helixi92 – 10918
    Helixi112 – 12110
    Helixi125 – 1295
    Helixi134 – 1363
    Helixi138 – 1436
    Helixi148 – 1514
    Turni152 – 1576
    Helixi158 – 16710
    Turni168 – 1703
    Helixi174 – 1774
    Helixi180 – 1823
    Helixi190 – 1967
    Helixi198 – 21013
    Beta strandi215 – 2173
    Helixi220 – 2278
    Turni228 – 2303

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZLAX-ray3.20A/B/C/D/E/F/G/H1-233[»]
    4IJSX-ray3.20A/B/C/D2-233[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001784. Bunya_nucleocap.
    [Graphical view]
    PfamiPF00952. Bunya_nucleocap. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
    ProDomiPD001909. Bunya_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform N (identifier: P16495-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIELEFHDVA ANTSSTFDPE VAYANFKRVH TTGLSYDHIR IFYIKGREIK    50
    TSLAKRSEWE VTLNLGGWKI TVYNTNFPGN RNNPVPDDGL TLHRLSGFLA 100
    RYLLEKMLKV SEPEKLIIKS KIINPLAEKN GITWNDGEEV YLSFFPGSEM 150
    FLGTFRFYPL AIGIYKVQRK EMEPKYLEKT MRQRYMGLEA ATWTVSKLTE 200
    VQSALTVVSS LGWKKTNVSA AARDFLAKFG INM 233
    Length:233
    Mass (Da):26,664
    Last modified:August 1, 1990 - v1
    Checksum:iD44C80C93FA8A066
    GO
    Isoform NSS (identifier: P16494-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P16494.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:101
    Mass (Da):11,024
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00353 Genomic RNA. Translation: BAA00261.1.
    PIRiA31365. VHVUBV.
    RefSeqiNP_047213.1. NC_001927.1. [P16495-1]

    Genome annotation databases

    GeneIDi2648217.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00353 Genomic RNA. Translation: BAA00261.1 .
    PIRi A31365. VHVUBV.
    RefSeqi NP_047213.1. NC_001927.1. [P16495-1 ]

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZLA X-ray 3.20 A/B/C/D/E/F/G/H 1-233 [» ]
    4IJS X-ray 3.20 A/B/C/D 2-233 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2648217.

    Family and domain databases

    InterProi IPR001784. Bunya_nucleocap.
    [Graphical view ]
    Pfami PF00952. Bunya_nucleocap. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
    ProDomi PD001909. Bunya_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of the small (S) RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
      Elliott R.M.
      J. Gen. Virol. 70:1281-1285(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation."
      Blakqori G., van Knippenberg I., Elliott R.M.
      J. Virol. 83:3637-3646(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HOST PABP1.

    Entry informationi

    Entry nameiNCAP_BUNYW
    AccessioniPrimary (citable) accession number: P16495
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3