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P16494 (NSS_BUNYW) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein NS-S
Gene names
Name:N
OrganismBunyamwera virus (BUNV) [Reference proteome]
Taxonomic identifier35304 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1. Ref.2 Ref.3

Sequence similarities

Belongs to the orthobunyavirus NS-S protein family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform NSS (identifier: P16494-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.
Isoform N (identifier: P16495-1)

The sequence of this isoform can be found in the external entry P16495.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 101101Non-structural protein NS-S
PRO_0000221976

Sequences

Sequence LengthMass (Da)Tools
Isoform NSS [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 823C9F75448C6368

FASTA10111,024
        10         20         30         40         50         60 
MMSLLTPAVL LTQRSHTLTL SVSTPLGLVM TTYESSTLKD ARLKLVSQKE VNGKLHLTLG 

        70         80         90        100 
AGRLLYIIRI FLATGTTQFL TMVLPSTASV DSLPGTYLRR C 

« Hide

Isoform N [UniParc].

See P16495.

References

[1]"Nucleotide sequence analysis of the small (S) RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
Elliott R.M.
J. Gen. Virol. 70:1281-1285(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist."
Thomas D., Blakqori G., Wagner V., Banholzer M., Kessler N., Elliott R.M., Haller O., Weber F.
J. Biol. Chem. 279:31471-31477(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation."
Blakqori G., van Knippenberg I., Elliott R.M.
J. Virol. 83:3637-3646(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00353 Genomic RNA. Translation: BAA00262.1.
PIRMNVUBV. B31365.
RefSeqNP_047214.1. NC_001927.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2648218.

Family and domain databases

InterProIPR000797. Bunya_NSs.
[Graphical view]
PfamPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSS_BUNYW
AccessionPrimary (citable) accession number: P16494
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 24, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families