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P16494

- NSS_BUNYW

UniProt

P16494 - NSS_BUNYW

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Protein

Non-structural protein NS-S

Gene

N

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1.2 Publications

GO - Biological processi

  1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:N
OrganismiBunyamwera virus (BUNV)
Taxonomic identifieri35304 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002476: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Non-structural protein NS-SPRO_0000221976Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000797. Bunya_NSs.
[Graphical view]
PfamiPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform NSS (identifier: P16494) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSLLTPAVL LTQRSHTLTL SVSTPLGLVM TTYESSTLKD ARLKLVSQKE
60 70 80 90 100
VNGKLHLTLG AGRLLYIIRI FLATGTTQFL TMVLPSTASV DSLPGTYLRR

C

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:101
Mass (Da):11,024
Last modified:August 1, 1990 - v1
Checksum:i823C9F75448C6368
GO
Isoform N (identifier: P16495-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P16495.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:233
Mass (Da):26,664
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00353 Genomic RNA. Translation: BAA00262.1.
PIRiB31365. MNVUBV.
RefSeqiNP_047214.1. NC_001927.1. [P16494-1]

Genome annotation databases

GeneIDi2648218.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00353 Genomic RNA. Translation: BAA00262.1 .
PIRi B31365. MNVUBV.
RefSeqi NP_047214.1. NC_001927.1. [P16494-1 ]

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2648218.

Family and domain databases

InterProi IPR000797. Bunya_NSs.
[Graphical view ]
Pfami PF01104. Bunya_NS-S. 1 hit.
[Graphical view ]
PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence analysis of the small (S) RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
    Elliott R.M.
    J. Gen. Virol. 70:1281-1285(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist."
    Thomas D., Blakqori G., Wagner V., Banholzer M., Kessler N., Elliott R.M., Haller O., Weber F.
    J. Biol. Chem. 279:31471-31477(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation."
    Blakqori G., van Knippenberg I., Elliott R.M.
    J. Virol. 83:3637-3646(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNSS_BUNYW
AccessioniPrimary (citable) accession number: P16494
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3