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P16494

- NSS_BUNYW

UniProt

P16494 - NSS_BUNYW

Protein

Non-structural protein NS-S

Gene

N

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1.2 Publications

    GO - Biological processi

    1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:N
    OrganismiBunyamwera virus (BUNV)
    Taxonomic identifieri35304 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002476: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 101101Non-structural protein NS-SPRO_0000221976Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000797. Bunya_NSs.
    [Graphical view]
    PfamiPF01104. Bunya_NS-S. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform NSS (identifier: P16494-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMSLLTPAVL LTQRSHTLTL SVSTPLGLVM TTYESSTLKD ARLKLVSQKE    50
    VNGKLHLTLG AGRLLYIIRI FLATGTTQFL TMVLPSTASV DSLPGTYLRR 100
    C 101

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:101
    Mass (Da):11,024
    Last modified:August 1, 1990 - v1
    Checksum:i823C9F75448C6368
    GO
    Isoform N (identifier: P16495-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P16495.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:233
    Mass (Da):26,664
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00353 Genomic RNA. Translation: BAA00262.1.
    PIRiB31365. MNVUBV.
    RefSeqiNP_047214.1. NC_001927.1. [P16494-1]

    Genome annotation databases

    GeneIDi2648218.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00353 Genomic RNA. Translation: BAA00262.1 .
    PIRi B31365. MNVUBV.
    RefSeqi NP_047214.1. NC_001927.1. [P16494-1 ]

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2648218.

    Family and domain databases

    InterProi IPR000797. Bunya_NSs.
    [Graphical view ]
    Pfami PF01104. Bunya_NS-S. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of the small (S) RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae."
      Elliott R.M.
      J. Gen. Virol. 70:1281-1285(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist."
      Thomas D., Blakqori G., Wagner V., Banholzer M., Kessler N., Elliott R.M., Haller O., Weber F.
      J. Biol. Chem. 279:31471-31477(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation."
      Blakqori G., van Knippenberg I., Elliott R.M.
      J. Virol. 83:3637-3646(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNSS_BUNYW
    AccessioniPrimary (citable) accession number: P16494
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3