P16493GP_HANTHEnvelopment polyproteinM polyproteinGlycoprotein NGnGlycoprotein G1Glycoprotein CGcGlycoprotein G2GPHantaan virus (strain Hojo)Hojo virusKorean hemorrhagic fever virusVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesHantaviridaeMammantavirinaeOrthohantavirusOrthohantavirus hantanenseApodemus agrariusEurasian field mouseHomo sapiensHumanConservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients.NUCLEOTIDE SEQUENCE [GENOMIC RNA]Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly.REVIEWGlycoprotein NForms homotetramers with glycoprotein C at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). May also bind to host C1QBP for virus entry into the host cell (By similarity). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (By similarity). May dysregulate normal immune and endothelial cell responses through an ITAM motif (By similarity). Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (By similarity). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (By similarity). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (By similarity). Interacts with the viral genomic RNA (By similarity).Glycoprotein CForms homotetramers with glycoprotein N at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). May also bind to host C1QBP for virus entry into the host cell (By similarity). Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).Glycoprotein NHomodimer (By similarity). Homotetramer; forms heterotetrameric Gn-Gc spikes in the pre-fusion conformation (By similarity). Interacts (via C-terminus) with the nucleoprotein (By similarity). Interacts with host TUFM; this interaction contributes to the virus-induced degradation of mitochondria by autophagy, which leads to degradation of host MAVS and inhibition of type I interferon (IFN) responses (By similarity). Interacts with host MAP1LC3B; this interaction contributes to the virus-induced degradation of mitochondria by autophagy, which leads to degradation of host MAVS and inhibition of type I interferon (IFN) responses (By similarity).Glycoprotein CHomodimer. Homotetramer; forms heterotetrameric Gn-Gc spikes in the pre-fusion conformation. Homotrimer; forms homotrimer in the post-fusion conformation at acidic pH (By similarity). Interacts (via C-terminus) with the nucleoprotein (By similarity).Glycoprotein NVirion membraneMulti-pass membrane proteinHost cell surfaceHost Golgi apparatus membraneMulti-pass membrane proteinHost endoplasmic reticulum membraneMulti-pass membrane proteinHost mitochondrionInteraction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs.Glycoprotein CVirion membraneSingle-pass type I membrane proteinHost cell surfaceHost Golgi apparatus membraneSingle-pass type I membrane proteinHost endoplasmic reticulum membraneSingle-pass type I membrane proteinBudding probably takes place at the host Golgi (Probable). Glycoprotein C cytoplasmic tail is important for efficient Golgi localization (By similarity).Glycoprotein NThe YxxL motif at the C-terminus is indispensable for the interaction with MAP1LC3B and for the Gn-mediated induction of mitochondrial autophagy (By similarity). The cytoplasmic tail is involved in the inhibition of the host innate immune response (By similarity). The C-terminus of the cytoplasmic tail is involved in binding to the viral genome and the nucleocapsid (By similarity). Contains 2 contiguous zinc-fingers (By similarity).Glycoprotein CThe C-terminus is necessary for proper localization in the Golgi (By similarity). The cytoplasmic tail is involved in binding to the nucleocapsid (By similarity).Envelopment polyproteinEnvelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase.Belongs to the hantavirus envelope glycoprotein family.Disulfide bondFusion of virus membrane with host endosomal membraneFusion of virus membrane with host membraneGlycoproteinHost endoplasmic reticulumHost Golgi apparatusHost membraneHost mitochondrionHost-virus interactionInhibition of host innate immune response by virusInhibition of host RLR pathway by virusInhibition of host TRAFs by virusMembraneMetal-bindingPhosphoproteinRepeatSignalTransmembraneTransmembrane helixViral attachment to host cellViral envelope proteinViral immunoevasionViral penetration into host cytoplasmVirionVirus endocytosis by hostVirus entry into host cellZincZinc-fingerMGIWKWLVMASLVWPVLTLRNVYDMKIECPHTVSFGENSVIGYVELPPMPLADTAQLVPESSCSMDNHQSLNTITKYTQVSWRGKADQSQSSQNSFETVSTEVDLKGTCVLKHKMVEESYRSRKSITCYDLSCNSTYCKPTLYMIVPIHACNMMKSCLIALGPYRVQVVYERTYCMTGVLIEGKCFVPDQSVVSIIKHGIFDIASVHIVCFFVAVKGNTYKIFEQVKKSFESTCNDTENKVQGYYICIVGGNSAPIYVPTLDDFRSMEAFTGIFRSPHGEDHDLAGEETATYSIVGPANAKVPHSASSDTLSLIAFSGIPSYSSLSILTSSTEAKHVFSPGLFPKLNHTNCDKGAIPLMWTGMIDVPRYYDGIHPFTVFCVLSGPGASCEAFSEGGIFNITSPMCLVSKQNRFRLTEQQVNFVCQRVDVDIVVYCNGQRKVILTKTLVIGQCIYTITSLFSLLPGVAHSIAVELCVPGFHGWATAALLVTFCFGWVLIPAVTFIILAILKFIANIFHTSNQENRLKSVLRKIKEEFEKTKGSMVCDVCKYECETYKELKAHGVSCPQSQCPYCFTHCEPTEAAFQAHYKVCQVTHRFRDDLKKTVTPQNFTPGCYRTLNLFRYKSRCYIFTMWIFLLVLESILWAASASETPLTPVWNDNAHGVGSIPMHTDLELDFSLTSSSKYTYRRKLTNPLEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHYERDYQYETSWGCNPSDCPGCGTGCTACGLYLDRLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWRTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFKCCHGEDCSPNGLHAAAPHLDKVNGISEIENSKEYDDGAPQCGIKCWFVKSGEWISGIFSGNWIVLIVLCVFLLFSLVLLSILCPVRKHKKS
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