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P16493

- GP_HANTH

UniProt

P16493 - GP_HANTH

Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei648 – 6492Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. signal transduction Source: InterPro
    4. suppression by virus of host innate immune response Source: UniProtKB-KW
    5. suppression by virus of host TRAF activity Source: UniProtKB-KW
    6. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiHantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
    Taxonomic identifieri11583 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
    Homo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 11341116Envelope glycoproteinPRO_0000036809Add
    BLAST
    Chaini19 – 648630Glycoprotein G1By similarityPRO_0000036810Add
    BLAST
    Chaini649 – 1134486Glycoprotein G2By similarityPRO_0000036811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi927 – 9271N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 487469LumenalSequence AnalysisAdd
    BLAST
    Topological domaini509 – 648140CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 1104456LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1126 – 11349CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1105 – 112521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini611 – 63424ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16493-1 [UniParc]FASTAAdd to Basket

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    MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPMP     50
    LADTAQLVPE SSCSMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS 100
    TEVDLKGTCV LKHKMVEESY RSRKSITCYD LSCNSTYCKP TLYMIVPIHA 150
    CNMMKSCLIA LGPYRVQVVY ERTYCMTGVL IEGKCFVPDQ SVVSIIKHGI 200
    FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG 250
    GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEETA TYSIVGPANA 300
    KVPHSASSDT LSLIAFSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN 350
    CDKGAIPLMW TGMIDVPRYY DGIHPFTVFC VLSGPGASCE AFSEGGIFNI 400
    TSPMCLVSKQ NRFRLTEQQV NFVCQRVDVD IVVYCNGQRK VILTKTLVIG 450
    QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA 500
    VTFIILAILK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY 550
    ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD 600
    LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE 650
    TPLTPVWNDN AHGVGSIPMH TDLELDFSLT SSSKYTYRRK LTNPLEAQSI 700
    DLHIEIEEQT IGVDVHALGH WFDGRLNLKT SFHCYGACTK YEYPWHTAKC 750
    HYERDYQYET SWGCNPSDCP GCGTGCTACG LYLDRLKPVG SAYKIITIRY 800
    SRRVCVQFGE ENLCKIIDMN DCFVSRHVKV CIIGTVSKFS QGDTLLFFGP 850
    LEGGGLIFKH WRTSTCQFGD PGDIMSPRDK GFLCPEFPGS FRKKCNFATT 900
    PICEYDGNMV SGYKKVMATI DSFQSFNTST MHFTDERIEW KDPDGMLRDH 950
    INILVTKDID FDNLGENPCK IGLQTSSIEG AWGSGVGFTL TCLVSLTECP 1000
    TFLTSIKACD KAICYGAESV TLTRGQNTVK VSGKGGHSGS TFKCCHGEDC 1050
    SPNGLHAAAP HLDKVNGISE IENSKEYDDG APQCGIKCWF VKSGEWISGI 1100
    FSGNWIVLIV LCVFLLFSLV LLSILCPVRK HKKS 1134
    Length:1,134
    Mass (Da):126,405
    Last modified:August 1, 1990 - v1
    Checksum:i01E59250FC267D23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00376 Genomic RNA. Translation: BAA00279.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00376 Genomic RNA. Translation: BAA00279.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients."
      Schmaljohn C.S., Arikawa J., Hasty S.E., Rasmussen L., Lee H.W., Lee P.W., Dalrymple J.M.
      J. Gen. Virol. 69:1949-1955(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_HANTH
    AccessioniPrimary (citable) accession number: P16493
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3