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P16493

- GP_HANTH

UniProt

P16493 - GP_HANTH

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Protein
Envelope glycoprotein
Gene
GP
Organism
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei648 – 6492Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. signal transduction Source: InterPro
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. suppression by virus of host innate immune response Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
Taxonomic identifieri11583 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 487469Lumenal Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST
Topological domaini509 – 648140Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini649 – 1104456Lumenal Reviewed prediction
Add
BLAST
Transmembranei1105 – 112521Helical; Reviewed prediction
Add
BLAST
Topological domaini1126 – 11349Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 11341116Envelope glycoprotein
PRO_0000036809Add
BLAST
Chaini19 – 648630Glycoprotein G1 By similarity
PRO_0000036810Add
BLAST
Chaini649 – 1134486Glycoprotein G2 By similarity
PRO_0000036811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi235 – 2351N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi399 – 3991N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi927 – 9271N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 63424ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16493-1 [UniParc]FASTAAdd to Basket

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MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPMP     50
LADTAQLVPE SSCSMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS 100
TEVDLKGTCV LKHKMVEESY RSRKSITCYD LSCNSTYCKP TLYMIVPIHA 150
CNMMKSCLIA LGPYRVQVVY ERTYCMTGVL IEGKCFVPDQ SVVSIIKHGI 200
FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG 250
GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEETA TYSIVGPANA 300
KVPHSASSDT LSLIAFSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN 350
CDKGAIPLMW TGMIDVPRYY DGIHPFTVFC VLSGPGASCE AFSEGGIFNI 400
TSPMCLVSKQ NRFRLTEQQV NFVCQRVDVD IVVYCNGQRK VILTKTLVIG 450
QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA 500
VTFIILAILK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY 550
ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD 600
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE 650
TPLTPVWNDN AHGVGSIPMH TDLELDFSLT SSSKYTYRRK LTNPLEAQSI 700
DLHIEIEEQT IGVDVHALGH WFDGRLNLKT SFHCYGACTK YEYPWHTAKC 750
HYERDYQYET SWGCNPSDCP GCGTGCTACG LYLDRLKPVG SAYKIITIRY 800
SRRVCVQFGE ENLCKIIDMN DCFVSRHVKV CIIGTVSKFS QGDTLLFFGP 850
LEGGGLIFKH WRTSTCQFGD PGDIMSPRDK GFLCPEFPGS FRKKCNFATT 900
PICEYDGNMV SGYKKVMATI DSFQSFNTST MHFTDERIEW KDPDGMLRDH 950
INILVTKDID FDNLGENPCK IGLQTSSIEG AWGSGVGFTL TCLVSLTECP 1000
TFLTSIKACD KAICYGAESV TLTRGQNTVK VSGKGGHSGS TFKCCHGEDC 1050
SPNGLHAAAP HLDKVNGISE IENSKEYDDG APQCGIKCWF VKSGEWISGI 1100
FSGNWIVLIV LCVFLLFSLV LLSILCPVRK HKKS 1134
Length:1,134
Mass (Da):126,405
Last modified:August 1, 1990 - v1
Checksum:i01E59250FC267D23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00376 Genomic RNA. Translation: BAA00279.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00376 Genomic RNA. Translation: BAA00279.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients."
    Schmaljohn C.S., Arikawa J., Hasty S.E., Rasmussen L., Lee H.W., Lee P.W., Dalrymple J.M.
    J. Gen. Virol. 69:1949-1955(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_HANTH
AccessioniPrimary (citable) accession number: P16493
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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