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P16471 (PRLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 164. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prolactin receptor

Short name=PRL-R
Gene names
Name:PRLR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Ref.6 Ref.7

Subunit structure

Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent. Ref.4 Ref.13 Ref.14 Ref.15 Ref.17

Subcellular location

Membrane; Single-pass type I membrane protein Ref.4 Ref.6.

Isoform 7: Secreted Ref.4 Ref.6.

Tissue specificity

Expressed in breast, placenta, kidney, liver and pancreas. Ref.4 Ref.6

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Contains 2 fibronectin type-III domains.

Ontologies

Keywords
   Cellular componentMembrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandMetal-binding
Zinc
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJAK-STAT cascade involved in growth hormone signaling pathway

Traceable author statement. Source: Reactome

T cell activation

Non-traceable author statement Ref.2. Source: UniProtKB

activation of JAK2 kinase activity

Non-traceable author statement Ref.2. Source: UniProtKB

activation of transmembrane receptor protein tyrosine kinase activity

Inferred from direct assay Ref.2. Source: UniProtKB

cell surface receptor signaling pathway

Non-traceable author statement Ref.2. Source: UniProtKB

embryo implantation

Traceable author statement PubMed 9009200. Source: ProtInc

lactation

Non-traceable author statement Ref.2. Source: UniProtKB

negative regulation of apoptotic process

Non-traceable author statement Ref.2. Source: UniProtKB

prolactin signaling pathway

Non-traceable author statement Ref.2. Source: GOC

steroid biosynthetic process

Non-traceable author statement Ref.2. Source: UniProtKB

   Cellular_componentcell surface

Inferred from direct assay Ref.2. Source: UniProtKB

endosome lumen

Traceable author statement. Source: Reactome

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

ornithine decarboxylase activator activity

Non-traceable author statement Ref.2. Source: UniProtKB

peptide hormone binding

Inferred from physical interaction Ref.16. Source: BHF-UCL

prolactin receptor activity

Non-traceable author statement Ref.2. Source: UniProtKB

protein homodimerization activity

Non-traceable author statement Ref.2. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRLP012364EBI-6903057,EBI-6903064

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P16471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P16471-2)

Also known as: Delta-S1;

The sequence of this isoform differs from the canonical sequence as follows:
     24-124: Missing.
Isoform 3 (identifier: P16471-3)

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: DF → AW
     231-622: Missing.
Note: Soluble isoform that appears specific for the BT-474 breast cancer cell line.
Isoform 4 (identifier: P16471-4)

Also known as: SF1a; Short form 1a;

The sequence of this isoform differs from the canonical sequence as follows:
     338-376: MKPTYLDPDT...PQANPSTFYD → DPLMLGASHY...FTKATLTTVQ
     377-622: Missing.
Note: Includes exon 11. Does not transduce prolactin signaling.
Isoform 5 (identifier: P16471-5)

Also known as: Intermediate;

The sequence of this isoform differs from the canonical sequence as follows:
     337-349: GMKPTYLDPDTDS → EREQRQAQEARDS
     350-622: Missing.
Note: Produced by deletion of part of exon 10 and frameshift.
Isoform 6 (identifier: P16471-6)

Also known as: SF1b; Short form 1b;

The sequence of this isoform differs from the canonical sequence as follows:
     286-288: KGK → VTP
     289-622: Missing.
Note: Does not transduce prolactin signaling.
Isoform 7 (identifier: P16471-7)

Also known as: Delta 7/11;

The sequence of this isoform differs from the canonical sequence as follows:
     229-268: DFTMNDTTVW...KGYSMVTCIF → GDPLMLGASH...FTKATLTTVQ
     269-622: Missing.
Note: Splices from exon 7 to exon 11.
Isoform 8 (identifier: P16471-8)

Also known as: Delta 4-SF1b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     286-288: KGK → VTP
     289-622: Missing.
Note: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 9 (identifier: P16471-9)

Also known as: SF1c; Short form 1c;

The sequence of this isoform differs from the canonical sequence as follows:
     286-309: KGKSEELLSALGCQDFPPTSDYED → DRLCTPGRCCVSTGLTDLDYSCST
     310-622: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 622598Prolactin receptor
PRO_0000010977

Regions

Topological domain25 – 234210Extracellular Potential
Transmembrane235 – 25824Helical; Potential
Topological domain259 – 622364Cytoplasmic Potential
Domain27 – 128102Fibronectin type-III 1
Domain129 – 229101Fibronectin type-III 2
Motif215 – 2195WSXWS motif
Motif267 – 2759Box 1 motif

Sites

Metal binding2111Zinc
Metal binding2121Zinc

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 46 Ref.17
Disulfide bond75 ↔ 86 Ref.17

Natural variations

Alternative sequence1 – 7171Missing in isoform 8.
VSP_026531
Alternative sequence24 – 124101Missing in isoform 2.
VSP_001720
Alternative sequence229 – 26840DFTMN…VTCIF → GDPLMLGASHYKNLKSYRPR KISSQGRLAVFTKATLTTVQ in isoform 7.
VSP_026532
Alternative sequence229 – 2302DF → AW in isoform 3.
VSP_012620
Alternative sequence231 – 622392Missing in isoform 3.
VSP_012621
Alternative sequence269 – 622354Missing in isoform 7.
VSP_026533
Alternative sequence286 – 30924KGKSE…SDYED → DRLCTPGRCCVSTGLTDLDY SCST in isoform 9.
VSP_047882
Alternative sequence286 – 2883KGK → VTP in isoform 6 and isoform 8.
VSP_026534
Alternative sequence289 – 622334Missing in isoform 6 and isoform 8.
VSP_026535
Alternative sequence310 – 622313Missing in isoform 9.
VSP_047883
Alternative sequence337 – 34913GMKPT…PDTDS → EREQRQAQEARDS in isoform 5.
VSP_026536
Alternative sequence338 – 37639MKPTY…STFYD → DPLMLGASHYKNLKSYRPRK ISSQGRLAVFTKATLTTVQ in isoform 4.
VSP_026537
Alternative sequence350 – 622273Missing in isoform 5.
VSP_026538
Alternative sequence377 – 622246Missing in isoform 4.
VSP_026539
Natural variant1001I → V.
Corresponds to variant rs2228482 [ dbSNP | Ensembl ].
VAR_049172

Secondary structure

.............................................. 622
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: DB7FD0328608C787

FASTA62269,506
        10         20         30         40         50         60 
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 

        70         80         90        100        110        120 
SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 

       130        140        150        160        170        180 
VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 

       190        200        210        220        230        240 
EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 

       250        260        270        280        290        300 
VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 

       310        320        330        340        350        360 
FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL 

       370        380        390        400        410        420 
SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ 

       430        440        450        460        470        480 
PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE 

       490        500        510        520        530        540 
SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP 

       550        560        570        580        590        600 
ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS 

       610        620 
KCRLQLGGLD YLDPACFTHS FH 

« Hide

Isoform 2 (Delta-S1) [UniParc].

Checksum: 1CF312424037E85B
Show »

FASTA52157,953
Isoform 3 [UniParc].

Checksum: 5288BCF71248D291
Show »

FASTA23026,545
Isoform 4 (SF1a) (Short form 1a) [UniParc].

Checksum: 112DC2555FBC4601
Show »

FASTA37642,639
Isoform 5 (Intermediate) [UniParc].

Checksum: 932F200E850CDD27
Show »

FASTA34939,806
Isoform 6 (SF1b) (Short form 1b) [UniParc].

Checksum: B45203EC045EB417
Show »

FASTA28832,760
Isoform 7 (Delta 7/11) [UniParc].

Checksum: FBB498AB649A078C
Show »

FASTA26830,705
Isoform 8 (Delta 4-SF1b) [UniParc].

Checksum: E59A9BB9016C3397
Show »

FASTA21724,773
Isoform 9 (SF1c) (Short form 1c) [UniParc].

Checksum: 1FC88E4E2F4E9DEB
Show »

FASTA30935,011

References

« Hide 'large scale' references
[1]"Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells."
Boutin J.-M., Edery M., Shirota M., Jolicoeur C., Lesueur L., Ali S., Gould D., Djiane J., Kelly P.A.
Mol. Endocrinol. 3:1455-1461(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Functional characterization of the intermediate isoform of the human prolactin receptor."
Kline J.B., Roehrs H., Clevenger C.V.
J. Biol. Chem. 274:35461-35468(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]"The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N)."
Hu Z.-Z., Zhuang L., Meng J., Leondires M., Dufau M.L.
J. Clin. Endocrinol. Metab. 84:1153-1156(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11."
Hu Z.Z., Meng J., Dufau M.L.
J. Biol. Chem. 276:41086-41094(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 6), INTERACTION WITH GH1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]"Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain."
Kline J.B., Rycyzyn M.A., Clevenger C.V.
Mol. Endocrinol. 16:2310-2322(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Mammary carcinoma.
[6]"Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein."
Trott J.F., Hovey R.C., Koduri S., Vonderhaar B.K.
J. Mol. Endocrinol. 30:31-47(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 6; 7 AND 8), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]"Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation."
Pujianto D.A., Curry B.J., Aitken R.J.
Endocrinology 151:1269-1279(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 9), FUNCTION.
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
[9]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[12]"Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines."
Fuh G., Wells J.A.
J. Biol. Chem. 270:13133-13137(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-622 (ISOFORM 3).
Tissue: Mammary carcinoma.
[13]"Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.
Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NEK3 AND VAV2.
[14]"Crystal structure and site 1 binding energetics of human placental lactogen."
Walsh S.T., Kossiakoff A.A.
J. Mol. Biol. 358:773-784(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, ZINC-BINDING SITES.
[15]"The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells."
Lazzaro M.A., Pepin D., Pescador N., Murphy B.D., Vanderhyden B.C., Picketts D.J.
Mol. Endocrinol. 20:2406-2417(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SMARCA1.
[16]"The X-ray structure of a growth hormone-prolactin receptor complex."
Somers W., Ultsch M., de Vos A.M., Kossiakoff A.A.
Nature 372:478-481(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-235.
[17]"Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor."
Svensson L.A., Bondensgaard K., Noerskov-Lauritsen L., Christensen L., Becker P., Andersen M.D., Maltesen M.J., Rand K.D., Breinholt J.
J. Biol. Chem. 283:19085-19094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-234 IN COMPLEX WITH PRL, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31661 mRNA. Translation: AAA60174.1.
AF166329 mRNA. Translation: AAD49855.1.
AF091870 expand/collapse EMBL AC list , AF091863, AF091864, AF091865, AF091866, AF091867, AF091868, AF091869 Genomic DNA. Translation: AAD32032.1.
AF349939 mRNA. Translation: AAK32703.1.
AF416618 mRNA. Translation: AAL23914.1.
AF416619 mRNA. Translation: AAL23915.1.
AF492470 mRNA. Translation: AAM18048.1.
AF493069 mRNA. Translation: AAM11661.1.
GU133399 mRNA. Translation: ACZ04321.1.
AK313270 mRNA. Translation: BAG36079.1.
AC010368 Genomic DNA. No translation available.
AC091851 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55919.1.
BC059392 mRNA. Translation: AAH59392.1.
S78505 mRNA. Translation: AAB34470.1.
PIRA40144.
A59405.
B59405.
RefSeqNP_000940.1. NM_000949.5.
NP_001191243.1. NM_001204314.1.
NP_001191244.1. NM_001204315.1.
NP_001191245.1. NM_001204316.1.
NP_001191246.1. NM_001204317.1.
NP_001191247.1. NM_001204318.1.
UniGeneHs.368587.
Hs.602914.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BP3X-ray2.90B25-235[»]
2LFGNMR-A123-234[»]
3D48X-ray2.50R25-234[»]
3MZGX-ray2.10B26-234[»]
3N06X-ray2.00B26-234[»]
3N0PX-ray2.10B26-234[»]
3NCBX-ray2.10B26-234[»]
3NCCX-ray2.50B26-234[»]
3NCEX-ray2.00B26-234[»]
3NCFX-ray2.80B26-234[»]
4I18X-ray3.24C/R25-235[»]
ProteinModelPortalP16471.
SMRP16471. Positions 26-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111603. 14 interactions.
DIPDIP-288N.
IntActP16471. 4 interactions.
MINTMINT-268499.

Chemistry

BindingDBP16471.
ChEMBLCHEMBL5588.
DrugBankDB00858. Dromostanolone.
DB01185. Fluoxymesterone.
DB00082. Pegvisomant.
DB00052. Somatropin recombinant.
GuidetoPHARMACOLOGY1721.

PTM databases

PhosphoSiteP16471.

Polymorphism databases

DMDM130321.

Proteomic databases

PaxDbP16471.
PRIDEP16471.

Protocols and materials databases

DNASU5618.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231423; ENSP00000231423; ENSG00000113494. [P16471-4]
ENST00000310101; ENSP00000309008; ENSG00000113494. [P16471-5]
ENST00000342362; ENSP00000339213; ENSG00000113494. [P16471-2]
ENST00000348262; ENSP00000311613; ENSG00000113494. [P16471-7]
ENST00000382002; ENSP00000371432; ENSG00000113494. [P16471-1]
ENST00000511486; ENSP00000422556; ENSG00000113494. [P16471-2]
ENST00000513753; ENSP00000424841; ENSG00000113494. [P16471-6]
ENST00000542609; ENSP00000441813; ENSG00000113494. [P16471-9]
GeneID5618.
KEGGhsa:5618.
UCSCuc003jjg.2. human. [P16471-4]
uc003jjh.2. human. [P16471-6]
uc003jji.2. human. [P16471-8]
uc003jjj.2. human. [P16471-7]
uc003jjl.4. human. [P16471-2]
uc003jjm.3. human. [P16471-1]
uc010iuw.1. human. [P16471-3]
uc021xxl.1. human. [P16471-5]

Organism-specific databases

CTD5618.
GeneCardsGC05M035084.
HGNCHGNC:9446. PRLR.
MIM176761. gene.
neXtProtNX_P16471.
PharmGKBPA33791.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG29671.
HOVERGENHBG007314.
InParanoidP16471.
KOK05081.
OMASGPNSCY.
OrthoDBEOG7Q5HCH.
PhylomeDBP16471.
TreeFamTF330851.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.
SignaLinkP16471.

Gene expression databases

ArrayExpressP16471.
BgeeP16471.
CleanExHS_PRLR.
GenevestigatorP16471.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]
PfamPF09067. EpoR_lig-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP16471.
GenomeRNAi5618.
NextBio21832.
PROP16471.
SOURCESearch...

Entry information

Entry namePRLR_HUMAN
AccessionPrimary (citable) accession number: P16471
Secondary accession number(s): B2R882 expand/collapse secondary AC list , D1MDP1, Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM