Reviewed, UniProtKB/Swiss-Prot P16471 (PRLR_HUMAN)

Names and origin

Protein names

Recommended name:
    Prolactin receptor
      Short name=PRL-R

Gene names

Name:

PRLR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling. Ref.6
Subunit structure	Interacts with SMARCA1. Interacts with GH1. Ref.4 Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein. Secreted. Note: Isoform 7. Ref.6 Ref.4
Tissue specificity	Expressed in breast, placenta, kidney, liver and pancreas. Ref.6 Ref.4
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	T cell activation Ref.2 Non-traceable author statement. Source: UniProtKB activation of JAK2 kinase activity Ref.2 Non-traceable author statement. Source: UniProtKB activation of transmembrane receptor protein tyrosine kinase activity Ref.2 Inferred from direct assay. Source: UniProtKB anti-apoptosis Ref.2 Non-traceable author statement. Source: UniProtKB embryo implantation Traceable author statement. Source: ProtInc lactation Ref.2 Non-traceable author statement. Source: UniProtKB steroid biosynthetic process Ref.2 Non-traceable author statement. Source: UniProtKB
Cellular component	cell surface Ref.2 Inferred from direct assay. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activator activity Ref.2 Non-traceable author statement. Source: UniProtKB peptide hormone binding Ref.10 Inferred from physical interaction. Source: UniProtKB prolactin receptor activity Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB protein homodimerization activity Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GH1	P01241	1	EBI-476182,EBI-1026046
NEK3	P51956	1	EBI-476182,EBI-476041
VAV2	P52735	1	EBI-476182,EBI-297549

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P16471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P16471-2)

Also known as: Delta-S1;

The sequence of this isoform differs from the canonical sequence as follows:
     24-124: Missing.

Isoform 3 (identifier: P16471-3)

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: DF → AW
     231-622: Missing.

Note: Soluble isoform that appears specific for the BT-474 breast cancer cell line.

Isoform 4 (identifier: P16471-4)

Also known as: SF1a; Short form 1a;

The sequence of this isoform differs from the canonical sequence as follows:
     338-376: MKPTYLDPDT...PQANPSTFYD → DPLMLGASHY...FTKATLTTVQ
     377-622: Missing.

Note: Includes exon 11. Does not transduce prolactin signaling.

Isoform 5 (identifier: P16471-5)

Also known as: Intermediate;

The sequence of this isoform differs from the canonical sequence as follows:
     337-349: GMKPTYLDPDTDS → EREQRQAQEARDS
     350-622: Missing.

Note: Produced by deletion of part of exon 10 and frameshift.

Isoform 6 (identifier: P16471-6)

Also known as: SF1b; Short form 1b;

The sequence of this isoform differs from the canonical sequence as follows:
     286-288: KGK → VTP
     289-622: Missing.

Note: Does not transduce prolactin signaling.

Isoform 7 (identifier: P16471-7)

Also known as: Delta 7/11;

The sequence of this isoform differs from the canonical sequence as follows:
     229-268: DFTMNDTTVW...KGYSMVTCIF → GDPLMLGASH...FTKATLTTVQ
     269-622: Missing.

Note: Splices from exon 7 to exon 11. Secreted.

Isoform 8 (identifier: P16471-8)

Also known as: Delta 4-SF1b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     286-288: KGK → VTP
     289-622: Missing.

Note: SF1b with deletion of exon 4.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Chain

25 – 622

598

Prolactin receptor

PRO_0000010977

Regions

Topological domain

25 – 234

210

Extracellular Potential

Transmembrane

235 – 258

24

Potential

Topological domain

259 – 622

364

Cytoplasmic Potential

Domain

27 – 121

95

Fibronectin type-III 1

Domain

127 – 227

101

Fibronectin type-III 2

Motif

215 – 219

5

WSXWS motif

Motif

267 – 275

9

Box 1 motif

Amino acid modifications

Glycosylation

59

1

N-linked (GlcNAc...) Potential

Glycosylation

104

1

N-linked (GlcNAc...) Potential

Glycosylation

233

1

N-linked (GlcNAc...) Potential

Disulfide bond

36 ↔ 46

Ref.11

Disulfide bond

75 ↔ 86

Ref.11

Natural variations

Alternative sequence

1 – 71

71

Missing in isoform 8.

VSP_026531

Alternative sequence

24 – 124

101

Missing in isoform 2.

VSP_001720

Alternative sequence

229 – 268

40

DFTMN…VTCIF → GDPLMLGASHYKNLKSYRPR KISSQGRLAVFTKATLTTVQ in isoform 7.

VSP_026532

Alternative sequence

229 – 230

2

DF → AW in isoform 3.

VSP_012620

Alternative sequence

231 – 622

392

Missing in isoform 3.

VSP_012621

Alternative sequence

269 – 622

354

Missing in isoform 7.

VSP_026533

Alternative sequence

286 – 288

3

KGK → VTP in isoform 6 and isoform 8.

VSP_026534

Alternative sequence

289 – 622

334

Missing in isoform 6 and isoform 8.

VSP_026535

Alternative sequence

337 – 349

13

GMKPT…PDTDS → EREQRQAQEARDS in isoform 5.

VSP_026536

Alternative sequence

338 – 376

39

MKPTY…STFYD → DPLMLGASHYKNLKSYRPRK ISSQGRLAVFTKATLTTVQ in isoform 4.

VSP_026537

Alternative sequence

350 – 622

273

Missing in isoform 5.

VSP_026538

Alternative sequence

377 – 622

246

Missing in isoform 4.

VSP_026539

Natural variant

100

1

I → V: dbSNP rs2228482.

VAR_049172

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

622

Helix Strand Turn

Details...

Beta strand

31 – 42

12

Beta strand

44 – 50

7

Beta strand

61 – 68

8

Beta strand

83 – 88

6

Beta strand

98 – 106

9

Beta strand

117 – 120

4

Helix

121 – 123

3

Beta strand

141 – 143

3

Turn

159 – 162

4

Beta strand

166 – 176

11

Beta strand

181 – 186

6

Beta strand

189 – 191

3

Beta strand

201 – 210

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: DB7FD0328608C787	FASTA	622	69,506
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 350 360 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL 370 380 390 400 410 420 SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ 430 440 450 460 470 480 PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE 490 500 510 520 530 540 SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP 550 560 570 580 590 600 ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS 610 620 KCRLQLGGLD YLDPACFTHS FH
	Isoform 2 (Delta-S1). Checksum: 1CF312424037E85B	FASTA	521	57,953
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNVQPDPPL ELAVEVKQPE DRKPYLWIKW SPPTLIDLKT 70 80 90 100 110 120 GWFTLLYEIR LKPEKAAEWE IHFAGQQTEF KILSLHPGQK YLVQVRCKPD HGYWSAWSPA 130 140 150 160 170 180 TFIQIPSDFT MNDTTVWISV AVLSAVICLI IVWAVALKGY SMVTCIFPPV PGPKIKGFDA 190 200 210 220 230 240 HLLEKGKSEE LLSALGCQDF PPTSDYEDLL VEYLEVDDSE DQHLMSVHSK EHPSQGMKPT 250 260 270 280 290 300 YLDPDTDSGR GSCDSPSLLS EKCEEPQANP STFYDPEVIE KPENPETTHT WDPQCISMEG 310 320 330 340 350 360 KIPYFHAGGS KCSTWPLPQP SQHNPRSSYH NITDVCELAV GPAGAPATLL NEAGKDALKS 370 380 390 400 410 420 SQTIKSREEG KATQQREVES FHSETDQDTP WLLPQEKTPF GSAKPLDYVE IHKVNKDGAL 430 440 450 460 470 480 SLLPKQRENS GKPKKPGTPE NNKEYAKVSG VMDNNILVLV PDPHAKNVAC FEESAKEAPP 490 500 510 520 SLEQNQAEKA LANFTATSSK CRLQLGGLDY LDPACFTHSF H
	Isoform 3. Checksum: 5288BCF71248D291	FASTA	230	26,545
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSAW
	Isoform 4 (SF1a) (Short form 1a). Checksum: 112DC2555FBC4601	FASTA	376	42,639
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 350 360 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGDPL MLGASHYKNL KSYRPRKISS 370 QGRLAVFTKA TLTTVQ
	Isoform 5 (Intermediate). Checksum: 932F200E850CDD27	FASTA	349	39,806
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQEREQ RQAQEARDS
	Isoform 6 (SF1b) (Short form 1b). Checksum: B45203EC045EB417	FASTA	288	32,760
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEVTP
	Isoform 7 (Delta 7/11). Checksum: FBB498AB649A078C	FASTA	268	30,705
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSGD PLMLGASHYK 250 260 NLKSYRPRKI SSQGRLAVFT KATLTTVQ
	Isoform 8 (Delta 4-SF1b). Checksum: E59A9BB9016C3397	FASTA	217	24,773
	10 20 30 40 50 60 MHECPDYITG GPNSCHFGKQ YTSMWRTYIM MVNATNQMGS SFSDELYVDV TYIVQPDPPL 70 80 90 100 110 120 ELAVEVKQPE DRKPYLWIKW SPPTLIDLKT GWFTLLYEIR LKPEKAAEWE IHFAGQQTEF 130 140 150 160 170 180 KILSLHPGQK YLVQVRCKPD HGYWSAWSPA TFIQIPSDFT MNDTTVWISV AVLSAVICLI 190 200 210 IVWAVALKGY SMVTCIFPPV PGPKIKGFDA HLLEVTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells." Boutin J.-M., Edery M., Shirota M., Jolicoeur C., Lesueur L., Ali S., Gould D., Djiane J., Kelly P.A. Mol. Endocrinol. 3:1455-1461(1989) [PubMed: 2558309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Functional characterization of the intermediate isoform of the human prolactin receptor." Kline J.B., Roehrs H., Clevenger C.V. J. Biol. Chem. 274:35461-35468(1999) [PubMed: 10585417] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]	"The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N)." Hu Z.-Z., Zhuang L., Meng J., Leondires M., Dufau M.L. J. Clin. Endocrinol. Metab. 84:1153-1156(1999) [PubMed: 10084611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11." Hu Z.Z., Meng J., Dufau M.L. J. Biol. Chem. 276:41086-41094(2001) [PubMed: 11518703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 6), INTERACTION WITH GH1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain." Kline J.B., Rycyzyn M.A., Clevenger C.V. Mol. Endocrinol. 16:2310-2322(2002) [PubMed: 12351696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Mammary carcinoma.
[6]	"Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein." Trott J.F., Hovey R.C., Koduri S., Vonderhaar B.K. J. Mol. Endocrinol. 30:31-47(2003) [PubMed: 12580759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 6; 7 AND 8), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[8]	"Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines." Fuh G., Wells J.A. J. Biol. Chem. 270:13133-13137(1995) [PubMed: 7768908] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Mammary carcinoma.
[9]	"The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells." Lazzaro M.A., Pepin D., Pescador N., Murphy B.D., Vanderhyden B.C., Picketts D.J. Mol. Endocrinol. 20:2406-2417(2006) [PubMed: 16740656] [Abstract] Cited for: INTERACTION WITH SMARCA1.
[10]	"The X-ray structure of a growth hormone-prolactin receptor complex." Somers W., Ultsch M., de Vos A.M., Kossiakoff A.A. Nature 372:478-481(1994) [PubMed: 7984244] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-235.
[11]	"Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor." Svensson L.A., Bondensgaard K., Noerskov-Lauritsen L., Christensen L., Becker P., Andersen M.D., Maltesen M.J., Rand K.D., Breinholt J. J. Biol. Chem. 283:19085-19094(2008) [PubMed: 18467331] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-234 IN COMPLEX WITH PRL, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBLGenBankDDBJ

M31661 mRNA. Translation: AAA60174.1.
AF166329 mRNA. Translation: AAD49855.1.
AF091870 , AF091863, AF091864, AF091865, AF091866, AF091867, AF091868, AF091869 Genomic DNA. Translation: AAD32032.1.
AF349939 mRNA. Translation: AAK32703.1.
AF416618 mRNA. Translation: AAL23914.1.
AF416619 mRNA. Translation: AAL23915.1.
AF493069 mRNA. Translation: AAM11661.1.
AF492470 mRNA. Translation: AAM18048.1.
BC059392 mRNA. Translation: AAH59392.1.
S78505 mRNA. Translation: AAB34470.1.

IPI

IPI00028640.
IPI00044214.
IPI00152476.
IPI00163730.
IPI00219095.
IPI00852725.
IPI00853144.
IPI00853288.

PIR

A40144.
A59405.
B59405.

RefSeq

NP_000940.1.

UniGene

Hs.368587

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BP3	X-ray	2.90	B	25-235	[»]
3D48	X-ray	2.50	R	25-234	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:288N.

IntAct

P16471. 3 interactions.

PTM databases

PhosphoSite

P16471.

Proteomic databases

PRIDE

P16471.

Genome annotation databases

Ensembl

ENSG00000113494. Homo sapiens. [Contig view]

GeneID

5618.

KEGG

hsa:5618.

Organism-specific databases

GeneCards

GC05M035084.

H-InvDB

HIX0004802.

HGNC

HGNC:9446. PRLR.

MIM

176761. gene.

Orphanet

50920. Mammary polyadenomatosis.

PharmGKB

PA33791.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P16471.

HOVERGEN

P16471.

OMA

P16471. YTEEARE.

Enzyme and pathway databases

Pathway_Interaction_DB

ptp1bpathway. Signaling events mediated by PTP1B.

Gene expression databases

ArrayExpress

P16471.

Bgee

P16471.

CleanEx

HS_PRLR.

GermOnline

ENSG00000113494. Homo sapiens.

Family and domain databases

InterPro

IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]

Gene3D

G3DSA:2.60.40.30. FN_III-like. 2 hits.

Pfam

PF00041. fn3. 2 hits.
[Graphical view]

SMART

SM00060. FN3. 2 hits.
[Graphical view]

PROSITE

PS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00858. Dromostanolone.
DB01185. Fluoxymesterone.
DB00082. Pegvisomant.
DB00052. Somatropin recombinant.

NextBio

21832.

SOURCE

Search...

Entry information

Entry name

PRLR_HUMAN

Accession

Primary (citable) accession number: P16471
Secondary accession number(s): Q16354 , Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	June 16, 2009
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)