P16471 (PRLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prolactin receptor
Short name=PRL-R

Gene names

Name:

PRLR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Ref.6
Subunit structure	Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent. Ref.4 Ref.11 Ref.12 Ref.13 Ref.15
Subcellular location	Membrane; Single-pass type I membrane protein Ref.4 Ref.6. Isoform 7: Secreted Ref.4 Ref.6.
Tissue specificity	Expressed in breast, placenta, kidney, liver and pancreas. Ref.4 Ref.6
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	JAK-STAT cascade involved in growth hormone signaling pathway Traceable author statement. Source: Reactome T cell activation Non-traceable author statement Ref.2. Source: UniProtKB activation of JAK2 kinase activity Non-traceable author statement Ref.2. Source: UniProtKB activation of transmembrane receptor protein tyrosine kinase activity Inferred from direct assay Ref.2. Source: UniProtKB embryo implantation Traceable author statement PubMed 9009200. Source: ProtInc lactation Non-traceable author statement Ref.2. Source: UniProtKB negative regulation of apoptotic process Non-traceable author statement Ref.2. Source: UniProtKB steroid biosynthetic process Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	cell surface Inferred from direct assay Ref.2. Source: UniProtKB endosome lumen Traceable author statement. Source: Reactome extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ornithine decarboxylase activator activity Non-traceable author statement Ref.2. Source: UniProtKB peptide hormone binding Inferred from physical interaction Ref.14. Source: BHF-UCL prolactin receptor activity Non-traceable author statement Ref.2. Source: UniProtKB protein homodimerization activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P16471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P16471-2)

Also known as: Delta-S1;

The sequence of this isoform differs from the canonical sequence as follows:
     24-124: Missing.

Isoform 3 (identifier: P16471-3)

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: DF → AW
     231-622: Missing.

Note: Soluble isoform that appears specific for the BT-474 breast cancer cell line.

Isoform 4 (identifier: P16471-4)

Also known as: SF1a; Short form 1a;

The sequence of this isoform differs from the canonical sequence as follows:
     338-376: MKPTYLDPDT...PQANPSTFYD → DPLMLGASHY...FTKATLTTVQ
     377-622: Missing.

Note: Includes exon 11. Does not transduce prolactin signaling.

Isoform 5 (identifier: P16471-5)

Also known as: Intermediate;

The sequence of this isoform differs from the canonical sequence as follows:
     337-349: GMKPTYLDPDTDS → EREQRQAQEARDS
     350-622: Missing.

Note: Produced by deletion of part of exon 10 and frameshift.

Isoform 6 (identifier: P16471-6)

Also known as: SF1b; Short form 1b;

The sequence of this isoform differs from the canonical sequence as follows:
     286-288: KGK → VTP
     289-622: Missing.

Note: Does not transduce prolactin signaling.

Isoform 7 (identifier: P16471-7)

Also known as: Delta 7/11;

The sequence of this isoform differs from the canonical sequence as follows:
     229-268: DFTMNDTTVW...KGYSMVTCIF → GDPLMLGASH...FTKATLTTVQ
     269-622: Missing.

Note: Splices from exon 7 to exon 11.

Isoform 8 (identifier: P16471-8)

Also known as: Delta 4-SF1b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     286-288: KGK → VTP
     289-622: Missing.

Note: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Chain

25 – 622

598

Prolactin receptor

PRO_0000010977

Regions

Topological domain

25 – 234

210

Extracellular Potential

Transmembrane

235 – 258

24

Helical; Potential

Topological domain

259 – 622

364

Cytoplasmic Potential

Domain

27 – 121

95

Fibronectin type-III 1

Domain

127 – 227

101

Fibronectin type-III 2

Motif

215 – 219

5

WSXWS motif

Motif

267 – 275

9

Box 1 motif

Sites

Metal binding

211

1

Zinc

Metal binding

212

1

Zinc

Amino acid modifications

Glycosylation

59

1

N-linked (GlcNAc...) Potential

Glycosylation

104

1

N-linked (GlcNAc...) Potential

Glycosylation

233

1

N-linked (GlcNAc...) Potential

Disulfide bond

36 ↔ 46

Ref.15

Disulfide bond

75 ↔ 86

Ref.15

Natural variations

Alternative sequence

1 – 71

71

Missing in isoform 8.

VSP_026531

Alternative sequence

24 – 124

101

Missing in isoform 2.

VSP_001720

Alternative sequence

229 – 268

40

DFTMN…VTCIF → GDPLMLGASHYKNLKSYRPR KISSQGRLAVFTKATLTTVQ in isoform 7.

VSP_026532

Alternative sequence

229 – 230

2

DF → AW in isoform 3.

VSP_012620

Alternative sequence

231 – 622

392

Missing in isoform 3.

VSP_012621

Alternative sequence

269 – 622

354

Missing in isoform 7.

VSP_026533

Alternative sequence

286 – 288

3

KGK → VTP in isoform 6 and isoform 8.

VSP_026534

Alternative sequence

289 – 622

334

Missing in isoform 6 and isoform 8.

VSP_026535

Alternative sequence

337 – 349

13

GMKPT…PDTDS → EREQRQAQEARDS in isoform 5.

VSP_026536

Alternative sequence

338 – 376

39

MKPTY…STFYD → DPLMLGASHYKNLKSYRPRK ISSQGRLAVFTKATLTTVQ in isoform 4.

VSP_026537

Alternative sequence

350 – 622

273

Missing in isoform 5.

VSP_026538

Alternative sequence

377 – 622

246

Missing in isoform 4.

VSP_026539

Natural variant

100

1

I → V.
Corresponds to variant rs2228482 [ dbSNP | Ensembl ].

VAR_049172

Secondary structure

1

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622

Helix Strand Turn

Details...

Beta strand

32 – 42

11

Beta strand

44 – 49

6

Beta strand

52 – 54

3

Beta strand

58 – 66

9

Turn

67 – 69

3

Beta strand

85 – 88

4

Helix

90 – 92

3

Beta strand

95 – 97

3

Beta strand

99 – 107

9

Beta strand

110 – 113

4

Beta strand

117 – 119

3

Helix

121 – 123

3

Beta strand

131 – 138

8

Beta strand

141 – 143

3

Beta strand

146 – 152

7

Beta strand

155 – 157

3

Beta strand

162 – 164

3

Beta strand

166 – 173

8

Beta strand

181 – 186

6

Beta strand

189 – 193

5

Beta strand

201 – 213

13

Beta strand

222 – 225

4

Helix

228 – 230

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: DB7FD0328608C787	FASTA	622	69,506
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 350 360 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL 370 380 390 400 410 420 SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ 430 440 450 460 470 480 PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE 490 500 510 520 530 540 SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP 550 560 570 580 590 600 ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS 610 620 KCRLQLGGLD YLDPACFTHS FH
	Isoform 2 (Delta-S1) [UniParc]. Checksum: 1CF312424037E85B	FASTA	521	57,953
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNVQPDPPL ELAVEVKQPE DRKPYLWIKW SPPTLIDLKT 70 80 90 100 110 120 GWFTLLYEIR LKPEKAAEWE IHFAGQQTEF KILSLHPGQK YLVQVRCKPD HGYWSAWSPA 130 140 150 160 170 180 TFIQIPSDFT MNDTTVWISV AVLSAVICLI IVWAVALKGY SMVTCIFPPV PGPKIKGFDA 190 200 210 220 230 240 HLLEKGKSEE LLSALGCQDF PPTSDYEDLL VEYLEVDDSE DQHLMSVHSK EHPSQGMKPT 250 260 270 280 290 300 YLDPDTDSGR GSCDSPSLLS EKCEEPQANP STFYDPEVIE KPENPETTHT WDPQCISMEG 310 320 330 340 350 360 KIPYFHAGGS KCSTWPLPQP SQHNPRSSYH NITDVCELAV GPAGAPATLL NEAGKDALKS 370 380 390 400 410 420 SQTIKSREEG KATQQREVES FHSETDQDTP WLLPQEKTPF GSAKPLDYVE IHKVNKDGAL 430 440 450 460 470 480 SLLPKQRENS GKPKKPGTPE NNKEYAKVSG VMDNNILVLV PDPHAKNVAC FEESAKEAPP 490 500 510 520 SLEQNQAEKA LANFTATSSK CRLQLGGLDY LDPACFTHSF H
	Isoform 3 [UniParc]. Checksum: 5288BCF71248D291	FASTA	230	26,545
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSAW
	Isoform 4 (SF1a) (Short form 1a) [UniParc]. Checksum: 112DC2555FBC4601	FASTA	376	42,639
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 350 360 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGDPL MLGASHYKNL KSYRPRKISS 370 QGRLAVFTKA TLTTVQ
	Isoform 5 (Intermediate) [UniParc]. Checksum: 932F200E850CDD27	FASTA	349	39,806
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 290 300 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 310 320 330 340 FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQEREQ RQAQEARDS
	Isoform 6 (SF1b) (Short form 1b) [UniParc]. Checksum: B45203EC045EB417	FASTA	288	32,760
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS 250 260 270 280 VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEVTP
	Isoform 7 (Delta 7/11) [UniParc]. Checksum: FBB498AB649A078C	FASTA	268	30,705
	10 20 30 40 50 60 MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY 70 80 90 100 110 120 SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD 130 140 150 160 170 180 VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW 190 200 210 220 230 240 EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSGD PLMLGASHYK 250 260 NLKSYRPRKI SSQGRLAVFT KATLTTVQ
	Isoform 8 (Delta 4-SF1b) [UniParc]. Checksum: E59A9BB9016C3397	FASTA	217	24,773
	10 20 30 40 50 60 MHECPDYITG GPNSCHFGKQ YTSMWRTYIM MVNATNQMGS SFSDELYVDV TYIVQPDPPL 70 80 90 100 110 120 ELAVEVKQPE DRKPYLWIKW SPPTLIDLKT GWFTLLYEIR LKPEKAAEWE IHFAGQQTEF 130 140 150 160 170 180 KILSLHPGQK YLVQVRCKPD HGYWSAWSPA TFIQIPSDFT MNDTTVWISV AVLSAVICLI 190 200 210 IVWAVALKGY SMVTCIFPPV PGPKIKGFDA HLLEVTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells." Boutin J.-M., Edery M., Shirota M., Jolicoeur C., Lesueur L., Ali S., Gould D., Djiane J., Kelly P.A. Mol. Endocrinol. 3:1455-1461(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Functional characterization of the intermediate isoform of the human prolactin receptor." Kline J.B., Roehrs H., Clevenger C.V. J. Biol. Chem. 274:35461-35468(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]	"The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N)." Hu Z.-Z., Zhuang L., Meng J., Leondires M., Dufau M.L. J. Clin. Endocrinol. Metab. 84:1153-1156(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11." Hu Z.Z., Meng J., Dufau M.L. J. Biol. Chem. 276:41086-41094(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 6), INTERACTION WITH GH1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain." Kline J.B., Rycyzyn M.A., Clevenger C.V. Mol. Endocrinol. 16:2310-2322(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Mammary carcinoma.
[6]	"Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein." Trott J.F., Hovey R.C., Koduri S., Vonderhaar B.K. J. Mol. Endocrinol. 30:31-47(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4; 6; 7 AND 8), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Prostate.
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[10]	"Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines." Fuh G., Wells J.A. J. Biol. Chem. 270:13133-13137(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-622 (ISOFORM 3). Tissue: Mammary carcinoma.
[11]	"Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor." Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V. Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NEK3 AND VAV2.
[12]	"Crystal structure and site 1 binding energetics of human placental lactogen." Walsh S.T., Kossiakoff A.A. J. Mol. Biol. 358:773-784(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, ZINC-BINDING SITES.
[13]	"The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells." Lazzaro M.A., Pepin D., Pescador N., Murphy B.D., Vanderhyden B.C., Picketts D.J. Mol. Endocrinol. 20:2406-2417(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SMARCA1.
[14]	"The X-ray structure of a growth hormone-prolactin receptor complex." Somers W., Ultsch M., de Vos A.M., Kossiakoff A.A. Nature 372:478-481(1994) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 25-235.
[15]	"Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor." Svensson L.A., Bondensgaard K., Noerskov-Lauritsen L., Christensen L., Becker P., Andersen M.D., Maltesen M.J., Rand K.D., Breinholt J. J. Biol. Chem. 283:19085-19094(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-234 IN COMPLEX WITH PRL, SUBUNIT, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M31661 mRNA. Translation: AAA60174.1.
AF166329 mRNA. Translation: AAD49855.1.
AF091870 , AF091863, AF091864, AF091865, AF091866, AF091867, AF091868, AF091869 Genomic DNA. Translation: AAD32032.1.
AF349939 mRNA. Translation: AAK32703.1.
AF416618 mRNA. Translation: AAL23914.1.
AF416619 mRNA. Translation: AAL23915.1.
AF492470 mRNA. Translation: AAM18048.1.
AF493069 mRNA. Translation: AAM11661.1.
AK313270 mRNA. Translation: BAG36079.1.
CH471119 Genomic DNA. Translation: EAW55919.1.
BC059392 mRNA. Translation: AAH59392.1.
S78505 mRNA. Translation: AAB34470.1.

IPI

IPI00028640.
IPI00044214.
IPI00152476.
IPI00163730.
IPI00219095.
IPI00852725.
IPI00853288.
IPI00954795.

PIR

A40144.
A59405.
B59405.

RefSeq

NP_000940.1. NM_000949.5.
NP_001191243.1. NM_001204314.1.
NP_001191244.1. NM_001204315.1.
NP_001191245.1. NM_001204316.1.
NP_001191246.1. NM_001204317.1.
NP_001191247.1. NM_001204318.1.

UniGene

Hs.368587.
Hs.602914.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BP3	X-ray	2.90	B	25-235	[»]
2LFG	NMR	-	A	123-234	[»]
3D48	X-ray	2.50	R	25-234	[»]
3MZG	X-ray	2.10	B	26-234	[»]
3N06	X-ray	2.00	B	26-234	[»]
3N0P	X-ray	2.10	B	26-234	[»]
3NCB	X-ray	2.10	B	26-234	[»]
3NCC	X-ray	2.50	B	26-234	[»]
3NCE	X-ray	2.00	B	26-234	[»]
3NCF	X-ray	2.80	B	26-234	[»]

ProteinModelPortal

P16471.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-288N.

IntAct

P16471. 3 interactions.

MINT

MINT-268499.

PTM databases

PhosphoSite

P16471.

Polymorphism databases

DMDM

130321.

Proteomic databases

PaxDb

P16471.

PRIDE

P16471.

Protocols and materials databases

DNASU

5618.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000231423; ENSP00000231423; ENSG00000113494.
ENST00000310101; ENSP00000309008; ENSG00000113494.
ENST00000342362; ENSP00000339213; ENSG00000113494.
ENST00000348262; ENSP00000311613; ENSG00000113494.
ENST00000382002; ENSP00000371432; ENSG00000113494.
ENST00000511486; ENSP00000422556; ENSG00000113494.
ENST00000513753; ENSP00000424841; ENSG00000113494.

GeneID

5618.

KEGG

hsa:5618.

UCSC

uc003jjg.2. human.
uc003jjh.2. human.
uc003jji.2. human.
uc003jjj.2. human.
uc003jjl.4. human.
uc003jjm.3. human.
uc010iuw.1. human.
uc021xxl.1. human.

Organism-specific databases

CTD

5618.

GeneCards

GC05M035084.

HGNC

HGNC:9446. PRLR.

MIM

176761. gene.

neXtProt

NX_P16471.

Orphanet

50920. Mammary polyadenomatosis.

PharmGKB

PA33791.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG29671.

HOVERGEN

HBG007314.

InParanoid

P16471.

KO

K05081.

OMA

DTHLLEK.

OrthoDB

EOG4Z0B5N.

PhylomeDB

P16471.

Enzyme and pathway databases

Pathway_Interaction_DB

ptp1bpathway. Signaling events mediated by PTP1B.

Reactome

REACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P16471.

Bgee

P16471.

CleanEx

HS_PRLR.

Genevestigator

P16471.

GermOnline

ENSG00000113494. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]

Pfam

PF09067. EpoR_lig-bind. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 2 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P16471.

ChEMBL

CHEMBL5588.

DrugBank

DB00858. Dromostanolone.
DB01185. Fluoxymesterone.
DB00082. Pegvisomant.
DB00052. Somatropin recombinant.

EvolutionaryTrace

P16471.

GenomeRNAi

5618.

NextBio

21832.

SOURCE

Search...

Entry information

Entry name

PRLR_HUMAN

Accession

Primary (citable) accession number: P16471
Secondary accession number(s): B2R882 , Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 154 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.