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Protein

Telomere-binding protein subunit beta

Gene

MAC-41A

more
Organism
Sterkiella nova (Ciliate) (Oxytricha nova)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere-binding protein subunit beta
Alternative name(s):
TEBP beta
Telomere-binding protein 41 kDa subunit
Gene namesi
Name:MAC-41A
AND
Name:MAC-41S
OrganismiSterkiella nova (Ciliate) (Oxytricha nova)
Taxonomic identifieri200597 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaStichotrichiaSporadotrichidaOxytrichidaeStylonychinaeSterkiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Telomere-binding protein subunit betaPRO_0000121737Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

DIPiDIP-6195N.
MINTiMINT-203007.

Structurei

Secondary structure

1
385
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 2311Combined sources
Turni24 – 263Combined sources
Helixi28 – 303Combined sources
Helixi33 – 353Combined sources
Beta strandi39 – 457Combined sources
Beta strandi47 – 493Combined sources
Beta strandi51 – 599Combined sources
Beta strandi61 – 633Combined sources
Helixi65 – 7410Combined sources
Helixi80 – 823Combined sources
Beta strandi87 – 9913Combined sources
Turni102 – 1043Combined sources
Beta strandi112 – 12413Combined sources
Helixi138 – 1403Combined sources
Helixi142 – 16322Combined sources
Helixi172 – 1754Combined sources
Helixi178 – 1803Combined sources
Helixi185 – 1884Combined sources
Beta strandi189 – 1913Combined sources
Beta strandi196 – 1994Combined sources
Helixi215 – 2239Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JB7X-ray1.86B1-260[»]
1OTCX-ray2.80B1-260[»]
1PA6X-ray2.45B9-224[»]
1PH1X-ray2.51B8-224[»]
1PH2X-ray3.10B9-224[»]
1PH3X-ray2.30B9-224[»]
1PH4X-ray2.30B9-224[»]
1PH5X-ray2.30B9-224[»]
1PH6X-ray2.10B8-224[»]
1PH7X-ray2.90B9-224[»]
1PH8X-ray2.36B9-224[»]
1PH9X-ray2.50B9-224[»]
1PHJX-ray2.50B9-224[»]
2I0QX-ray1.91B1-385[»]
DisProtiDP00659.
ProteinModelPortaliP16458.
SMRiP16458. Positions 8-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16458.

Family & Domainsi

Family and domain databases

Gene3Di2.40.200.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR010874. TEBP_beta.
IPR023113. TEBP_beta_domain.
[Graphical view]
PfamiPF07404. TEBP_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF018412. TEBP_beta. 1 hit.
ProDomiPD028462. TEBP_beta. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

P16458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGASAPQQ QSAFKQLYTE LFNNEGDFSK VSSNLKKPLK CYVKESYPHF
60 70 80 90 100
LVTDGYFFVA PYFTKEAVNE FHAKFPNVNI VDLTDKVIVI NNWSLELRRV
110 120 130 140 150
NSAEVFTSYA NLEARLIVHS FKPNLQERLN PTRYPVNLFR DDEFKTTIQH
160 170 180 190 200
FRHTALQAAI NKTVKGDNLV DISKVADAAG KKGKVDAGIV KASASKGDEF
210 220 230 240 250
SDFSFKEGNT ATLKIADIFV QEKGKDALNK AADHTDGAKV KGGAKGKGKA
260 270 280 290 300
AAKAAKGKKL SAKKGDSSAA DVRKSVDKIV KYTPSKGSRK DTPQKSQAPA
310 320 330 340 350
AGKSSAKKGG KKAVPSAPSP SGKKSALTTD KMTMAQFVKY LDWHEKKKGG
360 370 380
KVSSGGKVLG KRSAGKASAT SGKASKASKK TAAKK
Length:385
Mass (Da):41,446
Last modified:August 1, 1990 - v1
Checksum:i743B51EFD7886352
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101A → S in MAC-41S.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31309 Genomic DNA. Translation: AAA29400.1.
M31310 Genomic DNA. Translation: AAA29401.1.
PIRiA34843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31309 Genomic DNA. Translation: AAA29400.1.
M31310 Genomic DNA. Translation: AAA29401.1.
PIRiA34843.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JB7X-ray1.86B1-260[»]
1OTCX-ray2.80B1-260[»]
1PA6X-ray2.45B9-224[»]
1PH1X-ray2.51B8-224[»]
1PH2X-ray3.10B9-224[»]
1PH3X-ray2.30B9-224[»]
1PH4X-ray2.30B9-224[»]
1PH5X-ray2.30B9-224[»]
1PH6X-ray2.10B8-224[»]
1PH7X-ray2.90B9-224[»]
1PH8X-ray2.36B9-224[»]
1PH9X-ray2.50B9-224[»]
1PHJX-ray2.50B9-224[»]
2I0QX-ray1.91B1-385[»]
DisProtiDP00659.
ProteinModelPortaliP16458.
SMRiP16458. Positions 8-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6195N.
MINTiMINT-203007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP16458.

Family and domain databases

Gene3Di2.40.200.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR010874. TEBP_beta.
IPR023113. TEBP_beta_domain.
[Graphical view]
PfamiPF07404. TEBP_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF018412. TEBP_beta. 1 hit.
ProDomiPD028462. TEBP_beta. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova."
    Hicke B.J., Celander D.W., Macdonald G.H., Price C.M., Cech T.R.
    Proc. Natl. Acad. Sci. U.S.A. 87:1481-1485(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 100-140.
  2. "Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA."
    Horvath M.P., Schweiker V.L., Bevilacqua J.M., Ruggles J.A., Schultz S.C.
    Cell 95:963-974(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiTEBB_STENO
AccessioniPrimary (citable) accession number: P16458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The sequence of MAC-41A is shown. MAC-41S differs in only one position.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.