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Protein

Telomere-binding protein subunit beta

Gene

MAC-41A

more
Organism
Sterkiella nova (Ciliate) (Oxytricha nova)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as protective capping of the single-stranded telomeric overhang. May also participate in telomere length regulation during DNA replication. Binds specifically to the T4G4-containing extension on the 3'strand and protects this region of the telomere from nuclease digestion and chemical modification.

Miscellaneous

The sequence of MAC-41A is shown. MAC-41S differs in only one position.

GO - Molecular functioni

  • protein heterodimerization activity Source: CAFA
  • single-stranded telomeric DNA binding Source: CAFA

GO - Biological processi

  • telomere capping Source: CAFA

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere-binding protein subunit beta
Alternative name(s):
TEBP beta
Telomere-binding protein 41 kDa subunit
Gene namesi
Name:MAC-41A
AND
Name:MAC-41S
OrganismiSterkiella nova (Ciliate) (Oxytricha nova)
Taxonomic identifieri200597 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaStichotrichiaSporadotrichidaOxytrichidaeStylonychinaeSterkiella

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • protein complex Source: CAFA
  • telomere cap complex Source: CAFA

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217371 – 385Telomere-binding protein subunit betaAdd BLAST385

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

  • protein heterodimerization activity Source: CAFA

Protein-protein interaction databases

DIPiDIP-6195N.
MINTiMINT-203007.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 23Combined sources11
Turni24 – 26Combined sources3
Helixi28 – 30Combined sources3
Helixi33 – 35Combined sources3
Beta strandi39 – 45Combined sources7
Beta strandi47 – 49Combined sources3
Beta strandi51 – 59Combined sources9
Beta strandi61 – 63Combined sources3
Helixi65 – 74Combined sources10
Helixi80 – 82Combined sources3
Beta strandi87 – 99Combined sources13
Turni102 – 104Combined sources3
Beta strandi112 – 124Combined sources13
Helixi138 – 140Combined sources3
Helixi142 – 163Combined sources22
Helixi172 – 175Combined sources4
Helixi178 – 180Combined sources3
Helixi185 – 188Combined sources4
Beta strandi189 – 191Combined sources3
Beta strandi196 – 199Combined sources4
Helixi215 – 223Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JB7X-ray1.86B1-260[»]
1OTCX-ray2.80B1-260[»]
1PA6X-ray2.45B9-224[»]
1PH1X-ray2.51B8-224[»]
1PH2X-ray3.10B9-224[»]
1PH3X-ray2.30B9-224[»]
1PH4X-ray2.30B9-224[»]
1PH5X-ray2.30B9-224[»]
1PH6X-ray2.10B8-224[»]
1PH7X-ray2.90B9-224[»]
1PH8X-ray2.36B9-224[»]
1PH9X-ray2.50B9-224[»]
1PHJX-ray2.50B9-224[»]
2I0QX-ray1.91B1-385[»]
DisProtiDP00659.
ProteinModelPortaliP16458.
SMRiP16458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16458.

Family & Domainsi

Family and domain databases

Gene3Di2.40.200.10. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR010874. TEBP_beta.
IPR023113. TEBP_beta_domain.
PfamiView protein in Pfam
PF07404. TEBP_beta. 1 hit.
PIRSFiPIRSF018412. TEBP_beta. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028462. TEBP_beta. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

P16458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGASAPQQ QSAFKQLYTE LFNNEGDFSK VSSNLKKPLK CYVKESYPHF
60 70 80 90 100
LVTDGYFFVA PYFTKEAVNE FHAKFPNVNI VDLTDKVIVI NNWSLELRRV
110 120 130 140 150
NSAEVFTSYA NLEARLIVHS FKPNLQERLN PTRYPVNLFR DDEFKTTIQH
160 170 180 190 200
FRHTALQAAI NKTVKGDNLV DISKVADAAG KKGKVDAGIV KASASKGDEF
210 220 230 240 250
SDFSFKEGNT ATLKIADIFV QEKGKDALNK AADHTDGAKV KGGAKGKGKA
260 270 280 290 300
AAKAAKGKKL SAKKGDSSAA DVRKSVDKIV KYTPSKGSRK DTPQKSQAPA
310 320 330 340 350
AGKSSAKKGG KKAVPSAPSP SGKKSALTTD KMTMAQFVKY LDWHEKKKGG
360 370 380
KVSSGGKVLG KRSAGKASAT SGKASKASKK TAAKK
Length:385
Mass (Da):41,446
Last modified:August 1, 1990 - v1
Checksum:i743B51EFD7886352
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti110A → S in MAC-41S. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31309 Genomic DNA. Translation: AAA29400.1.
M31310 Genomic DNA. Translation: AAA29401.1.
PIRiA34843.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTEBB_STENO
AccessioniPrimary (citable) accession number: P16458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references