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Protein

Selenide, water dikinase

Gene

selD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes selenophosphate from selenide and ATP.

Catalytic activityi

ATP + selenide + H2O = AMP + selenophosphate + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17Sequence analysis1
Sitei20Important for catalytic activity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi230 – 236ATPSequence analysis7

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: EcoCyc
  • selenide, water dikinase activity Source: EcoCyc

GO - Biological processi

  • selenocysteine biosynthetic process Source: EcoCyc
  • tRNA seleno-modification Source: EcoCyc

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Nucleotide-binding, Selenium

Enzyme and pathway databases

BioCyciEcoCyc:EG10943-MONOMER.
MetaCyc:EG10943-MONOMER.
BRENDAi2.7.9.3. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenide, water dikinase (EC:2.7.9.3)
Alternative name(s):
Selenium donor protein
Selenophosphate synthase
Gene namesi
Name:selD
Synonyms:fdhB
Ordered Locus Names:b1764, JW1753
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10943. selD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13H → N: No loss of activity. 1 Publication1
Mutagenesisi17C → S: Complete loss of activity. 1 Publication1
Mutagenesisi18G → V: Partial loss of activity. 1 Publication1
Mutagenesisi19C → S: No loss of activity. 1 Publication1
Mutagenesisi20K → Q: Complete loss of activity. 1 Publication1
Mutagenesisi20K → R: Marked loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001276201 – 347Selenide, water dikinaseAdd BLAST347

Proteomic databases

PaxDbiP16456.
PRIDEiP16456.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi4259138. 16 interactors.
DIPiDIP-10849N.
IntActiP16456. 11 interactors.
MINTiMINT-1256873.
STRINGi316385.ECDH10B_1902.

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 27Combined sources6
Beta strandi41 – 43Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi60 – 71Combined sources12
Helixi77 – 94Combined sources18
Beta strandi98 – 108Combined sources11
Turni110 – 112Combined sources3
Helixi115 – 131Combined sources17
Beta strandi136 – 143Combined sources8
Beta strandi148 – 158Combined sources11
Helixi159 – 161Combined sources3
Beta strandi173 – 178Combined sources6
Helixi182 – 190Combined sources9
Helixi196 – 198Combined sources3
Helixi201 – 207Combined sources7
Helixi212 – 216Combined sources5
Beta strandi222 – 227Combined sources6
Helixi232 – 244Combined sources13
Beta strandi246 – 251Combined sources6
Turni252 – 254Combined sources3
Helixi261 – 265Combined sources5
Helixi272 – 281Combined sources10
Helixi282 – 284Combined sources3
Helixi290 – 296Combined sources7
Beta strandi305 – 309Combined sources5
Helixi311 – 323Combined sources13
Beta strandi332 – 336Combined sources5
Beta strandi341 – 345Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U0OX-ray2.25A/B1-347[»]
ProteinModelPortaliP16456.
SMRiP16456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D4F. Bacteria.
COG0709. LUCA.
HOGENOMiHOG000219300.
InParanoidiP16456.
KOiK01008.
PhylomeDBiP16456.

Family and domain databases

CDDicd02195. SelD. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00625. SelD. 1 hit.
InterProiView protein in InterPro
IPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR023061. SelD_I.
IPR004536. SPS/SelD.
PANTHERiPTHR10256. PTHR10256. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
PIRSFiPIRSF036407. Selenphspht_syn. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.

Sequencei

Sequence statusi: Complete.

P16456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENSIRLTQ YSHGAGCGCK ISPKVLETIL HSEQAKFVDP NLLVGNETRD
60 70 80 90 100
DAAVYDLGNG TSVISTTDFF MPIVDNPFDF GRIAATNAIS DIFAMGGKPI
110 120 130 140 150
MAIAILGWPI NKLSPEIARE VTEGGRYACR QAGIALAGGH SIDAPEPIFG
160 170 180 190 200
LAVTGIVPTE RVKKNSTAQA GCKLFLTKPL GIGVLTTAEK KSLLKPEHQG
210 220 230 240 250
LATEVMCRMN IAGASFANIE GVKAMTDVTG FGLLGHLSEM CQGAGVQARV
260 270 280 290 300
DYEAIPKLPG VEEYIKLGAV PGGTERNFAS YGHLMGEMPR EVRDLLCDPQ
310 320 330 340
TSGGLLLAVM PEAENEVKAT AAEFGIELTA IGELVPARGG RAMVEIR
Length:347
Mass (Da):36,687
Last modified:August 1, 1990 - v1
Checksum:i595E5EC9F7B1370F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30184 Genomic DNA. Translation: AAA74748.1.
U00096 Genomic DNA. Translation: AAC74834.1.
AP009048 Genomic DNA. Translation: BAA15552.1.
J05076 Genomic DNA. Translation: AAA83922.1.
PIRiJW0033.
RefSeqiNP_416278.1. NC_000913.3.
WP_001295485.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74834; AAC74834; b1764.
BAA15552; BAA15552; BAA15552.
GeneIDi946768.
KEGGiecj:JW1753.
eco:b1764.
PATRICifig|1411691.4.peg.490.

Similar proteinsi

Entry informationi

Entry nameiSELD_ECOLI
AccessioniPrimary (citable) accession number: P16456
Secondary accession number(s): P78172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 30, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families