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Protein

Histidine decarboxylase

Gene

Hdc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.By similarity

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Enzyme regulationi

Phosphorylation of brain HDC by cAMP-dependent protein kinase leads to enzyme inactivation.

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (Hdc)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Substrate; via amide nitrogenBy similarity
Binding sitei197 – 1971SubstrateBy similarity

GO - Molecular functioni

  • amino acid binding Source: RGD
  • histidine decarboxylase activity Source: RGD
  • pyridoxal phosphate binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14635.
UniPathwayiUPA00822; UER00786.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:Hdc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2790. Hdc.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • dendrite Source: RGD
  • neuronal cell body Source: RGD
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3243911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Histidine decarboxylasePRO_0000146952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei308 – 3081N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei343 – 3431Phosphoserine; by PKASequence analysis
Modified residuei362 – 3621Phosphoserine; by PKASequence analysis

Post-translational modificationi

May be post-translationally processed.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP16453.
PRIDEiP16453.

PTM databases

PhosphoSiteiP16453.

Expressioni

Tissue specificityi

Brain, glandular regions of the stomach, mast cells and fetal liver.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041885.

Chemistry

BindingDBiP16453.

Structurei

3D structure databases

ProteinModelPortaliP16453.
SMRiP16453. Positions 8-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP16453.
PhylomeDBiP16453.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.
Isoform 1 (identifier: P16453-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEPSEYHEY QARGKEMVDY ICQYLSTVRE RQVTPNVKPG YLRAQIPSSA
60 70 80 90 100
PEEPDSWDSI FGDIEQIIMP GVVHWQSPHM HAYYPALTSW PSLLGDMLAD
110 120 130 140 150
AINCLGFTWA SSPACTELEM NIMDWLAKML GLPDFFLHHH PSSQGGGVLQ
160 170 180 190 200
RTVSESTLIA LLAARKNKIL EMKAHEPNAD ESSLNARLVA YASDQAHSSV
210 220 230 240 250
EKAGLISLVK IKFLPVDDNF SLRGEALQKA IEEDKQQGLV PVFVCATLGT
260 270 280 290 300
TGVCAFDKLS ELGPICAREG LWLHVDAAYA GTAFLRPELR GFLKGIEYAD
310 320 330 340 350
SFTFNPSKWM MVHFDCTGFW VKDKYKLQQT FSVNPIYLRH ANSGVATDFM
360 370 380 390 400
HWQIPLSRRF RSIKLWFVIR SFGVKNLQAH VRHGTDMAKY FESLVRSDPV
410 420 430 440 450
FEIPAERHLG LVVFRLKGPN CLTESVLKEI AKTGQVFLIP ATIQDKLIIR
460 470 480 490 500
FTVTSQFTTK DDILRDWNLI REAANLVLSQ HCTSQPSPRA KNLIPPPVTR
510 520 530 540 550
DSKDLTNGLS LESVNEGGDD PVQVRKIFRL PGDSLETTMD PFDDCFSEEA
560 570 580 590 600
SDTTKHKLSS FLFSYLSVQN KKKTMRSLSC NSMPMSAQKS PPPDASVKHG
610 620 630 640 650
GFFRARIFSG FPEEMMMMKK GGFKKLIKFY SVPSFPECSS QCGTLQLPCC

PLQAMV
Length:656
Mass (Da):73,636
Last modified:November 1, 1990 - v2
Checksum:iF21BB2B8D1A480F3
GO

Sequence cautioni

The sequence AAA63476 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81H → R.
Natural varianti28 – 281V → L.
Natural varianti286 – 2861R → C.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29591 mRNA. Translation: AAA41326.1.
M38759 mRNA. Translation: AAA63476.1. Different initiation.
PIRiA34890.
A39030.
UniGeneiRn.48653.

Genome annotation databases

UCSCiRGD:2790. rat. [P16453-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29591 mRNA. Translation: AAA41326.1.
M38759 mRNA. Translation: AAA63476.1. Different initiation.
PIRiA34890.
A39030.
UniGeneiRn.48653.

3D structure databases

ProteinModelPortaliP16453.
SMRiP16453. Positions 8-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041885.

Chemistry

BindingDBiP16453.
ChEMBLiCHEMBL3243911.

PTM databases

PhosphoSiteiP16453.

Proteomic databases

PaxDbiP16453.
PRIDEiP16453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2790. rat. [P16453-1]

Organism-specific databases

RGDi2790. Hdc.

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP16453.
PhylomeDBiP16453.

Enzyme and pathway databases

UniPathwayiUPA00822; UER00786.
BioCyciMetaCyc:MONOMER-14635.

Miscellaneous databases

PROiP16453.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCHS_RAT
AccessioniPrimary (citable) accession number: P16453
Secondary accession number(s): Q63029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A putative trans-splicing which involves HDC and SHBG gene regions produces a fusion protein expressed in fetal liver.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.