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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

Pitpna

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei61Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei86Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei90Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei97Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei195Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • phosphatidylinositol transporter activity Source: UniProtKB
  • phospholipid binding Source: MGI
  • stearic acid binding Source: UniProtKB

GO - Biological processi

  • phospholipid transport Source: UniProtKB

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
Gene namesi
Name:Pitpna
Synonyms:Pitpn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61885. Pitpna.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001916422 – 271Phosphatidylinositol transfer protein alpha isoformAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP16446.
PRIDEiP16446.

2D gel databases

World-2DPAGEi0004:P16446.

PTM databases

iPTMnetiP16446.
PhosphoSitePlusiP16446.

Expressioni

Tissue specificityi

Expressed in a wide range of tissues.

Gene expression databases

BgeeiENSRNOG00000003846.
ExpressionAtlasiP16446. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi248161. 1 interactor.
STRINGi10116.ENSRNOP00000005368.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Helixi15 – 32Combined sources18
Beta strandi38 – 49Combined sources12
Beta strandi55 – 64Combined sources10
Turni66 – 68Combined sources3
Helixi71 – 74Combined sources4
Turni79 – 82Combined sources4
Beta strandi84 – 91Combined sources8
Beta strandi94 – 100Combined sources7
Turni102 – 104Combined sources3
Helixi105 – 107Combined sources3
Beta strandi108 – 119Combined sources12
Turni124 – 127Combined sources4
Helixi133 – 136Combined sources4
Beta strandi138 – 142Combined sources5
Helixi147 – 149Combined sources3
Turni152 – 154Combined sources3
Helixi157 – 159Combined sources3
Turni161 – 163Combined sources3
Turni167 – 169Combined sources3
Helixi178 – 182Combined sources5
Beta strandi186 – 188Combined sources3
Beta strandi191 – 201Combined sources11
Turni204 – 206Combined sources3
Helixi207 – 231Combined sources25
Helixi233 – 236Combined sources4
Helixi241 – 260Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T27X-ray2.20A1-271[»]
ProteinModelPortaliP16446.
SMRiP16446.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16446.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00760000119216.
HOGENOMiHOG000006717.
HOVERGENiHBG058915.
InParanoidiP16446.
OrthoDBiEOG091G0CQQ.
PhylomeDBiP16446.
TreeFamiTF313279.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR001666. PI_transfer.
IPR023393. START-like_dom.
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiView protein in Pfam
PF02121. IP_trans. 1 hit.
PRINTSiPR00391. PITRANSFER.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK
60 70 80 90 100
DDGEKGQYTH KIYHLQSKVP TFVRMLAPEG ALNIHEKAWN AYPYCRTVIT
110 120 130 140 150
NEYMKEDFLI KIETWHKPDL GTQENVHKLE PEAWKHVEAI YIDIADRSQV
160 170 180 190 200
LSKDYKAEED PAKFKSIKTG RGPLGPNWKQ ELVNQKDCPY MCAYKLVTVK
210 220 230 240 250
FKWWGLQNKV ENFIHKQEKR LFTNFHRQLF CWLDKWVDLT MDDIRRMEEE
260 270
TKRQLDEMRQ KDPVKGMTAD D
Length:271
Mass (Da):31,907
Last modified:January 23, 2007 - v2
Checksum:iF06794CD1930EDA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → H AA sequence (PubMed:3606604).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25758 mRNA. Translation: AAA41984.1.
BC070945 mRNA. Translation: AAH70945.1.
PIRiA34391.
RefSeqiNP_058927.1. NM_017231.1.
UniGeneiRn.9771.

Genome annotation databases

EnsembliENSRNOT00000090554; ENSRNOP00000072145; ENSRNOG00000003846.
GeneIDi29525.
KEGGirno:29525.

Similar proteinsi

Entry informationi

Entry nameiPIPNA_RAT
AccessioniPrimary (citable) accession number: P16446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families