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Protein

D site-binding protein

Gene

Dbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • circadian rhythm Source: InterPro
  • liver development Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
D site albumin promoter-binding protein 1
Gene namesi
Name:Dbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2491. Dbp.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765091 – 325D site-binding proteinAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP16443.

PTM databases

iPTMnetiP16443.
PhosphoSitePlusiP16443.

Expressioni

Tissue specificityi

Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Developmental stagei

Expressed late in ontogeny.1 Publication

Gene expression databases

BgeeiENSRNOG00000021027.
ExpressionAtlasiP16443. baseline and differential.
GenevisibleiP16443. RN.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028547.

Structurei

3D structure databases

ProteinModelPortaliP16443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 318bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 279Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni283 – 297Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 135Poly-Pro7
Compositional biasi156 – 161Poly-Ser6
Compositional biasi188 – 239Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDK1. Eukaryota.
ENOG410YAPB. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiP16443.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG091G0EO0.
PhylomeDBiP16443.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 2 hits.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK
60 70 80 90 100
EKERKATLPS APVPGPVLET AGPADAPTGA VSGGGSPRGR SGPVAGPSLF
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP
160 170 180 190 200
SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGTL
Length:325
Mass (Da):34,436
Last modified:August 1, 1991 - v2
Checksum:iD9B2A53FF18455B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03179 mRNA. Translation: AAA41083.1.
BC087668 mRNA. Translation: AAH87668.1.
PIRiA34894.
RefSeqiNP_036675.1. NM_012543.3.
UniGeneiRn.11274.

Genome annotation databases

EnsembliENSRNOT00000028546; ENSRNOP00000028547; ENSRNOG00000021027.
GeneIDi24309.
KEGGirno:24309.
UCSCiRGD:2491. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03179 mRNA. Translation: AAA41083.1.
BC087668 mRNA. Translation: AAH87668.1.
PIRiA34894.
RefSeqiNP_036675.1. NM_012543.3.
UniGeneiRn.11274.

3D structure databases

ProteinModelPortaliP16443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028547.

PTM databases

iPTMnetiP16443.
PhosphoSitePlusiP16443.

Proteomic databases

PaxDbiP16443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028546; ENSRNOP00000028547; ENSRNOG00000021027.
GeneIDi24309.
KEGGirno:24309.
UCSCiRGD:2491. rat.

Organism-specific databases

CTDi1628.
RGDi2491. Dbp.

Phylogenomic databases

eggNOGiENOG410KDK1. Eukaryota.
ENOG410YAPB. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiP16443.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG091G0EO0.
PhylomeDBiP16443.
TreeFamiTF315869.

Miscellaneous databases

PROiP16443.

Gene expression databases

BgeeiENSRNOG00000021027.
ExpressionAtlasiP16443. baseline and differential.
GenevisibleiP16443. RN.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 2 hits.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP_RAT
AccessioniPrimary (citable) accession number: P16443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.