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Protein

Formate hydrogenlyase subunit 7

Gene

hycG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi51Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi115Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi145Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:HYCG-MONOMER
MetaCyc:HYCG-MONOMER

Protein family/group databases

TCDBi3.D.1.9.2 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase subunit 7
Short name:
FHL subunit 7
Alternative name(s):
Hydrogenase-3 component G
Gene namesi
Name:hycG
Synonyms:hevG
Ordered Locus Names:b2719, JW2689
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10480 hycG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001187801 – 255Formate hydrogenlyase subunit 7Add BLAST255

Proteomic databases

PaxDbiP16433
PRIDEiP16433

Interactioni

Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway molecular hydrogen and carbodioxide from formate are released.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4262939, 20 interactors
DIPiDIP-9977N
IntActiP16433, 10 interactors
MINTiP16433
STRINGi316385.ECDH10B_2887

Structurei

3D structure databases

ProteinModelPortaliP16433
SMRiP16433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4105C47 Bacteria
COG3260 LUCA
HOGENOMiHOG000228250
InParanoidiP16433
KOiK15832
OMAiAYGACGC
PhylomeDBiP16433

Family and domain databases

InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

P16433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLLGPRDA NGIPVPMTVD ESIASMKASL LKKIKRSAYV YRVDCGGCNG
60 70 80 90 100
CEIEIFATLS PLFDAERFGI KVVPSPRHAD ILLFTGAVTR AMRSPALRAW
110 120 130 140 150
QSAPDPKICI SYGACGNSGG IFHDLYCVWG GTDKIVPVDV YIPGCPPTPA
160 170 180 190 200
ATLYGFAMAL GLLEQKIHAR GPGELDEQPA EILHGDMVQP LRVKVDREAR
210 220 230 240 250
RLAGYRYGRQ IADDYLTQLG QGEEQVARWL EAENDPRLNE IVSHLNHVVE

EARIR
Length:255
Mass (Da):27,999
Last modified:November 1, 1997 - v2
Checksum:iB24FBAE3C44F3A10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → G in CAA35552 (PubMed:2187144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA Translation: CAA35552.1
U29579 Genomic DNA Translation: AAA69229.1
U00096 Genomic DNA Translation: AAC75761.1
AP009048 Genomic DNA Translation: BAE76796.1
PIRiS08625
RefSeqiNP_417199.1, NC_000913.3
WP_000067392.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75761; AAC75761; b2719
BAE76796; BAE76796; BAE76796
GeneIDi947191
KEGGiecj:JW2689
eco:b2719
PATRICifig|1411691.4.peg.4022

Similar proteinsi

Entry informationi

Entry nameiHYCG_ECOLI
AccessioniPrimary (citable) accession number: P16433
Secondary accession number(s): Q2MAB0, Q46881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health