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Protein

Formate hydrogenlyase subunit 6

Gene

hycF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Probable electron transfer protein for hydrogenase 3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi43Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi46Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi50Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi75Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi78Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi81Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi85Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:HYCF-MONOMER
MetaCyc:HYCF-MONOMER

Protein family/group databases

TCDBi3.D.1.9.2 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase subunit 6
Short name:
FHL subunit 6
Alternative name(s):
Hydrogenase-3 component F
Gene namesi
Name:hycF
Synonyms:hevF
Ordered Locus Names:b2720, JW2690
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10479 hycF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592661 – 180Formate hydrogenlyase subunit 6Add BLAST180

Proteomic databases

PaxDbiP16432
PRIDEiP16432

Interactioni

Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate.

Protein-protein interaction databases

BioGridi4262940, 11 interactors
IntActiP16432, 10 interactors
MINTiP16432
STRINGi316385.ECDH10B_2888

Structurei

3D structure databases

ProteinModelPortaliP16432
SMRiP16432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 604Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini66 – 954Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RG7 Bacteria
COG1143 LUCA
HOGENOMiHOG000278697
InParanoidiP16432
KOiK15831
OMAiHHRESFE
PhylomeDBiP16432

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P16432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTFIKKVIK TGTATSSYPL EPIAVDKNFR GKPEQNPQQC IGCAACVNAC
60 70 80 90 100
PSNALTVETD LATGELAWEF NLGHCIFCGR CEEVCPTAAI KLSQEYELAV
110 120 130 140 150
WKKEDFLQQS RFALCNCRVC NRPFAVQKEI DYAIALLKHN GDSRAENHRE
160 170 180
SFETCPECKR QKCLVPSDRI ELTRHMKEAI
Length:180
Mass (Da):20,309
Last modified:August 1, 1990 - v1
Checksum:i284B8C507B47DFDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA Translation: CAA35551.1
U29579 Genomic DNA Translation: AAA69230.1
U00096 Genomic DNA Translation: AAC75762.1
AP009048 Genomic DNA Translation: BAE76797.1
PIRiS08624
RefSeqiNP_417200.1, NC_000913.3
WP_000493781.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75762; AAC75762; b2720
BAE76797; BAE76797; BAE76797
GeneIDi947048
KEGGiecj:JW2690
eco:b2720
PATRICifig|1411691.4.peg.4021

Similar proteinsi

Entry informationi

Entry nameiHYCF_ECOLI
AccessioniPrimary (citable) accession number: P16432
Secondary accession number(s): Q2MAA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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