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Protein

Formate hydrogenlyase subunit 3

Gene

hycC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:HYCC-MONOMER
MetaCyc:HYCC-MONOMER

Protein family/group databases

TCDBi3.D.1.9.2 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase subunit 3
Short name:
FHL subunit 3
Alternative name(s):
Hydrogenase-3 component C
Gene namesi
Name:hycC
Synonyms:hevC
Ordered Locus Names:b2723, JW2693
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10476 hycC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 26HelicalSequence analysisAdd BLAST17
Transmembranei44 – 67HelicalSequence analysisAdd BLAST24
Transmembranei76 – 93HelicalSequence analysisAdd BLAST18
Transmembranei116 – 140HelicalSequence analysisAdd BLAST25
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei197 – 218HelicalSequence analysisAdd BLAST22
Transmembranei229 – 251HelicalSequence analysisAdd BLAST23
Transmembranei258 – 280HelicalSequence analysisAdd BLAST23
Transmembranei296 – 312HelicalSequence analysisAdd BLAST17
Transmembranei416 – 440HelicalSequence analysisAdd BLAST25
Transmembranei453 – 476HelicalSequence analysisAdd BLAST24
Transmembranei502 – 521HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180481 – 608Formate hydrogenlyase subunit 3Add BLAST608

Proteomic databases

PaxDbiP16429
PRIDEiP16429

Interactioni

Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway molecular hydrogen and carbodioxide from formate are released.

Protein-protein interaction databases

BioGridi4262104, 8 interactors
DIPiDIP-9973N
IntActiP16429, 2 interactors
STRINGi316385.ECDH10B_2891

Structurei

3D structure databases

ProteinModelPortaliP16429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107R30 Bacteria
COG0651 LUCA
HOGENOMiHOG000278686
InParanoidiP16429
KOiK15828
OMAiHSLFKTT
PhylomeDBiP16429

Family and domain databases

InterProiView protein in InterPro
IPR003918 NADH_UbQ_OxRdtase
IPR001750 ND/Mrp_mem
PfamiView protein in Pfam
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01437 NUOXDRDTASE4

Sequencei

Sequence statusi: Complete.

P16429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAISLINSG VAWFVAAAVL AFLFSFQKAL SGWIAGIGGA VGSLYTAAAG
60 70 80 90 100
FTVLTGAVGV SGALSLVSYD VQISPLNAIW LITLGLCGLF VSLYNIDWHR
110 120 130 140 150
HAQVKCNGLQ INMLMAAAVC AVIASNLGMF VVMAEIMALC AVFLTSNSKE
160 170 180 190 200
GKLWFALGRL GTLLLAIACW LLWQRYGTLD LRLLDMRMQQ LPLGSDIWLL
210 220 230 240 250
GVIGFGLLAG IIPLHGWVPQ AHANASAPAA ALFSTVVMKI GLLGILTLSL
260 270 280 290 300
LGGNAPLWWG IALLVLGMIT AFVGGLYALV EHNIQRLLAY HTLENIGIIL
310 320 330 340 350
LGLGAGVTGI ALEQPALIAL GLVGGLYHLL NHSLFKSVLF LGAGSVWFRT
360 370 380 390 400
GHRDIEKLGG IGKKMPVISI AMLVGLMAMA ALPPLNGFAG EWVIYQSFFK
410 420 430 440 450
LSNSGAFVAR LLGPLLAVGL AITGALAVMC MAKVYGVTFL GAPRTKEAEN
460 470 480 490 500
ATCAPLLMSV SVVALAICCV IGGVAAPWLL PMLSAAVPLP LEPANTTVSQ
510 520 530 540 550
PMITLLLIAC PLLPFIIMAI CKGDRLPSRS RGAAWVCGYD HEKSMVITAH
560 570 580 590 600
GFAMPVKQAF APVLKLRKWL NPVSLVPGWQ CEGSALLFRR MALVELAVLV

VIIVSRGA
Length:608
Mass (Da):64,077
Last modified:November 1, 1997 - v2
Checksum:i7E4F4C63626289B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227A → T in CAA35548 (PubMed:2187144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA Translation: CAA35548.1
U29579 Genomic DNA Translation: AAA69233.1
U00096 Genomic DNA Translation: AAC75765.1
AP009048 Genomic DNA Translation: BAE76800.1
PIRiG65052
RefSeqiNP_417203.1, NC_000913.3
WP_001274396.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75765; AAC75765; b2723
BAE76800; BAE76800; BAE76800
GeneIDi945327
KEGGiecj:JW2693
eco:b2723
PATRICifig|1411691.4.peg.4018

Similar proteinsi

Entry informationi

Entry nameiHYCC_ECOLI
AccessioniPrimary (citable) accession number: P16429
Secondary accession number(s): Q2MAA6, Q46882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health