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Protein

Formate hydrogenlyase subunit 3

Gene

hycC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:HYCC-MONOMER.
ECOL316407:JW2693-MONOMER.
MetaCyc:HYCC-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase subunit 3
Short name:
FHL subunit 3
Alternative name(s):
Hydrogenase-3 component C
Gene namesi
Name:hycC
Synonyms:hevC
Ordered Locus Names:b2723, JW2693
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10476. hycC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 26HelicalSequence analysisAdd BLAST17
Transmembranei44 – 67HelicalSequence analysisAdd BLAST24
Transmembranei76 – 93HelicalSequence analysisAdd BLAST18
Transmembranei116 – 140HelicalSequence analysisAdd BLAST25
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei197 – 218HelicalSequence analysisAdd BLAST22
Transmembranei229 – 251HelicalSequence analysisAdd BLAST23
Transmembranei258 – 280HelicalSequence analysisAdd BLAST23
Transmembranei296 – 312HelicalSequence analysisAdd BLAST17
Transmembranei416 – 440HelicalSequence analysisAdd BLAST25
Transmembranei453 – 476HelicalSequence analysisAdd BLAST24
Transmembranei502 – 521HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180481 – 608Formate hydrogenlyase subunit 3Add BLAST608

Proteomic databases

PaxDbiP16429.
PRIDEiP16429.

Interactioni

Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway molecular hydrogen and carbodioxide from formate are released.

Protein-protein interaction databases

BioGridi4262104. 5 interactors.
DIPiDIP-9973N.
IntActiP16429. 2 interactors.
MINTiMINT-1240211.
STRINGi511145.b2723.

Structurei

3D structure databases

ProteinModelPortaliP16429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107R30. Bacteria.
COG0651. LUCA.
HOGENOMiHOG000278686.
InParanoidiP16429.
KOiK15828.
OMAiHSLFKTT.
PhylomeDBiP16429.

Family and domain databases

InterProiIPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.

Sequencei

Sequence statusi: Complete.

P16429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAISLINSG VAWFVAAAVL AFLFSFQKAL SGWIAGIGGA VGSLYTAAAG
60 70 80 90 100
FTVLTGAVGV SGALSLVSYD VQISPLNAIW LITLGLCGLF VSLYNIDWHR
110 120 130 140 150
HAQVKCNGLQ INMLMAAAVC AVIASNLGMF VVMAEIMALC AVFLTSNSKE
160 170 180 190 200
GKLWFALGRL GTLLLAIACW LLWQRYGTLD LRLLDMRMQQ LPLGSDIWLL
210 220 230 240 250
GVIGFGLLAG IIPLHGWVPQ AHANASAPAA ALFSTVVMKI GLLGILTLSL
260 270 280 290 300
LGGNAPLWWG IALLVLGMIT AFVGGLYALV EHNIQRLLAY HTLENIGIIL
310 320 330 340 350
LGLGAGVTGI ALEQPALIAL GLVGGLYHLL NHSLFKSVLF LGAGSVWFRT
360 370 380 390 400
GHRDIEKLGG IGKKMPVISI AMLVGLMAMA ALPPLNGFAG EWVIYQSFFK
410 420 430 440 450
LSNSGAFVAR LLGPLLAVGL AITGALAVMC MAKVYGVTFL GAPRTKEAEN
460 470 480 490 500
ATCAPLLMSV SVVALAICCV IGGVAAPWLL PMLSAAVPLP LEPANTTVSQ
510 520 530 540 550
PMITLLLIAC PLLPFIIMAI CKGDRLPSRS RGAAWVCGYD HEKSMVITAH
560 570 580 590 600
GFAMPVKQAF APVLKLRKWL NPVSLVPGWQ CEGSALLFRR MALVELAVLV

VIIVSRGA
Length:608
Mass (Da):64,077
Last modified:November 1, 1997 - v2
Checksum:i7E4F4C63626289B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227A → T in CAA35548 (PubMed:2187144).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA. Translation: CAA35548.1.
U29579 Genomic DNA. Translation: AAA69233.1.
U00096 Genomic DNA. Translation: AAC75765.1.
AP009048 Genomic DNA. Translation: BAE76800.1.
PIRiG65052.
RefSeqiNP_417203.1. NC_000913.3.
WP_001274396.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75765; AAC75765; b2723.
BAE76800; BAE76800; BAE76800.
GeneIDi945327.
KEGGiecj:JW2693.
eco:b2723.
PATRICi32120846. VBIEscCol129921_2815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA. Translation: CAA35548.1.
U29579 Genomic DNA. Translation: AAA69233.1.
U00096 Genomic DNA. Translation: AAC75765.1.
AP009048 Genomic DNA. Translation: BAE76800.1.
PIRiG65052.
RefSeqiNP_417203.1. NC_000913.3.
WP_001274396.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP16429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262104. 5 interactors.
DIPiDIP-9973N.
IntActiP16429. 2 interactors.
MINTiMINT-1240211.
STRINGi511145.b2723.

Protein family/group databases

TCDBi3.D.1.9.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP16429.
PRIDEiP16429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75765; AAC75765; b2723.
BAE76800; BAE76800; BAE76800.
GeneIDi945327.
KEGGiecj:JW2693.
eco:b2723.
PATRICi32120846. VBIEscCol129921_2815.

Organism-specific databases

EchoBASEiEB0471.
EcoGeneiEG10476. hycC.

Phylogenomic databases

eggNOGiENOG4107R30. Bacteria.
COG0651. LUCA.
HOGENOMiHOG000278686.
InParanoidiP16429.
KOiK15828.
OMAiHSLFKTT.
PhylomeDBiP16429.

Enzyme and pathway databases

BioCyciEcoCyc:HYCC-MONOMER.
ECOL316407:JW2693-MONOMER.
MetaCyc:HYCC-MONOMER.

Miscellaneous databases

PROiP16429.

Family and domain databases

InterProiIPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
ProtoNetiSearch...

Entry informationi

Entry nameiHYCC_ECOLI
AccessioniPrimary (citable) accession number: P16429
Secondary accession number(s): Q2MAA6, Q46882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.