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Protein

Epithelial cell adhesion molecule

Gene

EPCAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.4 Publications

GO - Molecular functioni

  • protein complex binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of stem cell proliferation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • signal transduction involved in regulation of gene expression Source: UniProtKB
  • stem cell differentiation Source: UniProtKB
  • ureteric bud development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Protein family/group databases

MEROPSiI31.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell adhesion molecule
Short name:
Ep-CAM
Alternative name(s):
Adenocarcinoma-associated antigen
Cell surface glycoprotein Trop-1
Epithelial cell surface antigen
Epithelial glycoprotein
Short name:
EGP
Epithelial glycoprotein 314
Short name:
EGP314
Short name:
hEGP314
KS 1/4 antigen
KSA
Major gastrointestinal tumor-associated protein GA733-2
Tumor-associated calcium signal transducer 1
CD_antigen: CD326
Gene namesi
Name:EPCAM
Synonyms:GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11529. EPCAM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 265242ExtracellularSequence AnalysisAdd
BLAST
Transmembranei266 – 28823HelicalSequence AnalysisAdd
BLAST
Topological domaini289 – 31426CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: UniProtKB
  • cell surface Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Diarrhea 5, with tufting enteropathy, congenital (DIAR5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.

See also OMIM:613217
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661C → Y in DIAR5. 1 Publication
VAR_063829
Hereditary non-polyposis colorectal cancer 8 (HNPCC8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.

Disease descriptionAn autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.

See also OMIM:613244

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi74 – 741N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-111 and A-198. 1 Publication
Mutagenesisi111 – 1111N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-198. 1 Publication
Mutagenesisi198 – 1981N → A: Decreased glycosyation, reduced protein stability and significant decrease in protein expression. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-111. 1 Publication

Keywords - Diseasei

Disease mutation, Hereditary nonpolyposis colorectal cancer

Organism-specific databases

MIMi613217. phenotype.
613244. phenotype.
Orphaneti144. Hereditary nonpolyposis colon cancer.
92050. Intestinal epithelial dysplasia.
PharmGKBiPA35493.

Polymorphism and mutation databases

BioMutaiEPCAM.
DMDMi160266056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 314291Epithelial cell adhesion moleculePRO_0000022467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidCurated
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation1 Publication
Disulfide bondi29 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 48PROSITE-ProRule annotation1 Publication
Disulfide bondi66 ↔ 99PROSITE-ProRule annotation1 Publication
Glycosylationi74 – 741N-linked (GlcNAc...); partial2 Publications
Disulfide bondi110 ↔ 116PROSITE-ProRule annotation1 Publication
Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
Disulfide bondi118 ↔ 135PROSITE-ProRule annotation1 Publication
Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications

Post-translational modificationi

Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP16422.
PaxDbiP16422.
PRIDEiP16422.

PTM databases

PhosphoSiteiP16422.

Expressioni

Tissue specificityi

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.1 Publication

Gene expression databases

BgeeiP16422.
CleanExiHS_EPCAM.
ExpressionAtlasiP16422. baseline and differential.
GenevisibleiP16422. HS.

Organism-specific databases

HPAiCAB003809.
CAB030012.
HPA026761.

Interactioni

Subunit structurei

Monomer. Interacts with phosphorylated CLDN7.2 Publications

Protein-protein interaction databases

BioGridi110250. 4 interactions.
IntActiP16422. 1 interaction.
MINTiMINT-4999389.
STRINGi9606.ENSP00000263735.

Structurei

Secondary structure

1
314
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 406Combined sources
Beta strandi46 – 505Combined sources
Beta strandi56 – 583Combined sources
Helixi65 – 728Combined sources
Turni73 – 753Combined sources
Beta strandi107 – 1115Combined sources
Turni112 – 1143Combined sources
Beta strandi115 – 1206Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi141 – 15010Combined sources
Helixi159 – 17315Combined sources
Helixi178 – 1803Combined sources
Beta strandi181 – 1877Combined sources
Beta strandi190 – 1967Combined sources
Turni199 – 2013Combined sources
Helixi209 – 22012Combined sources
Beta strandi226 – 2283Combined sources
Helixi244 – 2463Combined sources
Beta strandi248 – 2558Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MZVX-ray1.86A24-265[»]
ProteinModelPortaliP16422.
SMRiP16422. Positions 24-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13573Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EPCAM family.Curated
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46689.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
InParanoidiP16422.
KOiK06737.
OrthoDBiEOG7N0C5D.
PhylomeDBiP16422.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS
60 70 80 90 100
VGAQNTVICS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD
110 120 130 140 150
ESGLFKAKQC NGTSMCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH
160 170 180 190 200
KAREKPYDSK SLRTALQKEI TTRYQLDPKF ITSILYENNV ITIDLVQNSS
210 220 230 240 250
QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL DLDPGQTLIY
260 270 280 290 300
YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA
310
EIKEMGEMHR ELNA
Length:314
Mass (Da):34,932
Last modified:November 13, 2007 - v2
Checksum:i023FCE418B2F1079
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771I → M in AAA36151 (PubMed:2463074).Curated
Sequence conflicti277 – 2771I → M in CAA32870 (PubMed:2463074).Curated
Sequence conflicti277 – 2771I → M in AAA59543 (PubMed:2469722).Curated
Sequence conflicti303 – 3031K → R in CAG47055 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661C → Y in DIAR5. 1 Publication
VAR_063829
Natural varianti115 – 1151M → T.4 Publications
Corresponds to variant rs1126497 [ dbSNP | Ensembl ].
VAR_018329

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32325 mRNA. Translation: AAA36151.1.
X14758 mRNA. Translation: CAA32870.1.
M26481 mRNA. Translation: AAA59543.1.
M32306 mRNA. Translation: AAA35723.1.
M33011 mRNA. Translation: AAA35861.1.
M93036
, M93029, M93030, M93031, M93032, M93033, M93034, M93035 Genomic DNA. Translation: AAB00775.1.
CR542259 mRNA. Translation: CAG47055.1.
CR542283 mRNA. Translation: CAG47078.1.
AC079775 Genomic DNA. Translation: AAY15095.1.
CH471053 Genomic DNA. Translation: EAX00218.1.
BC014785 mRNA. Translation: AAH14785.1.
CCDSiCCDS1833.1.
PIRiB48149.
RefSeqiNP_002345.2. NM_002354.2.
UniGeneiHs.542050.

Genome annotation databases

EnsembliENST00000263735; ENSP00000263735; ENSG00000119888.
GeneIDi4072.
KEGGihsa:4072.
UCSCiuc002rvx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32325 mRNA. Translation: AAA36151.1.
X14758 mRNA. Translation: CAA32870.1.
M26481 mRNA. Translation: AAA59543.1.
M32306 mRNA. Translation: AAA35723.1.
M33011 mRNA. Translation: AAA35861.1.
M93036
, M93029, M93030, M93031, M93032, M93033, M93034, M93035 Genomic DNA. Translation: AAB00775.1.
CR542259 mRNA. Translation: CAG47055.1.
CR542283 mRNA. Translation: CAG47078.1.
AC079775 Genomic DNA. Translation: AAY15095.1.
CH471053 Genomic DNA. Translation: EAX00218.1.
BC014785 mRNA. Translation: AAH14785.1.
CCDSiCCDS1833.1.
PIRiB48149.
RefSeqiNP_002345.2. NM_002354.2.
UniGeneiHs.542050.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4MZVX-ray1.86A24-265[»]
ProteinModelPortaliP16422.
SMRiP16422. Positions 24-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110250. 4 interactions.
IntActiP16422. 1 interaction.
MINTiMINT-4999389.
STRINGi9606.ENSP00000263735.

Protein family/group databases

MEROPSiI31.006.

PTM databases

PhosphoSiteiP16422.

Polymorphism and mutation databases

BioMutaiEPCAM.
DMDMi160266056.

Proteomic databases

MaxQBiP16422.
PaxDbiP16422.
PRIDEiP16422.

Protocols and materials databases

DNASUi4072.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263735; ENSP00000263735; ENSG00000119888.
GeneIDi4072.
KEGGihsa:4072.
UCSCiuc002rvx.3. human.

Organism-specific databases

CTDi4072.
GeneCardsiGC02P047572.
GeneReviewsiEPCAM.
H-InvDBHIX0002040.
HGNCiHGNC:11529. EPCAM.
HPAiCAB003809.
CAB030012.
HPA026761.
MIMi185535. gene.
613217. phenotype.
613244. phenotype.
neXtProtiNX_P16422.
Orphaneti144. Hereditary nonpolyposis colon cancer.
92050. Intestinal epithelial dysplasia.
PharmGKBiPA35493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46689.
GeneTreeiENSGT00390000018245.
HOGENOMiHOG000074086.
InParanoidiP16422.
KOiK06737.
OrthoDBiEOG7N0C5D.
PhylomeDBiP16422.
TreeFamiTF332767.

Miscellaneous databases

ChiTaRSiEPCAM. human.
GeneWikiiEpithelial_cell_adhesion_molecule.
GenomeRNAii4072.
NextBioi15964.
PROiP16422.
SOURCEiSearch...

Gene expression databases

BgeeiP16422.
CleanExiHS_EPCAM.
ExpressionAtlasiP16422. baseline and differential.
GenevisibleiP16422. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA."
    Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D., Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.
    Cancer Res. 49:314-317(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
    Tissue: Lung adenocarcinoma.
  2. "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker."
    Perez M.S., Walker L.E.
    J. Immunol. 142:3662-3667(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
  3. "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein."
    Simon B., Podolsky D.K., Moldenhauer G., Isselbacher K.J., Gattoni-Celli S., Brand S.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  5. "Retroposition in a family of carcinoma-associated antigen genes."
    Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
    Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphoma.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-115.
    Tissue: Ovary.
  10. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
    Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
    Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126.
    Tissue: Placenta.
  11. "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody."
    Bjoerk P., Joensson U., Svedberg H., Larsson K., Lind P., Dillner J., Hedlund G., Dohlsten M., Kalland T.
    J. Biol. Chem. 268:24232-24241(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-100, SUBUNIT.
  12. "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."
    Chong J.M., Speicher D.W.
    J. Biol. Chem. 276:5804-5813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-111.
  13. "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."
    Muenz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O.
    Oncogene 23:5748-5758(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  14. "The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."
    Muenz M., Zeidler R., Gires O.
    Cancer Lett. 225:151-157(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
    Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
    Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CLDN7.
  16. "Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."
    Munz M., Fellinger K., Hofmann T., Schmitt B., Gires O.
    Front. Biosci. 13:5195-5201(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-74; ASN-111 AND ASN-198, MUTAGENESIS OF ASN-74; ASN-111 AND ASN-198.
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
    Tissue: Liver.
  18. Cited for: INVOLVEMENT IN HNPCC8.
  19. "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells."
    Lu T.Y., Lu R.M., Liao M.Y., Yu J., Chung C.H., Kao C.F., Wu H.C.
    J. Biol. Chem. 285:8719-8732(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  20. "Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."
    Ng V.Y., Ang S.N., Chan J.X., Choo A.B.
    Stem Cells 28:29-35(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. Cited for: VARIANT DIAR5 TYR-66.

Entry informationi

Entry nameiEPCAM_HUMAN
AccessioniPrimary (citable) accession number: P16422
Secondary accession number(s): P18180
, Q6FG26, Q6FG49, Q96C47, Q9UCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 13, 2007
Last modified: June 24, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.