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P16422

- EPCAM_HUMAN

UniProt

P16422 - EPCAM_HUMAN

Protein

Epithelial cell adhesion molecule

Gene

EPCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.4 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein complex binding Source: UniProt

    GO - Biological processi

    1. negative regulation of cell-cell adhesion mediated by cadherin Source: UniProt
    2. positive regulation of cell proliferation Source: UniProtKB
    3. positive regulation of stem cell proliferation Source: UniProt
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProt
    5. signal transduction involved in regulation of gene expression Source: UniProt
    6. stem cell differentiation Source: UniProt
    7. ureteric bud development Source: Ensembl

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epithelial cell adhesion molecule
    Short name:
    Ep-CAM
    Alternative name(s):
    Adenocarcinoma-associated antigen
    Cell surface glycoprotein Trop-1
    Epithelial cell surface antigen
    Epithelial glycoprotein
    Short name:
    EGP
    Epithelial glycoprotein 314
    Short name:
    EGP314
    Short name:
    hEGP314
    KS 1/4 antigen
    KSA
    Major gastrointestinal tumor-associated protein GA733-2
    Tumor-associated calcium signal transducer 1
    CD_antigen: CD326
    Gene namesi
    Name:EPCAM
    Synonyms:GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11529. EPCAM.

    Subcellular locationi

    Lateral cell membrane; Single-pass type I membrane protein. Cell junctiontight junction
    Note: Colocalizes with CLDN7 at the lateral cell membrane and tight junction.

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basolateral plasma membrane Source: MGI
    3. cell surface Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of membrane Source: UniProtKB-KW
    6. lateral plasma membrane Source: UniProtKB
    7. plasma membrane Source: UniProtKB
    8. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Involvement in diseasei

    Diarrhea 5, with tufting enteropathy, congenital (DIAR5) [MIM:613217]: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661C → Y in DIAR5. 1 Publication
    VAR_063829
    Hereditary non-polyposis colorectal cancer 8 (HNPCC8) [MIM:613244]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi74 – 741N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-111 and A-198. 1 Publication
    Mutagenesisi111 – 1111N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-198. 1 Publication
    Mutagenesisi198 – 1981N → A: Decreased glycosyation, reduced protein stability and significant decrease in protein expression. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-111. 1 Publication

    Keywords - Diseasei

    Disease mutation, Hereditary nonpolyposis colorectal cancer

    Organism-specific databases

    MIMi613217. phenotype.
    613244. phenotype.
    Orphaneti144. Hereditary nonpolyposis colon cancer.
    92050. Intestinal epithelial dysplasia.
    PharmGKBiPA35493.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 314291Epithelial cell adhesion moleculePRO_0000022467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidCurated
    Disulfide bondi27 ↔ 461 PublicationPROSITE-ProRule annotation
    Disulfide bondi29 ↔ 591 PublicationPROSITE-ProRule annotation
    Disulfide bondi38 ↔ 481 PublicationPROSITE-ProRule annotation
    Disulfide bondi66 ↔ 991 PublicationPROSITE-ProRule annotation
    Glycosylationi74 – 741N-linked (GlcNAc...); partial2 Publications
    Disulfide bondi110 ↔ 1161 PublicationPROSITE-ProRule annotation
    Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
    Disulfide bondi118 ↔ 1351 PublicationPROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications

    Post-translational modificationi

    Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP16422.
    PaxDbiP16422.
    PRIDEiP16422.

    PTM databases

    PhosphoSiteiP16422.

    Expressioni

    Tissue specificityi

    Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.1 Publication

    Gene expression databases

    ArrayExpressiP16422.
    BgeeiP16422.
    CleanExiHS_EPCAM.
    GenevestigatoriP16422.

    Organism-specific databases

    HPAiCAB003809.
    CAB030012.
    HPA026761.

    Interactioni

    Subunit structurei

    Monomer. Interacts with phosphorylated CLDN7.2 Publications

    Protein-protein interaction databases

    BioGridi110250. 4 interactions.
    IntActiP16422. 1 interaction.
    MINTiMINT-4999389.
    STRINGi9606.ENSP00000263735.

    Structurei

    3D structure databases

    ProteinModelPortaliP16422.
    SMRiP16422. Positions 92-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 265242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 31426CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei266 – 28823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 13573Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPCAM family.Curated
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46689.
    HOGENOMiHOG000074086.
    KOiK06737.
    OrthoDBiEOG7N0C5D.
    PhylomeDBiP16422.
    TreeFamiTF332767.

    Family and domain databases

    Gene3Di4.10.800.10. 1 hit.
    InterProiIPR000716. Thyroglobulin_1.
    [Graphical view]
    PfamiPF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS    50
    VGAQNTVICS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD 100
    ESGLFKAKQC NGTSMCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH 150
    KAREKPYDSK SLRTALQKEI TTRYQLDPKF ITSILYENNV ITIDLVQNSS 200
    QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL DLDPGQTLIY 250
    YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 300
    EIKEMGEMHR ELNA 314
    Length:314
    Mass (Da):34,932
    Last modified:November 13, 2007 - v2
    Checksum:i023FCE418B2F1079
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti277 – 2771I → M in AAA36151. (PubMed:2463074)Curated
    Sequence conflicti277 – 2771I → M in CAA32870. (PubMed:2463074)Curated
    Sequence conflicti277 – 2771I → M in AAA59543. (PubMed:2469722)Curated
    Sequence conflicti303 – 3031K → R in CAG47055. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661C → Y in DIAR5. 1 Publication
    VAR_063829
    Natural varianti115 – 1151M → T.4 Publications
    Corresponds to variant rs1126497 [ dbSNP | Ensembl ].
    VAR_018329

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32325 mRNA. Translation: AAA36151.1.
    X14758 mRNA. Translation: CAA32870.1.
    M26481 mRNA. Translation: AAA59543.1.
    M32306 mRNA. Translation: AAA35723.1.
    M33011 mRNA. Translation: AAA35861.1.
    M93036
    , M93029, M93030, M93031, M93032, M93033, M93034, M93035 Genomic DNA. Translation: AAB00775.1.
    CR542259 mRNA. Translation: CAG47055.1.
    CR542283 mRNA. Translation: CAG47078.1.
    AC079775 Genomic DNA. Translation: AAY15095.1.
    CH471053 Genomic DNA. Translation: EAX00218.1.
    BC014785 mRNA. Translation: AAH14785.1.
    CCDSiCCDS1833.1.
    PIRiB48149.
    RefSeqiNP_002345.2. NM_002354.2.
    UniGeneiHs.542050.

    Genome annotation databases

    EnsembliENST00000263735; ENSP00000263735; ENSG00000119888.
    GeneIDi4072.
    KEGGihsa:4072.
    UCSCiuc002rvx.3. human.

    Polymorphism databases

    DMDMi160266056.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32325 mRNA. Translation: AAA36151.1 .
    X14758 mRNA. Translation: CAA32870.1 .
    M26481 mRNA. Translation: AAA59543.1 .
    M32306 mRNA. Translation: AAA35723.1 .
    M33011 mRNA. Translation: AAA35861.1 .
    M93036
    , M93029 , M93030 , M93031 , M93032 , M93033 , M93034 , M93035 Genomic DNA. Translation: AAB00775.1 .
    CR542259 mRNA. Translation: CAG47055.1 .
    CR542283 mRNA. Translation: CAG47078.1 .
    AC079775 Genomic DNA. Translation: AAY15095.1 .
    CH471053 Genomic DNA. Translation: EAX00218.1 .
    BC014785 mRNA. Translation: AAH14785.1 .
    CCDSi CCDS1833.1.
    PIRi B48149.
    RefSeqi NP_002345.2. NM_002354.2.
    UniGenei Hs.542050.

    3D structure databases

    ProteinModelPortali P16422.
    SMRi P16422. Positions 92-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110250. 4 interactions.
    IntActi P16422. 1 interaction.
    MINTi MINT-4999389.
    STRINGi 9606.ENSP00000263735.

    PTM databases

    PhosphoSitei P16422.

    Polymorphism databases

    DMDMi 160266056.

    Proteomic databases

    MaxQBi P16422.
    PaxDbi P16422.
    PRIDEi P16422.

    Protocols and materials databases

    DNASUi 4072.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263735 ; ENSP00000263735 ; ENSG00000119888 .
    GeneIDi 4072.
    KEGGi hsa:4072.
    UCSCi uc002rvx.3. human.

    Organism-specific databases

    CTDi 4072.
    GeneCardsi GC02P047572.
    GeneReviewsi EPCAM.
    H-InvDB HIX0002040.
    HGNCi HGNC:11529. EPCAM.
    HPAi CAB003809.
    CAB030012.
    HPA026761.
    MIMi 185535. gene.
    613217. phenotype.
    613244. phenotype.
    neXtProti NX_P16422.
    Orphaneti 144. Hereditary nonpolyposis colon cancer.
    92050. Intestinal epithelial dysplasia.
    PharmGKBi PA35493.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46689.
    HOGENOMi HOG000074086.
    KOi K06737.
    OrthoDBi EOG7N0C5D.
    PhylomeDBi P16422.
    TreeFami TF332767.

    Miscellaneous databases

    ChiTaRSi EPCAM. human.
    GeneWikii Epithelial_cell_adhesion_molecule.
    GenomeRNAii 4072.
    NextBioi 15964.
    PROi P16422.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P16422.
    Bgeei P16422.
    CleanExi HS_EPCAM.
    Genevestigatori P16422.

    Family and domain databases

    Gene3Di 4.10.800.10. 1 hit.
    InterProi IPR000716. Thyroglobulin_1.
    [Graphical view ]
    Pfami PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA."
      Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D., Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.
      Cancer Res. 49:314-317(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
      Tissue: Lung adenocarcinoma.
    2. "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker."
      Perez M.S., Walker L.E.
      J. Immunol. 142:3662-3667(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
    3. "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein."
      Simon B., Podolsky D.K., Moldenhauer G., Isselbacher K.J., Gattoni-Celli S., Brand S.J.
      Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    5. "Retroposition in a family of carcinoma-associated antigen genes."
      Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
      Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lymphoma.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-115.
      Tissue: Ovary.
    10. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
      Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
      Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126.
      Tissue: Placenta.
    11. "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody."
      Bjoerk P., Joensson U., Svedberg H., Larsson K., Lind P., Dillner J., Hedlund G., Dohlsten M., Kalland T.
      J. Biol. Chem. 268:24232-24241(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-100, SUBUNIT.
    12. "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."
      Chong J.M., Speicher D.W.
      J. Biol. Chem. 276:5804-5813(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-111.
    13. "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."
      Muenz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O.
      Oncogene 23:5748-5758(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    14. "The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."
      Muenz M., Zeidler R., Gires O.
      Cancer Lett. 225:151-157(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
      Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
      Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CLDN7.
    16. "Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."
      Munz M., Fellinger K., Hofmann T., Schmitt B., Gires O.
      Front. Biosci. 13:5195-5201(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-74; ASN-111 AND ASN-198, MUTAGENESIS OF ASN-74; ASN-111 AND ASN-198.
    17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
      Tissue: Liver.
    18. Cited for: INVOLVEMENT IN HNPCC8.
    19. "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells."
      Lu T.Y., Lu R.M., Liao M.Y., Yu J., Chung C.H., Kao C.F., Wu H.C.
      J. Biol. Chem. 285:8719-8732(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    20. "Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."
      Ng V.Y., Ang S.N., Chan J.X., Choo A.B.
      Stem Cells 28:29-35(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. Cited for: VARIANT DIAR5 TYR-66.

    Entry informationi

    Entry nameiEPCAM_HUMAN
    AccessioniPrimary (citable) accession number: P16422
    Secondary accession number(s): P18180
    , Q6FG26, Q6FG49, Q96C47, Q9UCD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3