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P16422

- EPCAM_HUMAN

UniProt

P16422 - EPCAM_HUMAN

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Protein

Epithelial cell adhesion molecule

Gene
EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.4 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein complex binding Source: UniProt

GO - Biological processi

  1. negative regulation of cell-cell adhesion mediated by cadherin Source: UniProt
  2. positive regulation of cell proliferation Source: UniProtKB
  3. positive regulation of stem cell proliferation Source: UniProt
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProt
  5. signal transduction involved in regulation of gene expression Source: UniProt
  6. stem cell differentiation Source: UniProt
  7. ureteric bud development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell adhesion molecule
Short name:
Ep-CAM
Alternative name(s):
Adenocarcinoma-associated antigen
Cell surface glycoprotein Trop-1
Epithelial cell surface antigen
Epithelial glycoprotein
Short name:
EGP
Epithelial glycoprotein 314
Short name:
EGP314
Short name:
hEGP314
KS 1/4 antigen
KSA
Major gastrointestinal tumor-associated protein GA733-2
Tumor-associated calcium signal transducer 1
CD_antigen: CD326
Gene namesi
Name:EPCAM
Synonyms:GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11529. EPCAM.

Subcellular locationi

Lateral cell membrane; Single-pass type I membrane protein. Cell junctiontight junction
Note: Colocalizes with CLDN7 at the lateral cell membrane and tight junction.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 265242Extracellular Reviewed predictionAdd
BLAST
Transmembranei266 – 28823Helical; Reviewed predictionAdd
BLAST
Topological domaini289 – 31426Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basolateral plasma membrane Source: MGI
  3. cell surface Source: Ensembl
  4. extracellular vesicular exosome Source: UniProt
  5. integral component of membrane Source: UniProtKB-KW
  6. lateral plasma membrane Source: UniProtKB
  7. plasma membrane Source: UniProtKB
  8. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Diarrhea 5, with tufting enteropathy, congenital (DIAR5) [MIM:613217]: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661C → Y in DIAR5. 1 Publication
VAR_063829
Hereditary non-polyposis colorectal cancer 8 (HNPCC8) [MIM:613244]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
Note: The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi74 – 741N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-111 and A-198. 1 Publication
Mutagenesisi111 – 1111N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-198. 1 Publication
Mutagenesisi198 – 1981N → A: Decreased glycosyation, reduced protein stability and significant decrease in protein expression. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-111. 1 Publication

Keywords - Diseasei

Disease mutation, Hereditary nonpolyposis colorectal cancer

Organism-specific databases

MIMi613217. phenotype.
613244. phenotype.
Orphaneti144. Hereditary nonpolyposis colon cancer.
92050. Intestinal epithelial dysplasia.
PharmGKBiPA35493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 314291Epithelial cell adhesion moleculePRO_0000022467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid Inferred
Disulfide bondi27 ↔ 461 Publication
Disulfide bondi29 ↔ 591 Publication
Disulfide bondi38 ↔ 481 Publication
Disulfide bondi66 ↔ 991 Publication
Glycosylationi74 – 741N-linked (GlcNAc...); partial2 Publications
Disulfide bondi110 ↔ 1161 Publication
Glycosylationi111 – 1111N-linked (GlcNAc...)2 Publications
Disulfide bondi118 ↔ 1351 Publication
Glycosylationi198 – 1981N-linked (GlcNAc...)2 Publications

Post-translational modificationi

Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP16422.
PaxDbiP16422.
PRIDEiP16422.

PTM databases

PhosphoSiteiP16422.

Expressioni

Tissue specificityi

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.1 Publication

Gene expression databases

ArrayExpressiP16422.
BgeeiP16422.
CleanExiHS_EPCAM.
GenevestigatoriP16422.

Organism-specific databases

HPAiCAB003809.
CAB030012.
HPA026761.

Interactioni

Subunit structurei

Monomer. Interacts with phosphorylated CLDN7.2 Publications

Protein-protein interaction databases

BioGridi110250. 4 interactions.
IntActiP16422. 1 interaction.
MINTiMINT-4999389.
STRINGi9606.ENSP00000263735.

Structurei

3D structure databases

ProteinModelPortaliP16422.
SMRiP16422. Positions 92-137.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13573Thyroglobulin type-1Add
BLAST

Sequence similaritiesi

Belongs to the EPCAM family.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46689.
HOGENOMiHOG000074086.
KOiK06737.
OrthoDBiEOG7N0C5D.
PhylomeDBiP16422.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16422-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS    50
VGAQNTVICS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD 100
ESGLFKAKQC NGTSMCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH 150
KAREKPYDSK SLRTALQKEI TTRYQLDPKF ITSILYENNV ITIDLVQNSS 200
QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL DLDPGQTLIY 250
YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 300
EIKEMGEMHR ELNA 314
Length:314
Mass (Da):34,932
Last modified:November 13, 2007 - v2
Checksum:i023FCE418B2F1079
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661C → Y in DIAR5. 1 Publication
VAR_063829
Natural varianti115 – 1151M → T.4 Publications
Corresponds to variant rs1126497 [ dbSNP | Ensembl ].
VAR_018329

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771I → M in AAA36151. 1 Publication
Sequence conflicti277 – 2771I → M in CAA32870. 1 Publication
Sequence conflicti277 – 2771I → M in AAA59543. 1 Publication
Sequence conflicti303 – 3031K → R in CAG47055. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32325 mRNA. Translation: AAA36151.1.
X14758 mRNA. Translation: CAA32870.1.
M26481 mRNA. Translation: AAA59543.1.
M32306 mRNA. Translation: AAA35723.1.
M33011 mRNA. Translation: AAA35861.1.
M93036
, M93029, M93030, M93031, M93032, M93033, M93034, M93035 Genomic DNA. Translation: AAB00775.1.
CR542259 mRNA. Translation: CAG47055.1.
CR542283 mRNA. Translation: CAG47078.1.
AC079775 Genomic DNA. Translation: AAY15095.1.
CH471053 Genomic DNA. Translation: EAX00218.1.
BC014785 mRNA. Translation: AAH14785.1.
CCDSiCCDS1833.1.
PIRiB48149.
RefSeqiNP_002345.2. NM_002354.2.
UniGeneiHs.542050.

Genome annotation databases

EnsembliENST00000263735; ENSP00000263735; ENSG00000119888.
GeneIDi4072.
KEGGihsa:4072.
UCSCiuc002rvx.3. human.

Polymorphism databases

DMDMi160266056.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32325 mRNA. Translation: AAA36151.1 .
X14758 mRNA. Translation: CAA32870.1 .
M26481 mRNA. Translation: AAA59543.1 .
M32306 mRNA. Translation: AAA35723.1 .
M33011 mRNA. Translation: AAA35861.1 .
M93036
, M93029 , M93030 , M93031 , M93032 , M93033 , M93034 , M93035 Genomic DNA. Translation: AAB00775.1 .
CR542259 mRNA. Translation: CAG47055.1 .
CR542283 mRNA. Translation: CAG47078.1 .
AC079775 Genomic DNA. Translation: AAY15095.1 .
CH471053 Genomic DNA. Translation: EAX00218.1 .
BC014785 mRNA. Translation: AAH14785.1 .
CCDSi CCDS1833.1.
PIRi B48149.
RefSeqi NP_002345.2. NM_002354.2.
UniGenei Hs.542050.

3D structure databases

ProteinModelPortali P16422.
SMRi P16422. Positions 92-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110250. 4 interactions.
IntActi P16422. 1 interaction.
MINTi MINT-4999389.
STRINGi 9606.ENSP00000263735.

PTM databases

PhosphoSitei P16422.

Polymorphism databases

DMDMi 160266056.

Proteomic databases

MaxQBi P16422.
PaxDbi P16422.
PRIDEi P16422.

Protocols and materials databases

DNASUi 4072.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263735 ; ENSP00000263735 ; ENSG00000119888 .
GeneIDi 4072.
KEGGi hsa:4072.
UCSCi uc002rvx.3. human.

Organism-specific databases

CTDi 4072.
GeneCardsi GC02P047572.
GeneReviewsi EPCAM.
H-InvDB HIX0002040.
HGNCi HGNC:11529. EPCAM.
HPAi CAB003809.
CAB030012.
HPA026761.
MIMi 185535. gene.
613217. phenotype.
613244. phenotype.
neXtProti NX_P16422.
Orphaneti 144. Hereditary nonpolyposis colon cancer.
92050. Intestinal epithelial dysplasia.
PharmGKBi PA35493.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46689.
HOGENOMi HOG000074086.
KOi K06737.
OrthoDBi EOG7N0C5D.
PhylomeDBi P16422.
TreeFami TF332767.

Miscellaneous databases

ChiTaRSi EPCAM. human.
GeneWikii Epithelial_cell_adhesion_molecule.
GenomeRNAii 4072.
NextBioi 15964.
PROi P16422.
SOURCEi Search...

Gene expression databases

ArrayExpressi P16422.
Bgeei P16422.
CleanExi HS_EPCAM.
Genevestigatori P16422.

Family and domain databases

Gene3Di 4.10.800.10. 1 hit.
InterProi IPR000716. Thyroglobulin_1.
[Graphical view ]
Pfami PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
SMARTi SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57610. SSF57610. 1 hit.
PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA."
    Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D., Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.
    Cancer Res. 49:314-317(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
    Tissue: Lung adenocarcinoma.
  2. "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker."
    Perez M.S., Walker L.E.
    J. Immunol. 142:3662-3667(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
  3. "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein."
    Simon B., Podolsky D.K., Moldenhauer G., Isselbacher K.J., Gattoni-Celli S., Brand S.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-115.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  5. "Retroposition in a family of carcinoma-associated antigen genes."
    Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.
    Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphoma.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-115.
    Tissue: Ovary.
  10. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."
    Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.
    Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126.
    Tissue: Placenta.
  11. "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody."
    Bjoerk P., Joensson U., Svedberg H., Larsson K., Lind P., Dillner J., Hedlund G., Dohlsten M., Kalland T.
    J. Biol. Chem. 268:24232-24241(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 82-100, SUBUNIT.
  12. "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."
    Chong J.M., Speicher D.W.
    J. Biol. Chem. 276:5804-5813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-111.
  13. "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."
    Muenz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O.
    Oncogene 23:5748-5758(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  14. "The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."
    Muenz M., Zeidler R., Gires O.
    Cancer Lett. 225:151-157(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
    Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
    Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CLDN7.
  16. "Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."
    Munz M., Fellinger K., Hofmann T., Schmitt B., Gires O.
    Front. Biosci. 13:5195-5201(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-74; ASN-111 AND ASN-198, MUTAGENESIS OF ASN-74; ASN-111 AND ASN-198.
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
    Tissue: Liver.
  18. Cited for: INVOLVEMENT IN HNPCC8.
  19. "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells."
    Lu T.Y., Lu R.M., Liao M.Y., Yu J., Chung C.H., Kao C.F., Wu H.C.
    J. Biol. Chem. 285:8719-8732(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  20. "Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."
    Ng V.Y., Ang S.N., Chan J.X., Choo A.B.
    Stem Cells 28:29-35(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. Cited for: VARIANT DIAR5 TYR-66.

Entry informationi

Entry nameiEPCAM_HUMAN
AccessioniPrimary (citable) accession number: P16422
Secondary accession number(s): P18180
, Q6FG26, Q6FG49, Q96C47, Q9UCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi