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P16415 (ZN823_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 823
Alternative name(s):
Zinc finger protein ZFP-36
Gene names
Name:ZNF823
Synonyms:ZFP36
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 16 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence CAA36064.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610Zinc finger protein 823
PRO_0000047778

Regions

Domain4 – 9794KRAB
Zinc finger164 – 18623C2H2-type 1
Zinc finger192 – 21423C2H2-type 2
Zinc finger220 – 24223C2H2-type 3
Zinc finger248 – 27023C2H2-type 4
Zinc finger276 – 29823C2H2-type 5
Zinc finger304 – 32623C2H2-type 6
Zinc finger332 – 35423C2H2-type 7
Zinc finger360 – 38223C2H2-type 8
Zinc finger388 – 41023C2H2-type 9
Zinc finger416 – 43823C2H2-type 10
Zinc finger444 – 46522C2H2-type 11; atypical
Zinc finger471 – 49323C2H2-type 12
Zinc finger499 – 52123C2H2-type 13
Zinc finger527 – 54923C2H2-type 14
Zinc finger555 – 57723C2H2-type 15
Zinc finger583 – 60523C2H2-type 16

Natural variations

Natural variant5661R → H.
Corresponds to variant rs3745663 [ dbSNP | Ensembl ].
VAR_052909

Sequences

Sequence LengthMass (Da)Tools
P16415 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: BDE96CD36953772B

FASTA61070,270
        10         20         30         40         50         60 
MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ NIGDQCQNAK 

        70         80         90        100        110        120 
RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS GECGEVVLGH SSLNCNIRVD 

       130        140        150        160        170        180 
TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS FQTHERPPTG KKPFDCKECA KTFSSLGNLR 

       190        200        210        220        230        240 
RHMAAHHGDG PYKCKLCGKA FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER 

       250        260        270        280        290        300 
IHTGEKAYEC KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG 

       310        320        330        340        350        360 
EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH ETTHTGEKPY 

       370        380        390        400        410        420 
ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP SLFQRHERTH TGEKPYQCKQ 

       430        440        450        460        470        480 
CGKAFSLAGS LRRHEATHTG VKPYKCQCGK AFSDLSSFQN HETTHTGEKP YECKECGKAF 

       490        500        510        520        530        540 
SCFKYLSQHK RTHTVEKPYE CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT 

       550        560        570        580        590        600 
CLLRHERIHT GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR 

       610 
HKRTHWKDTL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Uterus.
[2]Cunliffe V., Trowsdale J.
Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-548.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC052597 mRNA. Translation: AAH52597.1.
BC063560 mRNA. Translation: AAH63560.1.
X51760 mRNA. Translation: CAA36064.1. Different initiation.
PIRS08686.
RefSeqNP_001073962.1. NM_001080493.2.
UniGeneHs.142167.

3D structure databases

ProteinModelPortalP16415.
SMRP16415. Positions 4-52, 95-578.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120713. 2 interactions.
IntActP16415. 2 interactions.

PTM databases

PhosphoSiteP16415.

Polymorphism databases

DMDM148887464.

Proteomic databases

PaxDbP16415.
PRIDEP16415.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341191; ENSP00000340683; ENSG00000197933.
GeneID55552.
KEGGhsa:55552.
UCSCuc002msm.2. human.

Organism-specific databases

CTD55552.
GeneCardsGC19M011832.
HGNCHGNC:30936. ZNF823.
HPAHPA027058.
neXtProtNX_P16415.
PharmGKBPA162410690.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP16415.
KOK09228.
OMAFRSHMIT.
OrthoDBEOG7KSX7Q.
PhylomeDBP16415.
TreeFamTF338854.

Gene expression databases

ArrayExpressP16415.
BgeeP16415.
CleanExHS_ZFP36.
HS_ZNF823.
GenevestigatorP16415.

Family and domain databases

Gene3D3.30.160.60. 17 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55552.
NextBio60005.
PROP16415.

Entry information

Entry nameZN823_HUMAN
AccessionPrimary (citable) accession number: P16415
Secondary accession number(s): A0PJL4, Q6P4A9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM