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Protein

Zinc finger protein 823

Gene

ZNF823

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46522C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 823
Alternative name(s):
Zinc finger protein ZFP-36
Gene namesi
Name:ZNF823
Synonyms:ZFP36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30936. ZNF823.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Zinc finger protein 823PRO_0000047778Add
BLAST

Proteomic databases

MaxQBiP16415.
PaxDbiP16415.
PRIDEiP16415.

PTM databases

PhosphoSiteiP16415.

Expressioni

Gene expression databases

BgeeiP16415.
CleanExiHS_ZFP36.
HS_ZNF823.
ExpressionAtlasiP16415. baseline and differential.
GenevestigatoriP16415.

Organism-specific databases

HPAiHPA027058.

Interactioni

Protein-protein interaction databases

BioGridi120713. 2 interactions.
IntActiP16415. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP16415.
SMRiP16415. Positions 4-52, 75-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9794KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46522C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP16415.
KOiK09228.
OMAiFRSHMIT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP16415.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16415-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ
60 70 80 90 100
NIGDQCQNAK RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS
110 120 130 140 150
GECGEVVLGH SSLNCNIRVD TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS
160 170 180 190 200
FQTHERPPTG KKPFDCKECA KTFSSLGNLR RHMAAHHGDG PYKCKLCGKA
210 220 230 240 250
FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER IHTGEKAYEC
260 270 280 290 300
KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG
310 320 330 340 350
EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH
360 370 380 390 400
ETTHTGEKPY ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP
410 420 430 440 450
SLFQRHERTH TGEKPYQCKQ CGKAFSLAGS LRRHEATHTG VKPYKCQCGK
460 470 480 490 500
AFSDLSSFQN HETTHTGEKP YECKECGKAF SCFKYLSQHK RTHTVEKPYE
510 520 530 540 550
CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT CLLRHERIHT
560 570 580 590 600
GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR
610
HKRTHWKDTL
Length:610
Mass (Da):70,270
Last modified:June 11, 2007 - v2
Checksum:iBDE96CD36953772B
GO
Isoform 2 (identifier: P16415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: No experimental confirmation available.

Show »
Length:428
Mass (Da):49,594
Checksum:i6682B832965B1F77
GO

Sequence cautioni

The sequence CAA36064.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti566 – 5661R → H.
Corresponds to variant rs3745663 [ dbSNP | Ensembl ].
VAR_052909

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 182182Missing in isoform 2. 1 PublicationVSP_055972Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303213 mRNA. Translation: BAH13920.1.
AC008543 Genomic DNA. No translation available.
BC052597 mRNA. Translation: AAH52597.1.
BC063560 mRNA. Translation: AAH63560.1.
X51760 mRNA. Translation: CAA36064.1. Different initiation.
CCDSiCCDS45981.1. [P16415-1]
PIRiS08686.
RefSeqiNP_001073962.1. NM_001080493.3. [P16415-1]
NP_001284539.1. NM_001297610.1. [P16415-2]
NP_059977.1. NM_017507.1.
UniGeneiHs.142167.

Genome annotation databases

EnsembliENST00000341191; ENSP00000340683; ENSG00000197933. [P16415-1]
GeneIDi55552.
KEGGihsa:55552.
UCSCiuc002msm.2. human. [P16415-1]

Polymorphism databases

DMDMi148887464.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303213 mRNA. Translation: BAH13920.1.
AC008543 Genomic DNA. No translation available.
BC052597 mRNA. Translation: AAH52597.1.
BC063560 mRNA. Translation: AAH63560.1.
X51760 mRNA. Translation: CAA36064.1. Different initiation.
CCDSiCCDS45981.1. [P16415-1]
PIRiS08686.
RefSeqiNP_001073962.1. NM_001080493.3. [P16415-1]
NP_001284539.1. NM_001297610.1. [P16415-2]
NP_059977.1. NM_017507.1.
UniGeneiHs.142167.

3D structure databases

ProteinModelPortaliP16415.
SMRiP16415. Positions 4-52, 75-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120713. 2 interactions.
IntActiP16415. 2 interactions.

PTM databases

PhosphoSiteiP16415.

Polymorphism databases

DMDMi148887464.

Proteomic databases

MaxQBiP16415.
PaxDbiP16415.
PRIDEiP16415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341191; ENSP00000340683; ENSG00000197933. [P16415-1]
GeneIDi55552.
KEGGihsa:55552.
UCSCiuc002msm.2. human. [P16415-1]

Organism-specific databases

CTDi55552.
GeneCardsiGC19M011832.
HGNCiHGNC:30936. ZNF823.
HPAiHPA027058.
neXtProtiNX_P16415.
PharmGKBiPA162410690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP16415.
KOiK09228.
OMAiFRSHMIT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP16415.
TreeFamiTF338854.

Miscellaneous databases

GenomeRNAii55552.
NextBioi35480448.
PROiP16415.

Gene expression databases

BgeeiP16415.
CleanExiHS_ZFP36.
HS_ZNF823.
ExpressionAtlasiP16415. baseline and differential.
GenevestigatoriP16415.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Uterus.
  4. Cunliffe V., Trowsdale J.
    Submitted (JAN-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-548 (ISOFORM 1).

Entry informationi

Entry nameiZN823_HUMAN
AccessioniPrimary (citable) accession number: P16415
Secondary accession number(s): A0PJL4, B7Z8D4, Q6P4A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1990
Last sequence update: June 11, 2007
Last modified: January 6, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.