P16415 (ZN823_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 823

Alternative name(s):
Zinc finger protein ZFP-36

Gene names

Name:	ZNF823
Synonyms:	ZFP36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 16 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence CAA36064.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	Zinc finger protein 823		PRO_0000047778
Regions
	Domain	4 – 97	94	KRAB
	Zinc finger	164 – 186	23	C2H2-type 1
	Zinc finger	192 – 214	23	C2H2-type 2
	Zinc finger	220 – 242	23	C2H2-type 3
	Zinc finger	248 – 270	23	C2H2-type 4
	Zinc finger	276 – 298	23	C2H2-type 5
	Zinc finger	304 – 326	23	C2H2-type 6
	Zinc finger	332 – 354	23	C2H2-type 7
	Zinc finger	360 – 382	23	C2H2-type 8
	Zinc finger	388 – 410	23	C2H2-type 9
	Zinc finger	416 – 438	23	C2H2-type 10
	Zinc finger	444 – 465	22	C2H2-type 11; atypical
	Zinc finger	471 – 493	23	C2H2-type 12
	Zinc finger	499 – 521	23	C2H2-type 13
	Zinc finger	527 – 549	23	C2H2-type 14
	Zinc finger	555 – 577	23	C2H2-type 15
	Zinc finger	583 – 605	23	C2H2-type 16
Natural variations
	Natural variant	566	1	R → H. Corresponds to variant rs3745663 [ dbSNP | Ensembl ].		VAR_052909

Sequences

	Sequence		Length	Mass (Da)
	P16415 [UniParc]. Last modified June 12, 2007. Version 2. Checksum: BDE96CD36953772B	FASTA	610	70,270
	10 20 30 40 50 60 MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ NIGDQCQNAK 70 80 90 100 110 120 RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS GECGEVVLGH SSLNCNIRVD 130 140 150 160 170 180 TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS FQTHERPPTG KKPFDCKECA KTFSSLGNLR 190 200 210 220 230 240 RHMAAHHGDG PYKCKLCGKA FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER 250 260 270 280 290 300 IHTGEKAYEC KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG 310 320 330 340 350 360 EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH ETTHTGEKPY 370 380 390 400 410 420 ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP SLFQRHERTH TGEKPYQCKQ 430 440 450 460 470 480 CGKAFSLAGS LRRHEATHTG VKPYKCQCGK AFSDLSSFQN HETTHTGEKP YECKECGKAF 490 500 510 520 530 540 SCFKYLSQHK RTHTVEKPYE CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT 550 560 570 580 590 600 CLLRHERIHT GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR 610 HKRTHWKDTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Uterus.
[2]	Cunliffe V., Trowsdale J. Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-548.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC052597 mRNA. Translation: AAH52597.1. BC063560 mRNA. Translation: AAH63560.1. X51760 mRNA. Translation: CAA36064.1. Different initiation.
IPI	IPI00174902.
PIR	S08686.
RefSeq	NP_001073962.1. NM_001080493.2.
UniGene	Hs.142167.
3D structure databases
ProteinModelPortal	P16415.
ModBase	Search...
Protein-protein interaction databases
IntAct	P16415. 2 interactions.
PTM databases
PhosphoSite	P16415.
Polymorphism databases
DMDM	148887464.
Proteomic databases
PaxDb	P16415.
PRIDE	P16415.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341191; ENSP00000340683; ENSG00000197933.
GeneID	55552.
KEGG	hsa:55552.
UCSC	uc002msm.2. human.
Organism-specific databases
CTD	55552.
GeneCards	GC19M011832.
HGNC	HGNC:30936. ZNF823.
HPA	HPA027058.
neXtProt	NX_P16415.
PharmGKB	PA162410690.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P16415.
KO	K09228.
OMA	FRSHMIT.
OrthoDB	EOG4HX50G.
Gene expression databases
ArrayExpress	P16415.
Bgee	P16415.
CleanEx	HS_ZFP36. HS_ZNF823.
Genevestigator	P16415.
GermOnline	ENSG00000197933. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 17 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 16 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 15 hits. PS50157. ZINC_FINGER_C2H2_2. 16 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55552.
NextBio	60005.

Entry information

Entry name

ZN823_HUMAN

Accession

Primary (citable) accession number: P16415
Secondary accession number(s): A0PJL4, Q6P4A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.