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Protein

Zinc finger protein 823

Gene

ZNF823

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 465C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri471 – 493C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 823
Alternative name(s):
Zinc finger protein ZFP-36
Gene namesi
Name:ZNF823
Synonyms:ZFP36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197933.12
HGNCiHGNC:30936 ZNF823
neXtProtiNX_P16415

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197933
PharmGKBiPA162410690

Polymorphism and mutation databases

BioMutaiZNF823
DMDMi148887464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477781 – 610Zinc finger protein 823Add BLAST610

Proteomic databases

EPDiP16415
MaxQBiP16415
PaxDbiP16415
PeptideAtlasiP16415
PRIDEiP16415
ProteomicsDBi53358

PTM databases

iPTMnetiP16415
PhosphoSitePlusiP16415

Expressioni

Gene expression databases

BgeeiENSG00000197933
CleanExiHS_ZFP36
HS_ZNF823
ExpressionAtlasiP16415 baseline and differential
GenevisibleiP16415 HS

Interactioni

Protein-protein interaction databases

BioGridi120713, 1 interactor
IntActiP16415, 2 interactors
STRINGi9606.ENSP00000340683

Structurei

3D structure databases

ProteinModelPortaliP16415
SMRiP16415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 97KRABPROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 465C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri471 – 493C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP16415
KOiK09228
OMAiFRSHMIT
OrthoDBiEOG091G02KC
PhylomeDBiP16415
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16415-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ
60 70 80 90 100
NIGDQCQNAK RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS
110 120 130 140 150
GECGEVVLGH SSLNCNIRVD TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS
160 170 180 190 200
FQTHERPPTG KKPFDCKECA KTFSSLGNLR RHMAAHHGDG PYKCKLCGKA
210 220 230 240 250
FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER IHTGEKAYEC
260 270 280 290 300
KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG
310 320 330 340 350
EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH
360 370 380 390 400
ETTHTGEKPY ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP
410 420 430 440 450
SLFQRHERTH TGEKPYQCKQ CGKAFSLAGS LRRHEATHTG VKPYKCQCGK
460 470 480 490 500
AFSDLSSFQN HETTHTGEKP YECKECGKAF SCFKYLSQHK RTHTVEKPYE
510 520 530 540 550
CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT CLLRHERIHT
560 570 580 590 600
GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR
610
HKRTHWKDTL
Length:610
Mass (Da):70,270
Last modified:June 12, 2007 - v2
Checksum:iBDE96CD36953772B
GO
Isoform 2 (identifier: P16415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):49,594
Checksum:i6682B832965B1F77
GO

Sequence cautioni

The sequence CAA36064 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052909566R → H. Corresponds to variant dbSNP:rs3745663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559721 – 182Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303213 mRNA Translation: BAH13920.1
AC008543 Genomic DNA No translation available.
BC052597 mRNA Translation: AAH52597.1
BC063560 mRNA Translation: AAH63560.1
X51760 mRNA Translation: CAA36064.1 Different initiation.
CCDSiCCDS45981.1 [P16415-1]
PIRiS08686
RefSeqiNP_001073962.1, NM_001080493.3 [P16415-1]
NP_001284539.1, NM_001297610.1 [P16415-2]
NP_059977.1, NM_017507.1
XP_016882430.1, XM_017026941.1 [P16415-2]
XP_016882431.1, XM_017026942.1 [P16415-2]
UniGeneiHs.142167

Genome annotation databases

EnsembliENST00000341191; ENSP00000340683; ENSG00000197933 [P16415-1]
GeneIDi55552
KEGGihsa:55552
UCSCiuc002msm.3 human [P16415-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN823_HUMAN
AccessioniPrimary (citable) accession number: P16415
Secondary accession number(s): A0PJL4, B7Z8D4, Q6P4A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 12, 2007
Last modified: June 20, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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