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P16415

- ZN823_HUMAN

UniProt

P16415 - ZN823_HUMAN

Protein

Zinc finger protein 823

Gene

ZNF823

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 18623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46522C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri471 – 49323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 52123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 54923C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57723C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri583 – 60523C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 823
    Alternative name(s):
    Zinc finger protein ZFP-36
    Gene namesi
    Name:ZNF823
    Synonyms:ZFP36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30936. ZNF823.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410690.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610Zinc finger protein 823PRO_0000047778Add
    BLAST

    Proteomic databases

    MaxQBiP16415.
    PaxDbiP16415.
    PRIDEiP16415.

    PTM databases

    PhosphoSiteiP16415.

    Expressioni

    Gene expression databases

    ArrayExpressiP16415.
    BgeeiP16415.
    CleanExiHS_ZFP36.
    HS_ZNF823.
    GenevestigatoriP16415.

    Organism-specific databases

    HPAiHPA027058.

    Interactioni

    Protein-protein interaction databases

    BioGridi120713. 2 interactions.
    IntActiP16415. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP16415.
    SMRiP16415. Positions 4-52, 75-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 9794KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 18623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46522C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri471 – 49323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 52123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri527 – 54923C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57723C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri583 – 60523C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP16415.
    KOiK09228.
    OMAiFRSHMIT.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiP16415.
    TreeFamiTF338854.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P16415-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ    50
    NIGDQCQNAK RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS 100
    GECGEVVLGH SSLNCNIRVD TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS 150
    FQTHERPPTG KKPFDCKECA KTFSSLGNLR RHMAAHHGDG PYKCKLCGKA 200
    FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER IHTGEKAYEC 250
    KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG 300
    EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH 350
    ETTHTGEKPY ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP 400
    SLFQRHERTH TGEKPYQCKQ CGKAFSLAGS LRRHEATHTG VKPYKCQCGK 450
    AFSDLSSFQN HETTHTGEKP YECKECGKAF SCFKYLSQHK RTHTVEKPYE 500
    CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT CLLRHERIHT 550
    GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR 600
    HKRTHWKDTL 610
    Length:610
    Mass (Da):70,270
    Last modified:June 12, 2007 - v2
    Checksum:iBDE96CD36953772B
    GO
    Isoform 2 (identifier: P16415-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-182: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:428
    Mass (Da):49,594
    Checksum:i6682B832965B1F77
    GO

    Sequence cautioni

    The sequence CAA36064.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti566 – 5661R → H.
    Corresponds to variant rs3745663 [ dbSNP | Ensembl ].
    VAR_052909

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 182182Missing in isoform 2. 1 PublicationVSP_055972Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303213 mRNA. Translation: BAH13920.1.
    AC008543 Genomic DNA. No translation available.
    BC052597 mRNA. Translation: AAH52597.1.
    BC063560 mRNA. Translation: AAH63560.1.
    X51760 mRNA. Translation: CAA36064.1. Different initiation.
    CCDSiCCDS45981.1.
    PIRiS08686.
    RefSeqiNP_001073962.1. NM_001080493.2.
    XP_005260039.1. XM_005259982.2.
    UniGeneiHs.142167.

    Genome annotation databases

    EnsembliENST00000341191; ENSP00000340683; ENSG00000197933.
    ENST00000545749; ENSP00000440162; ENSG00000197933.
    GeneIDi55552.
    KEGGihsa:55552.
    UCSCiuc002msm.2. human.

    Polymorphism databases

    DMDMi148887464.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303213 mRNA. Translation: BAH13920.1 .
    AC008543 Genomic DNA. No translation available.
    BC052597 mRNA. Translation: AAH52597.1 .
    BC063560 mRNA. Translation: AAH63560.1 .
    X51760 mRNA. Translation: CAA36064.1 . Different initiation.
    CCDSi CCDS45981.1.
    PIRi S08686.
    RefSeqi NP_001073962.1. NM_001080493.2.
    XP_005260039.1. XM_005259982.2.
    UniGenei Hs.142167.

    3D structure databases

    ProteinModelPortali P16415.
    SMRi P16415. Positions 4-52, 75-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120713. 2 interactions.
    IntActi P16415. 2 interactions.

    PTM databases

    PhosphoSitei P16415.

    Polymorphism databases

    DMDMi 148887464.

    Proteomic databases

    MaxQBi P16415.
    PaxDbi P16415.
    PRIDEi P16415.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341191 ; ENSP00000340683 ; ENSG00000197933 .
    ENST00000545749 ; ENSP00000440162 ; ENSG00000197933 .
    GeneIDi 55552.
    KEGGi hsa:55552.
    UCSCi uc002msm.2. human.

    Organism-specific databases

    CTDi 55552.
    GeneCardsi GC19M011832.
    HGNCi HGNC:30936. ZNF823.
    HPAi HPA027058.
    neXtProti NX_P16415.
    PharmGKBi PA162410690.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P16415.
    KOi K09228.
    OMAi FRSHMIT.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi P16415.
    TreeFami TF338854.

    Miscellaneous databases

    GenomeRNAii 55552.
    NextBioi 60005.
    PROi P16415.

    Gene expression databases

    ArrayExpressi P16415.
    Bgeei P16415.
    CleanExi HS_ZFP36.
    HS_ZNF823.
    Genevestigatori P16415.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Uterus.
    4. Cunliffe V., Trowsdale J.
      Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-548 (ISOFORM 1).

    Entry informationi

    Entry nameiZN823_HUMAN
    AccessioniPrimary (citable) accession number: P16415
    Secondary accession number(s): A0PJL4, B7Z8D4, Q6P4A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3