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P16413

- GSTMU_CAVPO

UniProt

P16413 - GSTMU_CAVPO

Protein

Glutathione S-transferase B

Gene

GSTM1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    • Comment

    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase B (EC:2.5.1.18)
    Short name:
    GST B
    Alternative name(s):
    GST class-mu
    Gene namesi
    Name:GSTM1
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Glutathione S-transferase BPRO_0000185834Add
    BLAST

    Proteomic databases

    PRIDEiP16413.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000007027.

    Structurei

    3D structure databases

    ProteinModelPortaliP16413.
    SMRiP16413. Positions 1-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8787GST N-terminalAdd
    BLAST
    Domaini89 – 207119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni6 – 72Glutathione bindingBy similarity
    Regioni45 – 495Glutathione bindingBy similarity
    Regioni58 – 592Glutathione bindingBy similarity
    Regioni71 – 722Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiP16413.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P16413-1 [UniParc]FASTAAdd to Basket

    « Hide

    PMTLGYWNIR GLTHPIRLIL EYTNSGYEEK RYNMGDAPDY DRSQWLNEKF    50
    KLGLDFPNLP YLIDGTHKLT QSNAILRYIA RKHNLCGVTE EETIRMDILE 100
    NQVMDIRMQL IMLCYSPDFE QKKAEFLEGI PDKMKLFSQF LGKLPWFAGN 150
    KLTYVDFLAY DVLDQYRMLE PKCLEAFPNL KDFISRFEGL EKISSYMKSS 200
    RFLPKPLFSK FAFWNNK 217
    Length:217
    Mass (Da):25,719
    Last modified:August 1, 1990 - v1
    Checksum:iD29F7951D4E9365E
    GO

    Sequence databases

    PIRiJX0095.

    Cross-referencesi

    Sequence databases

    PIRi JX0095.

    3D structure databases

    ProteinModelPortali P16413.
    SMRi P16413. Positions 1-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000007027.

    Proteomic databases

    PRIDEi P16413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG300089.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi P16413.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of glutathione S-transferase b from guinea pig liver."
      Kamei K., Oshino R., Hara S.
      J. Biochem. 107:111-117(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTMU_CAVPO
    AccessioniPrimary (citable) accession number: P16413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3