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P16413

- GSTMU_CAVPO

UniProt

P16413 - GSTMU_CAVPO

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Protein

Glutathione S-transferase B

Gene

GSTM1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151SubstrateBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase B (EC:2.5.1.18)
Short name:
GST B
Alternative name(s):
GST class-mu
Gene namesi
Name:GSTM1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Glutathione S-transferase BPRO_0000185834Add
BLAST

Proteomic databases

PRIDEiP16413.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007027.

Structurei

3D structure databases

ProteinModelPortaliP16413.
SMRiP16413. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8787GST N-terminalAdd
BLAST
Domaini89 – 207119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni6 – 72Glutathione bindingBy similarity
Regioni45 – 495Glutathione bindingBy similarity
Regioni58 – 592Glutathione bindingBy similarity
Regioni71 – 722Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG300089.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP16413.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P16413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PMTLGYWNIR GLTHPIRLIL EYTNSGYEEK RYNMGDAPDY DRSQWLNEKF
60 70 80 90 100
KLGLDFPNLP YLIDGTHKLT QSNAILRYIA RKHNLCGVTE EETIRMDILE
110 120 130 140 150
NQVMDIRMQL IMLCYSPDFE QKKAEFLEGI PDKMKLFSQF LGKLPWFAGN
160 170 180 190 200
KLTYVDFLAY DVLDQYRMLE PKCLEAFPNL KDFISRFEGL EKISSYMKSS
210
RFLPKPLFSK FAFWNNK
Length:217
Mass (Da):25,719
Last modified:August 1, 1990 - v1
Checksum:iD29F7951D4E9365E
GO

Sequence databases

PIRiJX0095.

Cross-referencesi

Sequence databases

PIRi JX0095.

3D structure databases

ProteinModelPortali P16413.
SMRi P16413. Positions 1-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000007027.

Proteomic databases

PRIDEi P16413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG300089.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi P16413.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of glutathione S-transferase b from guinea pig liver."
    Kamei K., Oshino R., Hara S.
    J. Biochem. 107:111-117(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiGSTMU_CAVPO
AccessioniPrimary (citable) accession number: P16413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3