Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P16413 (GSTMU_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase B

Short name=GST B
EC=2.5.1.18
Alternative name(s):
GST class-mu
Gene names
Name:GSTM1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Glutathione S-transferase B
PRO_0000185834

Regions

Domain1 – 8787GST N-terminal
Domain89 – 207119GST C-terminal
Region6 – 72Glutathione binding By similarity
Region45 – 495Glutathione binding By similarity
Region58 – 592Glutathione binding By similarity
Region71 – 722Glutathione binding By similarity

Sites

Binding site1151Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P16413 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: D29F7951D4E9365E

FASTA21725,719
        10         20         30         40         50         60 
PMTLGYWNIR GLTHPIRLIL EYTNSGYEEK RYNMGDAPDY DRSQWLNEKF KLGLDFPNLP 

        70         80         90        100        110        120 
YLIDGTHKLT QSNAILRYIA RKHNLCGVTE EETIRMDILE NQVMDIRMQL IMLCYSPDFE 

       130        140        150        160        170        180 
QKKAEFLEGI PDKMKLFSQF LGKLPWFAGN KLTYVDFLAY DVLDQYRMLE PKCLEAFPNL 

       190        200        210 
KDFISRFEGL EKISSYMKSS RFLPKPLFSK FAFWNNK 

« Hide

References

[1]"Amino acid sequence of glutathione S-transferase b from guinea pig liver."
Kamei K., Oshino R., Hara S.
J. Biochem. 107:111-117(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Liver.

Cross-references

Sequence databases

PIRJX0095.

3D structure databases

ProteinModelPortalP16413.
SMRP16413. Positions 1-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000007027.

Proteomic databases

PRIDEP16413.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG300089.
HOGENOMHOG000115735.
HOVERGENHBG106842.
InParanoidP16413.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTMU_CAVPO
AccessionPrimary (citable) accession number: P16413
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 13, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families