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P16409

- MYL3_RAT

UniProt

P16409 - MYL3_RAT

Protein

Myosin light chain 3

Gene

Myl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regulatory light chain of myosin. Does not bind calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. motor activity Source: RGD

    GO - Biological processi

    1. cardiac muscle contraction Source: RGD
    2. metabolic process Source: GOC
    3. muscle contraction Source: RGD
    4. regulation of striated muscle contraction Source: Ensembl
    5. regulation of the force of heart contraction Source: Ensembl
    6. skeletal muscle tissue development Source: RGD
    7. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin light chain 3
    Alternative name(s):
    Myosin light chain 1, slow-twitch muscle B/ventricular isoform
    Short name:
    MLC1SB
    Ventricular/slow twitch myosin alkali light chain
    Gene namesi
    Name:Myl3
    Synonyms:Mlc1v
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3142. Myl3.

    Subcellular locationi

    GO - Cellular componenti

    1. A band Source: Ensembl
    2. I band Source: Ensembl
    3. myosin complex Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 200199Myosin light chain 3PRO_0000198698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N,N,N-trimethylalanineBy similarity

    Post-translational modificationi

    N-terminus is methylated by METTL11A/NTM1.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiP16409.
    PRIDEiP16409.

    PTM databases

    PhosphoSiteiP16409.

    Expressioni

    Gene expression databases

    GenevestigatoriP16409.

    Interactioni

    Subunit structurei

    Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Protein-protein interaction databases

    BioGridi246728. 1 interaction.
    STRINGi10116.ENSRNOP00000028458.

    Structurei

    3D structure databases

    ProteinModelPortaliP16409.
    SMRiP16409. Positions 50-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 9138EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 16836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 20033EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00590000082921.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiP16409.
    KOiK12749.
    OMAiGRPKQEE.
    OrthoDBiEOG7HQN9N.
    PhylomeDBiP16409.
    TreeFamiTF351553.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P16409-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKKPEPKK DDAKTAAPKA APAPAAAPAA APEPERPKEA EFDASKIKIE    50
    FTPEQIEEFK EAFQLFDRTP KGEMKITYGQ CGDVLRALGQ NPTQAEVLRV 100
    LGKPKQEELN SKMMDFETFL PMLQHISKNK DTGTYEDFVE GLRVFDKEGN 150
    GTVMGAELRH VLATLGERLT EDEVEKLMAG QEDSNGCINY EAFVKHIMAS 200
    Length:200
    Mass (Da):22,156
    Last modified:January 23, 2007 - v2
    Checksum:i2B8C832A9D364253
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14812 mRNA. Translation: CAA32917.1.
    X16325
    , X16326, X16327, X16329, X16330 Genomic DNA. Translation: CAA34388.1.
    BC081832 mRNA. Translation: AAH81832.1.
    PIRiS09573. MORT3V.
    RefSeqiNP_036738.1. NM_012606.2.
    UniGeneiRn.1955.

    Genome annotation databases

    EnsembliENSRNOT00000028458; ENSRNOP00000028458; ENSRNOG00000020955.
    GeneIDi24585.
    KEGGirno:24585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14812 mRNA. Translation: CAA32917.1 .
    X16325
    , X16326 , X16327 , X16329 , X16330 Genomic DNA. Translation: CAA34388.1 .
    BC081832 mRNA. Translation: AAH81832.1 .
    PIRi S09573. MORT3V.
    RefSeqi NP_036738.1. NM_012606.2.
    UniGenei Rn.1955.

    3D structure databases

    ProteinModelPortali P16409.
    SMRi P16409. Positions 50-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246728. 1 interaction.
    STRINGi 10116.ENSRNOP00000028458.

    PTM databases

    PhosphoSitei P16409.

    Proteomic databases

    PaxDbi P16409.
    PRIDEi P16409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028458 ; ENSRNOP00000028458 ; ENSRNOG00000020955 .
    GeneIDi 24585.
    KEGGi rno:24585.

    Organism-specific databases

    CTDi 4634.
    RGDi 3142. Myl3.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00590000082921.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi P16409.
    KOi K12749.
    OMAi GRPKQEE.
    OrthoDBi EOG7HQN9N.
    PhylomeDBi P16409.
    TreeFami TF351553.

    Miscellaneous databases

    NextBioi 603758.
    PROi P16409.

    Gene expression databases

    Genevestigatori P16409.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension."
      McNally E., Buttrick P., Leinwand L.
      Nucleic Acids Res. 17:2753-2767(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart ventricle.
    2. "Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles."
      Periasamy M., Wodgaonkar R., Kumar C., Martin B.J., Siddiqui M.A.Q.
      Nucleic Acids Res. 17:7723-7734(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
      Tissue: Heart ventricle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiMYL3_RAT
    AccessioniPrimary (citable) accession number: P16409
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3