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P16409 (MYL3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin light chain 3
Alternative name(s):
Myosin light chain 1, slow-twitch muscle B/ventricular isoform
Short name=MLC1SB
Ventricular/slow twitch myosin alkali light chain
Gene names
Name:Myl3
Synonyms:Mlc1v
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory light chain of myosin. Does not bind calcium.

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Post-translational modification

N-terminus is methylated by METTL11A/NTM1 By similarity.

Sequence similarities

Contains 3 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 200199Myosin light chain 3
PRO_0000198698

Regions

Domain54 – 9138EF-hand 1
Domain133 – 16836EF-hand 2
Domain168 – 20033EF-hand 3

Amino acid modifications

Modified residue21N,N,N-trimethylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
P16409 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2B8C832A9D364253

FASTA20022,156
        10         20         30         40         50         60 
MAPKKPEPKK DDAKTAAPKA APAPAAAPAA APEPERPKEA EFDASKIKIE FTPEQIEEFK 

        70         80         90        100        110        120 
EAFQLFDRTP KGEMKITYGQ CGDVLRALGQ NPTQAEVLRV LGKPKQEELN SKMMDFETFL 

       130        140        150        160        170        180 
PMLQHISKNK DTGTYEDFVE GLRVFDKEGN GTVMGAELRH VLATLGERLT EDEVEKLMAG 

       190        200 
QEDSNGCINY EAFVKHIMAS 

« Hide

References

« Hide 'large scale' references
[1]"Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension."
McNally E., Buttrick P., Leinwand L.
Nucleic Acids Res. 17:2753-2767(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart ventricle.
[2]"Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles."
Periasamy M., Wodgaonkar R., Kumar C., Martin B.J., Siddiqui M.A.Q.
Nucleic Acids Res. 17:7723-7734(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
Tissue: Heart ventricle.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14812 mRNA. Translation: CAA32917.1.
X16325 expand/collapse EMBL AC list , X16326, X16327, X16329, X16330 Genomic DNA. Translation: CAA34388.1.
BC081832 mRNA. Translation: AAH81832.1.
PIRMORT3V. S09573.
RefSeqNP_036738.1. NM_012606.2.
UniGeneRn.1955.

3D structure databases

ProteinModelPortalP16409.
SMRP16409. Positions 50-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246728. 1 interaction.
STRING10116.ENSRNOP00000028458.

PTM databases

PhosphoSiteP16409.

Proteomic databases

PaxDbP16409.
PRIDEP16409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028458; ENSRNOP00000028458; ENSRNOG00000020955.
GeneID24585.
KEGGrno:24585.

Organism-specific databases

CTD4634.
RGD3142. Myl3.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00590000082921.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidP16409.
KOK12749.
OMARPKEAEF.
OrthoDBEOG7HQN9N.
PhylomeDBP16409.
TreeFamTF351553.

Gene expression databases

GenevestigatorP16409.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio603758.
PROP16409.

Entry information

Entry nameMYL3_RAT
AccessionPrimary (citable) accession number: P16409
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families