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Protein

Lectin

Gene
N/A
Organism
Erythrina corallodendron (Coral tree)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Galactose and N-acetyllactosamine specific lectin. Binds to the H-2 blood type determinant fucosyl-N-acetyllactosamine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Lectin
Alternative name(s):
ECorL
OrganismiErythrina corallodendron (Coral tree)
Taxonomic identifieri3843 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeErythrina

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001761727 – 268LectinAdd BLAST242
PropeptideiPRO_0000017618269 – 281Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)1 Publication1
Glycosylationi139N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

A minor C-terminal proteolytic processing site is observed at position 268.1 Publication

Keywords - PTMi

Glycoprotein

PTM databases

UniCarbKBiP16404.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 36Combined sources9
Beta strandi42 – 48Combined sources7
Beta strandi58 – 61Combined sources4
Beta strandi67 – 69Combined sources3
Beta strandi74 – 81Combined sources8
Turni88 – 90Combined sources3
Beta strandi95 – 103Combined sources9
Beta strandi109 – 111Combined sources3
Beta strandi115 – 123Combined sources9
Helixi132 – 134Combined sources3
Turni135 – 137Combined sources3
Beta strandi138 – 142Combined sources5
Helixi145 – 147Combined sources3
Beta strandi150 – 155Combined sources6
Beta strandi166 – 177Combined sources12
Beta strandi179 – 183Combined sources5
Beta strandi192 – 199Combined sources8
Turni200 – 203Combined sources4
Beta strandi204 – 210Combined sources7
Turni212 – 214Combined sources3
Beta strandi217 – 223Combined sources7
Helixi226 – 228Combined sources3
Beta strandi232 – 242Combined sources11
Beta strandi253 – 263Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AX0X-ray1.90A27-265[»]
1AX1X-ray1.95A27-265[»]
1AX2X-ray1.95A27-265[»]
1AXYX-ray1.95A27-265[»]
1AXZX-ray1.95A27-265[»]
1FYUX-ray2.60A/B27-281[»]
1LTEX-ray2.00A27-265[»]
1SFYX-ray2.55A/B/C/D/E/F27-265[»]
3N35X-ray2.00A27-268[»]
3N36X-ray2.30A27-268[»]
3N3HX-ray2.00A27-268[»]
ProteinModelPortaliP16404.
SMRiP16404.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16404.

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYKLCSVL ALSLTLFLLI LNKVNSVETI SFSFSEFEPG NDNLTLQGAA
60 70 80 90 100
LITQSGVLQL TKINQNGMPA WDSTGRTLYA KPVHIWDMTT GTVASFETRF
110 120 130 140 150
SFSIEQPYTR PLPADGLVFF MGPTKSKPAQ GYGYLGIFNN SKQDNSYQTL
160 170 180 190 200
GVEFDTFSNP WDPPQVPHIG IDVNSIRSIK TQPFQLDNGQ VANVVIKYDA
210 220 230 240 250
SSKILHAVLV YPSSGAIYTI AEIVDVKQVL PEWVDVGLSG ATGAQRDAAE
260 270 280
THDVYSWSFQ ASLPETNDAV IPTSNHNTFA I
Length:281
Mass (Da):30,752
Last modified:July 15, 1998 - v3
Checksum:i311DE5A43AEF1E67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 54AALITQ → DSIPET AA sequence (PubMed:2806566).Curated6
Sequence conflicti139N → F AA sequence (PubMed:2806566).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti48G → A.1
Natural varianti160P → Q.1 Publication1
Natural varianti225D → V.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52782 mRNA. Translation: CAA36986.1.
PIRiS09697.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52782 mRNA. Translation: CAA36986.1.
PIRiS09697.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AX0X-ray1.90A27-265[»]
1AX1X-ray1.95A27-265[»]
1AX2X-ray1.95A27-265[»]
1AXYX-ray1.95A27-265[»]
1AXZX-ray1.95A27-265[»]
1FYUX-ray2.60A/B27-281[»]
1LTEX-ray2.00A27-265[»]
1SFYX-ray2.55A/B/C/D/E/F27-265[»]
3N35X-ray2.00A27-268[»]
3N36X-ray2.30A27-268[»]
3N3HX-ray2.00A27-268[»]
ProteinModelPortaliP16404.
SMRiP16404.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

UniCarbKBiP16404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP16404.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEC_ERYCO
AccessioniPrimary (citable) accession number: P16404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.