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Protein

Histone H1.2

Gene

HIST1H1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-211227. Activation of DNA fragmentation factor.
R-HSA-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.2
Alternative name(s):
Histone H1c
Histone H1d
Histone H1s-1
Gene namesi
Name:HIST1H1C
Synonyms:H1F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4716. HIST1H1C.

Subcellular locationi

  • Nucleus
  • Chromosome

  • Note: Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.

GO - Cellular componenti

  • nuclear euchromatin Source: UniProtKB
  • nucleosome Source: InterPro
  • nucleus Source: UniProtKB
  • transcriptionally active chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi187 – 1871K → R: Abolishes methylation. 1 Publication

Organism-specific databases

PharmGKBiPA29094.

Polymorphism and mutation databases

BioMutaiHIST1H1C.
DMDMi417101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources3 Publications
Chaini2 – 213212Histone H1.2PRO_0000195906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine; partialCombined sources2 Publications
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
Cross-linki17 – 17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residuei26 – 261N6-acetyllysine; alternateBy similarity
Modified residuei26 – 261N6-methyllysine; alternateBy similarity
Modified residuei34 – 341N6-crotonyllysine; alternate1 Publication
Modified residuei34 – 341N6-methyllysine; alternate1 Publication
Modified residuei34 – 341N6-succinyllysine; alternateBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei46 – 461N6-acetyllysineBy similarity
Modified residuei54 – 541CitrullineBy similarity
Modified residuei64 – 641N6-crotonyllysine1 Publication
Modified residuei75 – 751N6-acetyllysineBy similarity
Modified residuei85 – 851N6-crotonyllysine1 Publication
Modified residuei90 – 901N6-acetyllysine; alternateBy similarity
Modified residuei90 – 901N6-crotonyllysine; alternate1 Publication
Modified residuei97 – 971N6-crotonyllysine; alternate1 Publication
Modified residuei97 – 971N6-succinyllysine; alternateBy similarity
Modified residuei104 – 1041Phosphoserine; by PKCBy similarity
Modified residuei146 – 1461PhosphothreonineCombined sources
Modified residuei154 – 1541PhosphothreonineBy similarity
Modified residuei159 – 1591N6-crotonyllysine1 Publication
Modified residuei168 – 1681N6-acetyllysine; alternateBy similarity
Modified residuei168 – 1681N6-crotonyllysine; alternate1 Publication
Modified residuei173 – 1731PhosphoserineBy similarity
Modified residuei187 – 1871N6-methyllysine; by EHMT1 and EHMT21 Publication
Modified residuei188 – 1881PhosphoserineBy similarity
Cross-linki206 – 206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP16403.
MaxQBiP16403.
PaxDbiP16403.
PeptideAtlasiP16403.
PRIDEiP16403.
TopDownProteomicsiP16403.

PTM databases

iPTMnetiP16403.
PhosphoSiteiP16403.
SwissPalmiP16403.

Expressioni

Gene expression databases

BgeeiENSG00000187837.
CleanExiHS_HIST1H1C.
GenevisibleiP16403. HS.

Organism-specific databases

HPAiCAB011507.

Interactioni

Protein-protein interaction databases

BioGridi109261. 95 interactions.
DIPiDIP-36359N.
IntActiP16403. 27 interactions.
MINTiMINT-1149485.
STRINGi9606.ENSP00000339566.

Structurei

3D structure databases

ProteinModelPortaliP16403.
SMRiP16403. Positions 36-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10974H15PROSITE-ProRule annotationAdd
BLAST

Domaini

The C-terminal domain is required for high-affinity binding to chromatin.By similarity

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiP16403.
KOiK11275.
OMAiMSETAPX.
OrthoDBiEOG091G0XGD.
PhylomeDBiP16403.
TreeFamiTF313664.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA
60 70 80 90 100
SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG
110 120 130 140 150
ASGSFKLNKK AASGEAKPKV KKAGGTKPKK PVGAAKKPKK AAGGATPKKS
160 170 180 190 200
AKKTPKKAKK PAAATVTKKV AKSPKKAKVA KPKKAAKSAA KAVKPKAAKP
210
KVVKPKKAAP KKK
Length:213
Mass (Da):21,365
Last modified:January 23, 2007 - v2
Checksum:iAA66EA1901D8D56B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181A → V.
Corresponds to variant rs2230653 [ dbSNP | Ensembl ].
VAR_003618
Natural varianti113 – 1131S → A.
Corresponds to variant rs34810376 [ dbSNP | Ensembl ].
VAR_049304
Natural varianti124 – 1241G → A.
Corresponds to variant rs12111009 [ dbSNP | Ensembl ].
VAR_049305

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57129 Genomic DNA. Translation: CAA40408.1.
AF531300 Genomic DNA. Translation: AAN06700.1.
AK290947 mRNA. Translation: BAF83636.1.
AB451259 mRNA. Translation: BAG70073.1.
AB451385 mRNA. Translation: BAG70199.1.
U91328 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55515.1.
BC002649 mRNA. No translation available.
CCDSiCCDS4577.1.
PIRiS26364. HSHU11.
RefSeqiNP_005310.1. NM_005319.3.
UniGeneiHs.7644.

Genome annotation databases

EnsembliENST00000343677; ENSP00000339566; ENSG00000187837.
GeneIDi3006.
KEGGihsa:3006.
UCSCiuc003nfw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57129 Genomic DNA. Translation: CAA40408.1.
AF531300 Genomic DNA. Translation: AAN06700.1.
AK290947 mRNA. Translation: BAF83636.1.
AB451259 mRNA. Translation: BAG70073.1.
AB451385 mRNA. Translation: BAG70199.1.
U91328 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55515.1.
BC002649 mRNA. No translation available.
CCDSiCCDS4577.1.
PIRiS26364. HSHU11.
RefSeqiNP_005310.1. NM_005319.3.
UniGeneiHs.7644.

3D structure databases

ProteinModelPortaliP16403.
SMRiP16403. Positions 36-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109261. 95 interactions.
DIPiDIP-36359N.
IntActiP16403. 27 interactions.
MINTiMINT-1149485.
STRINGi9606.ENSP00000339566.

PTM databases

iPTMnetiP16403.
PhosphoSiteiP16403.
SwissPalmiP16403.

Polymorphism and mutation databases

BioMutaiHIST1H1C.
DMDMi417101.

Proteomic databases

EPDiP16403.
MaxQBiP16403.
PaxDbiP16403.
PeptideAtlasiP16403.
PRIDEiP16403.
TopDownProteomicsiP16403.

Protocols and materials databases

DNASUi3006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343677; ENSP00000339566; ENSG00000187837.
GeneIDi3006.
KEGGihsa:3006.
UCSCiuc003nfw.4. human.

Organism-specific databases

CTDi3006.
GeneCardsiHIST1H1C.
HGNCiHGNC:4716. HIST1H1C.
HPAiCAB011507.
MIMi142710. gene.
neXtProtiNX_P16403.
PharmGKBiPA29094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00670000097781.
HOGENOMiHOG000251627.
HOVERGENiHBG009035.
InParanoidiP16403.
KOiK11275.
OMAiMSETAPX.
OrthoDBiEOG091G0XGD.
PhylomeDBiP16403.
TreeFamiTF313664.

Enzyme and pathway databases

ReactomeiR-HSA-211227. Activation of DNA fragmentation factor.
R-HSA-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Miscellaneous databases

ChiTaRSiHIST1H1C. human.
GeneWikiiHIST1H1C.
GenomeRNAii3006.
PROiP16403.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187837.
CleanExiHS_HIST1H1C.
GenevisibleiP16403. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH12_HUMAN
AccessioniPrimary (citable) accession number: P16403
Secondary accession number(s): A8K4I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.