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Protein

RT1 class I histocompatibility antigen, AA alpha chain

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
RT1 class I histocompatibility antigen, AA alpha chain
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 311ExtracellularSequence analysisAdd BLAST287
Transmembranei312 – 336HelicalSequence analysisAdd BLAST25
Topological domaini337 – 371CytoplasmicAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001894425 – 371RT1 class I histocompatibility antigen, AA alpha chainAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Modified residuei362PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP16391.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Protein-protein interaction databases

MINTiMINT-253310.

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 36Combined sources11
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 128Combined sources11
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 162Combined sources6
Helixi163 – 173Combined sources11
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi221 – 235Combined sources15
Beta strandi238 – 243Combined sources6
Turni248 – 251Combined sources4
Beta strandi261 – 263Combined sources3
Beta strandi265 – 273Combined sources9
Helixi278 – 280Combined sources3
Beta strandi281 – 285Combined sources5
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55A/D25-299[»]
1KJMX-ray2.35A25-300[»]
ProteinModelPortaliP16391.
SMRiP16391.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 311Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMAPRTLL LLLAAALAPT QTRAGSHSLR YFYTAVSRPG LGEPRFIAVG
60 70 80 90 100
YVDDTEFVRF DSDAENPRME PRARWMEREG PEYWEQQTRI AKEWEQIYRV
110 120 130 140 150
DLRTLRGYYN QSEGGSHTIQ EMYGCDVGSD GSLLRGYRQD AYDGRDYIAL
160 170 180 190 200
NEDLKTWTAA DFAAQITRNK WERARYAERL RAYLEGTCVE WLSRYLELGK
210 220 230 240 250
ETLLRSDPPE AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ
260 270 280 290 300
DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PKPLSQRWEP
310 320 330 340 350
SPSTDSNMET TVIYVILGAV AMIGAVAIIG AMVAVVRRRK RNTGGKGGDY
360 370
APAPGRDSSQ SSDVSLPDCK A
Length:371
Mass (Da):41,830
Last modified:July 15, 1998 - v2
Checksum:i79C162463E1746D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31018 mRNA. Translation: AAB49324.1.
PIRiA35090.
UniGeneiRn.116785.
Rn.116787.
Rn.128939.
Rn.145377.
Rn.217243.
Rn.219012.
Rn.222446.
Rn.228833.
Rn.233151.
Rn.40130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31018 mRNA. Translation: AAB49324.1.
PIRiA35090.
UniGeneiRn.116785.
Rn.116787.
Rn.128939.
Rn.145377.
Rn.217243.
Rn.219012.
Rn.222446.
Rn.228833.
Rn.233151.
Rn.40130.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55A/D25-299[»]
1KJMX-ray2.35A25-300[»]
ProteinModelPortaliP16391.
SMRiP16391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-253310.

Proteomic databases

PRIDEiP16391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG016709.

Miscellaneous databases

EvolutionaryTraceiP16391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA12_RAT
AccessioniPrimary (citable) accession number: P16391
Secondary accession number(s): O02940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.