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P16390

- KCNA3_MOUSE

UniProt

P16390 - KCNA3_MOUSE

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Protein
Potassium voltage-gated channel subfamily A member 3
Gene
Kcna3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. outward rectifier potassium channel activity Source: Ensembl

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
MK3
Voltage-gated potassium channel subunit Kv1.3
Gene namesi
Name:Kcna3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96660. Kcna3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 187187Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei188 – 20619Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini207 – 24741Extracellular Reviewed prediction
Add
BLAST
Transmembranei248 – 26922Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini270 – 28011Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei281 – 30121Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini302 – 31514Extracellular Reviewed prediction
Add
BLAST
Transmembranei316 – 33419Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini335 – 35016Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei351 – 37020Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini371 – 41141Extracellular Reviewed prediction
Add
BLAST
Transmembranei412 – 43423Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini435 – 52894Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Potassium voltage-gated channel subfamily A member 3
PRO_0000053978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction
Lipidationi270 – 2701S-palmitoyl cysteine Reviewed prediction
Modified residuei473 – 4731Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

N-glycosylation promotes the cell surface expression By similarity.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP16390.
PRIDEiP16390.

PTM databases

PhosphoSiteiP16390.

Expressioni

Gene expression databases

BgeeiP16390.
GenevestigatoriP16390.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG4 By similarity.

Protein-protein interaction databases

IntActiP16390. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP16390.
SMRiP16390. Positions 57-444.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi397 – 4026Selectivity filter By similarity
Motifi526 – 5283PDZ-binding By similarity

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115256.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiA3KMM2.
KOiK04876.
OMAiKRRMRYF.
OrthoDBiEOG7M0NRD.
PhylomeDBiP16390.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004050. K_chnl_volt-dep_Kv1.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01510. KV13CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P16390-1 [UniParc]FASTAAdd to Basket

« Hide

MTVVPGDHLL EPEAAGGGGG DPPQGGCGSG GGGGGCDRYE PLPPALPAAG    50
EQDCCGERVV INISGLRFET QLKTLCQFPE TLLGDPKRRM RYFDPLRNEY 100
FFDRNRPSFD AILYYYQSGG RIRRPVNVPI DIFSEEIRFY QLGEEAMEKF 150
REDEGFLREE ERPLPRRDFQ RQVWLLFEYP ESSGPARGIA IVSVLVILIS 200
IVIFCLETLP EFRDEKDYPA SPSQDVFEAA NNSTSGAPSG ASSFSDPFFV 250
VETLCIIWFS FELLVRFFAC PSKATFSRNI MNLIDIVAII PYFITLGTEL 300
AERQGNGQQA MSLAILRVIR LVRVFRIFKL SRHSKGLQIL GQTLKASMRE 350
LGLLIFFLFI GVILFSSAVY FAEADDPSSG FNSIPDAFWW AVVTMTTVGY 400
GDMHPVTIGG KIVGSLCAIA GVLTIALPVP VIVSNFNYFY HRETEGEEQA 450
QYMHVGSCQH LSSSAEELRK ARSNSTLSKS EYMVIEEGGM NHSAFPQTPF 500
KTGNSTATCT TNNNPNSCVN IKKIFTDV 528
Length:528
Mass (Da):58,564
Last modified:November 25, 2008 - v3
Checksum:i12AC94FB13A523E7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691V → A in AAA39716. 1 Publication
Sequence conflicti492 – 4921H → Q in AAA39716. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30441 Genomic DNA. Translation: AAA39716.1.
CH466607 Genomic DNA. Translation: EDL01888.1.
BC132349 mRNA. Translation: AAI32350.1.
BC137667 mRNA. Translation: AAI37668.1.
CCDSiCCDS17730.1.
PIRiC40090. I84205.
S09044.
RefSeqiNP_032444.2. NM_008418.2.
UniGeneiMm.30640.

Genome annotation databases

EnsembliENSMUST00000052718; ENSMUSP00000050680; ENSMUSG00000047959.
GeneIDi16491.
KEGGimmu:16491.
UCSCiuc008qwp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30441 Genomic DNA. Translation: AAA39716.1 .
CH466607 Genomic DNA. Translation: EDL01888.1 .
BC132349 mRNA. Translation: AAI32350.1 .
BC137667 mRNA. Translation: AAI37668.1 .
CCDSi CCDS17730.1.
PIRi C40090. I84205.
S09044.
RefSeqi NP_032444.2. NM_008418.2.
UniGenei Mm.30640.

3D structure databases

ProteinModelPortali P16390.
SMRi P16390. Positions 57-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P16390. 1 interaction.

Chemistry

BindingDBi P16390.
ChEMBLi CHEMBL4818.
GuidetoPHARMACOLOGYi 540.

PTM databases

PhosphoSitei P16390.

Proteomic databases

PaxDbi P16390.
PRIDEi P16390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052718 ; ENSMUSP00000050680 ; ENSMUSG00000047959 .
GeneIDi 16491.
KEGGi mmu:16491.
UCSCi uc008qwp.2. mouse.

Organism-specific databases

CTDi 3738.
MGIi MGI:96660. Kcna3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115256.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi A3KMM2.
KOi K04876.
OMAi KRRMRYF.
OrthoDBi EOG7M0NRD.
PhylomeDBi P16390.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289791.
PROi P16390.
SOURCEi Search...

Gene expression databases

Bgeei P16390.
Genevestigatori P16390.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004050. K_chnl_volt-dep_Kv1.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01510. KV13CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of three mouse potassium channel genes with intronless coding regions."
    Chandy K.G., Williams C.B., Spencer R.H., Aguilar B.A., Ghanshani S., Tempel B.L., Gutman G.A.
    Science 247:973-975(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNA3_MOUSE
AccessioniPrimary (citable) accession number: P16390
Secondary accession number(s): A3KMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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