Potassium voltage-gated channel subfamily A member 3

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P16390 (KCNA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily A member 3

Alternative name(s):
MK3
Voltage-gated potassium channel subunit Kv1.3

Gene names

Name:

Kcna3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG4 By similarity.
Subcellular location	Cell membrane By similarity; Multi-pass membrane protein.
Domain	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Post-translational modification	N-glycosylation promotes the cell surface expression By similarity.
Sequence similarities	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane raft Inferred from electronic annotation. Source: Compara voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome outward rectifier potassium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 528

528

Potassium voltage-gated channel subfamily A member 3

PRO_0000053978

Regions

Topological domain

1 – 187

187

Cytoplasmic Potential

Transmembrane

188 – 206

Helical; Name=Segment S1; Potential

Topological domain

207 – 247

Extracellular Potential

Transmembrane

248 – 269

Helical; Name=Segment S2; Potential

Topological domain

270 – 280

Cytoplasmic Potential

Transmembrane

281 – 301

Helical; Name=Segment S3; Potential

Topological domain

302 – 315

Extracellular Potential

Transmembrane

316 – 334

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

335 – 350

Cytoplasmic Potential

Transmembrane

351 – 370

Helical; Name=Segment S5; Potential

Topological domain

371 – 411

Extracellular Potential

Transmembrane

412 – 434

Helical; Name=Segment S6; Potential

Topological domain

435 – 528

Cytoplasmic Potential

Motif

397 – 402

Selectivity filter By similarity

Motif

526 – 528

PDZ-binding By similarity

Amino acid modifications

Modified residue

473

Phosphoserine; by PKA Potential

Lipidation

270

S-palmitoyl cysteine Potential

Glycosylation

232

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

369

V → A in AAA39716. Ref.1

Sequence conflict

492

H → Q in AAA39716. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P16390 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 12AC94FB13A523E7
Show »

FASTA

528

58,564

        10         20         30         40         50         60 
MTVVPGDHLL EPEAAGGGGG DPPQGGCGSG GGGGGCDRYE PLPPALPAAG EQDCCGERVV 

        70         80         90        100        110        120 
INISGLRFET QLKTLCQFPE TLLGDPKRRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG 

       130        140        150        160        170        180 
RIRRPVNVPI DIFSEEIRFY QLGEEAMEKF REDEGFLREE ERPLPRRDFQ RQVWLLFEYP 

       190        200        210        220        230        240 
ESSGPARGIA IVSVLVILIS IVIFCLETLP EFRDEKDYPA SPSQDVFEAA NNSTSGAPSG 

       250        260        270        280        290        300 
ASSFSDPFFV VETLCIIWFS FELLVRFFAC PSKATFSRNI MNLIDIVAII PYFITLGTEL 

       310        320        330        340        350        360 
AERQGNGQQA MSLAILRVIR LVRVFRIFKL SRHSKGLQIL GQTLKASMRE LGLLIFFLFI 

       370        380        390        400        410        420 
GVILFSSAVY FAEADDPSSG FNSIPDAFWW AVVTMTTVGY GDMHPVTIGG KIVGSLCAIA 

       430        440        450        460        470        480 
GVLTIALPVP VIVSNFNYFY HRETEGEEQA QYMHVGSCQH LSSSAEELRK ARSNSTLSKS 

       490        500        510        520 
EYMVIEEGGM NHSAFPQTPF KTGNSTATCT TNNNPNSCVN IKKIFTDV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of three mouse potassium channel genes with intronless coding regions." Chandy K.G., Williams C.B., Spencer R.H., Aguilar B.A., Ghanshani S., Tempel B.L., Gutman G.A. Science 247:973-975(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M30441 Genomic DNA. Translation: AAA39716.1. CH466607 Genomic DNA. Translation: EDL01888.1. BC132349 mRNA. Translation: AAI32350.1. BC137667 mRNA. Translation: AAI37668.1.
IPI	IPI00133732.
PIR	I84205. C40090. S09044.
RefSeq	NP_032444.2. NM_008418.2.
UniGene	Mm.30640.
3D structure databases
ProteinModelPortal	P16390.
SMR	P16390. Positions 57-444.
ModBase	Search...
Protein-protein interaction databases
IntAct	P16390. 1 interaction.
PTM databases
PhosphoSite	P16390.
Proteomic databases
PaxDb	P16390.
PRIDE	P16390.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052718; ENSMUSP00000050680; ENSMUSG00000047959.
GeneID	16491.
KEGG	mmu:16491.
UCSC	uc008qwp.2. mouse.
Organism-specific databases
CTD	3738.
MGI	MGI:96660. Kcna3.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00560000076957.
HOGENOM	HOG000231015.
HOVERGEN	HBG052230.
InParanoid	A3KMM2.
KO	K04876.
OMA	CDRYEPL.
OrthoDB	EOG4QC155.
Gene expression databases
Bgee	P16390.
Genevestigator	P16390.
GermOnline	ENSMUSG00000047959. Mus musculus.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR004050. K_chnl_volt-dep_Kv1.3. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01510. KV13CHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
BindingDB	P16390.
ChEMBL	CHEMBL4818.
NextBio	289791.
SOURCE	Search...

Entry information

Entry name

KCNA3_MOUSE

Accession

Primary (citable) accession number: P16390
Secondary accession number(s): A3KMM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents