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P16390 (KCNA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
MK3
Voltage-gated potassium channel subunit Kv1.3
Gene names
Name:Kcna3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG4 By similarity.

Subcellular location

Cell membrane By similarity; Multi-pass membrane protein.

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification

N-glycosylation promotes the cell surface expression By similarity.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Potassium voltage-gated channel subfamily A member 3
PRO_0000053978

Regions

Topological domain1 – 187187Cytoplasmic Potential
Transmembrane188 – 20619Helical; Name=Segment S1; Potential
Topological domain207 – 24741Extracellular Potential
Transmembrane248 – 26922Helical; Name=Segment S2; Potential
Topological domain270 – 28011Cytoplasmic Potential
Transmembrane281 – 30121Helical; Name=Segment S3; Potential
Topological domain302 – 31514Extracellular Potential
Transmembrane316 – 33419Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain335 – 35016Cytoplasmic Potential
Transmembrane351 – 37020Helical; Name=Segment S5; Potential
Topological domain371 – 41141Extracellular Potential
Transmembrane412 – 43423Helical; Name=Segment S6; Potential
Topological domain435 – 52894Cytoplasmic Potential
Motif397 – 4026Selectivity filter By similarity
Motif526 – 5283PDZ-binding By similarity

Amino acid modifications

Modified residue4731Phosphoserine; by PKA Potential
Lipidation2701S-palmitoyl cysteine Potential
Glycosylation2321N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3691V → A in AAA39716. Ref.1
Sequence conflict4921H → Q in AAA39716. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P16390 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 12AC94FB13A523E7

FASTA52858,564
        10         20         30         40         50         60 
MTVVPGDHLL EPEAAGGGGG DPPQGGCGSG GGGGGCDRYE PLPPALPAAG EQDCCGERVV 

        70         80         90        100        110        120 
INISGLRFET QLKTLCQFPE TLLGDPKRRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG 

       130        140        150        160        170        180 
RIRRPVNVPI DIFSEEIRFY QLGEEAMEKF REDEGFLREE ERPLPRRDFQ RQVWLLFEYP 

       190        200        210        220        230        240 
ESSGPARGIA IVSVLVILIS IVIFCLETLP EFRDEKDYPA SPSQDVFEAA NNSTSGAPSG 

       250        260        270        280        290        300 
ASSFSDPFFV VETLCIIWFS FELLVRFFAC PSKATFSRNI MNLIDIVAII PYFITLGTEL 

       310        320        330        340        350        360 
AERQGNGQQA MSLAILRVIR LVRVFRIFKL SRHSKGLQIL GQTLKASMRE LGLLIFFLFI 

       370        380        390        400        410        420 
GVILFSSAVY FAEADDPSSG FNSIPDAFWW AVVTMTTVGY GDMHPVTIGG KIVGSLCAIA 

       430        440        450        460        470        480 
GVLTIALPVP VIVSNFNYFY HRETEGEEQA QYMHVGSCQH LSSSAEELRK ARSNSTLSKS 

       490        500        510        520 
EYMVIEEGGM NHSAFPQTPF KTGNSTATCT TNNNPNSCVN IKKIFTDV 

« Hide

References

« Hide 'large scale' references
[1]"A family of three mouse potassium channel genes with intronless coding regions."
Chandy K.G., Williams C.B., Spencer R.H., Aguilar B.A., Ghanshani S., Tempel B.L., Gutman G.A.
Science 247:973-975(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30441 Genomic DNA. Translation: AAA39716.1.
CH466607 Genomic DNA. Translation: EDL01888.1.
BC132349 mRNA. Translation: AAI32350.1.
BC137667 mRNA. Translation: AAI37668.1.
CCDSCCDS17730.1.
PIRI84205. C40090.
S09044.
RefSeqNP_032444.2. NM_008418.2.
UniGeneMm.30640.

3D structure databases

ProteinModelPortalP16390.
SMRP16390. Positions 57-444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP16390. 1 interaction.

Chemistry

BindingDBP16390.
ChEMBLCHEMBL4818.
GuidetoPHARMACOLOGY540.

PTM databases

PhosphoSiteP16390.

Proteomic databases

PaxDbP16390.
PRIDEP16390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052718; ENSMUSP00000050680; ENSMUSG00000047959.
GeneID16491.
KEGGmmu:16491.
UCSCuc008qwp.2. mouse.

Organism-specific databases

CTD3738.
MGIMGI:96660. Kcna3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115256.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidA3KMM2.
KOK04876.
OMAKRRMRYF.
OrthoDBEOG7M0NRD.
PhylomeDBP16390.
TreeFamTF313103.

Gene expression databases

BgeeP16390.
GenevestigatorP16390.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004050. K_chnl_volt-dep_Kv1.3.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01510. KV13CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio289791.
PROP16390.
SOURCESearch...

Entry information

Entry nameKCNA3_MOUSE
AccessionPrimary (citable) accession number: P16390
Secondary accession number(s): A3KMM2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot