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P16389

- KCNA2_HUMAN

UniProt

P16389 - KCNA2_HUMAN

Protein

Potassium voltage-gated channel subfamily A member 2

Gene

KCNA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: ProtInc
    2. outward rectifier potassium channel activity Source: Ensembl
    3. potassium channel activity Source: ProtInc
    4. voltage-gated potassium channel activity Source: ProtInc

    GO - Biological processi

    1. optic nerve structural organization Source: Ensembl
    2. potassium ion transport Source: ProtInc
    3. protein homooligomerization Source: InterPro
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.2.10. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 2
    Alternative name(s):
    NGK1
    Voltage-gated K(+) channel HuKIV
    Voltage-gated potassium channel HBK5
    Voltage-gated potassium channel subunit Kv1.2
    Gene namesi
    Name:KCNA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6220. KCNA2.

    Subcellular locationi

    GO - Cellular componenti

    1. juxtaparanode region of axon Source: BHF-UCL
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA206.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Potassium voltage-gated channel subfamily A member 2PRO_0000053972Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Lipidationi244 – 2441S-palmitoyl cysteineSequence Analysis
    Modified residuei429 – 4291PhosphotyrosineBy similarity
    Modified residuei449 – 4491Phosphoserine; by PKASequence Analysis

    Post-translational modificationi

    Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP16389.
    PaxDbiP16389.
    PRIDEiP16389.

    PTM databases

    PhosphoSiteiP16389.

    Expressioni

    Gene expression databases

    BgeeiP16389.
    CleanExiHS_KCNA2.
    GenevestigatoriP16389.

    Organism-specific databases

    HPAiCAB001976.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109940. 16 interactions.
    STRINGi9606.ENSP00000314520.

    Structurei

    3D structure databases

    ProteinModelPortaliP16389.
    SMRiP16389. Positions 3-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei164 – 18219Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24322Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei293 – 31119Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei328 – 34720Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei389 – 41123Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi374 – 3796Selectivity filterBy similarity
    Motifi497 – 4993PDZ-bindingBy similarity

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiP16389.
    KOiK04875.
    OMAiITHVETW.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiP16389.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004049. K_chnl_volt-dep_Kv1.2.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01509. KV12CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P16389-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVATGDPAD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT    50
    LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR 100
    PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW 150
    LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGSGV 200
    TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF 250
    FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR 300
    VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE 350
    ADERESQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL 400
    TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA 450
    STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV 499
    Length:499
    Mass (Da):56,717
    Last modified:February 1, 1996 - v2
    Checksum:i4B03F1B46A826C39
    GO
    Isoform 2 (identifier: P16389-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         299-499: VRVFRIFKLS...VNITKMLTDV → ERRPLQSQKS...PAVTTLHRMY

    Note: No experimental confirmation available.

    Show »
    Length:356
    Mass (Da):40,966
    Checksum:i9917ABBFCCCF7411
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei299 – 499201VRVFR…MLTDV → ERRPLQSQKSKRGRQHLNTS HDCTLGINLVAGMTVQWTRA SGPDDRQTPAVTTLHRMY in isoform 2. 1 PublicationVSP_043077Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02752 mRNA. Translation: AAA36141.1.
    AL365361 Genomic DNA. Translation: CAH71982.1.
    BC043564 mRNA. Translation: AAH43564.1.
    CCDSiCCDS55625.1. [P16389-2]
    CCDS827.1. [P16389-1]
    PIRiI77466.
    RefSeqiNP_001191198.1. NM_001204269.1. [P16389-2]
    NP_004965.1. NM_004974.3. [P16389-1]
    UniGeneiHs.248139.
    Hs.657199.
    Hs.731191.

    Genome annotation databases

    EnsembliENST00000316361; ENSP00000314520; ENSG00000177301. [P16389-1]
    ENST00000369770; ENSP00000358785; ENSG00000177301. [P16389-2]
    ENST00000485317; ENSP00000433109; ENSG00000177301. [P16389-1]
    GeneIDi3737.
    KEGGihsa:3737.
    UCSCiuc009wfv.2. human. [P16389-2]
    uc009wfw.3. human. [P16389-1]

    Polymorphism databases

    DMDMi1345813.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02752 mRNA. Translation: AAA36141.1 .
    AL365361 Genomic DNA. Translation: CAH71982.1 .
    BC043564 mRNA. Translation: AAH43564.1 .
    CCDSi CCDS55625.1. [P16389-2 ]
    CCDS827.1. [P16389-1 ]
    PIRi I77466.
    RefSeqi NP_001191198.1. NM_001204269.1. [P16389-2 ]
    NP_004965.1. NM_004974.3. [P16389-1 ]
    UniGenei Hs.248139.
    Hs.657199.
    Hs.731191.

    3D structure databases

    ProteinModelPortali P16389.
    SMRi P16389. Positions 3-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109940. 16 interactions.
    STRINGi 9606.ENSP00000314520.

    Chemistry

    BindingDBi P16389.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 539.

    Protein family/group databases

    TCDBi 1.A.1.2.10. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei P16389.

    Polymorphism databases

    DMDMi 1345813.

    Proteomic databases

    MaxQBi P16389.
    PaxDbi P16389.
    PRIDEi P16389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316361 ; ENSP00000314520 ; ENSG00000177301 . [P16389-1 ]
    ENST00000369770 ; ENSP00000358785 ; ENSG00000177301 . [P16389-2 ]
    ENST00000485317 ; ENSP00000433109 ; ENSG00000177301 . [P16389-1 ]
    GeneIDi 3737.
    KEGGi hsa:3737.
    UCSCi uc009wfv.2. human. [P16389-2 ]
    uc009wfw.3. human. [P16389-1 ]

    Organism-specific databases

    CTDi 3737.
    GeneCardsi GC01M111137.
    HGNCi HGNC:6220. KCNA2.
    HPAi CAB001976.
    MIMi 176262. gene.
    neXtProti NX_P16389.
    PharmGKBi PA206.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi P16389.
    KOi K04875.
    OMAi ITHVETW.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi P16389.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNA2.
    GenomeRNAii 3737.
    NextBioi 14627.
    PROi P16389.
    SOURCEi Search...

    Gene expression databases

    Bgeei P16389.
    CleanExi HS_KCNA2.
    Genevestigatori P16389.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004049. K_chnl_volt-dep_Kv1.2.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01509. KV12CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human potassium channel genes: molecular cloning and functional expression."
      Ramaswami M., Gautam M., Kamb A., Rudy B., Tanouye M.A., Mathew M.K.
      Mol. Cell. Neurosci. 1:214-223(1990)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Blood.

    Entry informationi

    Entry nameiKCNA2_HUMAN
    AccessioniPrimary (citable) accession number: P16389
    Secondary accession number(s): Q86XG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3