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P16389

- KCNA2_HUMAN

UniProt

P16389 - KCNA2_HUMAN

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Protein

Potassium voltage-gated channel subfamily A member 2

Gene

KCNA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: ProtInc
  2. outward rectifier potassium channel activity Source: Ensembl
  3. potassium channel activity Source: ProtInc
  4. voltage-gated potassium channel activity Source: ProtInc

GO - Biological processi

  1. optic nerve structural organization Source: Ensembl
  2. potassium ion transport Source: ProtInc
  3. protein homooligomerization Source: InterPro
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.10. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 2
Alternative name(s):
NGK1
Voltage-gated K(+) channel HuKIV
Voltage-gated potassium channel HBK5
Voltage-gated potassium channel subunit Kv1.2
Gene namesi
Name:KCNA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6220. KCNA2.

Subcellular locationi

GO - Cellular componenti

  1. juxtaparanode region of axon Source: BHF-UCL
  2. plasma membrane Source: Reactome
  3. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Potassium voltage-gated channel subfamily A member 2PRO_0000053972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Lipidationi244 – 2441S-palmitoyl cysteineSequence Analysis
Modified residuei429 – 4291PhosphotyrosineBy similarity
Modified residuei449 – 4491Phosphoserine; by PKASequence Analysis

Post-translational modificationi

Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP16389.
PaxDbiP16389.
PRIDEiP16389.

PTM databases

PhosphoSiteiP16389.

Expressioni

Gene expression databases

BgeeiP16389.
CleanExiHS_KCNA2.
GenevestigatoriP16389.

Organism-specific databases

HPAiCAB001976.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi109940. 16 interactions.
STRINGi9606.ENSP00000314520.

Structurei

3D structure databases

ProteinModelPortaliP16389.
SMRiP16389. Positions 3-421.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei164 – 18219Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei222 – 24322Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei293 – 31119Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei328 – 34720Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei389 – 41123Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi374 – 3796Selectivity filterBy similarity
Motifi497 – 4993PDZ-bindingBy similarity

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP16389.
KOiK04875.
OMAiITHVETW.
OrthoDBiEOG7M0NRD.
PhylomeDBiP16389.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004049. K_chnl_volt-dep_Kv1.2.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01509. KV12CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P16389-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVATGDPAD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT
60 70 80 90 100
LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR
110 120 130 140 150
PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW
160 170 180 190 200
LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGSGV
210 220 230 240 250
TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF
260 270 280 290 300
FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR
310 320 330 340 350
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE
360 370 380 390 400
ADERESQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL
410 420 430 440 450
TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA
460 470 480 490
STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV
Length:499
Mass (Da):56,717
Last modified:February 1, 1996 - v2
Checksum:i4B03F1B46A826C39
GO
Isoform 2 (identifier: P16389-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-499: VRVFRIFKLS...VNITKMLTDV → ERRPLQSQKS...PAVTTLHRMY

Note: No experimental confirmation available.

Show »
Length:356
Mass (Da):40,966
Checksum:i9917ABBFCCCF7411
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei299 – 499201VRVFR…MLTDV → ERRPLQSQKSKRGRQHLNTS HDCTLGINLVAGMTVQWTRA SGPDDRQTPAVTTLHRMY in isoform 2. 1 PublicationVSP_043077Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02752 mRNA. Translation: AAA36141.1.
AL365361 Genomic DNA. Translation: CAH71982.1.
BC043564 mRNA. Translation: AAH43564.1.
CCDSiCCDS55625.1. [P16389-2]
CCDS827.1. [P16389-1]
PIRiI77466.
RefSeqiNP_001191198.1. NM_001204269.1. [P16389-2]
NP_004965.1. NM_004974.3. [P16389-1]
UniGeneiHs.248139.
Hs.657199.
Hs.731191.

Genome annotation databases

EnsembliENST00000316361; ENSP00000314520; ENSG00000177301. [P16389-1]
ENST00000369770; ENSP00000358785; ENSG00000177301. [P16389-2]
ENST00000485317; ENSP00000433109; ENSG00000177301. [P16389-1]
GeneIDi3737.
KEGGihsa:3737.
UCSCiuc009wfv.2. human. [P16389-2]
uc009wfw.3. human. [P16389-1]

Polymorphism databases

DMDMi1345813.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02752 mRNA. Translation: AAA36141.1 .
AL365361 Genomic DNA. Translation: CAH71982.1 .
BC043564 mRNA. Translation: AAH43564.1 .
CCDSi CCDS55625.1. [P16389-2 ]
CCDS827.1. [P16389-1 ]
PIRi I77466.
RefSeqi NP_001191198.1. NM_001204269.1. [P16389-2 ]
NP_004965.1. NM_004974.3. [P16389-1 ]
UniGenei Hs.248139.
Hs.657199.
Hs.731191.

3D structure databases

ProteinModelPortali P16389.
SMRi P16389. Positions 3-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109940. 16 interactions.
STRINGi 9606.ENSP00000314520.

Chemistry

BindingDBi P16389.
ChEMBLi CHEMBL2086.
DrugBanki DB06637. Dalfampridine.
GuidetoPHARMACOLOGYi 539.

Protein family/group databases

TCDBi 1.A.1.2.10. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei P16389.

Polymorphism databases

DMDMi 1345813.

Proteomic databases

MaxQBi P16389.
PaxDbi P16389.
PRIDEi P16389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316361 ; ENSP00000314520 ; ENSG00000177301 . [P16389-1 ]
ENST00000369770 ; ENSP00000358785 ; ENSG00000177301 . [P16389-2 ]
ENST00000485317 ; ENSP00000433109 ; ENSG00000177301 . [P16389-1 ]
GeneIDi 3737.
KEGGi hsa:3737.
UCSCi uc009wfv.2. human. [P16389-2 ]
uc009wfw.3. human. [P16389-1 ]

Organism-specific databases

CTDi 3737.
GeneCardsi GC01M111137.
HGNCi HGNC:6220. KCNA2.
HPAi CAB001976.
MIMi 176262. gene.
neXtProti NX_P16389.
PharmGKBi PA206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi P16389.
KOi K04875.
OMAi ITHVETW.
OrthoDBi EOG7M0NRD.
PhylomeDBi P16389.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNA2.
GenomeRNAii 3737.
NextBioi 14627.
PROi P16389.
SOURCEi Search...

Gene expression databases

Bgeei P16389.
CleanExi HS_KCNA2.
Genevestigatori P16389.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004049. K_chnl_volt-dep_Kv1.2.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01509. KV12CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human potassium channel genes: molecular cloning and functional expression."
    Ramaswami M., Gautam M., Kamb A., Rudy B., Tanouye M.A., Mathew M.K.
    Mol. Cell. Neurosci. 1:214-223(1990)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.

Entry informationi

Entry nameiKCNA2_HUMAN
AccessioniPrimary (citable) accession number: P16389
Secondary accession number(s): Q86XG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3