Potassium voltage-gated channel subfamily A member 1

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P16388 (KCNA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily A member 1

Alternative name(s):
MBK1
MKI
Voltage-gated potassium channel subunit Kv1.1

Gene names

Name:

Kcna1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heterotetramer of potassium channel proteins. Binds KCNAB2 and PDZ domains of DLG1, DLG2 and DLG4 By similarity. Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Post-translational modification	Palmitoylated on Cys-243; which may be required for membrane targeting By similarity.
Sequence similarities	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. [View classification]
RNA editing	Edited at position 400. Partially edited. RNA editing varies from 35% in the frontal cortex to 75% in the spinal chord. Ref.3

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara juxtaparanode region of axon Inferred from direct assay PubMed 12963709. Source: BHF-UCL neuronal cell body Inferred from electronic annotation. Source: Compara voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 495

495

Potassium voltage-gated channel subfamily A member 1

PRO_0000053969

Regions

Transmembrane

168 – 186

Helical; Name=Segment S1; Potential

Transmembrane

221 – 242

Helical; Name=Segment S2; Potential

Transmembrane

254 – 274

Helical; Name=Segment S3; Potential

Transmembrane

290 – 309

Helical; Voltage-sensor; Name=Segment S4; Potential

Transmembrane

326 – 345

Helical; Name=Segment S5; Potential

Transmembrane

387 – 408

Helical; Name=Segment S6; Potential

Motif

372 – 377

Selectivity filter By similarity

Motif

493 – 495

PDZ-binding By similarity

Amino acid modifications

Modified residue

322

Phosphoserine; by PKA Potential

Modified residue

446

Phosphoserine; by PKA Potential

Lipidation

243

S-palmitoyl cysteine By similarity

Glycosylation

207

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

400

I → V in RNA edited version.

Sequences

Sequence

Length

Mass (Da)

Tools

P16388 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: C9249F130E943D3D
Show »

FASTA

495

56,409

        10         20         30         40         50         60 
MTVMSGENAD EASTAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET QLKTLAQFPN 

        70         80         90        100        110        120 
TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLRRPVNVPL DMFSEEIKFY 

       130        140        150        160        170        180 
ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ RQVWLLFEYP ESSGPARVIA IVSVMVILIS 

       190        200        210        220        230        240 
IVIFCLETLP ELKDDKDFTG TIHRIDNTTV IYTSNIFTDP FFIVETLCII WFSFELVVRF 

       250        260        270        280        290        300 
FACPSKTDFF KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF 

       310        320        330        340        350        360 
RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE EAESHFSSIP 

       370        380        390        400        410        420 
DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE 

       430        440        450        460        470        480 
GEEQAQLLHV SSPNLASDSD LSRRSSSTIS KSEYMEIEED MNNSIAHYRQ ANIRTGNCTT 

       490 
ADQNCVNKSK LLTDV

« Hide

References

[1]	"A family of three mouse potassium channel genes with intronless coding regions." Chandy K.G., Williams C.B., Spencer R.H., Aguilar B.A., Ghanshani S., Tempel B.L., Gutman G.A. Science 247:973-975(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of a probable potassium channel gene from mouse brain." Tempel B.L., Jan Y.N., Jan L.Y. Nature 332:837-839(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Nervous system targets of RNA editing identified by comparative genomics." Hoopengardner B., Bhalla T., Staber C., Reenan R. Science 301:832-836(2003) [PubMed] [Europe PMC] [Abstract] Cited for: RNA EDITING OF POSITION 400.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M30439 Genomic DNA. Translation: AAA39711.1. Y00305 mRNA. Translation: CAA68408.1.
IPI	IPI00133719.
PIR	A40090. S09042.
RefSeq	NP_034725.3. NM_010595.3.
UniGene	Mm.40424.
3D structure databases
ProteinModelPortal	P16388.
SMR	P16388. Positions 36-419.
ModBase	Search...
Protein-protein interaction databases
IntAct	P16388. 1 interaction.
PTM databases
PhosphoSite	P16388.
Proteomic databases
PaxDb	P16388.
PRIDE	P16388.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055168; ENSMUSP00000055225; ENSMUSG00000047976.
GeneID	16485.
KEGG	mmu:16485.
UCSC	uc009dvb.1. mouse.
Organism-specific databases
CTD	3736.
MGI	MGI:96654. Kcna1.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00560000076957.
HOGENOM	HOG000231015.
HOVERGEN	HBG052230.
InParanoid	P16388.
KO	K04874.
OMA	YPRPAEH.
OrthoDB	EOG4DR9CB.
Gene expression databases
ArrayExpress	P16388.
Bgee	P16388.
Genevestigator	P16388.
GermOnline	ENSMUSG00000047976. Mus musculus.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR004048. K_chnl_volt-dep_Kv1.1. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01508. KV11CHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	289783.
SOURCE	Search...

Entry information

Entry name

KCNA1_MOUSE

Accession

Primary (citable) accession number: P16388

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents