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P16388

- KCNA1_MOUSE

UniProt

P16388 - KCNA1_MOUSE

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Protein

Potassium voltage-gated channel subfamily A member 1

Gene

Kcna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 1
Alternative name(s):
MBK1
MKI
Voltage-gated potassium channel subunit Kv1.1
Gene namesi
Name:Kcna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96654. Kcna1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell surface Source: MGI
  3. dendrite Source: MGI
  4. juxtaparanode region of axon Source: BHF-UCL
  5. neuronal cell body Source: MGI
  6. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Potassium voltage-gated channel subfamily A member 1PRO_0000053969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Lipidationi243 – 2431S-palmitoyl cysteineBy similarity
Modified residuei322 – 3221Phosphoserine; by PKASequence Analysis
Modified residuei446 – 4461Phosphoserine; by PKASequence Analysis

Post-translational modificationi

Palmitoylated on Cys-243; which may be required for membrane targeting.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP16388.
PaxDbiP16388.
PRIDEiP16388.

PTM databases

PhosphoSiteiP16388.

Expressioni

Gene expression databases

BgeeiP16388.
ExpressionAtlasiP16388. baseline and differential.
GenevestigatoriP16388.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds KCNAB2 and PDZ domains of DLG1, DLG2 and DLG4 By similarity. Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1 By similarity.By similarity

Protein-protein interaction databases

BioGridi200876. 1 interaction.
IntActiP16388. 2 interactions.
MINTiMINT-4099639.

Structurei

3D structure databases

ProteinModelPortaliP16388.
SMRiP16388. Positions 36-419.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei168 – 18619Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei221 – 24222Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei290 – 30920Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei326 – 34520Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei387 – 40822Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi372 – 3776Selectivity filterBy similarity
Motifi493 – 4953PDZ-bindingBy similarity

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP16388.
KOiK04874.
OMAiEHDDHEC.
OrthoDBiEOG7M0NRD.
PhylomeDBiP16388.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004048. K_chnl_volt-dep_Kv1.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01508. KV11CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P16388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVMSGENAD EASTAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET
60 70 80 90 100
QLKTLAQFPN TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG
110 120 130 140 150
RLRRPVNVPL DMFSEEIKFY ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ
160 170 180 190 200
RQVWLLFEYP ESSGPARVIA IVSVMVILIS IVIFCLETLP ELKDDKDFTG
210 220 230 240 250
TIHRIDNTTV IYTSNIFTDP FFIVETLCII WFSFELVVRF FACPSKTDFF
260 270 280 290 300
KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF
310 320 330 340 350
RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE
360 370 380 390 400
EAESHFSSIP DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI
410 420 430 440 450
ALPVPVIVSN FNYFYHRETE GEEQAQLLHV SSPNLASDSD LSRRSSSTIS
460 470 480 490
KSEYMEIEED MNNSIAHYRQ ANIRTGNCTT ADQNCVNKSK LLTDV
Length:495
Mass (Da):56,409
Last modified:August 1, 1990 - v1
Checksum:iC9249F130E943D3D
GO

RNA editingi

Partially edited. RNA editing varies from 35% in the frontal cortex to 75% in the spinal chord.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti400 – 4001I → V in RNA edited version.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30439 Genomic DNA. Translation: AAA39711.1.
Y00305 mRNA. Translation: CAA68408.1.
CCDSiCCDS20555.1.
PIRiA40090.
S09042.
RefSeqiNP_034725.3. NM_010595.3.
UniGeneiMm.40424.

Genome annotation databases

EnsembliENSMUST00000055168; ENSMUSP00000055225; ENSMUSG00000047976.
GeneIDi16485.
KEGGimmu:16485.
UCSCiuc009dvb.1. mouse.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30439 Genomic DNA. Translation: AAA39711.1 .
Y00305 mRNA. Translation: CAA68408.1 .
CCDSi CCDS20555.1.
PIRi A40090.
S09042.
RefSeqi NP_034725.3. NM_010595.3.
UniGenei Mm.40424.

3D structure databases

ProteinModelPortali P16388.
SMRi P16388. Positions 36-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200876. 1 interaction.
IntActi P16388. 2 interactions.
MINTi MINT-4099639.

Chemistry

ChEMBLi CHEMBL2429705.
GuidetoPHARMACOLOGYi 538.

PTM databases

PhosphoSitei P16388.

Proteomic databases

MaxQBi P16388.
PaxDbi P16388.
PRIDEi P16388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055168 ; ENSMUSP00000055225 ; ENSMUSG00000047976 .
GeneIDi 16485.
KEGGi mmu:16485.
UCSCi uc009dvb.1. mouse.

Organism-specific databases

CTDi 3736.
MGIi MGI:96654. Kcna1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi P16388.
KOi K04874.
OMAi EHDDHEC.
OrthoDBi EOG7M0NRD.
PhylomeDBi P16388.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289783.
PROi P16388.
SOURCEi Search...

Gene expression databases

Bgeei P16388.
ExpressionAtlasi P16388. baseline and differential.
Genevestigatori P16388.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004048. K_chnl_volt-dep_Kv1.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01508. KV11CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of three mouse potassium channel genes with intronless coding regions."
    Chandy K.G., Williams C.B., Spencer R.H., Aguilar B.A., Ghanshani S., Tempel B.L., Gutman G.A.
    Science 247:973-975(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of a probable potassium channel gene from mouse brain."
    Tempel B.L., Jan Y.N., Jan L.Y.
    Nature 332:837-839(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Nervous system targets of RNA editing identified by comparative genomics."
    Hoopengardner B., Bhalla T., Staber C., Reenan R.
    Science 301:832-836(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITION 400.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKCNA1_MOUSE
AccessioniPrimary (citable) accession number: P16388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3