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Protein

Putative ATP-dependent RNA helicase Pl10

Gene

D1Pas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 206ATPPROSITE-ProRule annotation8
Nucleotide bindingi223 – 230ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Helicase, Hydrolase, RNA-binding
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase Pl10 (EC:3.6.4.13)
Gene namesi
Name:D1Pas1
Synonyms:Pl10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:91842 D1Pas1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000550082 – 660Putative ATP-dependent RNA helicase Pl10Add BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei100Omega-N-methylarginineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei103PhosphotyrosineBy similarity1
Modified residuei109Omega-N-methylarginineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei455PhosphoserineBy similarity1
Modified residuei590Omega-N-methylarginineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei603PhosphoserineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei615Omega-N-methylarginineBy similarity1
Modified residuei630Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP16381
PaxDbiP16381
PRIDEiP16381

PTM databases

iPTMnetiP16381
PhosphoSitePlusiP16381

Expressioni

Tissue specificityi

Testis.

Developmental stagei

High levels of PL10 during the meiotic and haploid stages of spermatogenesis.

Gene expression databases

BgeeiENSMUSG00000039224
CleanExiMM_D1PAS1
ExpressionAtlasiP16381 baseline and differential
GenevisibleiP16381 MM

Interactioni

Protein-protein interaction databases

BioGridi226052, 3 interactors
IntActiP16381, 2 interactors
STRINGi10090.ENSMUSP00000035261

Structurei

3D structure databases

ProteinModelPortaliP16381
SMRiP16381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 402Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST193
Domaini413 – 574Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 207Q motifAdd BLAST29
Motifi346 – 349DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi581 – 660Gly/Ser-richAdd BLAST80

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0335 Eukaryota
ENOG410XNTI LUCA
GeneTreeiENSGT00900000140933
HOGENOMiHOG000268804
HOVERGENiHBG015893
InParanoidiP16381
KOiK11594
OMAiGPDWWGQ
OrthoDBiEOG091G04U3
PhylomeDBiP16381
TreeFamiTF300364

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHVAEEDEL GLDQQLAGLD LTSRDSQSGG STASKGRYIP PHLRNREAAK
60 70 80 90 100
AFYDKDGSRW SKDKDAYSSF GSRSDTRAKS SFFSDRGGSG SRGRFDERGR
110 120 130 140 150
SDYESVGSRG GRSGFGKFER GGNSRWCDKA DEDDWSKPLP PSERLEQELF
160 170 180 190 200
SGGNTGINFE KYDDIPVEAT GNNCPPHIES FSDVEMGEII MGNIELTRYT
210 220 230 240 250
RPTPVQKHAI PIIKEKRDLM ACAQTGSGKT AAFLLPILSQ IYTDGPGEAL
260 270 280 290 300
RAMKENGKYG RRKQYPISLV LAPTRELAVQ IYEEARKFSY RSRVRPCVVY
310 320 330 340 350
GGADIGQQIR DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR
360 370 380 390 400
MLDMGFEPQI RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI
410 420 430 440 450
FLAVGRVGST SENITQKVVW VEEADKRSFL LDLLNATGKD SLILVFVETK
460 470 480 490 500
KGADSLEDFL YHEGYACTSI HGDRSQRDRE EALHQFRSGK SPILVATAVA
510 520 530 540 550
ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA TSFFNERNIN
560 570 580 590 600
ITKDLLDLLV EAKQEVPSWL ENMAFEHHYK GGSRGRSKSR FSGGFGARDY
610 620 630 640 650
RQSSGASSSS FSSGRASNSR SGGGSHGSSR GFGGGSYGGF YNSDGYGGNY
660
SSQGVDWWGN
Length:660
Mass (Da):73,141
Last modified:August 1, 1990 - v1
Checksum:i50AD4E6A131AE603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04847 mRNA Translation: AAA39942.1
AK029542 mRNA Translation: BAC26505.1
CCDSiCCDS15603.1
PIRiA32378
RefSeqiNP_149068.1, NM_033077.3
UniGeneiMm.108054
Mm.487201

Genome annotation databases

EnsembliENSMUST00000045108; ENSMUSP00000035261; ENSMUSG00000039224
GeneIDi110957
KEGGimmu:110957
UCSCiuc007dzs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDDX3L_MOUSE
AccessioniPrimary (citable) accession number: P16381
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health