P16372 (ZFP58_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 58
Short name=Zfp-58

Alternative name(s):
Regulator of sex-limitation candidate 5
Zinc finger protein Mfg-1

Gene names

Name:	Zfp58
Synonyms:	Mfg-1, Rslcan5, Zfp817

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a role during differentiation processes. Ref.5
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in liver, testis and, at considerably lower levels, in brain, spleen and heart. Ref.5
Developmental stage	Expression increases upon differentiation and is not related to the cell cycle. Ref.5
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAH61200.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Zinc finger protein 58		PRO_0000047302
Regions
	Domain	2 – 73	72	KRAB
	Zinc finger	78 – 100	23	C2H2-type 1; degenerate
	Zinc finger	106 – 128	23	C2H2-type 2
	Zinc finger	134 – 156	23	C2H2-type 3
	Zinc finger	162 – 184	23	C2H2-type 4
	Zinc finger	190 – 212	23	C2H2-type 5
	Zinc finger	218 – 240	23	C2H2-type 6
	Zinc finger	246 – 268	23	C2H2-type 7
	Zinc finger	274 – 296	23	C2H2-type 8
	Zinc finger	302 – 324	23	C2H2-type 9
	Zinc finger	330 – 352	23	C2H2-type 10
	Zinc finger	358 – 380	23	C2H2-type 11
	Zinc finger	386 – 408	23	C2H2-type 12
	Zinc finger	410 – 432	23	C2H2-type 13
	Zinc finger	438 – 460	23	C2H2-type 14
	Zinc finger	466 – 488	23	C2H2-type 15
Experimental info
	Sequence conflict	190	1	Y → YKCEECGKAFSTSSNLSEHK RIHTGEKPI in AAA39531. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P16372 [UniParc]. Last modified April 20, 2010. Version 2. Checksum: 32A9FFF460AEE061	FASTA	489	57,232
	10 20 30 40 50 60 MLSFWDVAID FSPEERECLE PDQWDLYRDV MLENYSHLDF LGLALSKPFL VTFLEQRQGP 70 80 90 100 110 120 WDVKRQAAAA VHPGKTVNKC KDFSKAFFCK SLLTQHQRIR TGEKAFKCEE CGKAFNNRSN 130 140 150 160 170 180 LSEHKRIHTG EKPYKCEECG KAFRIRSKLS THQRVHTGEK PYKCEECGKA FNSHSNLSEH 190 200 210 220 230 240 KRIHTGEKPY KCEECGKAFS TRSTYYRHQK NHTGKKPYKC EECAKEFSYP SLLKVHQRIH 250 260 270 280 290 300 SAEKSYKCEE CGKPFYCPLL LKKHQIIHSA EKPYKCAECG KAFHYPSLLK RHQRIHAGKK 310 320 330 340 350 360 PCKCKDCDRA FYSSAFLKRH QRIHSEENSY KCGECGKRFC SFPHLQYHQR FHSGEKPYKC 370 380 390 400 410 420 EQCGKTFSTL SYLPWHKLRH SGEKSYKCEK CGKMFYSTLD LKKHQKIHEY KCGECHYGFP 430 440 450 460 470 480 NYAALTAHQR VHTGEKPHVC EQCGKDFSRI DSLNQHQLVH TGEKPYKCEK CGKCFYRSSS LKRHQGIHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression." Krebs C.J., Larkins L.K., Price R., Tullis K.M., Miller R.D., Robins D.M. Genes Dev. 17:2664-2674(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Aorta, Egg, Placenta and Vein.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Mouse genes coding for 'zinc-finger'-containing proteins: characterization and expression in differentiated cells." Passananti C., Felsani A., Caruso M., Amati P. Proc. Natl. Acad. Sci. U.S.A. 86:9417-9421(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-239, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BK001635 mRNA. Translation: DAA01860.1. AK041250 mRNA. Translation: BAC30880.1. AK162259 mRNA. Translation: BAE36821.1. AK167399 mRNA. Translation: BAE39488.1. CH466661 Genomic DNA. Translation: EDL10303.1. CH466661 Genomic DNA. Translation: EDL10304.1. BC061200 mRNA. Translation: AAH61200.1. Sequence problems. BC139150 mRNA. Translation: AAI39151.1. BC139151 mRNA. Translation: AAI39152.1. M28513 mRNA. Translation: AAA39531.1.
IPI	IPI00133683.
PIR	A39240.
RefSeq	NP_001007576.1. NM_001007575.2.
UniGene	Mm.478914.
3D structure databases
HSSP	HSSP built from PDB template 1UN6 based on UniProtKB P03001.
ProteinModelPortal	P16372.
SMR	P16372. Positions 79-489.
ModBase	Search...
Proteomic databases
PRIDE	P16372.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076123; ENSMUSP00000075487; ENSMUSG00000071291. ENSMUST00000171518; ENSMUSP00000132285; ENSMUSG00000071291.
GeneID	238693.
KEGG	mmu:238693.
UCSC	uc007rax.2. mouse.
Organism-specific databases
CTD	238693.
MGI	MGI:99205. Zfp58.
Phylogenomic databases
GeneTree	ENSGT00550000074383.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8BRV1.
KO	K09228.
OMA	HSHFTQD.
OrthoDB	EOG4ZW59K.
Gene expression databases
ArrayExpress	P16372.
Bgee	P16372.
CleanEx	MM_ZFP58.
Genevestigator	P16372.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 14 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	383868.
SOURCE	Search...

Entry information

Entry name

ZFP58_MOUSE

Accession

Primary (citable) accession number: P16372
Secondary accession number(s): Q3TS54 , Q6P8L3, Q7M6X1, Q8BRV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program